Amino acid dipepetide frequency for Helicobacter valdiviensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.608AlaAla: 2.608 ± 0.089	0.797AlaCys: 0.797 ± 0.047	2.174AlaAsp: 2.174 ± 0.066	2.544AlaGlu: 2.544 ± 0.068	3.602AlaPhe: 3.602 ± 0.082	3.644AlaGly: 3.644 ± 0.104	1.019AlaHis: 1.019 ± 0.039	5.662AlaIle: 5.662 ± 0.103	7.115AlaLys: 7.115 ± 0.114	8.266AlaLeu: 8.266 ± 0.126	1.717AlaMet: 1.717 ± 0.059	3.835AlaAsn: 3.835 ± 0.093	1.911AlaPro: 1.911 ± 0.055	2.44AlaGln: 2.44 ± 0.075	2.396AlaArg: 2.396 ± 0.071	4.128AlaSer: 4.128 ± 0.081	3.107AlaThr: 3.107 ± 0.076	2.853AlaVal: 2.853 ± 0.082	0.494AlaTrp: 0.494 ± 0.026	2.714AlaTyr: 2.714 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.047	0.123CysCys: 0.123 ± 0.015	0.639CysAsp: 0.639 ± 0.032	1.006CysGlu: 1.006 ± 0.043	0.679CysPhe: 0.679 ± 0.033	1.026CysGly: 1.026 ± 0.046	0.234CysHis: 0.234 ± 0.023	1.042CysIle: 1.042 ± 0.044	1.042CysLys: 1.042 ± 0.046	0.974CysLeu: 0.974 ± 0.039	0.295CysMet: 0.295 ± 0.021	0.561CysAsn: 0.561 ± 0.031	0.394CysPro: 0.394 ± 0.029	0.287CysGln: 0.287 ± 0.024	0.241CysArg: 0.241 ± 0.022	0.623CysSer: 0.623 ± 0.033	0.427CysThr: 0.427 ± 0.027	0.894CysVal: 0.894 ± 0.041	0.069CysTrp: 0.069 ± 0.01	0.427CysTyr: 0.427 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.343AspAla: 2.343 ± 0.069	0.792AspCys: 0.792 ± 0.033	1.838AspAsp: 1.838 ± 0.067	3.679AspGlu: 3.679 ± 0.089	4.09AspPhe: 4.09 ± 0.09	2.726AspGly: 2.726 ± 0.079	0.411AspHis: 0.411 ± 0.028	4.339AspIle: 4.339 ± 0.093	4.616AspLys: 4.616 ± 0.096	5.069AspLeu: 5.069 ± 0.084	1.049AspMet: 1.049 ± 0.037	2.533AspAsn: 2.533 ± 0.069	1.111AspPro: 1.111 ± 0.051	0.618AspGln: 0.618 ± 0.032	1.578AspArg: 1.578 ± 0.047	3.121AspSer: 3.121 ± 0.08	2.341AspThr: 2.341 ± 0.065	2.563AspVal: 2.563 ± 0.073	0.371AspTrp: 0.371 ± 0.023	2.448AspTyr: 2.448 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	5.577GluAla: 5.577 ± 0.097	0.861GluCys: 0.861 ± 0.037	3.79GluAsp: 3.79 ± 0.088	7.46GluGlu: 7.46 ± 0.162	4.184GluPhe: 4.184 ± 0.085	4.12GluGly: 4.12 ± 0.081	1.098GluHis: 1.098 ± 0.048	7.388GluIle: 7.388 ± 0.13	6.361GluLys: 6.361 ± 0.131	7.896GluLeu: 7.896 ± 0.133	1.583GluMet: 1.583 ± 0.045	4.995GluAsn: 4.995 ± 0.107	1.505GluPro: 1.505 ± 0.05	2.531GluGln: 2.531 ± 0.074	2.501GluArg: 2.501 ± 0.07	3.875GluSer: 3.875 ± 0.086	2.227GluThr: 2.227 ± 0.06	4.707GluVal: 4.707 ± 0.091	0.622GluTrp: 0.622 ± 0.027	2.686GluTyr: 2.686 ± 0.075	0.0GluXaa: 0.0 ± 0.0
Phe	3.481PheAla: 3.481 ± 0.077	0.894PheCys: 0.894 ± 0.039	2.695PheAsp: 2.695 ± 0.063	3.095PheGlu: 3.095 ± 0.081	3.207PhePhe: 3.207 ± 0.09	3.778PheGly: 3.778 ± 0.086	0.746PheHis: 0.746 ± 0.039	4.61PheIle: 4.61 ± 0.093	4.697PheLys: 4.697 ± 0.099	6.733PheLeu: 6.733 ± 0.134	1.377PheMet: 1.377 ± 0.053	3.084PheAsn: 3.084 ± 0.069	1.318PhePro: 1.318 ± 0.048	1.187PheGln: 1.187 ± 0.039	1.619PheArg: 1.619 ± 0.044	4.72PheSer: 4.72 ± 0.092	2.106PheThr: 2.106 ± 0.059	3.365PheVal: 3.365 ± 0.077	0.513PheTrp: 0.513 ± 0.031	2.694PheTyr: 2.694 ± 0.07	0.0PheXaa: 0.0 ± 0.0
Gly	4.284GlyAla: 4.284 ± 0.099	0.661GlyCys: 0.661 ± 0.036	3.076GlyAsp: 3.076 ± 0.077	4.646GlyGlu: 4.646 ± 0.091	3.824GlyPhe: 3.824 ± 0.089	4.841GlyGly: 4.841 ± 0.151	0.894GlyHis: 0.894 ± 0.035	5.942GlyIle: 5.942 ± 0.126	4.802GlyLys: 4.802 ± 0.1	5.231GlyLeu: 5.231 ± 0.111	1.557GlyMet: 1.557 ± 0.059	3.019GlyAsn: 3.019 ± 0.089	0.69GlyPro: 0.69 ± 0.037	1.291GlyGln: 1.291 ± 0.051	1.863GlyArg: 1.863 ± 0.066	3.779GlySer: 3.779 ± 0.088	2.287GlyThr: 2.287 ± 0.068	4.39GlyVal: 4.39 ± 0.101	0.414GlyTrp: 0.414 ± 0.029	2.691GlyTyr: 2.691 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	0.789HisAla: 0.789 ± 0.035	0.233HisCys: 0.233 ± 0.022	0.542HisAsp: 0.542 ± 0.032	0.684HisGlu: 0.684 ± 0.031	1.175HisPhe: 1.175 ± 0.042	0.786HisGly: 0.786 ± 0.039	0.384HisHis: 0.384 ± 0.027	1.435HisIle: 1.435 ± 0.052	1.694HisLys: 1.694 ± 0.057	1.983HisLeu: 1.983 ± 0.057	0.239HisMet: 0.239 ± 0.019	0.995HisAsn: 0.995 ± 0.035	0.73HisPro: 0.73 ± 0.032	0.654HisGln: 0.654 ± 0.036	0.563HisArg: 0.563 ± 0.034	1.254HisSer: 1.254 ± 0.042	1.036HisThr: 1.036 ± 0.04	0.341HisVal: 0.341 ± 0.023	0.102HisTrp: 0.102 ± 0.016	0.752HisTyr: 0.752 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.325IleAla: 6.325 ± 0.101	1.125IleCys: 1.125 ± 0.047	4.249IleAsp: 4.249 ± 0.088	5.8IleGlu: 5.8 ± 0.109	4.659IlePhe: 4.659 ± 0.103	5.022IleGly: 5.022 ± 0.113	1.538IleHis: 1.538 ± 0.05	6.184IleIle: 6.184 ± 0.116	7.681IleLys: 7.681 ± 0.123	9.772IleLeu: 9.772 ± 0.187	1.527IleMet: 1.527 ± 0.048	4.598IleAsn: 4.598 ± 0.111	2.92IlePro: 2.92 ± 0.085	2.753IleGln: 2.753 ± 0.067	2.416IleArg: 2.416 ± 0.066	5.854IleSer: 5.854 ± 0.097	4.025IleThr: 4.025 ± 0.087	4.511IleVal: 4.511 ± 0.093	0.512IleTrp: 0.512 ± 0.027	3.484IleTyr: 3.484 ± 0.079	0.0IleXaa: 0.0 ± 0.0
Lys	5.525LysAla: 5.525 ± 0.108	0.646LysCys: 0.646 ± 0.034	5.749LysAsp: 5.749 ± 0.104	11.463LysGlu: 11.463 ± 0.204	3.15LysPhe: 3.15 ± 0.076	4.699LysGly: 4.699 ± 0.092	1.264LysHis: 1.264 ± 0.046	8.915LysIle: 8.915 ± 0.166	7.719LysLys: 7.719 ± 0.143	7.35LysLeu: 7.35 ± 0.124	2.198LysMet: 2.198 ± 0.065	6.97LysAsn: 6.97 ± 0.118	2.436LysPro: 2.436 ± 0.074	3.156LysGln: 3.156 ± 0.074	3.102LysArg: 3.102 ± 0.068	5.271LysSer: 5.271 ± 0.085	4.045LysThr: 4.045 ± 0.076	4.367LysVal: 4.367 ± 0.078	0.526LysTrp: 0.526 ± 0.027	2.947LysTyr: 2.947 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	6.836LeuAla: 6.836 ± 0.108	1.454LeuCys: 1.454 ± 0.053	5.475LeuAsp: 5.475 ± 0.107	10.075LeuGlu: 10.075 ± 0.176	5.196LeuPhe: 5.196 ± 0.117	6.742LeuGly: 6.742 ± 0.12	1.683LeuHis: 1.683 ± 0.054	7.157LeuIle: 7.157 ± 0.113	11.07LeuLys: 11.07 ± 0.166	10.88LeuLeu: 10.88 ± 0.193	2.257LeuMet: 2.257 ± 0.063	6.146LeuAsn: 6.146 ± 0.105	3.582LeuPro: 3.582 ± 0.081	4.452LeuGln: 4.452 ± 0.099	3.35LeuArg: 3.35 ± 0.073	8.276LeuSer: 8.276 ± 0.123	3.765LeuThr: 3.765 ± 0.082	5.097LeuVal: 5.097 ± 0.088	0.733LeuTrp: 0.733 ± 0.034	3.766LeuTyr: 3.766 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	1.473MetAla: 1.473 ± 0.049	0.244MetCys: 0.244 ± 0.018	1.092MetAsp: 1.092 ± 0.043	1.565MetGlu: 1.565 ± 0.054	0.917MetPhe: 0.917 ± 0.044	1.626MetGly: 1.626 ± 0.06	0.357MetHis: 0.357 ± 0.024	1.635MetIle: 1.635 ± 0.05	1.527MetLys: 1.527 ± 0.047	2.538MetLeu: 2.538 ± 0.068	0.486MetMet: 0.486 ± 0.029	0.923MetAsn: 0.923 ± 0.035	0.987MetPro: 0.987 ± 0.039	1.578MetGln: 1.578 ± 0.051	0.894MetArg: 0.894 ± 0.038	1.382MetSer: 1.382 ± 0.05	0.542MetThr: 0.542 ± 0.032	1.361MetVal: 1.361 ± 0.048	0.143MetTrp: 0.143 ± 0.016	0.544MetTyr: 0.544 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	4.276AsnAla: 4.276 ± 0.078	0.515AsnCys: 0.515 ± 0.028	2.372AsnAsp: 2.372 ± 0.068	3.735AsnGlu: 3.735 ± 0.077	3.465AsnPhe: 3.465 ± 0.085	3.432AsnGly: 3.432 ± 0.101	1.101AsnHis: 1.101 ± 0.041	5.344AsnIle: 5.344 ± 0.134	5.019AsnLys: 5.019 ± 0.108	6.967AsnLeu: 6.967 ± 0.13	1.017AsnMet: 1.017 ± 0.043	3.468AsnAsn: 3.468 ± 0.119	2.679AsnPro: 2.679 ± 0.066	2.082AsnGln: 2.082 ± 0.062	1.632AsnArg: 1.632 ± 0.048	3.715AsnSer: 3.715 ± 0.079	3.033AsnThr: 3.033 ± 0.082	2.571AsnVal: 2.571 ± 0.073	0.312AsnTrp: 0.312 ± 0.024	2.377AsnTyr: 2.377 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	1.379ProAla: 1.379 ± 0.053	0.362ProCys: 0.362 ± 0.026	1.017ProAsp: 1.017 ± 0.041	1.317ProGlu: 1.317 ± 0.056	1.981ProPhe: 1.981 ± 0.058	0.886ProGly: 0.886 ± 0.041	0.703ProHis: 0.703 ± 0.033	2.646ProIle: 2.646 ± 0.067	3.358ProLys: 3.358 ± 0.07	3.927ProLeu: 3.927 ± 0.076	0.633ProMet: 0.633 ± 0.029	2.048ProAsn: 2.048 ± 0.052	0.929ProPro: 0.929 ± 0.041	1.299ProGln: 1.299 ± 0.047	0.759ProArg: 0.759 ± 0.033	2.195ProSer: 2.195 ± 0.062	1.624ProThr: 1.624 ± 0.052	1.191ProVal: 1.191 ± 0.054	0.223ProTrp: 0.223 ± 0.021	1.457ProTyr: 1.457 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	1.984GlnAla: 1.984 ± 0.063	0.255GlnCys: 0.255 ± 0.021	1.905GlnAsp: 1.905 ± 0.066	3.884GlnGlu: 3.884 ± 0.096	1.084GlnPhe: 1.084 ± 0.042	1.624GlnGly: 1.624 ± 0.049	0.359GlnHis: 0.359 ± 0.023	3.079GlnIle: 3.079 ± 0.076	4.388GlnLys: 4.388 ± 0.106	2.05GlnLeu: 2.05 ± 0.058	0.818GlnMet: 0.818 ± 0.034	3.213GlnAsn: 3.213 ± 0.073	0.596GlnPro: 0.596 ± 0.034	0.875GlnGln: 0.875 ± 0.044	1.246GlnArg: 1.246 ± 0.045	2.369GlnSer: 2.369 ± 0.074	1.839GlnThr: 1.839 ± 0.063	1.529GlnVal: 1.529 ± 0.046	0.202GlnTrp: 0.202 ± 0.019	0.931GlnTyr: 0.931 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.219ArgAla: 2.219 ± 0.065	0.263ArgCys: 0.263 ± 0.022	1.718ArgAsp: 1.718 ± 0.054	2.891ArgGlu: 2.891 ± 0.076	1.9ArgPhe: 1.9 ± 0.05	1.988ArgGly: 1.988 ± 0.065	0.536ArgHis: 0.536 ± 0.029	2.89ArgIle: 2.89 ± 0.062	2.29ArgLys: 2.29 ± 0.065	3.17ArgLeu: 3.17 ± 0.078	0.768ArgMet: 0.768 ± 0.04	1.581ArgAsn: 1.581 ± 0.052	0.814ArgPro: 0.814 ± 0.04	0.961ArgGln: 0.961 ± 0.042	1.127ArgArg: 1.127 ± 0.048	1.704ArgSer: 1.704 ± 0.055	1.156ArgThr: 1.156 ± 0.041	2.085ArgVal: 2.085 ± 0.068	0.182ArgTrp: 0.182 ± 0.018	1.415ArgTyr: 1.415 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.99SerAla: 3.99 ± 0.086	0.701SerCys: 0.701 ± 0.038	2.697SerAsp: 2.697 ± 0.059	3.268SerGlu: 3.268 ± 0.08	4.458SerPhe: 4.458 ± 0.105	4.304SerGly: 4.304 ± 0.106	1.283SerHis: 1.283 ± 0.042	5.886SerIle: 5.886 ± 0.102	6.168SerLys: 6.168 ± 0.096	8.137SerLeu: 8.137 ± 0.146	1.449SerMet: 1.449 ± 0.053	3.698SerAsn: 3.698 ± 0.095	2.013SerPro: 2.013 ± 0.062	2.306SerGln: 2.306 ± 0.066	1.701SerArg: 1.701 ± 0.064	4.621SerSer: 4.621 ± 0.096	2.836SerThr: 2.836 ± 0.073	3.459SerVal: 3.459 ± 0.08	0.526SerTrp: 0.526 ± 0.034	2.944SerTyr: 2.944 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	2.04ThrAla: 2.04 ± 0.061	0.44ThrCys: 0.44 ± 0.026	1.513ThrAsp: 1.513 ± 0.059	1.642ThrGlu: 1.642 ± 0.053	2.359ThrPhe: 2.359 ± 0.073	1.929ThrGly: 1.929 ± 0.063	1.132ThrHis: 1.132 ± 0.04	3.33ThrIle: 3.33 ± 0.088	4.235ThrLys: 4.235 ± 0.082	6.175ThrLeu: 6.175 ± 0.105	0.83ThrMet: 0.83 ± 0.035	2.52ThrAsn: 2.52 ± 0.079	2.231ThrPro: 2.231 ± 0.07	2.453ThrGln: 2.453 ± 0.074	1.331ThrArg: 1.331 ± 0.042	2.925ThrSer: 2.925 ± 0.061	2.173ThrThr: 2.173 ± 0.066	0.821ThrVal: 0.821 ± 0.038	0.308ThrTrp: 0.308 ± 0.022	1.809ThrTyr: 1.809 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.955ValAla: 3.955 ± 0.094	0.864ValCys: 0.864 ± 0.043	2.734ValAsp: 2.734 ± 0.074	3.486ValGlu: 3.486 ± 0.084	2.947ValPhe: 2.947 ± 0.076	3.958ValGly: 3.958 ± 0.101	0.706ValHis: 0.706 ± 0.034	4.275ValIle: 4.275 ± 0.083	3.591ValLys: 3.591 ± 0.092	5.874ValLeu: 5.874 ± 0.116	1.162ValMet: 1.162 ± 0.045	2.399ValAsn: 2.399 ± 0.061	1.517ValPro: 1.517 ± 0.048	1.407ValGln: 1.407 ± 0.054	1.667ValArg: 1.667 ± 0.052	3.652ValSer: 3.652 ± 0.083	1.707ValThr: 1.707 ± 0.056	3.755ValVal: 3.755 ± 0.098	0.392ValTrp: 0.392 ± 0.026	1.954ValTyr: 1.954 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.375TrpAla: 0.375 ± 0.025	0.11TrpCys: 0.11 ± 0.013	0.4TrpAsp: 0.4 ± 0.028	0.558TrpGlu: 0.558 ± 0.028	0.351TrpPhe: 0.351 ± 0.023	0.523TrpGly: 0.523 ± 0.035	0.169TrpHis: 0.169 ± 0.016	0.65TrpIle: 0.65 ± 0.032	0.451TrpLys: 0.451 ± 0.029	0.818TrpLeu: 0.818 ± 0.039	0.161TrpMet: 0.161 ± 0.016	0.426TrpAsn: 0.426 ± 0.03	0.073TrpPro: 0.073 ± 0.011	0.352TrpGln: 0.352 ± 0.025	0.252TrpArg: 0.252 ± 0.021	0.371TrpSer: 0.371 ± 0.024	0.18TrpThr: 0.18 ± 0.019	0.426TrpVal: 0.426 ± 0.026	0.108TrpTrp: 0.108 ± 0.014	0.285TrpTyr: 0.285 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.681TyrAla: 2.681 ± 0.069	0.531TyrCys: 0.531 ± 0.033	1.961TyrAsp: 1.961 ± 0.058	3.169TyrGlu: 3.169 ± 0.067	2.692TyrPhe: 2.692 ± 0.076	2.533TyrGly: 2.533 ± 0.074	0.752TyrHis: 0.752 ± 0.032	2.55TyrIle: 2.55 ± 0.068	3.669TyrLys: 3.669 ± 0.086	4.184TyrLeu: 4.184 ± 0.094	0.689TyrMet: 0.689 ± 0.032	2.101TyrAsn: 2.101 ± 0.062	1.497TyrPro: 1.497 ± 0.052	1.548TyrGln: 1.548 ± 0.055	1.42TyrArg: 1.42 ± 0.049	2.609TyrSer: 2.609 ± 0.067	1.739TyrThr: 1.739 ± 0.056	1.717TyrVal: 1.717 ± 0.052	0.285TyrTrp: 0.285 ± 0.019	1.83TyrTyr: 1.83 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2073 proteins (627387 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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