Amino acid dipepetide frequency for Rhodobacteraceae bacterium HTCC2083

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.103AlaAla: 13.103 ± 0.147	1.088AlaCys: 1.088 ± 0.035	6.376AlaAsp: 6.376 ± 0.081	6.825AlaGlu: 6.825 ± 0.085	4.27AlaPhe: 4.27 ± 0.064	9.139AlaGly: 9.139 ± 0.099	2.34AlaHis: 2.34 ± 0.047	6.211AlaIle: 6.211 ± 0.08	4.717AlaLys: 4.717 ± 0.075	12.537AlaLeu: 12.537 ± 0.128	3.802AlaMet: 3.802 ± 0.058	3.282AlaAsn: 3.282 ± 0.053	4.884AlaPro: 4.884 ± 0.072	4.502AlaGln: 4.502 ± 0.073	6.836AlaArg: 6.836 ± 0.091	6.134AlaSer: 6.134 ± 0.083	5.558AlaThr: 5.558 ± 0.073	7.282AlaVal: 7.282 ± 0.082	1.301AlaTrp: 1.301 ± 0.037	2.561AlaTyr: 2.561 ± 0.047	0.002AlaXaa: 0.002 ± 0.001
Cys	1.188CysAla: 1.188 ± 0.032	0.123CysCys: 0.123 ± 0.012	0.656CysAsp: 0.656 ± 0.025	0.535CysGlu: 0.535 ± 0.025	0.4CysPhe: 0.4 ± 0.018	0.986CysGly: 0.986 ± 0.032	0.286CysHis: 0.286 ± 0.016	0.522CysIle: 0.522 ± 0.022	0.325CysLys: 0.325 ± 0.017	0.903CysLeu: 0.903 ± 0.026	0.24CysMet: 0.24 ± 0.015	0.304CysAsn: 0.304 ± 0.015	0.489CysPro: 0.489 ± 0.023	0.249CysGln: 0.249 ± 0.015	0.446CysArg: 0.446 ± 0.021	0.556CysSer: 0.556 ± 0.02	0.483CysThr: 0.483 ± 0.024	0.699CysVal: 0.699 ± 0.025	0.117CysTrp: 0.117 ± 0.01	0.259CysTyr: 0.259 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.332AspAla: 7.332 ± 0.086	0.504AspCys: 0.504 ± 0.021	3.334AspAsp: 3.334 ± 0.067	3.561AspGlu: 3.561 ± 0.056	2.414AspPhe: 2.414 ± 0.048	5.145AspGly: 5.145 ± 0.087	1.316AspHis: 1.316 ± 0.04	3.524AspIle: 3.524 ± 0.053	2.09AspLys: 2.09 ± 0.048	6.094AspLeu: 6.094 ± 0.079	1.89AspMet: 1.89 ± 0.04	1.476AspAsn: 1.476 ± 0.035	3.15AspPro: 3.15 ± 0.057	1.979AspGln: 1.979 ± 0.038	3.176AspArg: 3.176 ± 0.058	2.285AspSer: 2.285 ± 0.047	3.141AspThr: 3.141 ± 0.049	4.868AspVal: 4.868 ± 0.067	1.029AspTrp: 1.029 ± 0.034	1.503AspTyr: 1.503 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.002GluAla: 7.002 ± 0.089	0.451GluCys: 0.451 ± 0.021	3.341GluAsp: 3.341 ± 0.06	3.36GluGlu: 3.36 ± 0.07	2.025GluPhe: 2.025 ± 0.048	4.461GluGly: 4.461 ± 0.067	1.302GluHis: 1.302 ± 0.034	3.827GluIle: 3.827 ± 0.05	2.551GluLys: 2.551 ± 0.051	5.282GluLeu: 5.282 ± 0.074	1.976GluMet: 1.976 ± 0.044	2.251GluAsn: 2.251 ± 0.047	2.326GluPro: 2.326 ± 0.047	2.182GluGln: 2.182 ± 0.048	3.965GluArg: 3.965 ± 0.067	2.334GluSer: 2.334 ± 0.047	3.895GluThr: 3.895 ± 0.055	4.201GluVal: 4.201 ± 0.067	0.777GluTrp: 0.777 ± 0.028	1.216GluTyr: 1.216 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.579PheAla: 4.579 ± 0.069	0.489PheCys: 0.489 ± 0.02	2.855PheAsp: 2.855 ± 0.049	2.679PheGlu: 2.679 ± 0.058	1.608PhePhe: 1.608 ± 0.046	3.926PheGly: 3.926 ± 0.064	0.775PheHis: 0.775 ± 0.027	2.046PheIle: 2.046 ± 0.045	1.407PheLys: 1.407 ± 0.039	3.517PheLeu: 3.517 ± 0.062	1.075PheMet: 1.075 ± 0.03	1.264PheAsn: 1.264 ± 0.034	1.563PhePro: 1.563 ± 0.039	1.139PheGln: 1.139 ± 0.031	1.826PheArg: 1.826 ± 0.042	2.452PheSer: 2.452 ± 0.047	2.202PheThr: 2.202 ± 0.052	2.885PheVal: 2.885 ± 0.057	0.599PheTrp: 0.599 ± 0.023	1.042PheTyr: 1.042 ± 0.032	0.001PheXaa: 0.001 ± 0.001
Gly	9.101GlyAla: 9.101 ± 0.097	0.888GlyCys: 0.888 ± 0.029	4.447GlyAsp: 4.447 ± 0.074	4.409GlyGlu: 4.409 ± 0.059	3.833GlyPhe: 3.833 ± 0.06	6.953GlyGly: 6.953 ± 0.115	1.875GlyHis: 1.875 ± 0.043	4.691GlyIle: 4.691 ± 0.065	3.584GlyLys: 3.584 ± 0.059	8.401GlyLeu: 8.401 ± 0.087	2.653GlyMet: 2.653 ± 0.051	2.286GlyAsn: 2.286 ± 0.052	3.214GlyPro: 3.214 ± 0.053	2.923GlyGln: 2.923 ± 0.054	4.59GlyArg: 4.59 ± 0.063	4.377GlySer: 4.377 ± 0.063	4.683GlyThr: 4.683 ± 0.073	6.288GlyVal: 6.288 ± 0.062	1.326GlyTrp: 1.326 ± 0.038	2.383GlyTyr: 2.383 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.244HisAla: 2.244 ± 0.05	0.243HisCys: 0.243 ± 0.014	1.236HisAsp: 1.236 ± 0.035	1.129HisGlu: 1.129 ± 0.031	0.929HisPhe: 0.929 ± 0.028	1.845HisGly: 1.845 ± 0.041	0.586HisHis: 0.586 ± 0.032	1.195HisIle: 1.195 ± 0.038	0.714HisLys: 0.714 ± 0.026	2.124HisLeu: 2.124 ± 0.043	0.685HisMet: 0.685 ± 0.022	0.567HisAsn: 0.567 ± 0.025	1.262HisPro: 1.262 ± 0.037	0.637HisGln: 0.637 ± 0.023	1.176HisArg: 1.176 ± 0.037	1.205HisSer: 1.205 ± 0.032	0.976HisThr: 0.976 ± 0.031	1.587HisVal: 1.587 ± 0.035	0.361HisTrp: 0.361 ± 0.019	0.601HisTyr: 0.601 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.32IleAla: 7.32 ± 0.087	0.725IleCys: 0.725 ± 0.027	3.684IleAsp: 3.684 ± 0.062	4.043IleGlu: 4.043 ± 0.062	2.094IlePhe: 2.094 ± 0.043	5.269IleGly: 5.269 ± 0.085	1.022IleHis: 1.022 ± 0.03	2.961IleIle: 2.961 ± 0.057	2.123IleLys: 2.123 ± 0.046	5.141IleLeu: 5.141 ± 0.075	1.339IleMet: 1.339 ± 0.039	1.828IleAsn: 1.828 ± 0.044	2.515IlePro: 2.515 ± 0.054	1.365IleGln: 1.365 ± 0.031	2.862IleArg: 2.862 ± 0.051	3.675IleSer: 3.675 ± 0.064	3.32IleThr: 3.32 ± 0.054	4.117IleVal: 4.117 ± 0.07	0.837IleTrp: 0.837 ± 0.031	1.362IleTyr: 1.362 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.616LysAla: 4.616 ± 0.066	0.288LysCys: 0.288 ± 0.015	2.418LysAsp: 2.418 ± 0.045	2.032LysGlu: 2.032 ± 0.048	1.272LysPhe: 1.272 ± 0.034	3.329LysGly: 3.329 ± 0.054	0.856LysHis: 0.856 ± 0.029	2.268LysIle: 2.268 ± 0.046	1.719LysLys: 1.719 ± 0.045	3.746LysLeu: 3.746 ± 0.057	1.244LysMet: 1.244 ± 0.031	1.245LysAsn: 1.245 ± 0.036	1.982LysPro: 1.982 ± 0.045	1.245LysGln: 1.245 ± 0.033	2.725LysArg: 2.725 ± 0.048	2.474LysSer: 2.474 ± 0.047	2.54LysThr: 2.54 ± 0.048	2.723LysVal: 2.723 ± 0.052	0.489LysTrp: 0.489 ± 0.021	0.855LysTyr: 0.855 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.075LeuAla: 11.075 ± 0.109	1.062LeuCys: 1.062 ± 0.035	5.8LeuAsp: 5.8 ± 0.08	5.565LeuGlu: 5.565 ± 0.072	3.652LeuPhe: 3.652 ± 0.062	8.154LeuGly: 8.154 ± 0.095	1.888LeuHis: 1.888 ± 0.04	5.644LeuIle: 5.644 ± 0.081	4.053LeuLys: 4.053 ± 0.059	8.537LeuLeu: 8.537 ± 0.121	2.823LeuMet: 2.823 ± 0.055	3.291LeuAsn: 3.291 ± 0.053	4.915LeuPro: 4.915 ± 0.074	2.909LeuGln: 2.909 ± 0.056	6.096LeuArg: 6.096 ± 0.081	7.133LeuSer: 7.133 ± 0.089	5.566LeuThr: 5.566 ± 0.082	6.311LeuVal: 6.311 ± 0.085	1.172LeuTrp: 1.172 ± 0.036	1.933LeuTyr: 1.933 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.194MetAla: 3.194 ± 0.055	0.266MetCys: 0.266 ± 0.015	1.603MetAsp: 1.603 ± 0.04	1.491MetGlu: 1.491 ± 0.039	1.027MetPhe: 1.027 ± 0.029	2.525MetGly: 2.525 ± 0.049	0.561MetHis: 0.561 ± 0.024	1.91MetIle: 1.91 ± 0.043	1.329MetLys: 1.329 ± 0.034	2.846MetLeu: 2.846 ± 0.055	0.939MetMet: 0.939 ± 0.035	1.089MetAsn: 1.089 ± 0.032	1.507MetPro: 1.507 ± 0.04	1.13MetGln: 1.13 ± 0.027	2.074MetArg: 2.074 ± 0.041	2.186MetSer: 2.186 ± 0.05	2.072MetThr: 2.072 ± 0.04	1.832MetVal: 1.832 ± 0.039	0.285MetTrp: 0.285 ± 0.016	0.437MetTyr: 0.437 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.751AsnAla: 3.751 ± 0.064	0.323AsnCys: 0.323 ± 0.017	1.914AsnAsp: 1.914 ± 0.049	1.664AsnGlu: 1.664 ± 0.033	1.265AsnPhe: 1.265 ± 0.036	2.78AsnGly: 2.78 ± 0.051	0.615AsnHis: 0.615 ± 0.024	1.797AsnIle: 1.797 ± 0.04	1.053AsnLys: 1.053 ± 0.035	2.919AsnLeu: 2.919 ± 0.059	0.913AsnMet: 0.913 ± 0.027	0.966AsnAsn: 0.966 ± 0.035	1.94AsnPro: 1.94 ± 0.045	0.873AsnGln: 0.873 ± 0.029	1.659AsnArg: 1.659 ± 0.038	1.639AsnSer: 1.639 ± 0.036	1.766AsnThr: 1.766 ± 0.044	2.273AsnVal: 2.273 ± 0.046	0.525AsnTrp: 0.525 ± 0.02	0.817AsnTyr: 0.817 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.526ProAla: 4.526 ± 0.072	0.36ProCys: 0.36 ± 0.019	3.293ProAsp: 3.293 ± 0.055	3.647ProGlu: 3.647 ± 0.065	2.022ProPhe: 2.022 ± 0.04	2.929ProGly: 2.929 ± 0.05	1.017ProHis: 1.017 ± 0.031	2.582ProIle: 2.582 ± 0.048	2.176ProLys: 2.176 ± 0.042	4.297ProLeu: 4.297 ± 0.068	1.391ProMet: 1.391 ± 0.037	1.707ProAsn: 1.707 ± 0.04	1.698ProPro: 1.698 ± 0.046	1.428ProGln: 1.428 ± 0.035	2.216ProArg: 2.216 ± 0.043	2.743ProSer: 2.743 ± 0.052	2.505ProThr: 2.505 ± 0.049	3.541ProVal: 3.541 ± 0.054	0.608ProTrp: 0.608 ± 0.023	1.154ProTyr: 1.154 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.614GlnAla: 3.614 ± 0.061	0.24GlnCys: 0.24 ± 0.015	1.829GlnAsp: 1.829 ± 0.037	1.625GlnGlu: 1.625 ± 0.038	1.188GlnPhe: 1.188 ± 0.03	2.48GlnGly: 2.48 ± 0.046	0.697GlnHis: 0.697 ± 0.027	2.4GlnIle: 2.4 ± 0.044	1.375GlnLys: 1.375 ± 0.04	3.007GlnLeu: 3.007 ± 0.055	1.245GlnMet: 1.245 ± 0.031	1.223GlnAsn: 1.223 ± 0.029	1.407GlnPro: 1.407 ± 0.04	1.113GlnGln: 1.113 ± 0.035	1.993GlnArg: 1.993 ± 0.037	2.181GlnSer: 2.181 ± 0.044	2.031GlnThr: 2.031 ± 0.045	2.391GlnVal: 2.391 ± 0.046	0.405GlnTrp: 0.405 ± 0.019	0.686GlnTyr: 0.686 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.579ArgAla: 6.579 ± 0.085	0.497ArgCys: 0.497 ± 0.026	3.549ArgAsp: 3.549 ± 0.051	3.447ArgGlu: 3.447 ± 0.052	2.505ArgPhe: 2.505 ± 0.055	3.908ArgGly: 3.908 ± 0.052	1.303ArgHis: 1.303 ± 0.037	3.441ArgIle: 3.441 ± 0.054	2.484ArgLys: 2.484 ± 0.05	5.839ArgLeu: 5.839 ± 0.08	1.78ArgMet: 1.78 ± 0.042	1.712ArgAsn: 1.712 ± 0.038	2.387ArgPro: 2.387 ± 0.053	1.939ArgGln: 1.939 ± 0.043	3.605ArgArg: 3.605 ± 0.057	3.168ArgSer: 3.168 ± 0.053	2.801ArgThr: 2.801 ± 0.051	4.174ArgVal: 4.174 ± 0.07	0.795ArgTrp: 0.795 ± 0.025	1.437ArgTyr: 1.437 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.404SerAla: 6.404 ± 0.076	0.513SerCys: 0.513 ± 0.023	3.812SerAsp: 3.812 ± 0.06	3.405SerGlu: 3.405 ± 0.063	2.602SerPhe: 2.602 ± 0.045	5.481SerGly: 5.481 ± 0.08	1.224SerHis: 1.224 ± 0.036	3.214SerIle: 3.214 ± 0.06	2.474SerLys: 2.474 ± 0.045	5.398SerLeu: 5.398 ± 0.067	1.633SerMet: 1.633 ± 0.035	1.961SerAsn: 1.961 ± 0.045	2.347SerPro: 2.347 ± 0.045	1.949SerGln: 1.949 ± 0.045	2.943SerArg: 2.943 ± 0.055	3.132SerSer: 3.132 ± 0.057	2.908SerThr: 2.908 ± 0.049	4.182SerVal: 4.182 ± 0.065	0.678SerTrp: 0.678 ± 0.027	1.423SerTyr: 1.423 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.742ThrAla: 5.742 ± 0.079	0.56ThrCys: 0.56 ± 0.024	3.128ThrAsp: 3.128 ± 0.054	2.864ThrGlu: 2.864 ± 0.055	2.175ThrPhe: 2.175 ± 0.045	5.109ThrGly: 5.109 ± 0.075	1.288ThrHis: 1.288 ± 0.037	3.05ThrIle: 3.05 ± 0.055	2.006ThrLys: 2.006 ± 0.041	6.227ThrLeu: 6.227 ± 0.091	1.47ThrMet: 1.47 ± 0.034	1.62ThrAsn: 1.62 ± 0.042	3.279ThrPro: 3.279 ± 0.055	1.92ThrGln: 1.92 ± 0.04	3.133ThrArg: 3.133 ± 0.054	3.237ThrSer: 3.237 ± 0.06	3.016ThrThr: 3.016 ± 0.051	4.029ThrVal: 4.029 ± 0.061	0.679ThrTrp: 0.679 ± 0.028	1.36ThrTyr: 1.36 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.651ValAla: 7.651 ± 0.096	0.732ValCys: 0.732 ± 0.025	4.096ValAsp: 4.096 ± 0.064	4.422ValGlu: 4.422 ± 0.064	3.036ValPhe: 3.036 ± 0.06	5.347ValGly: 5.347 ± 0.067	1.419ValHis: 1.419 ± 0.036	4.502ValIle: 4.502 ± 0.072	2.544ValLys: 2.544 ± 0.055	6.971ValLeu: 6.971 ± 0.082	2.222ValMet: 2.222 ± 0.045	2.236ValAsn: 2.236 ± 0.043	3.312ValPro: 3.312 ± 0.055	2.338ValGln: 2.338 ± 0.045	3.687ValArg: 3.687 ± 0.059	4.561ValSer: 4.561 ± 0.063	4.438ValThr: 4.438 ± 0.057	5.209ValVal: 5.209 ± 0.081	0.88ValTrp: 0.88 ± 0.028	1.467ValTyr: 1.467 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.246TrpAla: 1.246 ± 0.032	0.148TrpCys: 0.148 ± 0.011	0.803TrpAsp: 0.803 ± 0.027	0.638TrpGlu: 0.638 ± 0.023	0.595TrpPhe: 0.595 ± 0.025	1.004TrpGly: 1.004 ± 0.031	0.373TrpHis: 0.373 ± 0.017	0.725TrpIle: 0.725 ± 0.025	0.504TrpLys: 0.504 ± 0.021	1.529TrpLeu: 1.529 ± 0.041	0.417TrpMet: 0.417 ± 0.018	0.454TrpAsn: 0.454 ± 0.018	0.621TrpPro: 0.621 ± 0.025	0.535TrpGln: 0.535 ± 0.021	0.935TrpArg: 0.935 ± 0.03	0.85TrpSer: 0.85 ± 0.028	0.701TrpThr: 0.701 ± 0.027	0.877TrpVal: 0.877 ± 0.032	0.221TrpTrp: 0.221 ± 0.013	0.277TrpTyr: 0.277 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.485TyrAla: 2.485 ± 0.055	0.268TyrCys: 0.268 ± 0.016	1.638TyrAsp: 1.638 ± 0.041	1.382TyrGlu: 1.382 ± 0.039	1.016TyrPhe: 1.016 ± 0.029	2.136TyrGly: 2.136 ± 0.048	0.558TyrHis: 0.558 ± 0.024	1.09TyrIle: 1.09 ± 0.027	0.837TyrLys: 0.837 ± 0.027	2.264TyrLeu: 2.264 ± 0.044	0.564TyrMet: 0.564 ± 0.021	0.689TyrAsn: 0.689 ± 0.021	1.044TyrPro: 1.044 ± 0.033	0.775TyrGln: 0.775 ± 0.032	1.407TyrArg: 1.407 ± 0.041	1.36TyrSer: 1.36 ± 0.038	1.29TyrThr: 1.29 ± 0.034	1.601TyrVal: 1.601 ± 0.035	0.371TyrTrp: 0.371 ± 0.019	0.586TyrTyr: 0.586 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.025XaaXaa: 0.025 ± 0.016

Statistics based on 4108 proteins (1152315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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