Amino acid dipepetide frequency for Eimeria mitis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	87.231AlaAla: 87.231 ± 0.84	1.442AlaCys: 1.442 ± 0.024	4.837AlaAsp: 4.837 ± 0.049	7.694AlaGlu: 7.694 ± 0.08	2.125AlaPhe: 2.125 ± 0.026	7.237AlaGly: 7.237 ± 0.063	1.296AlaHis: 1.296 ± 0.019	2.032AlaIle: 2.032 ± 0.024	2.878AlaLys: 2.878 ± 0.044	7.165AlaLeu: 7.165 ± 0.061	1.108AlaMet: 1.108 ± 0.018	1.763AlaAsn: 1.763 ± 0.021	7.357AlaPro: 7.357 ± 0.083	3.179AlaGln: 3.179 ± 0.035	4.132AlaArg: 4.132 ± 0.039	7.269AlaSer: 7.269 ± 0.05	8.913AlaThr: 8.913 ± 0.081	6.677AlaVal: 6.677 ± 0.063	0.683AlaTrp: 0.683 ± 0.013	1.195AlaTyr: 1.195 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.02	1.685CysCys: 1.685 ± 0.033	0.443CysAsp: 0.443 ± 0.011	0.567CysGlu: 0.567 ± 0.015	0.567CysPhe: 0.567 ± 0.015	1.067CysGly: 1.067 ± 0.019	0.207CysHis: 0.207 ± 0.007	0.679CysIle: 0.679 ± 0.013	0.449CysLys: 0.449 ± 0.013	1.771CysLeu: 1.771 ± 0.024	0.462CysMet: 0.462 ± 0.01	0.412CysAsn: 0.412 ± 0.01	0.711CysPro: 0.711 ± 0.023	0.343CysGln: 0.343 ± 0.009	1.042CysArg: 1.042 ± 0.018	2.786CysSer: 2.786 ± 0.038	0.796CysThr: 0.796 ± 0.016	0.912CysVal: 0.912 ± 0.017	0.241CysTrp: 0.241 ± 0.009	0.27CysTyr: 0.27 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.575AspAla: 4.575 ± 0.053	0.676AspCys: 0.676 ± 0.014	2.001AspAsp: 2.001 ± 0.039	2.72AspGlu: 2.72 ± 0.032	0.902AspPhe: 0.902 ± 0.017	2.407AspGly: 2.407 ± 0.033	0.412AspHis: 0.412 ± 0.011	1.29AspIle: 1.29 ± 0.019	1.359AspLys: 1.359 ± 0.032	2.503AspLeu: 2.503 ± 0.033	0.592AspMet: 0.592 ± 0.012	0.742AspAsn: 0.742 ± 0.016	1.959AspPro: 1.959 ± 0.03	0.905AspGln: 0.905 ± 0.016	1.968AspArg: 1.968 ± 0.041	3.141AspSer: 3.141 ± 0.029	2.026AspThr: 2.026 ± 0.024	1.858AspVal: 1.858 ± 0.027	0.372AspTrp: 0.372 ± 0.01	0.505AspTyr: 0.505 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	7.505GluAla: 7.505 ± 0.079	0.656GluCys: 0.656 ± 0.019	2.729GluAsp: 2.729 ± 0.035	7.515GluGlu: 7.515 ± 0.137	1.018GluPhe: 1.018 ± 0.018	4.457GluGly: 4.457 ± 0.048	0.866GluHis: 0.866 ± 0.014	1.407GluIle: 1.407 ± 0.024	3.15GluLys: 3.15 ± 0.07	4.427GluLeu: 4.427 ± 0.051	0.921GluMet: 0.921 ± 0.016	1.171GluAsn: 1.171 ± 0.022	2.099GluPro: 2.099 ± 0.029	5.526GluGln: 5.526 ± 0.067	3.563GluArg: 3.563 ± 0.051	2.718GluSer: 2.718 ± 0.039	4.086GluThr: 4.086 ± 0.07	2.47GluVal: 2.47 ± 0.03	0.475GluTrp: 0.475 ± 0.01	0.741GluTyr: 0.741 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.073PheAla: 2.073 ± 0.025	0.641PheCys: 0.641 ± 0.012	0.87PheAsp: 0.87 ± 0.017	0.96PheGlu: 0.96 ± 0.018	0.922PhePhe: 0.922 ± 0.017	1.301PheGly: 1.301 ± 0.026	0.365PheHis: 0.365 ± 0.009	0.814PheIle: 0.814 ± 0.016	0.652PheLys: 0.652 ± 0.015	2.284PheLeu: 2.284 ± 0.03	0.362PheMet: 0.362 ± 0.01	0.521PheAsn: 0.521 ± 0.011	1.034PhePro: 1.034 ± 0.016	0.634PheGln: 0.634 ± 0.013	1.134PheArg: 1.134 ± 0.016	2.004PheSer: 2.004 ± 0.024	0.921PheThr: 0.921 ± 0.018	1.564PheVal: 1.564 ± 0.023	0.237PheTrp: 0.237 ± 0.007	0.476PheTyr: 0.476 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	7.392GlyAla: 7.392 ± 0.08	1.153GlyCys: 1.153 ± 0.022	3.059GlyAsp: 3.059 ± 0.045	3.625GlyGlu: 3.625 ± 0.038	1.44GlyPhe: 1.44 ± 0.02	7.098GlyGly: 7.098 ± 0.095	0.78GlyHis: 0.78 ± 0.015	1.461GlyIle: 1.461 ± 0.024	1.666GlyLys: 1.666 ± 0.023	4.12GlyLeu: 4.12 ± 0.039	0.759GlyMet: 0.759 ± 0.014	1.141GlyAsn: 1.141 ± 0.022	4.445GlyPro: 4.445 ± 0.093	1.636GlyGln: 1.636 ± 0.024	3.089GlyArg: 3.089 ± 0.032	5.169GlySer: 5.169 ± 0.049	2.494GlyThr: 2.494 ± 0.03	3.332GlyVal: 3.332 ± 0.036	0.573GlyTrp: 0.573 ± 0.011	0.856GlyTyr: 0.856 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.882HisAla: 1.882 ± 0.023	0.374HisCys: 0.374 ± 0.009	0.554HisAsp: 0.554 ± 0.012	1.109HisGlu: 1.109 ± 0.016	0.492HisPhe: 0.492 ± 0.012	0.948HisGly: 0.948 ± 0.017	1.904HisHis: 1.904 ± 0.07	0.628HisIle: 0.628 ± 0.012	0.788HisLys: 0.788 ± 0.015	2.078HisLeu: 2.078 ± 0.026	0.41HisMet: 0.41 ± 0.01	0.497HisAsn: 0.497 ± 0.011	1.473HisPro: 1.473 ± 0.023	3.179HisGln: 3.179 ± 0.066	1.532HisArg: 1.532 ± 0.023	1.514HisSer: 1.514 ± 0.019	0.943HisThr: 0.943 ± 0.016	0.776HisVal: 0.776 ± 0.013	0.217HisTrp: 0.217 ± 0.008	0.33HisTyr: 0.33 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.115IleAla: 2.115 ± 0.027	0.619IleCys: 0.619 ± 0.011	1.236IleAsp: 1.236 ± 0.025	1.617IleGlu: 1.617 ± 0.025	0.653IlePhe: 0.653 ± 0.012	1.223IleGly: 1.223 ± 0.02	0.652IleHis: 0.652 ± 0.016	0.841IleIle: 0.841 ± 0.02	1.023IleLys: 1.023 ± 0.02	1.849IleLeu: 1.849 ± 0.028	0.35IleMet: 0.35 ± 0.011	0.78IleAsn: 0.78 ± 0.016	1.364IlePro: 1.364 ± 0.024	1.169IleGln: 1.169 ± 0.02	1.4IleArg: 1.4 ± 0.018	2.162IleSer: 2.162 ± 0.029	1.116IleThr: 1.116 ± 0.022	1.159IleVal: 1.159 ± 0.021	0.216IleTrp: 0.216 ± 0.007	0.523IleTyr: 0.523 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.989LysAla: 2.989 ± 0.047	0.409LysCys: 0.409 ± 0.01	1.394LysAsp: 1.394 ± 0.022	3.605LysGlu: 3.605 ± 0.077	0.543LysPhe: 0.543 ± 0.012	2.224LysGly: 2.224 ± 0.034	0.793LysHis: 0.793 ± 0.012	0.885LysIle: 0.885 ± 0.017	2.748LysLys: 2.748 ± 0.074	2.436LysLeu: 2.436 ± 0.031	0.549LysMet: 0.549 ± 0.014	0.904LysAsn: 0.904 ± 0.015	1.573LysPro: 1.573 ± 0.032	3.918LysGln: 3.918 ± 0.044	2.516LysArg: 2.516 ± 0.031	1.63LysSer: 1.63 ± 0.025	1.863LysThr: 1.863 ± 0.028	1.252LysVal: 1.252 ± 0.021	0.268LysTrp: 0.268 ± 0.009	0.549LysTyr: 0.549 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	5.925LeuAla: 5.925 ± 0.049	1.512LeuCys: 1.512 ± 0.019	2.455LeuAsp: 2.455 ± 0.032	3.913LeuGlu: 3.913 ± 0.044	2.114LeuPhe: 2.114 ± 0.032	3.971LeuGly: 3.971 ± 0.039	2.407LeuHis: 2.407 ± 0.025	1.793LeuIle: 1.793 ± 0.025	2.715LeuLys: 2.715 ± 0.035	17.043LeuLeu: 17.043 ± 0.171	1.356LeuMet: 1.356 ± 0.021	1.497LeuAsn: 1.497 ± 0.022	5.266LeuPro: 5.266 ± 0.042	12.343LeuGln: 12.343 ± 0.122	5.682LeuArg: 5.682 ± 0.052	5.992LeuSer: 5.992 ± 0.045	2.827LeuThr: 2.827 ± 0.034	3.475LeuVal: 3.475 ± 0.04	0.875LeuTrp: 0.875 ± 0.017	1.387LeuTyr: 1.387 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	0.995MetAla: 0.995 ± 0.017	0.182MetCys: 0.182 ± 0.007	0.48MetAsp: 0.48 ± 0.011	0.842MetGlu: 0.842 ± 0.016	0.301MetPhe: 0.301 ± 0.009	0.901MetGly: 0.901 ± 0.018	0.515MetHis: 0.515 ± 0.012	0.322MetIle: 0.322 ± 0.009	0.645MetLys: 0.645 ± 0.014	1.614MetLeu: 1.614 ± 0.023	0.384MetMet: 0.384 ± 0.013	0.345MetAsn: 0.345 ± 0.01	0.729MetPro: 0.729 ± 0.014	1.761MetGln: 1.761 ± 0.028	1.021MetArg: 1.021 ± 0.016	0.771MetSer: 0.771 ± 0.012	0.536MetThr: 0.536 ± 0.012	0.603MetVal: 0.603 ± 0.021	0.149MetTrp: 0.149 ± 0.005	0.275MetTyr: 0.275 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	1.892AsnAla: 1.892 ± 0.025	0.52AsnCys: 0.52 ± 0.013	0.763AsnAsp: 0.763 ± 0.015	1.148AsnGlu: 1.148 ± 0.021	0.487AsnPhe: 0.487 ± 0.013	1.241AsnGly: 1.241 ± 0.021	0.419AsnHis: 0.419 ± 0.01	0.812AsnIle: 0.812 ± 0.017	1.142AsnLys: 1.142 ± 0.017	1.291AsnLeu: 1.291 ± 0.022	0.334AsnMet: 0.334 ± 0.009	1.365AsnAsn: 1.365 ± 0.034	1.248AsnPro: 1.248 ± 0.018	0.782AsnGln: 0.782 ± 0.016	1.222AsnArg: 1.222 ± 0.022	4.219AsnSer: 4.219 ± 0.064	1.41AsnThr: 1.41 ± 0.018	0.848AsnVal: 0.848 ± 0.017	0.188AsnTrp: 0.188 ± 0.007	0.319AsnTyr: 0.319 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	7.594ProAla: 7.594 ± 0.065	0.763ProCys: 0.763 ± 0.017	1.52ProAsp: 1.52 ± 0.021	2.775ProGlu: 2.775 ± 0.039	1.448ProPhe: 1.448 ± 0.024	2.937ProGly: 2.937 ± 0.045	1.499ProHis: 1.499 ± 0.023	1.144ProIle: 1.144 ± 0.017	1.612ProLys: 1.612 ± 0.031	5.552ProLeu: 5.552 ± 0.049	0.727ProMet: 0.727 ± 0.017	0.894ProAsn: 0.894 ± 0.015	6.897ProPro: 6.897 ± 0.1	4.257ProGln: 4.257 ± 0.055	2.841ProArg: 2.841 ± 0.034	4.893ProSer: 4.893 ± 0.057	2.742ProThr: 2.742 ± 0.035	2.555ProVal: 2.555 ± 0.029	0.583ProTrp: 0.583 ± 0.013	0.805ProTyr: 0.805 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.262GlnAla: 3.262 ± 0.038	0.495GlnCys: 0.495 ± 0.011	1.575GlnAsp: 1.575 ± 0.022	5.528GlnGlu: 5.528 ± 0.067	0.707GlnPhe: 0.707 ± 0.014	2.721GlnGly: 2.721 ± 0.035	4.853GlnHis: 4.853 ± 0.078	1.148GlnIle: 1.148 ± 0.019	3.363GlnLys: 3.363 ± 0.046	9.381GlnLeu: 9.381 ± 0.093	1.256GlnMet: 1.256 ± 0.022	1.011GlnAsn: 1.011 ± 0.015	3.609GlnPro: 3.609 ± 0.053	91.176GlnGln: 91.176 ± 1.058	5.284GlnArg: 5.284 ± 0.047	2.053GlnSer: 2.053 ± 0.024	2.387GlnThr: 2.387 ± 0.022	1.86GlnVal: 1.86 ± 0.023	0.531GlnTrp: 0.531 ± 0.012	0.712GlnTyr: 0.712 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.27ArgAla: 4.27 ± 0.041	1.262ArgCys: 1.262 ± 0.018	2.102ArgAsp: 2.102 ± 0.037	3.851ArgGlu: 3.851 ± 0.046	1.216ArgPhe: 1.216 ± 0.02	4.049ArgGly: 4.049 ± 0.049	1.394ArgHis: 1.394 ± 0.019	1.533ArgIle: 1.533 ± 0.019	2.255ArgLys: 2.255 ± 0.031	5.325ArgLeu: 5.325 ± 0.051	1.103ArgMet: 1.103 ± 0.016	1.359ArgAsn: 1.359 ± 0.02	2.409ArgPro: 2.409 ± 0.029	4.549ArgGln: 4.549 ± 0.053	5.72ArgArg: 5.72 ± 0.06	4.764ArgSer: 4.764 ± 0.047	2.061ArgThr: 2.061 ± 0.025	2.584ArgVal: 2.584 ± 0.027	0.64ArgTrp: 0.64 ± 0.013	0.874ArgTyr: 0.874 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	7.48SerAla: 7.48 ± 0.055	1.881SerCys: 1.881 ± 0.028	2.34SerAsp: 2.34 ± 0.032	2.942SerGlu: 2.942 ± 0.038	2.007SerPhe: 2.007 ± 0.025	4.381SerGly: 4.381 ± 0.047	1.032SerHis: 1.032 ± 0.017	2.254SerIle: 2.254 ± 0.031	2.687SerLys: 2.687 ± 0.033	6.048SerLeu: 6.048 ± 0.051	1.014SerMet: 1.014 ± 0.015	4.544SerAsn: 4.544 ± 0.066	4.925SerPro: 4.925 ± 0.053	2.159SerGln: 2.159 ± 0.026	5.168SerArg: 5.168 ± 0.047	37.106SerSer: 37.106 ± 0.455	4.012SerThr: 4.012 ± 0.042	3.365SerVal: 3.365 ± 0.031	0.683SerTrp: 0.683 ± 0.014	0.934SerTyr: 0.934 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	10.44ThrAla: 10.44 ± 0.099	0.623ThrCys: 0.623 ± 0.017	1.848ThrAsp: 1.848 ± 0.026	3.313ThrGlu: 3.313 ± 0.053	0.837ThrPhe: 0.837 ± 0.016	2.662ThrGly: 2.662 ± 0.03	0.85ThrHis: 0.85 ± 0.016	1.138ThrIle: 1.138 ± 0.027	1.646ThrLys: 1.646 ± 0.027	2.94ThrLeu: 2.94 ± 0.031	0.492ThrMet: 0.492 ± 0.013	1.24ThrAsn: 1.24 ± 0.019	3.537ThrPro: 3.537 ± 0.042	2.036ThrGln: 2.036 ± 0.023	2.016ThrArg: 2.016 ± 0.02	3.397ThrSer: 3.397 ± 0.041	3.651ThrThr: 3.651 ± 0.053	2.047ThrVal: 2.047 ± 0.029	0.316ThrTrp: 0.316 ± 0.01	0.633ThrTyr: 0.633 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	5.847ValAla: 5.847 ± 0.057	1.097ValCys: 1.097 ± 0.02	1.877ValAsp: 1.877 ± 0.028	2.608ValGlu: 2.608 ± 0.034	1.335ValPhe: 1.335 ± 0.019	2.663ValGly: 2.663 ± 0.035	0.934ValHis: 0.934 ± 0.015	1.031ValIle: 1.031 ± 0.019	1.318ValLys: 1.318 ± 0.02	4.494ValLeu: 4.494 ± 0.046	0.707ValMet: 0.707 ± 0.017	0.849ValAsn: 0.849 ± 0.016	2.317ValPro: 2.317 ± 0.032	2.231ValGln: 2.231 ± 0.025	2.17ValArg: 2.17 ± 0.027	3.76ValSer: 3.76 ± 0.037	1.643ValThr: 1.643 ± 0.027	3.196ValVal: 3.196 ± 0.053	0.468ValTrp: 0.468 ± 0.011	1.126ValTyr: 1.126 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.604TrpAla: 0.604 ± 0.012	0.168TrpCys: 0.168 ± 0.006	0.305TrpAsp: 0.305 ± 0.009	0.448TrpGlu: 0.448 ± 0.01	0.206TrpPhe: 0.206 ± 0.008	0.97TrpGly: 0.97 ± 0.018	0.154TrpHis: 0.154 ± 0.006	0.231TrpIle: 0.231 ± 0.007	0.351TrpLys: 0.351 ± 0.009	0.96TrpLeu: 0.96 ± 0.016	0.185TrpMet: 0.185 ± 0.007	0.181TrpAsn: 0.181 ± 0.006	0.334TrpPro: 0.334 ± 0.008	0.549TrpGln: 0.549 ± 0.015	0.854TrpArg: 0.854 ± 0.017	0.523TrpSer: 0.523 ± 0.011	0.312TrpThr: 0.312 ± 0.009	0.441TrpVal: 0.441 ± 0.012	0.156TrpTrp: 0.156 ± 0.007	0.098TrpTyr: 0.098 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.075TyrAla: 1.075 ± 0.018	0.321TyrCys: 0.321 ± 0.012	0.528TyrAsp: 0.528 ± 0.012	0.721TyrGlu: 0.721 ± 0.016	0.451TyrPhe: 0.451 ± 0.012	0.829TyrGly: 0.829 ± 0.016	0.295TyrHis: 0.295 ± 0.01	0.625TyrIle: 0.625 ± 0.015	0.599TyrLys: 0.599 ± 0.012	1.27TyrLeu: 1.27 ± 0.018	0.299TyrMet: 0.299 ± 0.009	0.434TyrAsn: 0.434 ± 0.011	0.749TyrPro: 0.749 ± 0.015	0.578TyrGln: 0.578 ± 0.013	0.965TyrArg: 0.965 ± 0.016	1.088TyrSer: 1.088 ± 0.02	0.923TyrThr: 0.923 ± 0.015	0.698TyrVal: 0.698 ± 0.014	0.161TyrTrp: 0.161 ± 0.006	0.318TyrTyr: 0.318 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10057 proteins (4481553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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