Amino acid dipepetide frequency for Calothrix sp. 336/3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.36AlaAla: 7.36 ± 0.094	0.787AlaCys: 0.787 ± 0.024	3.882AlaAsp: 3.882 ± 0.05	5.119AlaGlu: 5.119 ± 0.061	2.838AlaPhe: 2.838 ± 0.044	5.166AlaGly: 5.166 ± 0.061	1.275AlaHis: 1.275 ± 0.031	7.141AlaIle: 7.141 ± 0.075	4.232AlaLys: 4.232 ± 0.054	7.981AlaLeu: 7.981 ± 0.097	1.704AlaMet: 1.704 ± 0.031	3.501AlaAsn: 3.501 ± 0.058	2.93AlaPro: 2.93 ± 0.054	3.912AlaGln: 3.912 ± 0.06	3.44AlaArg: 3.44 ± 0.053	4.664AlaSer: 4.664 ± 0.065	4.763AlaThr: 4.763 ± 0.05	5.385AlaVal: 5.385 ± 0.07	1.049AlaTrp: 1.049 ± 0.03	2.324AlaTyr: 2.324 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.625CysAla: 0.625 ± 0.019	0.158CysCys: 0.158 ± 0.01	0.59CysAsp: 0.59 ± 0.022	0.541CysGlu: 0.541 ± 0.018	0.421CysPhe: 0.421 ± 0.018	0.822CysGly: 0.822 ± 0.024	0.302CysHis: 0.302 ± 0.015	0.626CysIle: 0.626 ± 0.021	0.336CysLys: 0.336 ± 0.015	1.173CysLeu: 1.173 ± 0.029	0.163CysMet: 0.163 ± 0.01	0.382CysAsn: 0.382 ± 0.016	0.528CysPro: 0.528 ± 0.021	0.66CysGln: 0.66 ± 0.024	0.502CysArg: 0.502 ± 0.02	0.597CysSer: 0.597 ± 0.019	0.486CysThr: 0.486 ± 0.02	0.629CysVal: 0.629 ± 0.02	0.143CysTrp: 0.143 ± 0.01	0.332CysTyr: 0.332 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.473AspAla: 3.473 ± 0.05	0.56AspCys: 0.56 ± 0.017	2.286AspAsp: 2.286 ± 0.048	2.767AspGlu: 2.767 ± 0.046	2.429AspPhe: 2.429 ± 0.044	3.358AspGly: 3.358 ± 0.058	0.58AspHis: 0.58 ± 0.021	3.85AspIle: 3.85 ± 0.062	2.49AspLys: 2.49 ± 0.049	5.134AspLeu: 5.134 ± 0.069	0.841AspMet: 0.841 ± 0.023	2.257AspAsn: 2.257 ± 0.042	1.838AspPro: 1.838 ± 0.035	1.275AspGln: 1.275 ± 0.029	2.947AspArg: 2.947 ± 0.044	2.876AspSer: 2.876 ± 0.049	2.647AspThr: 2.647 ± 0.038	3.021AspVal: 3.021 ± 0.051	0.855AspTrp: 0.855 ± 0.025	1.849AspTyr: 1.849 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.98GluAla: 4.98 ± 0.071	0.464GluCys: 0.464 ± 0.018	2.527GluAsp: 2.527 ± 0.046	4.04GluGlu: 4.04 ± 0.067	2.527GluPhe: 2.527 ± 0.043	3.035GluGly: 3.035 ± 0.043	0.952GluHis: 0.952 ± 0.031	5.217GluIle: 5.217 ± 0.076	3.965GluLys: 3.965 ± 0.055	6.836GluLeu: 6.836 ± 0.069	1.455GluMet: 1.455 ± 0.031	3.114GluAsn: 3.114 ± 0.054	2.228GluPro: 2.228 ± 0.038	3.194GluGln: 3.194 ± 0.052	3.137GluArg: 3.137 ± 0.051	3.444GluSer: 3.444 ± 0.056	3.539GluThr: 3.539 ± 0.046	4.179GluVal: 4.179 ± 0.059	0.759GluTrp: 0.759 ± 0.021	1.962GluTyr: 1.962 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.366PheAla: 3.366 ± 0.053	0.558PheCys: 0.558 ± 0.021	2.062PheAsp: 2.062 ± 0.034	1.837PheGlu: 1.837 ± 0.04	1.762PhePhe: 1.762 ± 0.039	2.789PheGly: 2.789 ± 0.046	0.889PheHis: 0.889 ± 0.027	2.493PheIle: 2.493 ± 0.047	1.434PheLys: 1.434 ± 0.031	4.276PheLeu: 4.276 ± 0.065	0.698PheMet: 0.698 ± 0.025	1.675PheAsn: 1.675 ± 0.038	2.012PhePro: 2.012 ± 0.038	1.977PheGln: 1.977 ± 0.034	1.819PheArg: 1.819 ± 0.035	3.03PheSer: 3.03 ± 0.053	2.542PheThr: 2.542 ± 0.042	2.421PheVal: 2.421 ± 0.042	0.701PheTrp: 0.701 ± 0.023	1.389PheTyr: 1.389 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.729GlyAla: 4.729 ± 0.064	0.823GlyCys: 0.823 ± 0.026	3.517GlyAsp: 3.517 ± 0.053	4.403GlyGlu: 4.403 ± 0.06	2.966GlyPhe: 2.966 ± 0.046	4.748GlyGly: 4.748 ± 0.075	1.166GlyHis: 1.166 ± 0.037	5.309GlyIle: 5.309 ± 0.07	4.813GlyLys: 4.813 ± 0.069	6.607GlyLeu: 6.607 ± 0.077	1.656GlyMet: 1.656 ± 0.04	3.314GlyAsn: 3.314 ± 0.059	1.0GlyPro: 1.0 ± 0.033	2.581GlyGln: 2.581 ± 0.047	3.169GlyArg: 3.169 ± 0.055	3.934GlySer: 3.934 ± 0.051	3.745GlyThr: 3.745 ± 0.06	4.872GlyVal: 4.872 ± 0.065	1.115GlyTrp: 1.115 ± 0.03	2.436GlyTyr: 2.436 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.027HisAla: 1.027 ± 0.026	0.257HisCys: 0.257 ± 0.016	0.783HisAsp: 0.783 ± 0.022	0.935HisGlu: 0.935 ± 0.024	0.789HisPhe: 0.789 ± 0.024	1.257HisGly: 1.257 ± 0.028	0.692HisHis: 0.692 ± 0.025	1.186HisIle: 1.186 ± 0.03	0.781HisLys: 0.781 ± 0.022	2.319HisLeu: 2.319 ± 0.048	0.239HisMet: 0.239 ± 0.014	0.771HisAsn: 0.771 ± 0.021	1.448HisPro: 1.448 ± 0.031	1.24HisGln: 1.24 ± 0.027	1.134HisArg: 1.134 ± 0.03	1.203HisSer: 1.203 ± 0.031	0.997HisThr: 0.997 ± 0.027	0.796HisVal: 0.796 ± 0.024	0.359HisTrp: 0.359 ± 0.015	0.69HisTyr: 0.69 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.467IleAla: 7.467 ± 0.076	0.831IleCys: 0.831 ± 0.023	3.703IleAsp: 3.703 ± 0.05	3.884IleGlu: 3.884 ± 0.054	2.931IlePhe: 2.931 ± 0.047	4.416IleGly: 4.416 ± 0.06	1.435IleHis: 1.435 ± 0.034	4.543IleIle: 4.543 ± 0.06	3.129IleLys: 3.129 ± 0.042	7.409IleLeu: 7.409 ± 0.078	0.94IleMet: 0.94 ± 0.027	3.27IleAsn: 3.27 ± 0.063	3.94IlePro: 3.94 ± 0.054	3.404IleGln: 3.404 ± 0.054	3.243IleArg: 3.243 ± 0.05	4.943IleSer: 4.943 ± 0.06	4.202IleThr: 4.202 ± 0.058	4.125IleVal: 4.125 ± 0.059	0.959IleTrp: 0.959 ± 0.027	2.218IleTyr: 2.218 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.655LysAla: 3.655 ± 0.051	0.334LysCys: 0.334 ± 0.014	2.108LysAsp: 2.108 ± 0.037	2.755LysGlu: 2.755 ± 0.044	1.967LysPhe: 1.967 ± 0.035	2.701LysGly: 2.701 ± 0.041	0.807LysHis: 0.807 ± 0.021	4.111LysIle: 4.111 ± 0.051	2.443LysLys: 2.443 ± 0.045	5.581LysLeu: 5.581 ± 0.063	1.104LysMet: 1.104 ± 0.027	2.441LysAsn: 2.441 ± 0.045	2.455LysPro: 2.455 ± 0.044	2.783LysGln: 2.783 ± 0.049	2.302LysArg: 2.302 ± 0.043	3.181LysSer: 3.181 ± 0.049	3.031LysThr: 3.031 ± 0.05	3.174LysVal: 3.174 ± 0.049	0.526LysTrp: 0.526 ± 0.018	1.749LysTyr: 1.749 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	9.269LeuAla: 9.269 ± 0.087	1.005LeuCys: 1.005 ± 0.029	5.102LeuAsp: 5.102 ± 0.062	6.972LeuGlu: 6.972 ± 0.081	3.797LeuPhe: 3.797 ± 0.06	7.737LeuGly: 7.737 ± 0.095	1.956LeuHis: 1.956 ± 0.037	6.765LeuIle: 6.765 ± 0.083	5.11LeuLys: 5.11 ± 0.059	10.965LeuLeu: 10.965 ± 0.111	2.045LeuMet: 2.045 ± 0.036	4.496LeuAsn: 4.496 ± 0.059	5.789LeuPro: 5.789 ± 0.064	6.151LeuGln: 6.151 ± 0.07	5.423LeuArg: 5.423 ± 0.066	7.307LeuSer: 7.307 ± 0.083	6.274LeuThr: 6.274 ± 0.066	7.032LeuVal: 7.032 ± 0.07	1.462LeuTrp: 1.462 ± 0.035	2.759LeuTyr: 2.759 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.035	0.136MetCys: 0.136 ± 0.009	0.769MetAsp: 0.769 ± 0.024	1.09MetGlu: 1.09 ± 0.027	0.55MetPhe: 0.55 ± 0.019	1.538MetGly: 1.538 ± 0.037	0.322MetHis: 0.322 ± 0.016	1.131MetIle: 1.131 ± 0.031	1.003MetLys: 1.003 ± 0.028	1.959MetLeu: 1.959 ± 0.039	0.515MetMet: 0.515 ± 0.018	0.912MetAsn: 0.912 ± 0.025	0.895MetPro: 0.895 ± 0.025	1.03MetGln: 1.03 ± 0.026	1.037MetArg: 1.037 ± 0.027	1.361MetSer: 1.361 ± 0.028	1.408MetThr: 1.408 ± 0.033	1.352MetVal: 1.352 ± 0.032	0.168MetTrp: 0.168 ± 0.01	0.408MetTyr: 0.408 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.933AsnAla: 2.933 ± 0.055	0.505AsnCys: 0.505 ± 0.017	1.568AsnAsp: 1.568 ± 0.041	1.617AsnGlu: 1.617 ± 0.035	2.079AsnPhe: 2.079 ± 0.038	2.602AsnGly: 2.602 ± 0.052	1.088AsnHis: 1.088 ± 0.027	3.276AsnIle: 3.276 ± 0.056	1.723AsnLys: 1.723 ± 0.043	5.798AsnLeu: 5.798 ± 0.075	0.682AsnMet: 0.682 ± 0.022	2.224AsnAsn: 2.224 ± 0.052	3.149AsnPro: 3.149 ± 0.06	2.927AsnGln: 2.927 ± 0.044	2.407AsnArg: 2.407 ± 0.038	3.313AsnSer: 3.313 ± 0.06	2.507AsnThr: 2.507 ± 0.047	2.113AsnVal: 2.113 ± 0.037	0.831AsnTrp: 0.831 ± 0.021	1.671AsnTyr: 1.671 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.016ProAla: 3.016 ± 0.049	0.352ProCys: 0.352 ± 0.015	2.765ProAsp: 2.765 ± 0.039	4.074ProGlu: 4.074 ± 0.068	1.682ProPhe: 1.682 ± 0.032	3.31ProGly: 3.31 ± 0.052	0.933ProHis: 0.933 ± 0.027	3.03ProIle: 3.03 ± 0.048	2.05ProLys: 2.05 ± 0.035	4.572ProLeu: 4.572 ± 0.051	0.796ProMet: 0.796 ± 0.024	2.165ProAsn: 2.165 ± 0.058	2.352ProPro: 2.352 ± 0.075	2.993ProGln: 2.993 ± 0.047	1.824ProArg: 1.824 ± 0.036	2.933ProSer: 2.933 ± 0.045	2.798ProThr: 2.798 ± 0.043	3.335ProVal: 3.335 ± 0.057	0.675ProTrp: 0.675 ± 0.022	1.305ProTyr: 1.305 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.766GlnAla: 4.766 ± 0.065	0.344GlnCys: 0.344 ± 0.015	2.142GlnAsp: 2.142 ± 0.041	4.008GlnGlu: 4.008 ± 0.058	1.726GlnPhe: 1.726 ± 0.031	3.62GlnGly: 3.62 ± 0.059	0.856GlnHis: 0.856 ± 0.027	3.907GlnIle: 3.907 ± 0.053	3.04GlnLys: 3.04 ± 0.047	5.765GlnLeu: 5.765 ± 0.072	1.109GlnMet: 1.109 ± 0.029	2.272GlnAsn: 2.272 ± 0.044	2.644GlnPro: 2.644 ± 0.044	3.834GlnGln: 3.834 ± 0.062	2.945GlnArg: 2.945 ± 0.047	2.915GlnSer: 2.915 ± 0.044	3.08GlnThr: 3.08 ± 0.048	3.944GlnVal: 3.944 ± 0.052	0.66GlnTrp: 0.66 ± 0.022	1.276GlnTyr: 1.276 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	3.121ArgAla: 3.121 ± 0.05	0.521ArgCys: 0.521 ± 0.02	2.545ArgAsp: 2.545 ± 0.045	3.412ArgGlu: 3.412 ± 0.054	2.063ArgPhe: 2.063 ± 0.036	3.014ArgGly: 3.014 ± 0.047	1.054ArgHis: 1.054 ± 0.028	3.32ArgIle: 3.32 ± 0.051	2.331ArgLys: 2.331 ± 0.041	5.614ArgLeu: 5.614 ± 0.061	1.035ArgMet: 1.035 ± 0.024	2.179ArgAsn: 2.179 ± 0.036	1.918ArgPro: 1.918 ± 0.035	3.271ArgGln: 3.271 ± 0.047	2.942ArgArg: 2.942 ± 0.052	3.064ArgSer: 3.064 ± 0.05	2.407ArgThr: 2.407 ± 0.041	3.34ArgVal: 3.34 ± 0.045	0.798ArgTrp: 0.798 ± 0.02	1.869ArgTyr: 1.869 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.369SerAla: 4.369 ± 0.048	0.634SerCys: 0.634 ± 0.023	3.062SerAsp: 3.062 ± 0.046	3.557SerGlu: 3.557 ± 0.052	2.488SerPhe: 2.488 ± 0.045	4.702SerGly: 4.702 ± 0.057	1.456SerHis: 1.456 ± 0.033	3.797SerIle: 3.797 ± 0.054	2.555SerLys: 2.555 ± 0.04	7.512SerLeu: 7.512 ± 0.078	1.201SerMet: 1.201 ± 0.028	2.684SerAsn: 2.684 ± 0.045	3.569SerPro: 3.569 ± 0.053	4.299SerGln: 4.299 ± 0.058	3.251SerArg: 3.251 ± 0.042	4.388SerSer: 4.388 ± 0.064	3.524SerThr: 3.524 ± 0.054	3.988SerVal: 3.988 ± 0.046	0.998SerTrp: 0.998 ± 0.028	1.863SerTyr: 1.863 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.873ThrAla: 4.873 ± 0.061	0.477ThrCys: 0.477 ± 0.017	2.675ThrAsp: 2.675 ± 0.043	3.554ThrGlu: 3.554 ± 0.055	2.101ThrPhe: 2.101 ± 0.038	4.301ThrGly: 4.301 ± 0.062	1.04ThrHis: 1.04 ± 0.026	3.911ThrIle: 3.911 ± 0.055	2.403ThrLys: 2.403 ± 0.041	6.182ThrLeu: 6.182 ± 0.061	0.866ThrMet: 0.866 ± 0.026	2.378ThrAsn: 2.378 ± 0.046	3.727ThrPro: 3.727 ± 0.055	3.031ThrGln: 3.031 ± 0.044	2.38ThrArg: 2.38 ± 0.042	3.738ThrSer: 3.738 ± 0.058	3.584ThrThr: 3.584 ± 0.051	4.105ThrVal: 4.105 ± 0.058	0.776ThrTrp: 0.776 ± 0.026	1.678ThrTyr: 1.678 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.663ValAla: 5.663 ± 0.072	0.714ValCys: 0.714 ± 0.02	3.154ValAsp: 3.154 ± 0.046	4.32ValGlu: 4.32 ± 0.048	2.571ValPhe: 2.571 ± 0.043	4.55ValGly: 4.55 ± 0.059	1.011ValHis: 1.011 ± 0.024	4.7ValIle: 4.7 ± 0.05	3.504ValLys: 3.504 ± 0.05	6.15ValLeu: 6.15 ± 0.075	1.538ValMet: 1.538 ± 0.031	3.102ValAsn: 3.102 ± 0.043	2.738ValPro: 2.738 ± 0.041	2.703ValGln: 2.703 ± 0.042	3.088ValArg: 3.088 ± 0.048	4.226ValSer: 4.226 ± 0.049	4.035ValThr: 4.035 ± 0.062	4.728ValVal: 4.728 ± 0.061	0.813ValTrp: 0.813 ± 0.027	1.866ValTyr: 1.866 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.854TrpAla: 0.854 ± 0.025	0.158TrpCys: 0.158 ± 0.01	0.661TrpAsp: 0.661 ± 0.029	0.998TrpGlu: 0.998 ± 0.025	0.634TrpPhe: 0.634 ± 0.022	1.041TrpGly: 1.041 ± 0.028	0.342TrpHis: 0.342 ± 0.017	0.826TrpIle: 0.826 ± 0.024	0.608TrpLys: 0.608 ± 0.02	1.824TrpLeu: 1.824 ± 0.045	0.332TrpMet: 0.332 ± 0.016	0.636TrpAsn: 0.636 ± 0.022	0.108TrpPro: 0.108 ± 0.009	1.494TrpGln: 1.494 ± 0.033	0.863TrpArg: 0.863 ± 0.026	0.806TrpSer: 0.806 ± 0.027	0.565TrpThr: 0.565 ± 0.02	0.969TrpVal: 0.969 ± 0.026	0.242TrpTrp: 0.242 ± 0.013	0.449TrpTyr: 0.449 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.038	0.401TyrCys: 0.401 ± 0.015	1.429TyrAsp: 1.429 ± 0.032	1.672TyrGlu: 1.672 ± 0.034	1.41TyrPhe: 1.41 ± 0.033	2.198TyrGly: 2.198 ± 0.04	0.744TyrHis: 0.744 ± 0.024	1.854TyrIle: 1.854 ± 0.037	1.258TyrLys: 1.258 ± 0.029	3.755TyrLeu: 3.755 ± 0.051	0.464TyrMet: 0.464 ± 0.017	1.239TyrAsn: 1.239 ± 0.032	1.692TyrPro: 1.692 ± 0.035	2.095TyrGln: 2.095 ± 0.043	1.966TyrArg: 1.966 ± 0.036	1.973TyrSer: 1.973 ± 0.038	1.646TyrThr: 1.646 ± 0.032	1.665TyrVal: 1.665 ± 0.033	0.523TyrTrp: 0.523 ± 0.019	1.114TyrTyr: 1.114 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5001 proteins (1597472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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