Amino acid dipepetide frequency for Wenzhou picorna-like virus 17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.566AlaAla: 3.566 ± 0.694
0.792AlaCys: 0.792 ± 0.426
2.773AlaAsp: 2.773 ± 0.837
1.981AlaGlu: 1.981 ± 0.412
3.566AlaPhe: 3.566 ± 0.041
3.566AlaGly: 3.566 ± 1.998
1.189AlaHis: 1.189 ± 0.014
3.962AlaIle: 3.962 ± 1.133
1.585AlaLys: 1.585 ± 0.199
5.151AlaLeu: 5.151 ± 0.157
1.189AlaMet: 1.189 ± 0.251
2.773AlaAsn: 2.773 ± 1.771
1.981AlaPro: 1.981 ± 1.545
2.377AlaGln: 2.377 ± 1.277
1.585AlaArg: 1.585 ± 0.453
5.151AlaSer: 5.151 ± 1.147
1.981AlaThr: 1.981 ± 0.893
3.17AlaVal: 3.17 ± 2.863
1.189AlaTrp: 1.189 ± 0.014
1.981AlaTyr: 1.981 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
1.981CysAla: 1.981 ± 1.064
0.396CysCys: 0.396 ± 0.213
0.396CysAsp: 0.396 ± 0.213
0.396CysGlu: 0.396 ± 0.213
0.0CysPhe: 0.0 ± 0.0
1.189CysGly: 1.189 ± 0.638
0.396CysHis: 0.396 ± 0.213
1.189CysIle: 1.189 ± 0.638
2.377CysLys: 2.377 ± 1.277
0.396CysLeu: 0.396 ± 0.213
0.0CysMet: 0.0 ± 0.0
0.792CysAsn: 0.792 ± 0.879
0.0CysPro: 0.0 ± 0.0
1.189CysGln: 1.189 ± 0.014
0.792CysArg: 0.792 ± 0.227
1.585CysSer: 1.585 ± 0.851
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.396CysTrp: 0.396 ± 0.213
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.585AspAla: 1.585 ± 0.199
0.396AspCys: 0.396 ± 0.213
1.981AspAsp: 1.981 ± 0.412
1.981AspGlu: 1.981 ± 0.412
5.943AspPhe: 5.943 ± 0.583
2.377AspGly: 2.377 ± 0.028
0.396AspHis: 0.396 ± 0.213
4.754AspIle: 4.754 ± 1.249
1.981AspLys: 1.981 ± 0.412
6.339AspLeu: 6.339 ± 0.796
0.396AspMet: 0.396 ± 0.213
3.566AspAsn: 3.566 ± 0.041
3.962AspPro: 3.962 ± 1.785
2.377AspGln: 2.377 ± 0.028
1.981AspArg: 1.981 ± 0.24
2.773AspSer: 2.773 ± 0.185
0.792AspThr: 0.792 ± 0.227
2.773AspVal: 2.773 ± 0.837
0.396AspTrp: 0.396 ± 0.439
3.17AspTyr: 3.17 ± 0.398
0.0AspXaa: 0.0 ± 0.0
Glu
0.396GluAla: 0.396 ± 0.213
0.792GluCys: 0.792 ± 0.426
3.17GluAsp: 3.17 ± 0.254
2.773GluGlu: 2.773 ± 0.467
1.981GluPhe: 1.981 ± 0.893
0.396GluGly: 0.396 ± 0.213
1.189GluHis: 1.189 ± 0.638
1.981GluIle: 1.981 ± 0.24
2.773GluLys: 2.773 ± 0.837
5.151GluLeu: 5.151 ± 0.81
1.981GluMet: 1.981 ± 0.24
3.17GluAsn: 3.17 ± 0.398
3.17GluPro: 3.17 ± 0.254
1.981GluGln: 1.981 ± 0.24
3.17GluArg: 3.17 ± 1.702
2.773GluSer: 2.773 ± 0.837
3.17GluThr: 3.17 ± 1.558
3.962GluVal: 3.962 ± 0.481
0.792GluTrp: 0.792 ± 0.227
2.773GluTyr: 2.773 ± 0.467
0.0GluXaa: 0.0 ± 0.0
Phe
2.773PheAla: 2.773 ± 0.185
2.377PheCys: 2.377 ± 0.624
4.754PheAsp: 4.754 ± 0.055
3.566PheGlu: 3.566 ± 0.041
2.773PhePhe: 2.773 ± 0.837
3.17PheGly: 3.17 ± 0.906
1.981PheHis: 1.981 ± 0.893
3.566PheIle: 3.566 ± 0.041
1.981PheLys: 1.981 ± 1.064
4.754PheLeu: 4.754 ± 1.249
1.585PheMet: 1.585 ± 0.199
1.585PheAsn: 1.585 ± 0.199
2.377PhePro: 2.377 ± 0.68
1.585PheGln: 1.585 ± 0.199
2.773PheArg: 2.773 ± 0.837
7.924PheSer: 7.924 ± 0.343
3.566PheThr: 3.566 ± 0.694
5.547PheVal: 5.547 ± 0.37
0.792PheTrp: 0.792 ± 0.426
2.773PheTyr: 2.773 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
3.566GlyAla: 3.566 ± 0.041
0.0GlyCys: 0.0 ± 0.0
3.962GlyAsp: 3.962 ± 0.171
3.566GlyGlu: 3.566 ± 0.611
1.585GlyPhe: 1.585 ± 0.199
3.962GlyGly: 3.962 ± 1.133
0.792GlyHis: 0.792 ± 0.426
1.981GlyIle: 1.981 ± 0.412
2.773GlyLys: 2.773 ± 0.185
6.735GlyLeu: 6.735 ± 1.009
1.189GlyMet: 1.189 ± 0.014
4.754GlyAsn: 4.754 ± 1.36
1.981GlyPro: 1.981 ± 0.412
0.792GlyGln: 0.792 ± 0.879
0.792GlyArg: 0.792 ± 0.879
4.754GlySer: 4.754 ± 1.36
3.17GlyThr: 3.17 ± 0.254
3.962GlyVal: 3.962 ± 1.476
1.189GlyTrp: 1.189 ± 0.666
2.377GlyTyr: 2.377 ± 1.277
0.0GlyXaa: 0.0 ± 0.0
His
1.585HisAla: 1.585 ± 0.453
0.0HisCys: 0.0 ± 0.0
0.792HisAsp: 0.792 ± 0.227
0.396HisGlu: 0.396 ± 0.213
3.17HisPhe: 3.17 ± 1.05
1.189HisGly: 1.189 ± 0.638
0.792HisHis: 0.792 ± 0.227
1.585HisIle: 1.585 ± 0.851
1.189HisLys: 1.189 ± 0.638
1.189HisLeu: 1.189 ± 0.014
0.396HisMet: 0.396 ± 0.439
0.396HisAsn: 0.396 ± 0.213
0.396HisPro: 0.396 ± 0.439
0.396HisGln: 0.396 ± 0.213
1.189HisArg: 1.189 ± 0.638
1.585HisSer: 1.585 ± 0.199
0.792HisThr: 0.792 ± 0.426
1.189HisVal: 1.189 ± 0.014
0.0HisTrp: 0.0 ± 0.0
1.189HisTyr: 1.189 ± 0.638
0.0HisXaa: 0.0 ± 0.0
Ile
3.566IleAla: 3.566 ± 0.694
0.0IleCys: 0.0 ± 0.0
3.17IleAsp: 3.17 ± 0.254
3.962IleGlu: 3.962 ± 1.476
3.962IlePhe: 3.962 ± 0.823
6.339IleGly: 6.339 ± 1.448
1.981IleHis: 1.981 ± 0.412
5.943IleIle: 5.943 ± 1.235
3.17IleLys: 3.17 ± 0.398
7.924IleLeu: 7.924 ± 2.951
0.792IleMet: 0.792 ± 0.227
4.358IleAsn: 4.358 ± 1.688
2.377IlePro: 2.377 ± 0.624
0.792IleGln: 0.792 ± 0.227
3.17IleArg: 3.17 ± 0.906
11.49IleSer: 11.49 ± 1.655
3.566IleThr: 3.566 ± 1.346
1.981IleVal: 1.981 ± 1.064
0.792IleTrp: 0.792 ± 0.227
3.17IleTyr: 3.17 ± 0.398
0.0IleXaa: 0.0 ± 0.0
Lys
2.773LysAla: 2.773 ± 0.185
0.396LysCys: 0.396 ± 0.213
1.981LysAsp: 1.981 ± 0.412
1.585LysGlu: 1.585 ± 0.199
2.773LysPhe: 2.773 ± 0.467
2.377LysGly: 2.377 ± 1.277
2.377LysHis: 2.377 ± 1.277
2.773LysIle: 2.773 ± 0.467
1.981LysLys: 1.981 ± 1.064
3.17LysLeu: 3.17 ± 0.906
1.189LysMet: 1.189 ± 0.014
4.358LysAsn: 4.358 ± 1.688
2.773LysPro: 2.773 ± 1.119
1.981LysGln: 1.981 ± 0.412
3.566LysArg: 3.566 ± 1.263
5.547LysSer: 5.547 ± 1.674
1.981LysThr: 1.981 ± 0.24
1.585LysVal: 1.585 ± 0.199
1.585LysTrp: 1.585 ± 0.851
2.773LysTyr: 2.773 ± 0.185
0.0LysXaa: 0.0 ± 0.0
Leu
4.754LeuAla: 4.754 ± 0.055
1.189LeuCys: 1.189 ± 0.014
3.17LeuAsp: 3.17 ± 1.05
5.547LeuGlu: 5.547 ± 1.022
5.943LeuPhe: 5.943 ± 3.191
4.754LeuGly: 4.754 ± 0.597
0.396LeuHis: 0.396 ± 0.213
8.716LeuIle: 8.716 ± 0.768
4.358LeuLys: 4.358 ± 1.688
11.886LeuLeu: 11.886 ± 0.514
2.773LeuMet: 2.773 ± 1.489
3.566LeuAsn: 3.566 ± 1.998
2.773LeuPro: 2.773 ± 0.837
1.585LeuGln: 1.585 ± 0.199
5.943LeuArg: 5.943 ± 1.887
8.716LeuSer: 8.716 ± 2.492
12.282LeuThr: 12.282 ± 1.882
5.943LeuVal: 5.943 ± 2.025
1.189LeuTrp: 1.189 ± 0.014
3.962LeuTyr: 3.962 ± 1.476
0.0LeuXaa: 0.0 ± 0.0
Met
1.981MetAla: 1.981 ± 0.24
0.792MetCys: 0.792 ± 0.426
1.981MetAsp: 1.981 ± 1.064
0.792MetGlu: 0.792 ± 0.426
0.396MetPhe: 0.396 ± 0.213
1.585MetGly: 1.585 ± 0.199
1.189MetHis: 1.189 ± 0.014
2.377MetIle: 2.377 ± 0.028
1.585MetLys: 1.585 ± 0.453
1.189MetLeu: 1.189 ± 0.014
0.792MetMet: 0.792 ± 0.227
0.792MetAsn: 0.792 ± 0.426
1.189MetPro: 1.189 ± 0.666
0.792MetGln: 0.792 ± 0.879
0.396MetArg: 0.396 ± 0.213
1.981MetSer: 1.981 ± 0.893
0.792MetThr: 0.792 ± 0.227
0.792MetVal: 0.792 ± 0.227
0.0MetTrp: 0.0 ± 0.0
2.377MetTyr: 2.377 ± 0.624
0.0MetXaa: 0.0 ± 0.0
Asn
1.585AsnAla: 1.585 ± 1.105
1.189AsnCys: 1.189 ± 0.638
2.773AsnAsp: 2.773 ± 0.467
3.566AsnGlu: 3.566 ± 1.998
3.962AsnPhe: 3.962 ± 0.823
3.17AsnGly: 3.17 ± 0.906
0.0AsnHis: 0.0 ± 0.0
4.358AsnIle: 4.358 ± 0.268
3.17AsnLys: 3.17 ± 0.906
5.151AsnLeu: 5.151 ± 0.495
1.189AsnMet: 1.189 ± 0.014
5.943AsnAsn: 5.943 ± 0.721
3.566AsnPro: 3.566 ± 0.611
1.585AsnGln: 1.585 ± 0.453
1.189AsnArg: 1.189 ± 0.638
5.547AsnSer: 5.547 ± 2.238
5.151AsnThr: 5.151 ± 2.451
3.17AsnVal: 3.17 ± 0.254
0.792AsnTrp: 0.792 ± 0.426
2.377AsnTyr: 2.377 ± 0.624
0.0AsnXaa: 0.0 ± 0.0
Pro
3.17ProAla: 3.17 ± 1.558
0.0ProCys: 0.0 ± 0.0
1.189ProAsp: 1.189 ± 0.014
1.585ProGlu: 1.585 ± 0.199
3.566ProPhe: 3.566 ± 1.346
2.377ProGly: 2.377 ± 0.028
0.396ProHis: 0.396 ± 0.213
2.377ProIle: 2.377 ± 0.68
1.981ProLys: 1.981 ± 0.412
6.339ProLeu: 6.339 ± 0.508
1.585ProMet: 1.585 ± 0.453
4.358ProAsn: 4.358 ± 1.572
1.981ProPro: 1.981 ± 0.412
0.792ProGln: 0.792 ± 0.426
1.189ProArg: 1.189 ± 0.014
3.962ProSer: 3.962 ± 1.133
1.189ProThr: 1.189 ± 0.014
3.17ProVal: 3.17 ± 1.558
1.585ProTrp: 1.585 ± 1.105
3.17ProTyr: 3.17 ± 1.558
0.0ProXaa: 0.0 ± 0.0
Gln
1.981GlnAla: 1.981 ± 1.064
1.189GlnCys: 1.189 ± 0.638
0.396GlnAsp: 0.396 ± 0.213
2.377GlnGlu: 2.377 ± 0.68
1.189GlnPhe: 1.189 ± 0.014
1.189GlnGly: 1.189 ± 0.014
0.396GlnHis: 0.396 ± 0.213
1.585GlnIle: 1.585 ± 0.851
1.189GlnLys: 1.189 ± 0.666
1.981GlnLeu: 1.981 ± 0.24
0.792GlnMet: 0.792 ± 0.227
2.377GlnAsn: 2.377 ± 0.624
1.981GlnPro: 1.981 ± 0.24
0.0GlnGln: 0.0 ± 0.0
0.792GlnArg: 0.792 ± 0.426
1.981GlnSer: 1.981 ± 0.24
1.981GlnThr: 1.981 ± 0.24
1.585GlnVal: 1.585 ± 0.851
0.396GlnTrp: 0.396 ± 0.213
2.377GlnTyr: 2.377 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
0.792ArgAla: 0.792 ± 0.227
0.0ArgCys: 0.0 ± 0.0
3.962ArgAsp: 3.962 ± 0.823
0.792ArgGlu: 0.792 ± 0.426
1.585ArgPhe: 1.585 ± 0.199
1.981ArgGly: 1.981 ± 0.24
0.0ArgHis: 0.0 ± 0.0
3.962ArgIle: 3.962 ± 0.823
1.189ArgLys: 1.189 ± 0.638
5.547ArgLeu: 5.547 ± 0.37
0.792ArgMet: 0.792 ± 0.227
1.585ArgAsn: 1.585 ± 0.199
3.566ArgPro: 3.566 ± 0.041
1.189ArgGln: 1.189 ± 0.638
1.981ArgArg: 1.981 ± 0.412
3.566ArgSer: 3.566 ± 0.611
1.189ArgThr: 1.189 ± 0.014
5.151ArgVal: 5.151 ± 0.157
0.792ArgTrp: 0.792 ± 0.227
3.17ArgTyr: 3.17 ± 0.398
0.0ArgXaa: 0.0 ± 0.0
Ser
5.943SerAla: 5.943 ± 1.373
0.792SerCys: 0.792 ± 0.426
4.754SerAsp: 4.754 ± 0.597
5.547SerGlu: 5.547 ± 0.934
5.151SerPhe: 5.151 ± 0.495
3.17SerGly: 3.17 ± 0.254
1.189SerHis: 1.189 ± 0.638
6.735SerIle: 6.735 ± 0.356
5.547SerLys: 5.547 ± 0.282
10.301SerLeu: 10.301 ± 0.337
1.189SerMet: 1.189 ± 0.168
5.943SerAsn: 5.943 ± 3.982
2.773SerPro: 2.773 ± 0.467
2.773SerGln: 2.773 ± 0.467
3.962SerArg: 3.962 ± 0.171
5.151SerSer: 5.151 ± 0.157
5.151SerThr: 5.151 ± 0.157
6.339SerVal: 6.339 ± 0.508
2.773SerTrp: 2.773 ± 0.837
4.358SerTyr: 4.358 ± 0.92
0.0SerXaa: 0.0 ± 0.0
Thr
1.189ThrAla: 1.189 ± 0.014
0.792ThrCys: 0.792 ± 0.426
2.773ThrAsp: 2.773 ± 2.423
2.377ThrGlu: 2.377 ± 1.332
4.358ThrPhe: 4.358 ± 0.92
3.17ThrGly: 3.17 ± 0.254
1.189ThrHis: 1.189 ± 0.014
6.735ThrIle: 6.735 ± 1.661
1.585ThrLys: 1.585 ± 0.453
5.151ThrLeu: 5.151 ± 1.147
2.377ThrMet: 2.377 ± 0.028
2.377ThrAsn: 2.377 ± 0.028
2.773ThrPro: 2.773 ± 1.771
3.17ThrGln: 3.17 ± 1.05
2.773ThrArg: 2.773 ± 1.119
4.754ThrSer: 4.754 ± 2.012
3.566ThrThr: 3.566 ± 1.998
4.358ThrVal: 4.358 ± 0.268
1.189ThrTrp: 1.189 ± 0.014
2.377ThrTyr: 2.377 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
5.547ValAla: 5.547 ± 3.542
1.189ValCys: 1.189 ± 0.014
2.773ValAsp: 2.773 ± 0.837
1.585ValGlu: 1.585 ± 0.199
3.566ValPhe: 3.566 ± 1.346
4.754ValGly: 4.754 ± 0.055
1.585ValHis: 1.585 ± 0.199
2.377ValIle: 2.377 ± 1.332
2.377ValLys: 2.377 ± 0.624
3.962ValLeu: 3.962 ± 1.476
1.189ValMet: 1.189 ± 0.638
3.962ValAsn: 3.962 ± 1.133
3.566ValPro: 3.566 ± 1.998
1.189ValGln: 1.189 ± 0.638
2.773ValArg: 2.773 ± 0.185
5.943ValSer: 5.943 ± 0.583
4.754ValThr: 4.754 ± 0.055
5.547ValVal: 5.547 ± 1.586
0.396ValTrp: 0.396 ± 0.213
4.358ValTyr: 4.358 ± 1.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.396TrpAla: 0.396 ± 0.439
0.396TrpCys: 0.396 ± 0.213
1.189TrpAsp: 1.189 ± 0.638
0.396TrpGlu: 0.396 ± 0.213
0.792TrpPhe: 0.792 ± 0.227
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.585TrpIle: 1.585 ± 0.851
2.377TrpLys: 2.377 ± 0.624
2.773TrpLeu: 2.773 ± 0.467
0.396TrpMet: 0.396 ± 0.439
0.396TrpAsn: 0.396 ± 0.213
0.0TrpPro: 0.0 ± 0.0
0.396TrpGln: 0.396 ± 0.213
1.189TrpArg: 1.189 ± 0.666
2.377TrpSer: 2.377 ± 0.028
0.792TrpThr: 0.792 ± 0.227
0.396TrpVal: 0.396 ± 0.213
0.0TrpTrp: 0.0 ± 0.0
1.189TrpTyr: 1.189 ± 0.666
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.377TyrAla: 2.377 ± 1.332
0.792TyrCys: 0.792 ± 0.227
1.981TyrAsp: 1.981 ± 0.24
2.773TyrGlu: 2.773 ± 0.185
5.943TyrPhe: 5.943 ± 1.235
3.17TyrGly: 3.17 ± 0.398
1.981TyrHis: 1.981 ± 0.412
3.962TyrIle: 3.962 ± 1.476
4.358TyrLys: 4.358 ± 0.384
4.358TyrLeu: 4.358 ± 1.036
1.585TyrMet: 1.585 ± 0.453
2.377TyrAsn: 2.377 ± 0.68
2.773TyrPro: 2.773 ± 1.771
0.792TyrGln: 0.792 ± 0.426
1.585TyrArg: 1.585 ± 0.851
2.377TyrSer: 2.377 ± 1.277
3.17TyrThr: 3.17 ± 1.05
2.773TyrVal: 2.773 ± 0.185
0.792TyrTrp: 0.792 ± 0.227
1.981TyrTyr: 1.981 ± 1.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski