Amino acid dipepetide frequency for Pseudacidovorax intermedius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.965AlaAla: 21.965 ± 0.211	1.314AlaCys: 1.314 ± 0.034	7.693AlaAsp: 7.693 ± 0.095	7.33AlaGlu: 7.33 ± 0.103	4.318AlaPhe: 4.318 ± 0.067	13.089AlaGly: 13.089 ± 0.176	2.966AlaHis: 2.966 ± 0.047	5.146AlaIle: 5.146 ± 0.065	3.234AlaLys: 3.234 ± 0.06	16.291AlaLeu: 16.291 ± 0.121	3.667AlaMet: 3.667 ± 0.052	2.817AlaAsn: 2.817 ± 0.093	7.617AlaPro: 7.617 ± 0.104	6.402AlaGln: 6.402 ± 0.08	10.657AlaArg: 10.657 ± 0.138	6.607AlaSer: 6.607 ± 0.11	6.664AlaThr: 6.664 ± 0.127	10.081AlaVal: 10.081 ± 0.087	2.135AlaTrp: 2.135 ± 0.045	2.444AlaTyr: 2.444 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.191CysAla: 1.191 ± 0.033	0.11CysCys: 0.11 ± 0.008	0.495CysAsp: 0.495 ± 0.02	0.499CysGlu: 0.499 ± 0.018	0.291CysPhe: 0.291 ± 0.015	0.94CysGly: 0.94 ± 0.03	0.24CysHis: 0.24 ± 0.013	0.39CysIle: 0.39 ± 0.019	0.16CysLys: 0.16 ± 0.01	0.762CysLeu: 0.762 ± 0.024	0.191CysMet: 0.191 ± 0.012	0.201CysAsn: 0.201 ± 0.011	0.437CysPro: 0.437 ± 0.02	0.228CysGln: 0.228 ± 0.013	0.591CysArg: 0.591 ± 0.021	0.445CysSer: 0.445 ± 0.018	0.459CysThr: 0.459 ± 0.021	0.652CysVal: 0.652 ± 0.024	0.119CysTrp: 0.119 ± 0.008	0.173CysTyr: 0.173 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.364AspAla: 8.364 ± 0.094	0.462AspCys: 0.462 ± 0.021	2.73AspAsp: 2.73 ± 0.051	3.052AspGlu: 3.052 ± 0.055	2.131AspPhe: 2.131 ± 0.04	5.326AspGly: 5.326 ± 0.084	1.092AspHis: 1.092 ± 0.028	2.245AspIle: 2.245 ± 0.047	1.435AspLys: 1.435 ± 0.034	5.368AspLeu: 5.368 ± 0.069	1.179AspMet: 1.179 ± 0.025	1.058AspAsn: 1.058 ± 0.028	2.965AspPro: 2.965 ± 0.055	1.511AspGln: 1.511 ± 0.034	3.501AspArg: 3.501 ± 0.053	1.971AspSer: 1.971 ± 0.04	2.499AspThr: 2.499 ± 0.046	4.153AspVal: 4.153 ± 0.067	1.061AspTrp: 1.061 ± 0.028	1.32AspTyr: 1.32 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.538GluAla: 7.538 ± 0.109	0.343GluCys: 0.343 ± 0.015	2.215GluAsp: 2.215 ± 0.04	2.324GluGlu: 2.324 ± 0.054	1.52GluPhe: 1.52 ± 0.039	4.034GluGly: 4.034 ± 0.059	1.155GluHis: 1.155 ± 0.027	2.18GluIle: 2.18 ± 0.045	1.418GluLys: 1.418 ± 0.037	5.475GluLeu: 5.475 ± 0.077	1.069GluMet: 1.069 ± 0.03	0.966GluAsn: 0.966 ± 0.024	2.563GluPro: 2.563 ± 0.049	2.225GluGln: 2.225 ± 0.048	4.639GluArg: 4.639 ± 0.078	2.173GluSer: 2.173 ± 0.043	2.121GluThr: 2.121 ± 0.046	3.958GluVal: 3.958 ± 0.056	0.678GluTrp: 0.678 ± 0.02	0.885GluTyr: 0.885 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.368PheAla: 4.368 ± 0.065	0.379PheCys: 0.379 ± 0.017	2.564PheAsp: 2.564 ± 0.037	1.85PheGlu: 1.85 ± 0.036	1.251PhePhe: 1.251 ± 0.035	3.428PheGly: 3.428 ± 0.059	0.697PheHis: 0.697 ± 0.021	1.359PheIle: 1.359 ± 0.032	0.982PheLys: 0.982 ± 0.025	2.851PheLeu: 2.851 ± 0.047	0.745PheMet: 0.745 ± 0.025	0.935PheAsn: 0.935 ± 0.027	1.403PhePro: 1.403 ± 0.031	1.007PheGln: 1.007 ± 0.028	1.835PheArg: 1.835 ± 0.034	1.845PheSer: 1.845 ± 0.039	1.821PheThr: 1.821 ± 0.04	2.704PheVal: 2.704 ± 0.043	0.487PheTrp: 0.487 ± 0.016	0.778PheTyr: 0.778 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.712GlyAla: 10.712 ± 0.141	0.898GlyCys: 0.898 ± 0.029	4.208GlyAsp: 4.208 ± 0.073	4.523GlyGlu: 4.523 ± 0.066	3.363GlyPhe: 3.363 ± 0.063	8.065GlyGly: 8.065 ± 0.144	2.042GlyHis: 2.042 ± 0.044	3.817GlyIle: 3.817 ± 0.051	2.696GlyLys: 2.696 ± 0.051	9.776GlyLeu: 9.776 ± 0.106	2.369GlyMet: 2.369 ± 0.041	2.246GlyAsn: 2.246 ± 0.102	3.636GlyPro: 3.636 ± 0.054	3.656GlyGln: 3.656 ± 0.054	6.771GlyArg: 6.771 ± 0.075	4.806GlySer: 4.806 ± 0.152	5.143GlyThr: 5.143 ± 0.159	6.693GlyVal: 6.693 ± 0.082	1.606GlyTrp: 1.606 ± 0.031	2.203GlyTyr: 2.203 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.996HisAla: 2.996 ± 0.052	0.264HisCys: 0.264 ± 0.014	1.174HisAsp: 1.174 ± 0.031	1.093HisGlu: 1.093 ± 0.027	0.858HisPhe: 0.858 ± 0.024	2.239HisGly: 2.239 ± 0.048	0.562HisHis: 0.562 ± 0.02	0.817HisIle: 0.817 ± 0.022	0.485HisLys: 0.485 ± 0.017	2.254HisLeu: 2.254 ± 0.04	0.478HisMet: 0.478 ± 0.017	0.433HisAsn: 0.433 ± 0.016	1.509HisPro: 1.509 ± 0.035	0.646HisGln: 0.646 ± 0.021	1.608HisArg: 1.608 ± 0.034	0.905HisSer: 0.905 ± 0.027	0.986HisThr: 0.986 ± 0.028	1.599HisVal: 1.599 ± 0.036	0.438HisTrp: 0.438 ± 0.018	0.583HisTyr: 0.583 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.05IleAla: 6.05 ± 0.068	0.334IleCys: 0.334 ± 0.015	2.957IleAsp: 2.957 ± 0.051	2.641IleGlu: 2.641 ± 0.048	1.058IlePhe: 1.058 ± 0.03	4.075IleGly: 4.075 ± 0.062	0.798IleHis: 0.798 ± 0.024	1.072IleIle: 1.072 ± 0.034	1.122IleLys: 1.122 ± 0.031	2.777IleLeu: 2.777 ± 0.05	0.577IleMet: 0.577 ± 0.02	1.172IleAsn: 1.172 ± 0.038	1.722IlePro: 1.722 ± 0.038	1.228IleGln: 1.228 ± 0.028	2.478IleArg: 2.478 ± 0.038	1.835IleSer: 1.835 ± 0.039	2.175IleThr: 2.175 ± 0.059	3.38IleVal: 3.38 ± 0.056	0.406IleTrp: 0.406 ± 0.017	0.821IleTyr: 0.821 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.66LysAla: 3.66 ± 0.055	0.123LysCys: 0.123 ± 0.008	1.391LysAsp: 1.391 ± 0.037	1.197LysGlu: 1.197 ± 0.032	0.719LysPhe: 0.719 ± 0.023	2.056LysGly: 2.056 ± 0.044	0.437LysHis: 0.437 ± 0.016	1.042LysIle: 1.042 ± 0.035	1.119LysLys: 1.119 ± 0.041	2.888LysLeu: 2.888 ± 0.053	0.626LysMet: 0.626 ± 0.023	0.705LysAsn: 0.705 ± 0.03	1.715LysPro: 1.715 ± 0.04	0.913LysGln: 0.913 ± 0.026	1.762LysArg: 1.762 ± 0.033	1.384LysSer: 1.384 ± 0.038	1.584LysThr: 1.584 ± 0.035	2.149LysVal: 2.149 ± 0.048	0.277LysTrp: 0.277 ± 0.015	0.495LysTyr: 0.495 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.88LeuAla: 16.88 ± 0.144	0.986LeuCys: 0.986 ± 0.03	6.092LeuAsp: 6.092 ± 0.071	4.58LeuGlu: 4.58 ± 0.072	3.207LeuPhe: 3.207 ± 0.055	9.261LeuGly: 9.261 ± 0.107	2.36LeuHis: 2.36 ± 0.052	3.783LeuIle: 3.783 ± 0.061	2.894LeuLys: 2.894 ± 0.049	11.581LeuLeu: 11.581 ± 0.14	2.55LeuMet: 2.55 ± 0.039	2.375LeuAsn: 2.375 ± 0.042	6.793LeuPro: 6.793 ± 0.091	4.448LeuGln: 4.448 ± 0.067	8.628LeuArg: 8.628 ± 0.118	5.605LeuSer: 5.605 ± 0.112	5.2LeuThr: 5.2 ± 0.114	8.05LeuVal: 8.05 ± 0.091	1.341LeuTrp: 1.341 ± 0.033	1.936LeuTyr: 1.936 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.323MetAla: 3.323 ± 0.048	0.154MetCys: 0.154 ± 0.011	1.156MetAsp: 1.156 ± 0.026	0.916MetGlu: 0.916 ± 0.031	0.608MetPhe: 0.608 ± 0.019	1.866MetGly: 1.866 ± 0.04	0.538MetHis: 0.538 ± 0.017	0.758MetIle: 0.758 ± 0.026	0.849MetLys: 0.849 ± 0.026	2.519MetLeu: 2.519 ± 0.045	0.458MetMet: 0.458 ± 0.019	0.721MetAsn: 0.721 ± 0.021	1.574MetPro: 1.574 ± 0.033	1.025MetGln: 1.025 ± 0.023	1.746MetArg: 1.746 ± 0.035	1.428MetSer: 1.428 ± 0.029	1.496MetThr: 1.496 ± 0.033	1.729MetVal: 1.729 ± 0.037	0.186MetTrp: 0.186 ± 0.012	0.354MetTyr: 0.354 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.168AsnAla: 3.168 ± 0.084	0.195AsnCys: 0.195 ± 0.013	1.21AsnAsp: 1.21 ± 0.042	0.932AsnGlu: 0.932 ± 0.029	0.838AsnPhe: 0.838 ± 0.027	2.102AsnGly: 2.102 ± 0.082	0.435AsnHis: 0.435 ± 0.015	1.004AsnIle: 1.004 ± 0.03	0.696AsnLys: 0.696 ± 0.031	2.38AsnLeu: 2.38 ± 0.036	0.471AsnMet: 0.471 ± 0.019	0.615AsnAsn: 0.615 ± 0.03	1.619AsnPro: 1.619 ± 0.036	0.773AsnGln: 0.773 ± 0.025	1.457AsnArg: 1.457 ± 0.034	0.932AsnSer: 0.932 ± 0.031	1.294AsnThr: 1.294 ± 0.044	1.848AsnVal: 1.848 ± 0.067	0.364AsnTrp: 0.364 ± 0.015	0.588AsnTyr: 0.588 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.842ProAla: 8.842 ± 0.11	0.344ProCys: 0.344 ± 0.016	3.203ProAsp: 3.203 ± 0.055	3.257ProGlu: 3.257 ± 0.054	1.804ProPhe: 1.804 ± 0.038	5.15ProGly: 5.15 ± 0.075	1.199ProHis: 1.199 ± 0.03	1.802ProIle: 1.802 ± 0.038	1.219ProLys: 1.219 ± 0.033	5.716ProLeu: 5.716 ± 0.076	1.317ProMet: 1.317 ± 0.03	1.123ProAsn: 1.123 ± 0.029	3.208ProPro: 3.208 ± 0.062	2.29ProGln: 2.29 ± 0.049	3.463ProArg: 3.463 ± 0.062	2.618ProSer: 2.618 ± 0.046	2.736ProThr: 2.736 ± 0.043	4.663ProVal: 4.663 ± 0.074	0.854ProTrp: 0.854 ± 0.025	1.175ProTyr: 1.175 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	6.506GlnAla: 6.506 ± 0.07	0.273GlnCys: 0.273 ± 0.015	1.688GlnAsp: 1.688 ± 0.036	1.448GlnGlu: 1.448 ± 0.036	1.126GlnPhe: 1.126 ± 0.027	3.203GlnGly: 3.203 ± 0.049	0.838GlnHis: 0.838 ± 0.024	1.549GlnIle: 1.549 ± 0.035	0.992GlnLys: 0.992 ± 0.027	4.38GlnLeu: 4.38 ± 0.062	0.932GlnMet: 0.932 ± 0.027	0.779GlnAsn: 0.779 ± 0.021	2.564GlnPro: 2.564 ± 0.046	1.973GlnGln: 1.973 ± 0.041	3.536GlnArg: 3.536 ± 0.061	1.784GlnSer: 1.784 ± 0.038	1.765GlnThr: 1.765 ± 0.04	3.147GlnVal: 3.147 ± 0.053	0.66GlnTrp: 0.66 ± 0.024	0.699GlnTyr: 0.699 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.118ArgAla: 9.118 ± 0.106	0.609ArgCys: 0.609 ± 0.025	3.623ArgAsp: 3.623 ± 0.053	4.175ArgGlu: 4.175 ± 0.082	2.856ArgPhe: 2.856 ± 0.044	5.24ArgGly: 5.24 ± 0.071	2.011ArgHis: 2.011 ± 0.044	3.56ArgIle: 3.56 ± 0.054	1.758ArgLys: 1.758 ± 0.041	8.973ArgLeu: 8.973 ± 0.12	1.964ArgMet: 1.964 ± 0.038	1.599ArgAsn: 1.599 ± 0.033	3.895ArgPro: 3.895 ± 0.063	3.209ArgGln: 3.209 ± 0.062	6.028ArgArg: 6.028 ± 0.112	3.427ArgSer: 3.427 ± 0.053	3.542ArgThr: 3.542 ± 0.051	5.298ArgVal: 5.298 ± 0.078	1.353ArgTrp: 1.353 ± 0.031	1.747ArgTyr: 1.747 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.495SerAla: 6.495 ± 0.104	0.364SerCys: 0.364 ± 0.016	2.312SerAsp: 2.312 ± 0.047	1.999SerGlu: 1.999 ± 0.039	1.848SerPhe: 1.848 ± 0.039	5.005SerGly: 5.005 ± 0.124	1.009SerHis: 1.009 ± 0.029	2.029SerIle: 2.029 ± 0.066	1.118SerLys: 1.118 ± 0.027	5.224SerLeu: 5.224 ± 0.086	1.15SerMet: 1.15 ± 0.029	1.168SerAsn: 1.168 ± 0.042	2.883SerPro: 2.883 ± 0.048	1.679SerGln: 1.679 ± 0.034	3.288SerArg: 3.288 ± 0.059	2.649SerSer: 2.649 ± 0.061	2.683SerThr: 2.683 ± 0.064	3.595SerVal: 3.595 ± 0.086	0.631SerTrp: 0.631 ± 0.022	1.126SerTyr: 1.126 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.694ThrAla: 6.694 ± 0.138	0.347ThrCys: 0.347 ± 0.015	2.594ThrAsp: 2.594 ± 0.047	2.199ThrGlu: 2.199 ± 0.043	1.52ThrPhe: 1.52 ± 0.039	5.116ThrGly: 5.116 ± 0.142	1.119ThrHis: 1.119 ± 0.03	1.855ThrIle: 1.855 ± 0.055	1.017ThrLys: 1.017 ± 0.031	6.29ThrLeu: 6.29 ± 0.106	0.984ThrMet: 0.984 ± 0.028	1.092ThrAsn: 1.092 ± 0.045	3.62ThrPro: 3.62 ± 0.056	1.913ThrGln: 1.913 ± 0.037	3.318ThrArg: 3.318 ± 0.053	2.375ThrSer: 2.375 ± 0.082	2.932ThrThr: 2.932 ± 0.138	4.493ThrVal: 4.493 ± 0.105	0.619ThrTrp: 0.619 ± 0.022	0.972ThrTyr: 0.972 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.292ValAla: 10.292 ± 0.098	0.707ValCys: 0.707 ± 0.024	4.285ValAsp: 4.285 ± 0.071	3.911ValGlu: 3.911 ± 0.056	2.649ValPhe: 2.649 ± 0.043	6.035ValGly: 6.035 ± 0.098	1.602ValHis: 1.602 ± 0.038	3.031ValIle: 3.031 ± 0.051	2.032ValLys: 2.032 ± 0.042	8.774ValLeu: 8.774 ± 0.114	1.876ValMet: 1.876 ± 0.036	2.02ValAsn: 2.02 ± 0.078	4.427ValPro: 4.427 ± 0.071	3.184ValGln: 3.184 ± 0.048	5.727ValArg: 5.727 ± 0.07	3.737ValSer: 3.737 ± 0.064	3.955ValThr: 3.955 ± 0.088	6.598ValVal: 6.598 ± 0.082	0.98ValTrp: 0.98 ± 0.027	1.505ValTyr: 1.505 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.038	0.162TrpCys: 0.162 ± 0.011	0.586TrpAsp: 0.586 ± 0.02	0.504TrpGlu: 0.504 ± 0.019	0.517TrpPhe: 0.517 ± 0.018	1.015TrpGly: 1.015 ± 0.029	0.416TrpHis: 0.416 ± 0.016	0.576TrpIle: 0.576 ± 0.02	0.428TrpLys: 0.428 ± 0.018	2.127TrpLeu: 2.127 ± 0.045	0.422TrpMet: 0.422 ± 0.02	0.4TrpAsn: 0.4 ± 0.016	0.835TrpPro: 0.835 ± 0.027	0.779TrpGln: 0.779 ± 0.022	1.392TrpArg: 1.392 ± 0.035	0.719TrpSer: 0.719 ± 0.026	0.798TrpThr: 0.798 ± 0.029	0.984TrpVal: 0.984 ± 0.023	0.271TrpTrp: 0.271 ± 0.015	0.261TrpTyr: 0.261 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.66TyrAla: 2.66 ± 0.047	0.207TyrCys: 0.207 ± 0.013	1.246TyrAsp: 1.246 ± 0.031	1.049TyrGlu: 1.049 ± 0.029	0.809TyrPhe: 0.809 ± 0.023	1.982TyrGly: 1.982 ± 0.039	0.41TyrHis: 0.41 ± 0.018	0.664TyrIle: 0.664 ± 0.019	0.588TyrLys: 0.588 ± 0.022	2.144TyrLeu: 2.144 ± 0.035	0.381TyrMet: 0.381 ± 0.015	0.495TyrAsn: 0.495 ± 0.024	0.997TyrPro: 0.997 ± 0.028	0.755TyrGln: 0.755 ± 0.025	1.561TyrArg: 1.561 ± 0.035	1.007TyrSer: 1.007 ± 0.028	1.215TyrThr: 1.215 ± 0.047	1.554TyrVal: 1.554 ± 0.029	0.341TyrTrp: 0.341 ± 0.016	0.51TyrTyr: 0.51 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4770 proteins (1558315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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