Amino acid dipepetide frequency for Sulfitobacter pseudonitzschiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.736AlaAla: 16.736 ± 0.143	1.17AlaCys: 1.17 ± 0.032	7.588AlaAsp: 7.588 ± 0.084	7.411AlaGlu: 7.411 ± 0.078	4.315AlaPhe: 4.315 ± 0.058	10.521AlaGly: 10.521 ± 0.086	2.498AlaHis: 2.498 ± 0.047	5.864AlaIle: 5.864 ± 0.074	3.87AlaLys: 3.87 ± 0.052	13.598AlaLeu: 13.598 ± 0.117	3.877AlaMet: 3.877 ± 0.051	2.801AlaAsn: 2.801 ± 0.045	5.712AlaPro: 5.712 ± 0.08	5.199AlaGln: 5.199 ± 0.072	8.527AlaArg: 8.527 ± 0.09	5.624AlaSer: 5.624 ± 0.064	6.298AlaThr: 6.298 ± 0.072	8.7AlaVal: 8.7 ± 0.083	1.434AlaTrp: 1.434 ± 0.035	2.489AlaTyr: 2.489 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.163CysAla: 1.163 ± 0.029	0.119CysCys: 0.119 ± 0.01	0.684CysAsp: 0.684 ± 0.023	0.412CysGlu: 0.412 ± 0.015	0.334CysPhe: 0.334 ± 0.016	0.906CysGly: 0.906 ± 0.026	0.237CysHis: 0.237 ± 0.013	0.423CysIle: 0.423 ± 0.016	0.238CysLys: 0.238 ± 0.012	0.844CysLeu: 0.844 ± 0.021	0.187CysMet: 0.187 ± 0.012	0.235CysAsn: 0.235 ± 0.013	0.476CysPro: 0.476 ± 0.02	0.226CysGln: 0.226 ± 0.012	0.472CysArg: 0.472 ± 0.022	0.419CysSer: 0.419 ± 0.018	0.492CysThr: 0.492 ± 0.019	0.655CysVal: 0.655 ± 0.018	0.117CysTrp: 0.117 ± 0.009	0.227CysTyr: 0.227 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.15AspAla: 8.15 ± 0.082	0.536AspCys: 0.536 ± 0.019	3.757AspAsp: 3.757 ± 0.072	3.289AspGlu: 3.289 ± 0.051	2.314AspPhe: 2.314 ± 0.042	5.732AspGly: 5.732 ± 0.083	1.496AspHis: 1.496 ± 0.034	3.215AspIle: 3.215 ± 0.049	1.815AspLys: 1.815 ± 0.041	6.499AspLeu: 6.499 ± 0.076	1.937AspMet: 1.937 ± 0.035	1.37AspAsn: 1.37 ± 0.033	3.559AspPro: 3.559 ± 0.066	1.98AspGln: 1.98 ± 0.034	4.245AspArg: 4.245 ± 0.061	2.364AspSer: 2.364 ± 0.04	3.571AspThr: 3.571 ± 0.061	4.752AspVal: 4.752 ± 0.058	1.17AspTrp: 1.17 ± 0.033	1.581AspTyr: 1.581 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.064GluAla: 7.064 ± 0.078	0.342GluCys: 0.342 ± 0.017	3.192GluAsp: 3.192 ± 0.051	2.919GluGlu: 2.919 ± 0.062	1.688GluPhe: 1.688 ± 0.037	4.176GluGly: 4.176 ± 0.055	1.045GluHis: 1.045 ± 0.026	3.281GluIle: 3.281 ± 0.05	1.966GluLys: 1.966 ± 0.048	4.824GluLeu: 4.824 ± 0.057	1.826GluMet: 1.826 ± 0.038	1.733GluAsn: 1.733 ± 0.036	2.24GluPro: 2.24 ± 0.044	1.973GluGln: 1.973 ± 0.038	3.74GluArg: 3.74 ± 0.058	1.992GluSer: 1.992 ± 0.038	3.774GluThr: 3.774 ± 0.056	4.147GluVal: 4.147 ± 0.053	0.66GluTrp: 0.66 ± 0.02	1.026GluTyr: 1.026 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.55PheAla: 4.55 ± 0.056	0.427PheCys: 0.427 ± 0.018	2.974PheAsp: 2.974 ± 0.046	2.132PheGlu: 2.132 ± 0.039	1.438PhePhe: 1.438 ± 0.036	3.737PheGly: 3.737 ± 0.056	0.774PheHis: 0.774 ± 0.024	1.613PheIle: 1.613 ± 0.033	0.982PheLys: 0.982 ± 0.029	3.267PheLeu: 3.267 ± 0.053	0.92PheMet: 0.92 ± 0.025	1.089PheAsn: 1.089 ± 0.027	1.458PhePro: 1.458 ± 0.029	1.097PheGln: 1.097 ± 0.028	2.038PheArg: 2.038 ± 0.04	2.1PheSer: 2.1 ± 0.037	1.97PheThr: 1.97 ± 0.038	2.805PheVal: 2.805 ± 0.057	0.562PheTrp: 0.562 ± 0.022	0.893PheTyr: 0.893 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.868GlyAla: 9.868 ± 0.095	0.792GlyCys: 0.792 ± 0.023	4.956GlyAsp: 4.956 ± 0.079	4.068GlyGlu: 4.068 ± 0.051	3.65GlyPhe: 3.65 ± 0.049	7.418GlyGly: 7.418 ± 0.104	1.921GlyHis: 1.921 ± 0.038	4.541GlyIle: 4.541 ± 0.056	3.136GlyLys: 3.136 ± 0.045	9.199GlyLeu: 9.199 ± 0.105	2.658GlyMet: 2.658 ± 0.044	2.293GlyAsn: 2.293 ± 0.044	3.605GlyPro: 3.605 ± 0.056	3.292GlyGln: 3.292 ± 0.051	5.453GlyArg: 5.453 ± 0.06	4.1GlySer: 4.1 ± 0.054	5.13GlyThr: 5.13 ± 0.065	6.596GlyVal: 6.596 ± 0.074	1.479GlyTrp: 1.479 ± 0.035	2.273GlyTyr: 2.273 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.39HisAla: 2.39 ± 0.045	0.24HisCys: 0.24 ± 0.013	1.372HisAsp: 1.372 ± 0.031	0.965HisGlu: 0.965 ± 0.024	0.809HisPhe: 0.809 ± 0.023	1.884HisGly: 1.884 ± 0.04	0.586HisHis: 0.586 ± 0.023	1.073HisIle: 1.073 ± 0.028	0.538HisLys: 0.538 ± 0.019	2.12HisLeu: 2.12 ± 0.039	0.618HisMet: 0.618 ± 0.02	0.49HisAsn: 0.49 ± 0.016	1.323HisPro: 1.323 ± 0.032	0.629HisGln: 0.629 ± 0.022	1.33HisArg: 1.33 ± 0.029	0.993HisSer: 0.993 ± 0.023	0.945HisThr: 0.945 ± 0.026	1.583HisVal: 1.583 ± 0.036	0.347HisTrp: 0.347 ± 0.017	0.519HisTyr: 0.519 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.032IleAla: 7.032 ± 0.075	0.57IleCys: 0.57 ± 0.019	3.608IleAsp: 3.608 ± 0.05	3.351IleGlu: 3.351 ± 0.048	1.707IlePhe: 1.707 ± 0.039	4.832IleGly: 4.832 ± 0.069	0.942IleHis: 0.942 ± 0.026	2.34IleIle: 2.34 ± 0.049	1.564IleLys: 1.564 ± 0.034	4.693IleLeu: 4.693 ± 0.061	1.153IleMet: 1.153 ± 0.03	1.495IleAsn: 1.495 ± 0.029	2.335IlePro: 2.335 ± 0.037	1.285IleGln: 1.285 ± 0.027	2.982IleArg: 2.982 ± 0.046	2.941IleSer: 2.941 ± 0.047	3.07IleThr: 3.07 ± 0.046	3.902IleVal: 3.902 ± 0.052	0.726IleTrp: 0.726 ± 0.024	1.211IleTyr: 1.211 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.964LysAla: 3.964 ± 0.048	0.175LysCys: 0.175 ± 0.012	1.846LysAsp: 1.846 ± 0.039	1.436LysGlu: 1.436 ± 0.035	0.957LysPhe: 0.957 ± 0.028	2.786LysGly: 2.786 ± 0.05	0.618LysHis: 0.618 ± 0.02	1.637LysIle: 1.637 ± 0.037	1.125LysLys: 1.125 ± 0.034	3.04LysLeu: 3.04 ± 0.047	0.922LysMet: 0.922 ± 0.029	0.803LysAsn: 0.803 ± 0.025	1.837LysPro: 1.837 ± 0.046	0.946LysGln: 0.946 ± 0.026	2.317LysArg: 2.317 ± 0.041	1.846LysSer: 1.846 ± 0.036	1.969LysThr: 1.969 ± 0.043	2.287LysVal: 2.287 ± 0.042	0.397LysTrp: 0.397 ± 0.017	0.622LysTyr: 0.622 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	12.486LeuAla: 12.486 ± 0.107	0.963LeuCys: 0.963 ± 0.025	6.148LeuAsp: 6.148 ± 0.066	5.04LeuGlu: 5.04 ± 0.065	3.407LeuPhe: 3.407 ± 0.062	8.532LeuGly: 8.532 ± 0.088	1.905LeuHis: 1.905 ± 0.04	5.248LeuIle: 5.248 ± 0.073	3.225LeuLys: 3.225 ± 0.055	8.898LeuLeu: 8.898 ± 0.111	2.836LeuMet: 2.836 ± 0.051	2.859LeuAsn: 2.859 ± 0.036	5.405LeuPro: 5.405 ± 0.055	2.832LeuGln: 2.832 ± 0.044	6.85LeuArg: 6.85 ± 0.071	6.432LeuSer: 6.432 ± 0.079	6.188LeuThr: 6.188 ± 0.072	6.833LeuVal: 6.833 ± 0.081	1.233LeuTrp: 1.233 ± 0.031	1.924LeuTyr: 1.924 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.634MetAla: 3.634 ± 0.052	0.206MetCys: 0.206 ± 0.011	1.609MetAsp: 1.609 ± 0.032	1.275MetGlu: 1.275 ± 0.032	0.914MetPhe: 0.914 ± 0.03	2.383MetGly: 2.383 ± 0.047	0.521MetHis: 0.521 ± 0.019	1.692MetIle: 1.692 ± 0.031	1.116MetLys: 1.116 ± 0.03	2.761MetLeu: 2.761 ± 0.049	0.901MetMet: 0.901 ± 0.027	0.926MetAsn: 0.926 ± 0.026	1.604MetPro: 1.604 ± 0.033	1.151MetGln: 1.151 ± 0.031	1.983MetArg: 1.983 ± 0.037	1.797MetSer: 1.797 ± 0.034	2.316MetThr: 2.316 ± 0.033	1.952MetVal: 1.952 ± 0.037	0.261MetTrp: 0.261 ± 0.014	0.394MetTyr: 0.394 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.403AsnAla: 3.403 ± 0.048	0.294AsnCys: 0.294 ± 0.015	1.621AsnAsp: 1.621 ± 0.041	1.164AsnGlu: 1.164 ± 0.033	0.997AsnPhe: 0.997 ± 0.026	2.48AsnGly: 2.48 ± 0.04	0.509AsnHis: 0.509 ± 0.017	1.457AsnIle: 1.457 ± 0.036	0.602AsnLys: 0.602 ± 0.021	2.575AsnLeu: 2.575 ± 0.044	0.794AsnMet: 0.794 ± 0.025	0.761AsnAsn: 0.761 ± 0.025	1.856AsnPro: 1.856 ± 0.038	0.754AsnGln: 0.754 ± 0.025	1.718AsnArg: 1.718 ± 0.038	1.178AsnSer: 1.178 ± 0.028	1.514AsnThr: 1.514 ± 0.033	1.933AsnVal: 1.933 ± 0.034	0.46AsnTrp: 0.46 ± 0.02	0.696AsnTyr: 0.696 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.748ProAla: 5.748 ± 0.069	0.351ProCys: 0.351 ± 0.017	4.075ProAsp: 4.075 ± 0.062	3.636ProGlu: 3.636 ± 0.05	1.913ProPhe: 1.913 ± 0.038	3.938ProGly: 3.938 ± 0.06	1.062ProHis: 1.062 ± 0.029	2.198ProIle: 2.198 ± 0.032	1.696ProLys: 1.696 ± 0.04	4.629ProLeu: 4.629 ± 0.06	1.378ProMet: 1.378 ± 0.034	1.3ProAsn: 1.3 ± 0.029	2.134ProPro: 2.134 ± 0.051	1.876ProGln: 1.876 ± 0.037	2.752ProArg: 2.752 ± 0.051	2.419ProSer: 2.419 ± 0.038	2.57ProThr: 2.57 ± 0.046	4.396ProVal: 4.396 ± 0.054	0.642ProTrp: 0.642 ± 0.021	1.164ProTyr: 1.164 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.469GlnAla: 4.469 ± 0.067	0.206GlnCys: 0.206 ± 0.012	1.951GlnAsp: 1.951 ± 0.038	1.561GlnGlu: 1.561 ± 0.033	1.137GlnPhe: 1.137 ± 0.029	2.811GlnGly: 2.811 ± 0.048	0.643GlnHis: 0.643 ± 0.022	2.106GlnIle: 2.106 ± 0.033	1.097GlnLys: 1.097 ± 0.03	2.869GlnLeu: 2.869 ± 0.044	1.323GlnMet: 1.323 ± 0.037	0.94GlnAsn: 0.94 ± 0.024	1.729GlnPro: 1.729 ± 0.038	1.176GlnGln: 1.176 ± 0.031	2.255GlnArg: 2.255 ± 0.045	1.929GlnSer: 1.929 ± 0.033	2.017GlnThr: 2.017 ± 0.043	2.591GlnVal: 2.591 ± 0.046	0.416GlnTrp: 0.416 ± 0.019	0.643GlnTyr: 0.643 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.058ArgAla: 8.058 ± 0.089	0.462ArgCys: 0.462 ± 0.018	4.304ArgAsp: 4.304 ± 0.06	3.418ArgGlu: 3.418 ± 0.049	2.624ArgPhe: 2.624 ± 0.043	4.518ArgGly: 4.518 ± 0.057	1.44ArgHis: 1.44 ± 0.03	3.746ArgIle: 3.746 ± 0.052	2.232ArgLys: 2.232 ± 0.045	6.716ArgLeu: 6.716 ± 0.076	1.961ArgMet: 1.961 ± 0.04	1.816ArgAsn: 1.816 ± 0.037	3.049ArgPro: 3.049 ± 0.047	2.157ArgGln: 2.157 ± 0.045	4.452ArgArg: 4.452 ± 0.068	3.106ArgSer: 3.106 ± 0.044	3.264ArgThr: 3.264 ± 0.047	4.699ArgVal: 4.699 ± 0.055	0.875ArgTrp: 0.875 ± 0.029	1.514ArgTyr: 1.514 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.785SerAla: 5.785 ± 0.066	0.42SerCys: 0.42 ± 0.018	3.437SerAsp: 3.437 ± 0.047	2.722SerGlu: 2.722 ± 0.039	2.187SerPhe: 2.187 ± 0.042	5.332SerGly: 5.332 ± 0.06	1.067SerHis: 1.067 ± 0.025	2.553SerIle: 2.553 ± 0.046	1.569SerLys: 1.569 ± 0.034	4.839SerLeu: 4.839 ± 0.062	1.385SerMet: 1.385 ± 0.037	1.351SerAsn: 1.351 ± 0.031	2.394SerPro: 2.394 ± 0.041	1.643SerGln: 1.643 ± 0.035	2.964SerArg: 2.964 ± 0.051	2.445SerSer: 2.445 ± 0.044	2.643SerThr: 2.643 ± 0.042	3.85SerVal: 3.85 ± 0.054	0.664SerTrp: 0.664 ± 0.022	1.353SerTyr: 1.353 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.672ThrAla: 6.672 ± 0.08	0.51ThrCys: 0.51 ± 0.018	3.51ThrAsp: 3.51 ± 0.059	3.04ThrGlu: 3.04 ± 0.048	2.105ThrPhe: 2.105 ± 0.038	5.629ThrGly: 5.629 ± 0.071	1.212ThrHis: 1.212 ± 0.029	2.771ThrIle: 2.771 ± 0.047	1.558ThrLys: 1.558 ± 0.033	6.442ThrLeu: 6.442 ± 0.071	1.424ThrMet: 1.424 ± 0.029	1.378ThrAsn: 1.378 ± 0.03	3.671ThrPro: 3.671 ± 0.051	1.871ThrGln: 1.871 ± 0.035	3.568ThrArg: 3.568 ± 0.052	2.784ThrSer: 2.784 ± 0.041	3.087ThrThr: 3.087 ± 0.053	4.518ThrVal: 4.518 ± 0.059	0.706ThrTrp: 0.706 ± 0.022	1.393ThrTyr: 1.393 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.078ValAla: 9.078 ± 0.078	0.679ValCys: 0.679 ± 0.021	4.271ValAsp: 4.271 ± 0.061	4.09ValGlu: 4.09 ± 0.055	2.869ValPhe: 2.869 ± 0.049	5.649ValGly: 5.649 ± 0.07	1.424ValHis: 1.424 ± 0.034	4.271ValIle: 4.271 ± 0.058	2.134ValLys: 2.134 ± 0.041	7.62ValLeu: 7.62 ± 0.08	2.351ValMet: 2.351 ± 0.043	2.084ValAsn: 2.084 ± 0.036	3.7ValPro: 3.7 ± 0.051	2.443ValGln: 2.443 ± 0.042	4.311ValArg: 4.311 ± 0.056	4.239ValSer: 4.239 ± 0.058	4.974ValThr: 4.974 ± 0.059	5.911ValVal: 5.911 ± 0.078	0.963ValTrp: 0.963 ± 0.027	1.579ValTyr: 1.579 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.37TrpAla: 1.37 ± 0.034	0.161TrpCys: 0.161 ± 0.01	0.76TrpAsp: 0.76 ± 0.023	0.561TrpGlu: 0.561 ± 0.02	0.563TrpPhe: 0.563 ± 0.02	1.019TrpGly: 1.019 ± 0.028	0.336TrpHis: 0.336 ± 0.018	0.709TrpIle: 0.709 ± 0.021	0.465TrpLys: 0.465 ± 0.019	1.558TrpLeu: 1.558 ± 0.036	0.431TrpMet: 0.431 ± 0.02	0.424TrpAsn: 0.424 ± 0.017	0.654TrpPro: 0.654 ± 0.023	0.632TrpGln: 0.632 ± 0.021	1.031TrpArg: 1.031 ± 0.029	0.773TrpSer: 0.773 ± 0.024	0.826TrpThr: 0.826 ± 0.025	0.906TrpVal: 0.906 ± 0.024	0.208TrpTrp: 0.208 ± 0.012	0.273TrpTyr: 0.273 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.613TyrAla: 2.613 ± 0.042	0.242TyrCys: 0.242 ± 0.013	1.671TyrAsp: 1.671 ± 0.035	1.119TyrGlu: 1.119 ± 0.031	0.897TyrPhe: 0.897 ± 0.025	2.142TyrGly: 2.142 ± 0.037	0.519TyrHis: 0.519 ± 0.018	1.003TyrIle: 1.003 ± 0.026	0.604TyrLys: 0.604 ± 0.022	2.251TyrLeu: 2.251 ± 0.041	0.515TyrMet: 0.515 ± 0.019	0.618TyrAsn: 0.618 ± 0.021	1.135TyrPro: 1.135 ± 0.034	0.71TyrGln: 0.71 ± 0.023	1.422TyrArg: 1.422 ± 0.033	1.122TyrSer: 1.122 ± 0.033	1.231TyrThr: 1.231 ± 0.028	1.621TyrVal: 1.621 ± 0.034	0.339TyrTrp: 0.339 ± 0.014	0.583TyrTyr: 0.583 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4679 proteins (1468902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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