Amino acid dipepetide frequency for Streptococcus satellite phage Javan295

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.703AlaAla: 0.703 ± 0.474
0.0AlaCys: 0.0 ± 0.0
2.11AlaAsp: 2.11 ± 0.872
4.219AlaGlu: 4.219 ± 1.152
2.813AlaPhe: 2.813 ± 1.164
1.758AlaGly: 1.758 ± 0.56
0.0AlaHis: 0.0 ± 0.0
3.165AlaIle: 3.165 ± 1.304
6.329AlaLys: 6.329 ± 1.215
2.813AlaLeu: 2.813 ± 1.075
1.055AlaMet: 1.055 ± 0.579
4.571AlaAsn: 4.571 ± 1.014
1.758AlaPro: 1.758 ± 0.839
1.055AlaGln: 1.055 ± 0.533
2.461AlaArg: 2.461 ± 0.831
1.055AlaSer: 1.055 ± 0.606
3.165AlaThr: 3.165 ± 0.694
2.461AlaVal: 2.461 ± 0.826
0.0AlaTrp: 0.0 ± 0.0
4.571AlaTyr: 4.571 ± 0.936
0.0AlaXaa: 0.0 ± 0.0
Cys
0.352CysAla: 0.352 ± 0.318
0.0CysCys: 0.0 ± 0.0
0.352CysAsp: 0.352 ± 0.328
0.352CysGlu: 0.352 ± 0.382
0.0CysPhe: 0.0 ± 0.0
1.055CysGly: 1.055 ± 0.606
0.0CysHis: 0.0 ± 0.0
0.352CysIle: 0.352 ± 0.325
0.352CysLys: 0.352 ± 0.326
0.703CysLeu: 0.703 ± 0.555
0.352CysMet: 0.352 ± 0.391
0.352CysAsn: 0.352 ± 0.346
0.703CysPro: 0.703 ± 0.41
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.352CysThr: 0.352 ± 0.278
0.352CysVal: 0.352 ± 0.328
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.703AspAla: 0.703 ± 0.444
0.703AspCys: 0.703 ± 0.407
5.626AspAsp: 5.626 ± 1.535
3.165AspGlu: 3.165 ± 0.898
4.923AspPhe: 4.923 ± 1.412
3.165AspGly: 3.165 ± 1.061
0.352AspHis: 0.352 ± 0.278
4.219AspIle: 4.219 ± 1.251
6.681AspLys: 6.681 ± 1.302
8.439AspLeu: 8.439 ± 1.538
1.055AspMet: 1.055 ± 0.582
4.219AspAsn: 4.219 ± 0.945
0.703AspPro: 0.703 ± 0.442
1.406AspGln: 1.406 ± 0.583
2.461AspArg: 2.461 ± 0.902
5.626AspSer: 5.626 ± 1.009
3.516AspThr: 3.516 ± 1.06
3.868AspVal: 3.868 ± 1.036
0.352AspTrp: 0.352 ± 0.328
3.516AspTyr: 3.516 ± 1.401
0.0AspXaa: 0.0 ± 0.0
Glu
3.516GluAla: 3.516 ± 1.096
1.055GluCys: 1.055 ± 0.448
5.977GluAsp: 5.977 ± 1.516
3.868GluGlu: 3.868 ± 1.132
3.165GluPhe: 3.165 ± 0.878
2.461GluGly: 2.461 ± 0.909
1.055GluHis: 1.055 ± 0.514
7.384GluIle: 7.384 ± 1.293
11.955GluLys: 11.955 ± 1.72
10.549GluLeu: 10.549 ± 1.806
1.758GluMet: 1.758 ± 1.262
6.681GluAsn: 6.681 ± 1.832
0.703GluPro: 0.703 ± 0.428
4.571GluGln: 4.571 ± 1.361
2.813GluArg: 2.813 ± 0.942
3.165GluSer: 3.165 ± 0.733
5.274GluThr: 5.274 ± 1.818
2.813GluVal: 2.813 ± 1.144
1.055GluTrp: 1.055 ± 0.499
3.868GluTyr: 3.868 ± 0.889
0.0GluXaa: 0.0 ± 0.0
Phe
1.406PheAla: 1.406 ± 0.694
0.352PheCys: 0.352 ± 0.328
3.868PheAsp: 3.868 ± 0.85
4.923PheGlu: 4.923 ± 0.999
2.813PhePhe: 2.813 ± 0.889
3.165PheGly: 3.165 ± 0.88
0.352PheHis: 0.352 ± 0.278
1.758PheIle: 1.758 ± 0.807
5.274PheLys: 5.274 ± 1.545
4.923PheLeu: 4.923 ± 1.06
0.703PheMet: 0.703 ± 0.424
1.055PheAsn: 1.055 ± 0.78
0.703PhePro: 0.703 ± 0.649
0.703PheGln: 0.703 ± 0.441
0.703PheArg: 0.703 ± 0.366
5.274PheSer: 5.274 ± 1.252
2.11PheThr: 2.11 ± 0.948
3.165PheVal: 3.165 ± 1.039
0.352PheTrp: 0.352 ± 0.278
0.703PheTyr: 0.703 ± 0.413
0.0PheXaa: 0.0 ± 0.0
Gly
1.055GlyAla: 1.055 ± 0.643
0.352GlyCys: 0.352 ± 0.278
2.11GlyAsp: 2.11 ± 0.978
2.11GlyGlu: 2.11 ± 0.789
2.11GlyPhe: 2.11 ± 0.667
2.461GlyGly: 2.461 ± 1.139
1.406GlyHis: 1.406 ± 0.592
2.11GlyIle: 2.11 ± 0.632
6.329GlyLys: 6.329 ± 1.364
4.219GlyLeu: 4.219 ± 1.109
0.703GlyMet: 0.703 ± 0.434
2.461GlyAsn: 2.461 ± 0.861
0.0GlyPro: 0.0 ± 0.0
1.055GlyGln: 1.055 ± 0.484
1.758GlyArg: 1.758 ± 0.581
4.219GlySer: 4.219 ± 1.444
2.461GlyThr: 2.461 ± 0.874
3.868GlyVal: 3.868 ± 0.926
1.055GlyTrp: 1.055 ± 0.571
3.868GlyTyr: 3.868 ± 1.073
0.0GlyXaa: 0.0 ± 0.0
His
2.813HisAla: 2.813 ± 1.24
0.0HisCys: 0.0 ± 0.0
0.352HisAsp: 0.352 ± 0.38
0.352HisGlu: 0.352 ± 0.412
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.352HisHis: 0.352 ± 0.318
1.406HisIle: 1.406 ± 0.57
1.406HisLys: 1.406 ± 0.687
2.461HisLeu: 2.461 ± 1.082
0.0HisMet: 0.0 ± 0.0
0.352HisAsn: 0.352 ± 0.316
0.0HisPro: 0.0 ± 0.0
0.703HisGln: 0.703 ± 0.434
0.0HisArg: 0.0 ± 0.0
0.703HisSer: 0.703 ± 0.458
2.461HisThr: 2.461 ± 0.854
0.352HisVal: 0.352 ± 0.312
0.352HisTrp: 0.352 ± 0.346
0.352HisTyr: 0.352 ± 0.385
0.0HisXaa: 0.0 ± 0.0
Ile
3.516IleAla: 3.516 ± 1.054
0.0IleCys: 0.0 ± 0.0
5.626IleAsp: 5.626 ± 1.285
5.274IleGlu: 5.274 ± 1.919
2.11IlePhe: 2.11 ± 0.896
3.868IleGly: 3.868 ± 0.92
0.703IleHis: 0.703 ± 0.458
5.274IleIle: 5.274 ± 1.029
7.384IleLys: 7.384 ± 1.402
7.384IleLeu: 7.384 ± 0.743
0.0IleMet: 0.0 ± 0.0
5.977IleAsn: 5.977 ± 1.351
2.461IlePro: 2.461 ± 0.73
4.571IleGln: 4.571 ± 0.88
1.758IleArg: 1.758 ± 0.578
4.923IleSer: 4.923 ± 1.131
3.165IleThr: 3.165 ± 0.941
1.406IleVal: 1.406 ± 0.577
0.0IleTrp: 0.0 ± 0.0
2.11IleTyr: 2.11 ± 0.673
0.0IleXaa: 0.0 ± 0.0
Lys
5.626LysAla: 5.626 ± 1.533
0.703LysCys: 0.703 ± 0.489
5.977LysAsp: 5.977 ± 1.301
11.603LysGlu: 11.603 ± 1.24
3.165LysPhe: 3.165 ± 1.134
6.329LysGly: 6.329 ± 1.376
2.11LysHis: 2.11 ± 0.801
8.439LysIle: 8.439 ± 1.508
10.549LysLys: 10.549 ± 1.971
8.439LysLeu: 8.439 ± 1.991
4.219LysMet: 4.219 ± 1.196
5.274LysAsn: 5.274 ± 1.019
2.11LysPro: 2.11 ± 0.873
5.626LysGln: 5.626 ± 1.314
8.087LysArg: 8.087 ± 1.4
5.977LysSer: 5.977 ± 1.452
7.384LysThr: 7.384 ± 1.69
6.329LysVal: 6.329 ± 0.999
0.703LysTrp: 0.703 ± 0.477
4.923LysTyr: 4.923 ± 1.459
0.0LysXaa: 0.0 ± 0.0
Leu
5.274LeuAla: 5.274 ± 1.548
0.352LeuCys: 0.352 ± 0.391
8.79LeuAsp: 8.79 ± 1.793
10.549LeuGlu: 10.549 ± 2.001
4.219LeuPhe: 4.219 ± 1.239
5.977LeuGly: 5.977 ± 0.993
2.11LeuHis: 2.11 ± 0.866
6.681LeuIle: 6.681 ± 1.36
9.494LeuLys: 9.494 ± 1.852
4.923LeuLeu: 4.923 ± 0.935
2.813LeuMet: 2.813 ± 0.812
5.274LeuAsn: 5.274 ± 1.79
2.11LeuPro: 2.11 ± 0.894
4.219LeuGln: 4.219 ± 0.852
4.571LeuArg: 4.571 ± 1.193
5.977LeuSer: 5.977 ± 1.034
5.977LeuThr: 5.977 ± 1.295
5.274LeuVal: 5.274 ± 1.148
0.352LeuTrp: 0.352 ± 0.325
2.11LeuTyr: 2.11 ± 1.018
0.0LeuXaa: 0.0 ± 0.0
Met
0.352MetAla: 0.352 ± 0.318
0.0MetCys: 0.0 ± 0.0
1.758MetAsp: 1.758 ± 0.664
2.813MetGlu: 2.813 ± 1.338
0.352MetPhe: 0.352 ± 0.412
0.352MetGly: 0.352 ± 0.385
0.0MetHis: 0.0 ± 0.0
1.055MetIle: 1.055 ± 0.581
2.11MetLys: 2.11 ± 0.534
1.406MetLeu: 1.406 ± 0.53
0.0MetMet: 0.0 ± 0.0
2.11MetAsn: 2.11 ± 0.666
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.758MetArg: 1.758 ± 0.775
1.055MetSer: 1.055 ± 0.619
2.813MetThr: 2.813 ± 1.361
1.406MetVal: 1.406 ± 0.628
0.0MetTrp: 0.0 ± 0.0
0.703MetTyr: 0.703 ± 0.491
0.0MetXaa: 0.0 ± 0.0
Asn
3.165AsnAla: 3.165 ± 0.75
0.352AsnCys: 0.352 ± 0.278
2.11AsnAsp: 2.11 ± 0.879
3.165AsnGlu: 3.165 ± 1.185
3.868AsnPhe: 3.868 ± 1.042
4.219AsnGly: 4.219 ± 1.187
1.406AsnHis: 1.406 ± 0.539
2.813AsnIle: 2.813 ± 0.874
5.977AsnLys: 5.977 ± 1.363
6.681AsnLeu: 6.681 ± 1.038
1.758AsnMet: 1.758 ± 0.925
4.571AsnAsn: 4.571 ± 1.243
2.11AsnPro: 2.11 ± 0.575
3.165AsnGln: 3.165 ± 1.039
2.461AsnArg: 2.461 ± 0.676
2.813AsnSer: 2.813 ± 0.949
3.868AsnThr: 3.868 ± 1.171
2.11AsnVal: 2.11 ± 1.183
0.352AsnTrp: 0.352 ± 0.325
4.219AsnTyr: 4.219 ± 1.222
0.0AsnXaa: 0.0 ± 0.0
Pro
1.055ProAla: 1.055 ± 0.509
0.0ProCys: 0.0 ± 0.0
2.11ProAsp: 2.11 ± 0.847
2.11ProGlu: 2.11 ± 0.774
0.703ProPhe: 0.703 ± 0.426
0.0ProGly: 0.0 ± 0.0
0.352ProHis: 0.352 ± 0.382
1.406ProIle: 1.406 ± 0.658
5.274ProLys: 5.274 ± 1.67
1.055ProLeu: 1.055 ± 0.526
0.0ProMet: 0.0 ± 0.0
0.352ProAsn: 0.352 ± 0.328
0.352ProPro: 0.352 ± 0.412
0.703ProGln: 0.703 ± 0.568
0.703ProArg: 0.703 ± 0.427
1.055ProSer: 1.055 ± 0.514
1.055ProThr: 1.055 ± 0.703
1.055ProVal: 1.055 ± 0.409
0.0ProTrp: 0.0 ± 0.0
1.758ProTyr: 1.758 ± 0.765
0.0ProXaa: 0.0 ± 0.0
Gln
4.571GlnAla: 4.571 ± 1.078
0.352GlnCys: 0.352 ± 0.326
2.11GlnAsp: 2.11 ± 0.709
3.868GlnGlu: 3.868 ± 0.986
2.11GlnPhe: 2.11 ± 0.882
0.352GlnGly: 0.352 ± 0.391
0.703GlnHis: 0.703 ± 0.555
1.758GlnIle: 1.758 ± 0.467
3.516GlnLys: 3.516 ± 0.851
2.813GlnLeu: 2.813 ± 0.905
0.703GlnMet: 0.703 ± 0.652
1.758GlnAsn: 1.758 ± 0.634
0.0GlnPro: 0.0 ± 0.0
1.055GlnGln: 1.055 ± 0.68
2.813GlnArg: 2.813 ± 0.925
3.165GlnSer: 3.165 ± 1.038
3.165GlnThr: 3.165 ± 1.152
3.868GlnVal: 3.868 ± 1.134
0.352GlnTrp: 0.352 ± 0.312
2.11GlnTyr: 2.11 ± 0.745
0.0GlnXaa: 0.0 ± 0.0
Arg
1.055ArgAla: 1.055 ± 0.611
0.352ArgCys: 0.352 ± 0.325
2.461ArgAsp: 2.461 ± 0.707
3.516ArgGlu: 3.516 ± 0.993
1.758ArgPhe: 1.758 ± 0.712
1.758ArgGly: 1.758 ± 0.709
0.703ArgHis: 0.703 ± 0.387
3.165ArgIle: 3.165 ± 0.744
7.736ArgLys: 7.736 ± 0.852
3.868ArgLeu: 3.868 ± 1.079
0.352ArgMet: 0.352 ± 0.311
3.516ArgAsn: 3.516 ± 1.073
1.055ArgPro: 1.055 ± 0.525
2.461ArgGln: 2.461 ± 0.769
1.758ArgArg: 1.758 ± 0.833
2.11ArgSer: 2.11 ± 0.865
3.516ArgThr: 3.516 ± 1.147
1.055ArgVal: 1.055 ± 0.56
0.0ArgTrp: 0.0 ± 0.0
2.813ArgTyr: 2.813 ± 1.258
0.0ArgXaa: 0.0 ± 0.0
Ser
2.11SerAla: 2.11 ± 0.758
0.352SerCys: 0.352 ± 0.325
4.219SerAsp: 4.219 ± 0.846
5.977SerGlu: 5.977 ± 0.907
3.516SerPhe: 3.516 ± 0.995
3.516SerGly: 3.516 ± 1.12
1.406SerHis: 1.406 ± 0.644
2.11SerIle: 2.11 ± 0.899
7.736SerLys: 7.736 ± 2.018
6.681SerLeu: 6.681 ± 1.509
1.758SerMet: 1.758 ± 0.885
2.813SerAsn: 2.813 ± 1.189
2.813SerPro: 2.813 ± 0.765
3.165SerGln: 3.165 ± 0.955
1.406SerArg: 1.406 ± 0.551
3.516SerSer: 3.516 ± 0.989
2.813SerThr: 2.813 ± 0.812
3.516SerVal: 3.516 ± 1.079
0.703SerTrp: 0.703 ± 0.482
1.758SerTyr: 1.758 ± 0.647
0.0SerXaa: 0.0 ± 0.0
Thr
2.813ThrAla: 2.813 ± 0.936
0.0ThrCys: 0.0 ± 0.0
1.055ThrAsp: 1.055 ± 0.646
4.923ThrGlu: 4.923 ± 1.035
2.461ThrPhe: 2.461 ± 0.731
3.868ThrGly: 3.868 ± 0.97
1.055ThrHis: 1.055 ± 0.577
4.923ThrIle: 4.923 ± 1.215
4.571ThrLys: 4.571 ± 1.183
7.384ThrLeu: 7.384 ± 1.188
0.703ThrMet: 0.703 ± 0.456
2.813ThrAsn: 2.813 ± 0.921
1.406ThrPro: 1.406 ± 0.545
2.813ThrGln: 2.813 ± 1.429
4.923ThrArg: 4.923 ± 1.579
3.165ThrSer: 3.165 ± 1.168
3.516ThrThr: 3.516 ± 0.788
5.626ThrVal: 5.626 ± 0.983
1.055ThrTrp: 1.055 ± 0.526
2.11ThrTyr: 2.11 ± 1.334
0.0ThrXaa: 0.0 ± 0.0
Val
3.516ValAla: 3.516 ± 0.93
0.352ValCys: 0.352 ± 0.328
5.274ValAsp: 5.274 ± 1.791
4.219ValGlu: 4.219 ± 1.027
1.406ValPhe: 1.406 ± 0.535
0.352ValGly: 0.352 ± 0.35
0.352ValHis: 0.352 ± 0.328
4.571ValIle: 4.571 ± 1.256
5.274ValLys: 5.274 ± 1.359
4.571ValLeu: 4.571 ± 1.116
0.352ValMet: 0.352 ± 0.435
4.923ValAsn: 4.923 ± 0.933
1.055ValPro: 1.055 ± 0.558
1.406ValGln: 1.406 ± 0.668
1.055ValArg: 1.055 ± 0.571
5.274ValSer: 5.274 ± 0.837
2.813ValThr: 2.813 ± 0.778
2.461ValVal: 2.461 ± 0.838
0.703ValTrp: 0.703 ± 0.506
2.461ValTyr: 2.461 ± 0.622
0.0ValXaa: 0.0 ± 0.0
Trp
1.406TrpAla: 1.406 ± 0.478
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.11TrpGlu: 2.11 ± 0.829
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.703TrpIle: 0.703 ± 0.495
0.703TrpLys: 0.703 ± 0.449
0.703TrpLeu: 0.703 ± 0.436
0.352TrpMet: 0.352 ± 0.311
0.352TrpAsn: 0.352 ± 0.312
0.0TrpPro: 0.0 ± 0.0
0.352TrpGln: 0.352 ± 0.278
0.352TrpArg: 0.352 ± 0.382
0.352TrpSer: 0.352 ± 0.278
0.0TrpThr: 0.0 ± 0.0
0.703TrpVal: 0.703 ± 0.486
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.055TyrAla: 1.055 ± 0.538
0.352TyrCys: 0.352 ± 0.382
2.813TyrAsp: 2.813 ± 1.237
4.571TyrGlu: 4.571 ± 1.25
2.813TyrPhe: 2.813 ± 0.723
1.055TyrGly: 1.055 ± 0.503
0.0TyrHis: 0.0 ± 0.0
4.219TyrIle: 4.219 ± 1.19
4.923TyrLys: 4.923 ± 1.432
7.032TyrLeu: 7.032 ± 1.574
1.055TyrMet: 1.055 ± 0.607
1.758TyrAsn: 1.758 ± 0.757
1.055TyrPro: 1.055 ± 0.582
2.11TyrGln: 2.11 ± 0.593
3.165TyrArg: 3.165 ± 1.223
2.461TyrSer: 2.461 ± 1.034
1.758TyrThr: 1.758 ± 0.555
1.055TyrVal: 1.055 ± 0.606
0.703TyrTrp: 0.703 ± 0.429
1.406TyrTyr: 1.406 ± 0.655
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski