Amino acid dipepetide frequency for Roseobacter phage RDJL Phi 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.074AlaAla: 11.074 ± 1.38
1.225AlaCys: 1.225 ± 0.266
6.442AlaAsp: 6.442 ± 0.542
7.72AlaGlu: 7.72 ± 0.837
3.408AlaPhe: 3.408 ± 0.381
7.56AlaGly: 7.56 ± 0.638
1.863AlaHis: 1.863 ± 0.332
5.324AlaIle: 5.324 ± 0.507
4.898AlaLys: 4.898 ± 0.801
9.211AlaLeu: 9.211 ± 1.127
3.195AlaMet: 3.195 ± 0.481
2.982AlaAsn: 2.982 ± 0.44
3.727AlaPro: 3.727 ± 0.474
3.195AlaGln: 3.195 ± 0.444
5.697AlaArg: 5.697 ± 0.611
5.377AlaSer: 5.377 ± 0.771
6.016AlaThr: 6.016 ± 0.826
5.218AlaVal: 5.218 ± 0.559
1.863AlaTrp: 1.863 ± 0.421
2.609AlaTyr: 2.609 ± 0.353
0.0AlaXaa: 0.0 ± 0.0
Cys
0.958CysAla: 0.958 ± 0.228
0.053CysCys: 0.053 ± 0.059
0.905CysAsp: 0.905 ± 0.228
0.905CysGlu: 0.905 ± 0.258
0.479CysPhe: 0.479 ± 0.157
0.745CysGly: 0.745 ± 0.237
0.373CysHis: 0.373 ± 0.155
0.266CysIle: 0.266 ± 0.104
0.745CysLys: 0.745 ± 0.171
0.905CysLeu: 0.905 ± 0.289
0.266CysMet: 0.266 ± 0.119
0.373CysAsn: 0.373 ± 0.13
0.799CysPro: 0.799 ± 0.235
0.213CysGln: 0.213 ± 0.103
0.586CysArg: 0.586 ± 0.203
0.692CysSer: 0.692 ± 0.207
0.426CysThr: 0.426 ± 0.149
0.479CysVal: 0.479 ± 0.196
0.266CysTrp: 0.266 ± 0.132
0.16CysTyr: 0.16 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
6.123AspAla: 6.123 ± 0.697
1.118AspCys: 1.118 ± 0.295
4.206AspAsp: 4.206 ± 0.501
6.07AspGlu: 6.07 ± 0.861
3.514AspPhe: 3.514 ± 0.386
6.549AspGly: 6.549 ± 0.583
1.065AspHis: 1.065 ± 0.295
2.449AspIle: 2.449 ± 0.343
3.141AspLys: 3.141 ± 0.468
7.134AspLeu: 7.134 ± 0.694
1.917AspMet: 1.917 ± 0.292
2.13AspAsn: 2.13 ± 0.368
4.153AspPro: 4.153 ± 0.525
2.875AspGln: 2.875 ± 0.469
2.928AspArg: 2.928 ± 0.441
2.715AspSer: 2.715 ± 0.464
4.472AspThr: 4.472 ± 0.495
5.218AspVal: 5.218 ± 0.587
1.704AspTrp: 1.704 ± 0.282
1.384AspTyr: 1.384 ± 0.288
0.0AspXaa: 0.0 ± 0.0
Glu
9.743GluAla: 9.743 ± 0.941
0.639GluCys: 0.639 ± 0.185
5.75GluAsp: 5.75 ± 0.717
7.028GluGlu: 7.028 ± 0.792
2.449GluPhe: 2.449 ± 0.446
5.644GluGly: 5.644 ± 0.448
1.331GluHis: 1.331 ± 0.312
2.396GluIle: 2.396 ± 0.377
2.769GluLys: 2.769 ± 0.451
7.827GluLeu: 7.827 ± 0.622
1.97GluMet: 1.97 ± 0.341
1.97GluAsn: 1.97 ± 0.305
3.301GluPro: 3.301 ± 0.576
2.769GluGln: 2.769 ± 0.439
4.366GluArg: 4.366 ± 0.562
1.863GluSer: 1.863 ± 0.344
4.845GluThr: 4.845 ± 0.474
5.377GluVal: 5.377 ± 0.416
1.384GluTrp: 1.384 ± 0.308
1.597GluTyr: 1.597 ± 0.312
0.0GluXaa: 0.0 ± 0.0
Phe
2.769PheAla: 2.769 ± 0.384
0.426PheCys: 0.426 ± 0.148
3.248PheAsp: 3.248 ± 0.425
3.354PheGlu: 3.354 ± 0.377
1.012PhePhe: 1.012 ± 0.19
2.449PheGly: 2.449 ± 0.376
0.532PheHis: 0.532 ± 0.165
2.502PheIle: 2.502 ± 0.34
2.023PheLys: 2.023 ± 0.277
2.715PheLeu: 2.715 ± 0.403
0.852PheMet: 0.852 ± 0.254
1.384PheAsn: 1.384 ± 0.257
2.023PhePro: 2.023 ± 0.361
1.757PheGln: 1.757 ± 0.251
2.023PheArg: 2.023 ± 0.309
2.13PheSer: 2.13 ± 0.396
2.875PheThr: 2.875 ± 0.411
1.331PheVal: 1.331 ± 0.292
0.532PheTrp: 0.532 ± 0.149
1.065PheTyr: 1.065 ± 0.236
0.0PheXaa: 0.0 ± 0.0
Gly
5.484GlyAla: 5.484 ± 0.555
0.799GlyCys: 0.799 ± 0.232
4.952GlyAsp: 4.952 ± 0.51
5.058GlyGlu: 5.058 ± 0.542
4.259GlyPhe: 4.259 ± 0.454
6.975GlyGly: 6.975 ± 0.762
1.384GlyHis: 1.384 ± 0.295
3.674GlyIle: 3.674 ± 0.443
4.046GlyLys: 4.046 ± 0.583
6.549GlyLeu: 6.549 ± 0.545
2.236GlyMet: 2.236 ± 0.36
2.396GlyAsn: 2.396 ± 0.496
2.769GlyPro: 2.769 ± 0.326
2.183GlyGln: 2.183 ± 0.367
5.963GlyArg: 5.963 ± 0.594
6.016GlySer: 6.016 ± 0.88
5.644GlyThr: 5.644 ± 0.731
5.005GlyVal: 5.005 ± 0.446
1.438GlyTrp: 1.438 ± 0.298
1.97GlyTyr: 1.97 ± 0.288
0.0GlyXaa: 0.0 ± 0.0
His
1.704HisAla: 1.704 ± 0.293
0.532HisCys: 0.532 ± 0.167
1.012HisAsp: 1.012 ± 0.214
1.384HisGlu: 1.384 ± 0.293
0.639HisPhe: 0.639 ± 0.235
1.438HisGly: 1.438 ± 0.374
0.852HisHis: 0.852 ± 0.262
0.852HisIle: 0.852 ± 0.207
0.692HisLys: 0.692 ± 0.241
1.651HisLeu: 1.651 ± 0.328
0.692HisMet: 0.692 ± 0.194
0.373HisAsn: 0.373 ± 0.137
1.384HisPro: 1.384 ± 0.303
0.532HisGln: 0.532 ± 0.257
0.905HisArg: 0.905 ± 0.209
1.331HisSer: 1.331 ± 0.244
0.958HisThr: 0.958 ± 0.221
1.118HisVal: 1.118 ± 0.245
0.479HisTrp: 0.479 ± 0.16
0.479HisTyr: 0.479 ± 0.168
0.0HisXaa: 0.0 ± 0.0
Ile
4.739IleAla: 4.739 ± 0.714
0.266IleCys: 0.266 ± 0.112
3.62IleAsp: 3.62 ± 0.485
3.94IleGlu: 3.94 ± 0.5
1.171IlePhe: 1.171 ± 0.24
3.514IleGly: 3.514 ± 0.495
0.586IleHis: 0.586 ± 0.197
1.438IleIle: 1.438 ± 0.26
2.076IleLys: 2.076 ± 0.329
3.887IleLeu: 3.887 ± 0.54
1.118IleMet: 1.118 ± 0.263
1.491IleAsn: 1.491 ± 0.311
2.023IlePro: 2.023 ± 0.309
1.597IleGln: 1.597 ± 0.312
3.195IleArg: 3.195 ± 0.417
2.13IleSer: 2.13 ± 0.31
3.035IleThr: 3.035 ± 0.403
2.822IleVal: 2.822 ± 0.432
1.012IleTrp: 1.012 ± 0.263
0.958IleTyr: 0.958 ± 0.236
0.0IleXaa: 0.0 ± 0.0
Lys
6.549LysAla: 6.549 ± 0.928
0.319LysCys: 0.319 ± 0.126
2.928LysAsp: 2.928 ± 0.456
2.875LysGlu: 2.875 ± 0.428
1.171LysPhe: 1.171 ± 0.228
3.301LysGly: 3.301 ± 0.503
0.905LysHis: 0.905 ± 0.23
1.597LysIle: 1.597 ± 0.251
2.502LysLys: 2.502 ± 0.551
3.727LysLeu: 3.727 ± 0.464
1.438LysMet: 1.438 ± 0.331
1.917LysAsn: 1.917 ± 0.365
2.236LysPro: 2.236 ± 0.385
1.863LysGln: 1.863 ± 0.366
3.354LysArg: 3.354 ± 0.503
2.982LysSer: 2.982 ± 0.505
3.035LysThr: 3.035 ± 0.447
3.248LysVal: 3.248 ± 0.438
1.118LysTrp: 1.118 ± 0.241
0.958LysTyr: 0.958 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
8.412LeuAla: 8.412 ± 0.867
0.639LeuCys: 0.639 ± 0.223
6.07LeuAsp: 6.07 ± 0.644
6.07LeuGlu: 6.07 ± 0.552
2.343LeuPhe: 2.343 ± 0.34
6.709LeuGly: 6.709 ± 0.596
1.917LeuHis: 1.917 ± 0.395
3.727LeuIle: 3.727 ± 0.445
4.153LeuLys: 4.153 ± 0.642
6.336LeuLeu: 6.336 ± 0.706
2.076LeuMet: 2.076 ± 0.389
3.78LeuAsn: 3.78 ± 0.434
3.78LeuPro: 3.78 ± 0.52
2.396LeuGln: 2.396 ± 0.399
5.803LeuArg: 5.803 ± 0.628
4.685LeuSer: 4.685 ± 0.55
7.454LeuThr: 7.454 ± 1.014
5.75LeuVal: 5.75 ± 0.639
1.118LeuTrp: 1.118 ± 0.233
2.023LeuTyr: 2.023 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
3.035MetAla: 3.035 ± 0.449
0.16MetCys: 0.16 ± 0.114
1.863MetAsp: 1.863 ± 0.268
1.438MetGlu: 1.438 ± 0.29
0.479MetPhe: 0.479 ± 0.176
2.183MetGly: 2.183 ± 0.375
0.479MetHis: 0.479 ± 0.156
1.065MetIle: 1.065 ± 0.172
1.065MetLys: 1.065 ± 0.199
1.917MetLeu: 1.917 ± 0.318
0.745MetMet: 0.745 ± 0.2
1.171MetAsn: 1.171 ± 0.265
1.171MetPro: 1.171 ± 0.227
1.278MetGln: 1.278 ± 0.315
1.544MetArg: 1.544 ± 0.358
1.97MetSer: 1.97 ± 0.382
2.13MetThr: 2.13 ± 0.446
1.438MetVal: 1.438 ± 0.28
0.319MetTrp: 0.319 ± 0.121
0.532MetTyr: 0.532 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
3.088AsnAla: 3.088 ± 0.441
0.266AsnCys: 0.266 ± 0.124
2.396AsnAsp: 2.396 ± 0.385
2.13AsnGlu: 2.13 ± 0.399
1.438AsnPhe: 1.438 ± 0.37
3.035AsnGly: 3.035 ± 0.316
0.852AsnHis: 0.852 ± 0.246
1.597AsnIle: 1.597 ± 0.425
1.331AsnLys: 1.331 ± 0.276
2.502AsnLeu: 2.502 ± 0.333
0.852AsnMet: 0.852 ± 0.207
1.544AsnAsn: 1.544 ± 0.357
1.863AsnPro: 1.863 ± 0.325
1.225AsnGln: 1.225 ± 0.369
3.141AsnArg: 3.141 ± 0.463
1.81AsnSer: 1.81 ± 0.349
1.81AsnThr: 1.81 ± 0.362
1.704AsnVal: 1.704 ± 0.314
0.799AsnTrp: 0.799 ± 0.238
0.852AsnTyr: 0.852 ± 0.25
0.0AsnXaa: 0.0 ± 0.0
Pro
4.526ProAla: 4.526 ± 0.435
0.692ProCys: 0.692 ± 0.211
4.046ProAsp: 4.046 ± 0.435
4.1ProGlu: 4.1 ± 0.523
1.438ProPhe: 1.438 ± 0.284
3.354ProGly: 3.354 ± 0.371
0.745ProHis: 0.745 ± 0.231
2.183ProIle: 2.183 ± 0.323
2.343ProLys: 2.343 ± 0.429
3.195ProLeu: 3.195 ± 0.422
0.692ProMet: 0.692 ± 0.211
1.704ProAsn: 1.704 ± 0.249
1.863ProPro: 1.863 ± 0.369
1.704ProGln: 1.704 ± 0.314
2.343ProArg: 2.343 ± 0.397
2.609ProSer: 2.609 ± 0.601
2.662ProThr: 2.662 ± 0.341
2.822ProVal: 2.822 ± 0.334
0.958ProTrp: 0.958 ± 0.241
1.384ProTyr: 1.384 ± 0.295
0.0ProXaa: 0.0 ± 0.0
Gln
4.153GlnAla: 4.153 ± 0.531
0.373GlnCys: 0.373 ± 0.129
2.13GlnAsp: 2.13 ± 0.325
2.396GlnGlu: 2.396 ± 0.37
1.491GlnPhe: 1.491 ± 0.317
2.236GlnGly: 2.236 ± 0.371
0.426GlnHis: 0.426 ± 0.184
1.651GlnIle: 1.651 ± 0.299
1.704GlnLys: 1.704 ± 0.274
3.674GlnLeu: 3.674 ± 0.452
0.692GlnMet: 0.692 ± 0.202
0.852GlnAsn: 0.852 ± 0.17
1.384GlnPro: 1.384 ± 0.269
1.651GlnGln: 1.651 ± 0.282
2.076GlnArg: 2.076 ± 0.319
2.023GlnSer: 2.023 ± 0.37
1.917GlnThr: 1.917 ± 0.303
3.141GlnVal: 3.141 ± 0.345
0.426GlnTrp: 0.426 ± 0.165
0.479GlnTyr: 0.479 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
4.739ArgAla: 4.739 ± 0.559
0.745ArgCys: 0.745 ± 0.214
4.685ArgAsp: 4.685 ± 0.448
4.206ArgGlu: 4.206 ± 0.462
3.195ArgPhe: 3.195 ± 0.347
4.206ArgGly: 4.206 ± 0.486
1.438ArgHis: 1.438 ± 0.288
3.301ArgIle: 3.301 ± 0.474
3.301ArgLys: 3.301 ± 0.601
5.537ArgLeu: 5.537 ± 0.615
1.651ArgMet: 1.651 ± 0.35
1.97ArgAsn: 1.97 ± 0.267
2.343ArgPro: 2.343 ± 0.324
2.289ArgGln: 2.289 ± 0.307
4.259ArgArg: 4.259 ± 0.592
3.461ArgSer: 3.461 ± 0.511
4.046ArgThr: 4.046 ± 0.503
3.567ArgVal: 3.567 ± 0.479
1.225ArgTrp: 1.225 ± 0.258
2.023ArgTyr: 2.023 ± 0.35
0.0ArgXaa: 0.0 ± 0.0
Ser
5.165SerAla: 5.165 ± 0.545
0.373SerCys: 0.373 ± 0.146
3.301SerAsp: 3.301 ± 0.466
2.662SerGlu: 2.662 ± 0.339
2.343SerPhe: 2.343 ± 0.352
5.218SerGly: 5.218 ± 0.598
1.118SerHis: 1.118 ± 0.283
2.822SerIle: 2.822 ± 0.441
3.088SerLys: 3.088 ± 0.464
3.94SerLeu: 3.94 ± 0.479
1.171SerMet: 1.171 ± 0.266
2.023SerAsn: 2.023 ± 0.318
2.076SerPro: 2.076 ± 0.4
1.81SerGln: 1.81 ± 0.402
2.982SerArg: 2.982 ± 0.435
3.248SerSer: 3.248 ± 0.59
3.088SerThr: 3.088 ± 0.578
4.792SerVal: 4.792 ± 0.541
1.651SerTrp: 1.651 ± 0.319
1.704SerTyr: 1.704 ± 0.266
0.0SerXaa: 0.0 ± 0.0
Thr
6.762ThrAla: 6.762 ± 0.828
0.532ThrCys: 0.532 ± 0.154
4.153ThrAsp: 4.153 ± 0.546
4.952ThrGlu: 4.952 ± 0.54
2.289ThrPhe: 2.289 ± 0.421
6.283ThrGly: 6.283 ± 1.004
0.852ThrHis: 0.852 ± 0.237
3.674ThrIle: 3.674 ± 0.52
2.875ThrLys: 2.875 ± 0.384
5.59ThrLeu: 5.59 ± 0.728
1.384ThrMet: 1.384 ± 0.24
2.183ThrAsn: 2.183 ± 0.407
3.727ThrPro: 3.727 ± 0.448
2.023ThrGln: 2.023 ± 0.395
3.461ThrArg: 3.461 ± 0.522
3.301ThrSer: 3.301 ± 0.491
4.685ThrThr: 4.685 ± 0.848
4.685ThrVal: 4.685 ± 0.682
1.278ThrTrp: 1.278 ± 0.248
2.023ThrTyr: 2.023 ± 0.367
0.0ThrXaa: 0.0 ± 0.0
Val
5.324ValAla: 5.324 ± 0.53
0.586ValCys: 0.586 ± 0.185
5.324ValAsp: 5.324 ± 0.356
5.484ValGlu: 5.484 ± 0.484
2.502ValPhe: 2.502 ± 0.326
4.1ValGly: 4.1 ± 0.457
0.958ValHis: 0.958 ± 0.23
2.662ValIle: 2.662 ± 0.4
3.141ValLys: 3.141 ± 0.441
5.537ValLeu: 5.537 ± 0.431
1.491ValMet: 1.491 ± 0.283
2.662ValAsn: 2.662 ± 0.549
2.662ValPro: 2.662 ± 0.423
2.289ValGln: 2.289 ± 0.37
4.1ValArg: 4.1 ± 0.383
3.727ValSer: 3.727 ± 0.462
4.845ValThr: 4.845 ± 0.499
4.259ValVal: 4.259 ± 0.668
0.852ValTrp: 0.852 ± 0.233
1.597ValTyr: 1.597 ± 0.286
0.0ValXaa: 0.0 ± 0.0
Trp
1.757TrpAla: 1.757 ± 0.35
0.319TrpCys: 0.319 ± 0.108
1.597TrpAsp: 1.597 ± 0.336
1.225TrpGlu: 1.225 ± 0.213
0.692TrpPhe: 0.692 ± 0.255
1.331TrpGly: 1.331 ± 0.296
0.586TrpHis: 0.586 ± 0.191
0.319TrpIle: 0.319 ± 0.141
1.118TrpLys: 1.118 ± 0.265
1.704TrpLeu: 1.704 ± 0.291
0.479TrpMet: 0.479 ± 0.139
0.373TrpAsn: 0.373 ± 0.151
0.745TrpPro: 0.745 ± 0.212
0.745TrpGln: 0.745 ± 0.19
1.118TrpArg: 1.118 ± 0.258
1.171TrpSer: 1.171 ± 0.229
1.438TrpThr: 1.438 ± 0.303
1.438TrpVal: 1.438 ± 0.277
0.532TrpTrp: 0.532 ± 0.165
0.532TrpTyr: 0.532 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.502TyrAla: 2.502 ± 0.47
0.532TyrCys: 0.532 ± 0.196
2.236TyrAsp: 2.236 ± 0.372
2.023TyrGlu: 2.023 ± 0.412
0.692TyrPhe: 0.692 ± 0.236
1.97TyrGly: 1.97 ± 0.453
0.745TyrHis: 0.745 ± 0.202
1.118TyrIle: 1.118 ± 0.273
1.012TyrLys: 1.012 ± 0.267
1.704TyrLeu: 1.704 ± 0.291
1.012TyrMet: 1.012 ± 0.249
0.958TyrAsn: 0.958 ± 0.217
1.331TyrPro: 1.331 ± 0.268
0.479TyrGln: 0.479 ± 0.145
2.343TyrArg: 2.343 ± 0.378
1.384TyrSer: 1.384 ± 0.261
1.331TyrThr: 1.331 ± 0.274
0.692TyrVal: 0.692 ± 0.188
0.266TyrTrp: 0.266 ± 0.097
0.639TyrTyr: 0.639 ± 0.175
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (18783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski