Amino acid dipepetide frequency for Nocardia sp. NRRL S-836

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.433AlaAla: 19.433 ± 0.139	1.033AlaCys: 1.033 ± 0.023	8.109AlaAsp: 8.109 ± 0.066	8.334AlaGlu: 8.334 ± 0.067	3.654AlaPhe: 3.654 ± 0.045	12.119AlaGly: 12.119 ± 0.093	2.738AlaHis: 2.738 ± 0.034	3.777AlaIle: 3.777 ± 0.045	2.932AlaLys: 2.932 ± 0.046	14.147AlaLeu: 14.147 ± 0.111	2.498AlaMet: 2.498 ± 0.035	2.369AlaAsn: 2.369 ± 0.035	5.813AlaPro: 5.813 ± 0.062	3.938AlaGln: 3.938 ± 0.045	9.329AlaArg: 9.329 ± 0.075	5.746AlaSer: 5.746 ± 0.05	6.942AlaThr: 6.942 ± 0.062	12.597AlaVal: 12.597 ± 0.093	1.886AlaTrp: 1.886 ± 0.026	2.25AlaTyr: 2.25 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.02	0.095CysCys: 0.095 ± 0.006	0.487CysAsp: 0.487 ± 0.014	0.395CysGlu: 0.395 ± 0.012	0.21CysPhe: 0.21 ± 0.01	0.97CysGly: 0.97 ± 0.023	0.201CysHis: 0.201 ± 0.01	0.157CysIle: 0.157 ± 0.008	0.126CysLys: 0.126 ± 0.008	0.746CysLeu: 0.746 ± 0.02	0.114CysMet: 0.114 ± 0.006	0.14CysAsn: 0.14 ± 0.007	0.466CysPro: 0.466 ± 0.016	0.193CysGln: 0.193 ± 0.01	0.623CysArg: 0.623 ± 0.017	0.491CysSer: 0.491 ± 0.015	0.518CysThr: 0.518 ± 0.015	0.702CysVal: 0.702 ± 0.016	0.129CysTrp: 0.129 ± 0.008	0.163CysTyr: 0.163 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.136AspAla: 7.136 ± 0.063	0.409AspCys: 0.409 ± 0.016	3.756AspAsp: 3.756 ± 0.047	4.091AspGlu: 4.091 ± 0.041	1.697AspPhe: 1.697 ± 0.027	6.023AspGly: 6.023 ± 0.063	1.555AspHis: 1.555 ± 0.027	1.678AspIle: 1.678 ± 0.022	1.097AspLys: 1.097 ± 0.024	6.682AspLeu: 6.682 ± 0.053	0.765AspMet: 0.765 ± 0.017	1.162AspAsn: 1.162 ± 0.027	4.159AspPro: 4.159 ± 0.045	1.754AspGln: 1.754 ± 0.031	5.021AspArg: 5.021 ± 0.055	2.452AspSer: 2.452 ± 0.035	2.939AspThr: 2.939 ± 0.039	5.898AspVal: 5.898 ± 0.056	0.995AspTrp: 0.995 ± 0.021	1.146AspTyr: 1.146 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.538GluAla: 6.538 ± 0.061	0.377GluCys: 0.377 ± 0.014	2.576GluAsp: 2.576 ± 0.034	3.018GluGlu: 3.018 ± 0.045	1.786GluPhe: 1.786 ± 0.028	3.499GluGly: 3.499 ± 0.04	1.776GluHis: 1.776 ± 0.032	2.266GluIle: 2.266 ± 0.031	1.358GluLys: 1.358 ± 0.027	7.457GluLeu: 7.457 ± 0.067	0.894GluMet: 0.894 ± 0.018	1.175GluAsn: 1.175 ± 0.022	3.253GluPro: 3.253 ± 0.043	2.505GluGln: 2.505 ± 0.034	4.901GluArg: 4.901 ± 0.05	2.423GluSer: 2.423 ± 0.034	2.551GluThr: 2.551 ± 0.034	5.38GluVal: 5.38 ± 0.049	0.815GluTrp: 0.815 ± 0.019	0.993GluTyr: 0.993 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.949PheAla: 3.949 ± 0.043	0.279PheCys: 0.279 ± 0.011	2.251PheAsp: 2.251 ± 0.032	1.562PheGlu: 1.562 ± 0.024	0.908PhePhe: 0.908 ± 0.023	3.272PheGly: 3.272 ± 0.037	0.67PheHis: 0.67 ± 0.015	0.724PheIle: 0.724 ± 0.017	0.52PheLys: 0.52 ± 0.016	2.71PheLeu: 2.71 ± 0.036	0.374PheMet: 0.374 ± 0.013	0.597PheAsn: 0.597 ± 0.014	1.422PhePro: 1.422 ± 0.024	0.745PheGln: 0.745 ± 0.016	1.924PheArg: 1.924 ± 0.028	1.609PheSer: 1.609 ± 0.028	2.171PheThr: 2.171 ± 0.029	2.632PheVal: 2.632 ± 0.038	0.445PheTrp: 0.445 ± 0.014	0.633PheTyr: 0.633 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	9.762GlyAla: 9.762 ± 0.076	0.812GlyCys: 0.812 ± 0.022	5.01GlyAsp: 5.01 ± 0.053	4.925GlyGlu: 4.925 ± 0.055	3.007GlyPhe: 3.007 ± 0.038	7.939GlyGly: 7.939 ± 0.091	2.201GlyHis: 2.201 ± 0.038	3.251GlyIle: 3.251 ± 0.045	2.523GlyLys: 2.523 ± 0.037	9.079GlyLeu: 9.079 ± 0.069	1.944GlyMet: 1.944 ± 0.028	1.991GlyAsn: 1.991 ± 0.037	4.369GlyPro: 4.369 ± 0.045	2.792GlyGln: 2.792 ± 0.037	6.713GlyArg: 6.713 ± 0.051	4.976GlySer: 4.976 ± 0.051	6.048GlyThr: 6.048 ± 0.061	8.43GlyVal: 8.43 ± 0.074	1.68GlyTrp: 1.68 ± 0.028	2.281GlyTyr: 2.281 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.727HisAla: 2.727 ± 0.037	0.223HisCys: 0.223 ± 0.01	1.564HisAsp: 1.564 ± 0.025	1.317HisGlu: 1.317 ± 0.023	0.644HisPhe: 0.644 ± 0.017	2.353HisGly: 2.353 ± 0.034	0.74HisHis: 0.74 ± 0.019	0.583HisIle: 0.583 ± 0.017	0.313HisLys: 0.313 ± 0.012	2.545HisLeu: 2.545 ± 0.035	0.297HisMet: 0.297 ± 0.012	0.487HisAsn: 0.487 ± 0.015	1.686HisPro: 1.686 ± 0.027	0.702HisGln: 0.702 ± 0.017	2.205HisArg: 2.205 ± 0.035	1.048HisSer: 1.048 ± 0.021	1.236HisThr: 1.236 ± 0.023	2.165HisVal: 2.165 ± 0.032	0.382HisTrp: 0.382 ± 0.013	0.497HisTyr: 0.497 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.01IleAla: 5.01 ± 0.053	0.281IleCys: 0.281 ± 0.011	2.312IleAsp: 2.312 ± 0.032	1.933IleGlu: 1.933 ± 0.03	0.704IlePhe: 0.704 ± 0.018	3.61IleGly: 3.61 ± 0.039	0.537IleHis: 0.537 ± 0.015	0.893IleIle: 0.893 ± 0.023	0.732IleLys: 0.732 ± 0.017	1.91IleLeu: 1.91 ± 0.032	0.435IleMet: 0.435 ± 0.015	0.794IleAsn: 0.794 ± 0.018	1.669IlePro: 1.669 ± 0.026	0.659IleGln: 0.659 ± 0.017	2.159IleArg: 2.159 ± 0.025	1.875IleSer: 1.875 ± 0.028	2.493IleThr: 2.493 ± 0.03	2.66IleVal: 2.66 ± 0.033	0.381IleTrp: 0.381 ± 0.013	0.555IleTyr: 0.555 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.952LysAla: 2.952 ± 0.043	0.132LysCys: 0.132 ± 0.008	1.166LysAsp: 1.166 ± 0.025	0.982LysGlu: 0.982 ± 0.025	0.559LysPhe: 0.559 ± 0.015	1.589LysGly: 1.589 ± 0.031	0.5LysHis: 0.5 ± 0.014	0.958LysIle: 0.958 ± 0.023	0.696LysLys: 0.696 ± 0.023	2.328LysLeu: 2.328 ± 0.037	0.387LysMet: 0.387 ± 0.014	0.495LysAsn: 0.495 ± 0.014	1.516LysPro: 1.516 ± 0.031	0.758LysGln: 0.758 ± 0.019	1.519LysArg: 1.519 ± 0.029	1.116LysSer: 1.116 ± 0.022	1.311LysThr: 1.311 ± 0.028	2.03LysVal: 2.03 ± 0.034	0.293LysTrp: 0.293 ± 0.011	0.42LysTyr: 0.42 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.914LeuAla: 14.914 ± 0.118	0.798LeuCys: 0.798 ± 0.018	7.006LeuAsp: 7.006 ± 0.057	4.709LeuGlu: 4.709 ± 0.052	2.723LeuPhe: 2.723 ± 0.037	9.207LeuGly: 9.207 ± 0.075	2.492LeuHis: 2.492 ± 0.038	3.005LeuIle: 3.005 ± 0.045	2.066LeuLys: 2.066 ± 0.036	11.156LeuLeu: 11.156 ± 0.099	1.547LeuMet: 1.547 ± 0.027	1.913LeuAsn: 1.913 ± 0.033	6.287LeuPro: 6.287 ± 0.052	2.34LeuGln: 2.34 ± 0.033	9.063LeuArg: 9.063 ± 0.074	5.625LeuSer: 5.625 ± 0.046	6.761LeuThr: 6.761 ± 0.051	10.388LeuVal: 10.388 ± 0.076	1.372LeuTrp: 1.372 ± 0.026	1.702LeuTyr: 1.702 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.029	0.138MetCys: 0.138 ± 0.007	0.818MetAsp: 0.818 ± 0.017	0.62MetGlu: 0.62 ± 0.016	0.514MetPhe: 0.514 ± 0.015	1.242MetGly: 1.242 ± 0.027	0.369MetHis: 0.369 ± 0.01	0.703MetIle: 0.703 ± 0.017	0.421MetLys: 0.421 ± 0.011	1.778MetLeu: 1.778 ± 0.028	0.288MetMet: 0.288 ± 0.011	0.391MetAsn: 0.391 ± 0.011	1.07MetPro: 1.07 ± 0.021	0.45MetGln: 0.45 ± 0.015	1.513MetArg: 1.513 ± 0.029	1.254MetSer: 1.254 ± 0.02	1.43MetThr: 1.43 ± 0.021	1.404MetVal: 1.404 ± 0.023	0.254MetTrp: 0.254 ± 0.01	0.286MetTyr: 0.286 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.615AsnAla: 2.615 ± 0.038	0.195AsnCys: 0.195 ± 0.01	1.141AsnAsp: 1.141 ± 0.023	0.946AsnGlu: 0.946 ± 0.02	0.545AsnPhe: 0.545 ± 0.014	2.351AsnGly: 2.351 ± 0.036	0.453AsnHis: 0.453 ± 0.014	0.616AsnIle: 0.616 ± 0.015	0.413AsnLys: 0.413 ± 0.012	1.911AsnLeu: 1.911 ± 0.032	0.293AsnMet: 0.293 ± 0.012	0.56AsnAsn: 0.56 ± 0.015	1.552AsnPro: 1.552 ± 0.024	0.617AsnGln: 0.617 ± 0.016	1.474AsnArg: 1.474 ± 0.027	1.043AsnSer: 1.043 ± 0.025	1.257AsnThr: 1.257 ± 0.027	1.756AsnVal: 1.756 ± 0.027	0.35AsnTrp: 0.35 ± 0.012	0.473AsnTyr: 0.473 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.543ProAla: 7.543 ± 0.074	0.376ProCys: 0.376 ± 0.014	4.326ProAsp: 4.326 ± 0.051	3.827ProGlu: 3.827 ± 0.04	1.627ProPhe: 1.627 ± 0.025	5.755ProGly: 5.755 ± 0.057	1.326ProHis: 1.326 ± 0.023	1.471ProIle: 1.471 ± 0.024	1.158ProLys: 1.158 ± 0.025	5.075ProLeu: 5.075 ± 0.046	0.996ProMet: 0.996 ± 0.02	1.133ProAsn: 1.133 ± 0.022	3.21ProPro: 3.21 ± 0.057	1.695ProGln: 1.695 ± 0.026	3.622ProArg: 3.622 ± 0.037	3.104ProSer: 3.104 ± 0.044	2.917ProThr: 2.917 ± 0.038	5.709ProVal: 5.709 ± 0.061	0.9ProTrp: 0.9 ± 0.02	1.008ProTyr: 1.008 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.884GlnAla: 3.884 ± 0.043	0.186GlnCys: 0.186 ± 0.009	1.404GlnAsp: 1.404 ± 0.028	1.446GlnGlu: 1.446 ± 0.026	0.832GlnPhe: 0.832 ± 0.019	2.131GlnGly: 2.131 ± 0.032	0.76GlnHis: 0.76 ± 0.019	1.058GlnIle: 1.058 ± 0.019	0.641GlnLys: 0.641 ± 0.019	3.425GlnLeu: 3.425 ± 0.041	0.455GlnMet: 0.455 ± 0.014	0.635GlnAsn: 0.635 ± 0.018	1.813GlnPro: 1.813 ± 0.032	1.329GlnGln: 1.329 ± 0.029	2.777GlnArg: 2.777 ± 0.037	1.29GlnSer: 1.29 ± 0.025	1.389GlnThr: 1.389 ± 0.025	2.835GlnVal: 2.835 ± 0.032	0.537GlnTrp: 0.537 ± 0.014	0.568GlnTyr: 0.568 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.231ArgAla: 9.231 ± 0.073	0.642ArgCys: 0.642 ± 0.017	4.352ArgAsp: 4.352 ± 0.044	4.581ArgGlu: 4.581 ± 0.047	2.62ArgPhe: 2.62 ± 0.037	5.657ArgGly: 5.657 ± 0.046	2.012ArgHis: 2.012 ± 0.025	2.933ArgIle: 2.933 ± 0.035	1.803ArgLys: 1.803 ± 0.029	8.39ArgLeu: 8.39 ± 0.081	1.847ArgMet: 1.847 ± 0.032	1.585ArgAsn: 1.585 ± 0.024	4.237ArgPro: 4.237 ± 0.051	2.481ArgGln: 2.481 ± 0.034	6.967ArgArg: 6.967 ± 0.059	4.256ArgSer: 4.256 ± 0.041	4.966ArgThr: 4.966 ± 0.049	6.384ArgVal: 6.384 ± 0.056	1.543ArgTrp: 1.543 ± 0.03	1.852ArgTyr: 1.852 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.63SerAla: 6.63 ± 0.056	0.457SerCys: 0.457 ± 0.017	2.678SerAsp: 2.678 ± 0.038	2.462SerGlu: 2.462 ± 0.037	1.669SerPhe: 1.669 ± 0.03	5.871SerGly: 5.871 ± 0.059	1.041SerHis: 1.041 ± 0.019	1.642SerIle: 1.642 ± 0.024	1.074SerLys: 1.074 ± 0.023	4.925SerLeu: 4.925 ± 0.042	1.094SerMet: 1.094 ± 0.019	1.037SerAsn: 1.037 ± 0.024	2.954SerPro: 2.954 ± 0.04	1.284SerGln: 1.284 ± 0.023	3.659SerArg: 3.659 ± 0.035	3.162SerSer: 3.162 ± 0.046	3.424SerThr: 3.424 ± 0.043	4.559SerVal: 4.559 ± 0.048	1.032SerTrp: 1.032 ± 0.019	1.177SerTyr: 1.177 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.399ThrAla: 8.399 ± 0.067	0.498ThrCys: 0.498 ± 0.016	3.378ThrAsp: 3.378 ± 0.04	3.062ThrGlu: 3.062 ± 0.035	1.832ThrPhe: 1.832 ± 0.027	6.466ThrGly: 6.466 ± 0.058	1.194ThrHis: 1.194 ± 0.023	2.011ThrIle: 2.011 ± 0.027	1.26ThrLys: 1.26 ± 0.025	5.395ThrLeu: 5.395 ± 0.052	0.953ThrMet: 0.953 ± 0.022	1.242ThrAsn: 1.242 ± 0.025	3.909ThrPro: 3.909 ± 0.046	1.413ThrGln: 1.413 ± 0.024	3.963ThrArg: 3.963 ± 0.042	3.413ThrSer: 3.413 ± 0.041	4.323ThrThr: 4.323 ± 0.057	5.927ThrVal: 5.927 ± 0.048	0.979ThrTrp: 0.979 ± 0.023	1.262ThrTyr: 1.262 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.792ValAla: 11.792 ± 0.076	0.732ValCys: 0.732 ± 0.017	5.874ValAsp: 5.874 ± 0.051	5.516ValGlu: 5.516 ± 0.047	2.642ValPhe: 2.642 ± 0.04	6.754ValGly: 6.754 ± 0.056	2.32ValHis: 2.32 ± 0.028	2.96ValIle: 2.96 ± 0.037	1.896ValLys: 1.896 ± 0.032	11.293ValLeu: 11.293 ± 0.093	1.372ValMet: 1.372 ± 0.025	1.949ValAsn: 1.949 ± 0.029	5.511ValPro: 5.511 ± 0.063	2.433ValGln: 2.433 ± 0.039	7.64ValArg: 7.64 ± 0.061	4.891ValSer: 4.891 ± 0.048	5.991ValThr: 5.991 ± 0.053	10.488ValVal: 10.488 ± 0.093	1.21ValTrp: 1.21 ± 0.022	1.543ValTyr: 1.543 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.654TrpAla: 1.654 ± 0.022	0.157TrpCys: 0.157 ± 0.009	0.883TrpAsp: 0.883 ± 0.018	0.76TrpGlu: 0.76 ± 0.017	0.559TrpPhe: 0.559 ± 0.016	1.013TrpGly: 1.013 ± 0.019	0.421TrpHis: 0.421 ± 0.013	0.518TrpIle: 0.518 ± 0.015	0.343TrpLys: 0.343 ± 0.012	1.943TrpLeu: 1.943 ± 0.034	0.294TrpMet: 0.294 ± 0.012	0.463TrpAsn: 0.463 ± 0.014	0.856TrpPro: 0.856 ± 0.018	0.667TrpGln: 0.667 ± 0.016	1.419TrpArg: 1.419 ± 0.025	0.989TrpSer: 0.989 ± 0.023	1.088TrpThr: 1.088 ± 0.023	1.178TrpVal: 1.178 ± 0.026	0.361TrpTrp: 0.361 ± 0.012	0.334TrpTyr: 0.334 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.293TyrAla: 2.293 ± 0.035	0.168TyrCys: 0.168 ± 0.008	1.324TyrAsp: 1.324 ± 0.026	1.053TyrGlu: 1.053 ± 0.021	0.667TyrPhe: 0.667 ± 0.017	1.91TyrGly: 1.91 ± 0.029	0.407TyrHis: 0.407 ± 0.014	0.399TyrIle: 0.399 ± 0.013	0.335TyrLys: 0.335 ± 0.014	2.181TyrLeu: 2.181 ± 0.032	0.217TyrMet: 0.217 ± 0.009	0.444TyrAsn: 0.444 ± 0.013	1.026TyrPro: 1.026 ± 0.021	0.64TyrGln: 0.64 ± 0.014	1.85TyrArg: 1.85 ± 0.032	1.07TyrSer: 1.07 ± 0.023	1.122TyrThr: 1.122 ± 0.023	1.686TyrVal: 1.686 ± 0.028	0.354TyrTrp: 0.354 ± 0.012	0.492TyrTyr: 0.492 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7876 proteins (2515523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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