Amino acid dipepetide frequency for Candidatus Methanohalarchaeum thermophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.307AlaAla: 3.307 ± 0.091
0.552AlaCys: 0.552 ± 0.044
2.617AlaAsp: 2.617 ± 0.077
4.12AlaGlu: 4.12 ± 0.102
2.086AlaPhe: 2.086 ± 0.077
4.069AlaGly: 4.069 ± 0.109
0.752AlaHis: 0.752 ± 0.042
4.836AlaIle: 4.836 ± 0.118
4.297AlaLys: 4.297 ± 0.098
5.068AlaLeu: 5.068 ± 0.1
1.245AlaMet: 1.245 ± 0.049
2.027AlaAsn: 2.027 ± 0.063
1.623AlaPro: 1.623 ± 0.06
1.226AlaGln: 1.226 ± 0.049
2.322AlaArg: 2.322 ± 0.083
3.309AlaSer: 3.309 ± 0.084
2.66AlaThr: 2.66 ± 0.078
3.496AlaVal: 3.496 ± 0.091
0.434AlaTrp: 0.434 ± 0.028
1.587AlaTyr: 1.587 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.367CysAla: 0.367 ± 0.025
0.122CysCys: 0.122 ± 0.015
0.567CysAsp: 0.567 ± 0.041
0.636CysGlu: 0.636 ± 0.038
0.371CysPhe: 0.371 ± 0.022
1.138CysGly: 1.138 ± 0.06
0.249CysHis: 0.249 ± 0.035
0.58CysIle: 0.58 ± 0.036
0.765CysLys: 0.765 ± 0.042
0.695CysLeu: 0.695 ± 0.041
0.202CysMet: 0.202 ± 0.017
0.464CysAsn: 0.464 ± 0.031
0.674CysPro: 0.674 ± 0.049
0.236CysGln: 0.236 ± 0.023
0.491CysArg: 0.491 ± 0.031
0.7CysSer: 0.7 ± 0.04
0.438CysThr: 0.438 ± 0.029
0.478CysVal: 0.478 ± 0.033
0.086CysTrp: 0.086 ± 0.012
0.335CysTyr: 0.335 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.62AspAla: 2.62 ± 0.08
0.54AspCys: 0.54 ± 0.035
2.362AspAsp: 2.362 ± 0.081
5.279AspGlu: 5.279 ± 0.11
2.784AspPhe: 2.784 ± 0.079
3.287AspGly: 3.287 ± 0.118
0.963AspHis: 0.963 ± 0.044
5.688AspIle: 5.688 ± 0.097
5.614AspLys: 5.614 ± 0.131
7.024AspLeu: 7.024 ± 0.128
1.216AspMet: 1.216 ± 0.048
2.257AspAsn: 2.257 ± 0.075
2.419AspPro: 2.419 ± 0.075
1.578AspGln: 1.578 ± 0.061
2.712AspArg: 2.712 ± 0.07
3.326AspSer: 3.326 ± 0.093
2.386AspThr: 2.386 ± 0.077
4.124AspVal: 4.124 ± 0.108
0.611AspTrp: 0.611 ± 0.035
2.411AspTyr: 2.411 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.708GluAla: 4.708 ± 0.101
0.755GluCys: 0.755 ± 0.048
5.627GluAsp: 5.627 ± 0.114
11.018GluGlu: 11.018 ± 0.223
3.066GluPhe: 3.066 ± 0.073
5.115GluGly: 5.115 ± 0.102
1.098GluHis: 1.098 ± 0.052
9.572GluIle: 9.572 ± 0.144
10.98GluLys: 10.98 ± 0.209
8.071GluLeu: 8.071 ± 0.144
1.92GluMet: 1.92 ± 0.06
4.836GluAsn: 4.836 ± 0.118
2.478GluPro: 2.478 ± 0.064
1.661GluGln: 1.661 ± 0.057
3.821GluArg: 3.821 ± 0.113
4.029GluSer: 4.029 ± 0.081
4.341GluThr: 4.341 ± 0.111
6.543GluVal: 6.543 ± 0.114
0.729GluTrp: 0.729 ± 0.04
2.676GluTyr: 2.676 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
1.8PheAla: 1.8 ± 0.073
0.432PheCys: 0.432 ± 0.03
2.531PheAsp: 2.531 ± 0.067
3.043PheGlu: 3.043 ± 0.076
2.072PhePhe: 2.072 ± 0.091
2.978PheGly: 2.978 ± 0.089
0.579PheHis: 0.579 ± 0.032
2.999PheIle: 2.999 ± 0.09
3.054PheLys: 3.054 ± 0.077
4.305PheLeu: 4.305 ± 0.105
0.755PheMet: 0.755 ± 0.041
2.188PheAsn: 2.188 ± 0.068
1.378PhePro: 1.378 ± 0.061
0.868PheGln: 0.868 ± 0.043
1.568PheArg: 1.568 ± 0.059
3.283PheSer: 3.283 ± 0.086
1.812PheThr: 1.812 ± 0.056
2.379PheVal: 2.379 ± 0.072
0.487PheTrp: 0.487 ± 0.035
1.505PheTyr: 1.505 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
3.894GlyAla: 3.894 ± 0.093
0.894GlyCys: 0.894 ± 0.041
3.686GlyAsp: 3.686 ± 0.108
5.679GlyGlu: 5.679 ± 0.109
3.302GlyPhe: 3.302 ± 0.094
4.836GlyGly: 4.836 ± 0.135
0.986GlyHis: 0.986 ± 0.045
5.814GlyIle: 5.814 ± 0.117
5.892GlyLys: 5.892 ± 0.115
6.392GlyLeu: 6.392 ± 0.136
1.393GlyMet: 1.393 ± 0.062
2.864GlyAsn: 2.864 ± 0.074
1.882GlyPro: 1.882 ± 0.063
1.34GlyGln: 1.34 ± 0.045
2.828GlyArg: 2.828 ± 0.085
4.503GlySer: 4.503 ± 0.103
3.448GlyThr: 3.448 ± 0.087
4.721GlyVal: 4.721 ± 0.11
0.742GlyTrp: 0.742 ± 0.042
2.797GlyTyr: 2.797 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.74HisAla: 0.74 ± 0.041
0.175HisCys: 0.175 ± 0.018
0.803HisAsp: 0.803 ± 0.04
1.163HisGlu: 1.163 ± 0.057
0.618HisPhe: 0.618 ± 0.032
1.087HisGly: 1.087 ± 0.048
0.35HisHis: 0.35 ± 0.027
1.184HisIle: 1.184 ± 0.048
1.132HisLys: 1.132 ± 0.047
1.545HisLeu: 1.545 ± 0.064
0.268HisMet: 0.268 ± 0.023
0.647HisAsn: 0.647 ± 0.035
0.849HisPro: 0.849 ± 0.045
0.487HisGln: 0.487 ± 0.031
0.689HisArg: 0.689 ± 0.038
1.005HisSer: 1.005 ± 0.046
0.691HisThr: 0.691 ± 0.04
0.824HisVal: 0.824 ± 0.043
0.181HisTrp: 0.181 ± 0.019
0.499HisTyr: 0.499 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
4.666IleAla: 4.666 ± 0.109
0.628IleCys: 0.628 ± 0.03
5.517IleAsp: 5.517 ± 0.091
7.995IleGlu: 7.995 ± 0.141
3.142IlePhe: 3.142 ± 0.097
6.307IleGly: 6.307 ± 0.149
1.243IleHis: 1.243 ± 0.054
5.854IleIle: 5.854 ± 0.165
8.506IleLys: 8.506 ± 0.157
7.395IleLeu: 7.395 ± 0.156
1.462IleMet: 1.462 ± 0.053
4.66IleAsn: 4.66 ± 0.102
3.275IlePro: 3.275 ± 0.089
2.166IleGln: 2.166 ± 0.065
3.538IleArg: 3.538 ± 0.093
6.177IleSer: 6.177 ± 0.134
4.32IleThr: 4.32 ± 0.103
4.541IleVal: 4.541 ± 0.099
0.685IleTrp: 0.685 ± 0.041
2.582IleTyr: 2.582 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
5.011LysAla: 5.011 ± 0.104
0.883LysCys: 0.883 ± 0.051
5.816LysAsp: 5.816 ± 0.111
11.681LysGlu: 11.681 ± 0.191
2.826LysPhe: 2.826 ± 0.08
5.235LysGly: 5.235 ± 0.122
1.182LysHis: 1.182 ± 0.05
8.63LysIle: 8.63 ± 0.156
11.597LysLys: 11.597 ± 0.214
7.953LysLeu: 7.953 ± 0.131
1.935LysMet: 1.935 ± 0.06
6.057LysAsn: 6.057 ± 0.142
2.893LysPro: 2.893 ± 0.077
2.594LysGln: 2.594 ± 0.091
4.333LysArg: 4.333 ± 0.109
4.801LysSer: 4.801 ± 0.1
4.954LysThr: 4.954 ± 0.122
5.382LysVal: 5.382 ± 0.107
0.74LysTrp: 0.74 ± 0.041
2.847LysTyr: 2.847 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
5.146LeuAla: 5.146 ± 0.113
0.697LeuCys: 0.697 ± 0.039
6.348LeuAsp: 6.348 ± 0.114
7.637LeuGlu: 7.637 ± 0.15
3.635LeuPhe: 3.635 ± 0.099
6.834LeuGly: 6.834 ± 0.128
1.281LeuHis: 1.281 ± 0.053
7.943LeuIle: 7.943 ± 0.178
8.556LeuLys: 8.556 ± 0.147
7.405LeuLeu: 7.405 ± 0.154
1.829LeuMet: 1.829 ± 0.061
5.132LeuAsn: 5.132 ± 0.1
3.378LeuPro: 3.378 ± 0.091
1.774LeuGln: 1.774 ± 0.063
3.836LeuArg: 3.836 ± 0.079
6.779LeuSer: 6.779 ± 0.139
4.428LeuThr: 4.428 ± 0.103
5.743LeuVal: 5.743 ± 0.125
0.609LeuTrp: 0.609 ± 0.037
2.459LeuTyr: 2.459 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.325MetAla: 1.325 ± 0.054
0.131MetCys: 0.131 ± 0.016
1.372MetAsp: 1.372 ± 0.052
1.815MetGlu: 1.815 ± 0.068
0.643MetPhe: 0.643 ± 0.035
1.401MetGly: 1.401 ± 0.06
0.272MetHis: 0.272 ± 0.024
1.385MetIle: 1.385 ± 0.053
2.002MetLys: 2.002 ± 0.064
1.597MetLeu: 1.597 ± 0.06
0.442MetMet: 0.442 ± 0.027
1.174MetAsn: 1.174 ± 0.048
0.7MetPro: 0.7 ± 0.034
0.445MetGln: 0.445 ± 0.032
0.792MetArg: 0.792 ± 0.039
1.503MetSer: 1.503 ± 0.049
1.016MetThr: 1.016 ± 0.05
1.336MetVal: 1.336 ± 0.056
0.147MetTrp: 0.147 ± 0.018
0.493MetTyr: 0.493 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.152AsnAla: 2.152 ± 0.059
0.552AsnCys: 0.552 ± 0.035
2.078AsnAsp: 2.078 ± 0.071
4.354AsnGlu: 4.354 ± 0.124
1.815AsnPhe: 1.815 ± 0.062
2.82AsnGly: 2.82 ± 0.078
0.738AsnHis: 0.738 ± 0.041
4.232AsnIle: 4.232 ± 0.087
5.736AsnLys: 5.736 ± 0.131
5.593AsnLeu: 5.593 ± 0.121
0.976AsnMet: 0.976 ± 0.041
2.537AsnAsn: 2.537 ± 0.085
2.297AsnPro: 2.297 ± 0.063
1.987AsnGln: 1.987 ± 0.068
2.322AsnArg: 2.322 ± 0.079
3.144AsnSer: 3.144 ± 0.089
2.228AsnThr: 2.228 ± 0.07
2.702AsnVal: 2.702 ± 0.082
0.575AsnTrp: 0.575 ± 0.033
1.977AsnTyr: 1.977 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.553ProAla: 1.553 ± 0.056
0.343ProCys: 0.343 ± 0.029
2.131ProAsp: 2.131 ± 0.069
3.427ProGlu: 3.427 ± 0.082
1.418ProPhe: 1.418 ± 0.05
2.377ProGly: 2.377 ± 0.075
0.746ProHis: 0.746 ± 0.036
2.868ProIle: 2.868 ± 0.086
2.95ProLys: 2.95 ± 0.076
2.87ProLeu: 2.87 ± 0.085
0.599ProMet: 0.599 ± 0.035
1.686ProAsn: 1.686 ± 0.05
1.323ProPro: 1.323 ± 0.06
0.948ProGln: 0.948 ± 0.042
1.467ProArg: 1.467 ± 0.052
2.683ProSer: 2.683 ± 0.072
1.905ProThr: 1.905 ± 0.062
2.485ProVal: 2.485 ± 0.071
0.381ProTrp: 0.381 ± 0.03
1.241ProTyr: 1.241 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
1.279GlnAla: 1.279 ± 0.048
0.185GlnCys: 0.185 ± 0.022
1.363GlnAsp: 1.363 ± 0.052
2.619GlnGlu: 2.619 ± 0.076
0.716GlnPhe: 0.716 ± 0.029
1.41GlnGly: 1.41 ± 0.052
0.36GlnHis: 0.36 ± 0.024
2.091GlnIle: 2.091 ± 0.066
2.914GlnLys: 2.914 ± 0.094
1.939GlnLeu: 1.939 ± 0.066
0.596GlnMet: 0.596 ± 0.036
1.463GlnAsn: 1.463 ± 0.054
0.778GlnPro: 0.778 ± 0.035
0.733GlnGln: 0.733 ± 0.044
1.157GlnArg: 1.157 ± 0.05
1.273GlnSer: 1.273 ± 0.054
1.174GlnThr: 1.174 ± 0.047
1.503GlnVal: 1.503 ± 0.058
0.158GlnTrp: 0.158 ± 0.017
0.67GlnTyr: 0.67 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.145ArgAla: 2.145 ± 0.067
0.558ArgCys: 0.558 ± 0.038
3.132ArgAsp: 3.132 ± 0.088
4.634ArgGlu: 4.634 ± 0.115
1.899ArgPhe: 1.899 ± 0.07
2.761ArgGly: 2.761 ± 0.084
0.672ArgHis: 0.672 ± 0.033
3.214ArgIle: 3.214 ± 0.081
4.584ArgLys: 4.584 ± 0.095
3.29ArgLeu: 3.29 ± 0.074
0.828ArgMet: 0.828 ± 0.04
2.11ArgAsn: 2.11 ± 0.069
1.246ArgPro: 1.246 ± 0.048
0.955ArgGln: 0.955 ± 0.049
1.911ArgArg: 1.911 ± 0.079
2.563ArgSer: 2.563 ± 0.074
1.802ArgThr: 1.802 ± 0.067
2.601ArgVal: 2.601 ± 0.079
0.421ArgTrp: 0.421 ± 0.03
1.602ArgTyr: 1.602 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
2.917SerAla: 2.917 ± 0.078
0.579SerCys: 0.579 ± 0.029
3.871SerAsp: 3.871 ± 0.111
5.471SerGlu: 5.471 ± 0.112
3.077SerPhe: 3.077 ± 0.095
4.581SerGly: 4.581 ± 0.093
0.993SerHis: 0.993 ± 0.049
5.505SerIle: 5.505 ± 0.114
5.888SerLys: 5.888 ± 0.12
6.052SerLeu: 6.052 ± 0.128
1.361SerMet: 1.361 ± 0.047
3.403SerAsn: 3.403 ± 0.086
2.329SerPro: 2.329 ± 0.066
1.638SerGln: 1.638 ± 0.052
2.719SerArg: 2.719 ± 0.071
4.489SerSer: 4.489 ± 0.123
3.07SerThr: 3.07 ± 0.078
3.519SerVal: 3.519 ± 0.097
0.559SerTrp: 0.559 ± 0.034
2.276SerTyr: 2.276 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
2.687ThrAla: 2.687 ± 0.083
0.388ThrCys: 0.388 ± 0.029
2.569ThrAsp: 2.569 ± 0.093
4.032ThrGlu: 4.032 ± 0.082
1.659ThrPhe: 1.659 ± 0.07
4.173ThrGly: 4.173 ± 0.108
0.834ThrHis: 0.834 ± 0.04
3.951ThrIle: 3.951 ± 0.093
4.28ThrLys: 4.28 ± 0.105
4.276ThrLeu: 4.276 ± 0.114
0.881ThrMet: 0.881 ± 0.042
2.364ThrAsn: 2.364 ± 0.067
2.046ThrPro: 2.046 ± 0.072
1.288ThrGln: 1.288 ± 0.056
1.922ThrArg: 1.922 ± 0.063
3.197ThrSer: 3.197 ± 0.084
2.66ThrThr: 2.66 ± 0.094
2.99ThrVal: 2.99 ± 0.087
0.468ThrTrp: 0.468 ± 0.035
1.614ThrTyr: 1.614 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
3.439ValAla: 3.439 ± 0.088
0.636ValCys: 0.636 ± 0.033
4.213ValAsp: 4.213 ± 0.103
5.382ValGlu: 5.382 ± 0.105
2.773ValPhe: 2.773 ± 0.085
4.525ValGly: 4.525 ± 0.126
1.007ValHis: 1.007 ± 0.042
4.961ValIle: 4.961 ± 0.098
5.159ValLys: 5.159 ± 0.099
5.462ValLeu: 5.462 ± 0.118
1.252ValMet: 1.252 ± 0.052
2.816ValAsn: 2.816 ± 0.081
2.261ValPro: 2.261 ± 0.065
1.281ValGln: 1.281 ± 0.05
2.541ValArg: 2.541 ± 0.065
4.584ValSer: 4.584 ± 0.1
3.068ValThr: 3.068 ± 0.097
4.425ValVal: 4.425 ± 0.103
0.457ValTrp: 0.457 ± 0.029
1.894ValTyr: 1.894 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.483TrpAla: 0.483 ± 0.032
0.107TrpCys: 0.107 ± 0.016
0.523TrpAsp: 0.523 ± 0.032
0.626TrpGlu: 0.626 ± 0.034
0.516TrpPhe: 0.516 ± 0.031
0.672TrpGly: 0.672 ± 0.042
0.122TrpHis: 0.122 ± 0.016
0.776TrpIle: 0.776 ± 0.042
0.915TrpLys: 0.915 ± 0.037
0.765TrpLeu: 0.765 ± 0.043
0.234TrpMet: 0.234 ± 0.022
0.478TrpAsn: 0.478 ± 0.03
0.234TrpPro: 0.234 ± 0.021
0.204TrpGln: 0.204 ± 0.019
0.417TrpArg: 0.417 ± 0.024
0.539TrpSer: 0.539 ± 0.033
0.384TrpThr: 0.384 ± 0.027
0.567TrpVal: 0.567 ± 0.033
0.129TrpTrp: 0.129 ± 0.016
0.301TrpTyr: 0.301 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.391TyrAla: 1.391 ± 0.052
0.438TyrCys: 0.438 ± 0.031
2.074TyrAsp: 2.074 ± 0.069
2.436TyrGlu: 2.436 ± 0.078
1.599TyrPhe: 1.599 ± 0.064
2.287TyrGly: 2.287 ± 0.064
0.512TyrHis: 0.512 ± 0.028
2.573TyrIle: 2.573 ± 0.071
2.527TyrLys: 2.527 ± 0.079
3.753TyrLeu: 3.753 ± 0.098
0.596TyrMet: 0.596 ± 0.033
1.652TyrAsn: 1.652 ± 0.063
1.338TyrPro: 1.338 ± 0.059
0.972TyrGln: 0.972 ± 0.045
1.545TyrArg: 1.545 ± 0.057
2.409TyrSer: 2.409 ± 0.075
1.494TyrThr: 1.494 ± 0.054
1.776TyrVal: 1.776 ± 0.059
0.394TyrTrp: 0.394 ± 0.028
1.246TyrTyr: 1.246 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2152 proteins (525482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski