Amino acid dipepetide frequency for Variovorax sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.483AlaAla: 18.483 ± 0.157	1.289AlaCys: 1.289 ± 0.038	6.607AlaAsp: 6.607 ± 0.082	6.726AlaGlu: 6.726 ± 0.097	4.415AlaPhe: 4.415 ± 0.067	11.16AlaGly: 11.16 ± 0.122	2.77AlaHis: 2.77 ± 0.055	5.562AlaIle: 5.562 ± 0.074	3.896AlaLys: 3.896 ± 0.068	15.085AlaLeu: 15.085 ± 0.136	3.678AlaMet: 3.678 ± 0.063	2.911AlaAsn: 2.911 ± 0.059	6.556AlaPro: 6.556 ± 0.086	5.406AlaGln: 5.406 ± 0.068	9.225AlaArg: 9.225 ± 0.107	6.693AlaSer: 6.693 ± 0.069	6.318AlaThr: 6.318 ± 0.078	9.523AlaVal: 9.523 ± 0.092	1.917AlaTrp: 1.917 ± 0.044	2.48AlaTyr: 2.48 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.134CysAla: 1.134 ± 0.034	0.116CysCys: 0.116 ± 0.01	0.522CysAsp: 0.522 ± 0.02	0.54CysGlu: 0.54 ± 0.021	0.296CysPhe: 0.296 ± 0.014	1.037CysGly: 1.037 ± 0.031	0.26CysHis: 0.26 ± 0.017	0.448CysIle: 0.448 ± 0.019	0.218CysLys: 0.218 ± 0.014	0.773CysLeu: 0.773 ± 0.023	0.223CysMet: 0.223 ± 0.014	0.265CysAsn: 0.265 ± 0.016	0.448CysPro: 0.448 ± 0.02	0.239CysGln: 0.239 ± 0.013	0.549CysArg: 0.549 ± 0.022	0.516CysSer: 0.516 ± 0.02	0.541CysThr: 0.541 ± 0.03	0.739CysVal: 0.739 ± 0.025	0.131CysTrp: 0.131 ± 0.011	0.169CysTyr: 0.169 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.617AspAla: 7.617 ± 0.113	0.457AspCys: 0.457 ± 0.02	2.736AspAsp: 2.736 ± 0.055	3.111AspGlu: 3.111 ± 0.054	2.1AspPhe: 2.1 ± 0.047	4.634AspGly: 4.634 ± 0.065	1.129AspHis: 1.129 ± 0.035	2.404AspIle: 2.404 ± 0.051	1.746AspLys: 1.746 ± 0.039	5.196AspLeu: 5.196 ± 0.076	1.303AspMet: 1.303 ± 0.027	1.275AspAsn: 1.275 ± 0.035	2.842AspPro: 2.842 ± 0.049	1.431AspGln: 1.431 ± 0.035	3.394AspArg: 3.394 ± 0.057	2.107AspSer: 2.107 ± 0.04	2.607AspThr: 2.607 ± 0.04	4.167AspVal: 4.167 ± 0.064	0.928AspTrp: 0.928 ± 0.032	1.396AspTyr: 1.396 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.936GluAla: 6.936 ± 0.086	0.396GluCys: 0.396 ± 0.018	2.142GluAsp: 2.142 ± 0.043	2.434GluGlu: 2.434 ± 0.049	1.8GluPhe: 1.8 ± 0.04	3.945GluGly: 3.945 ± 0.065	1.214GluHis: 1.214 ± 0.03	2.663GluIle: 2.663 ± 0.043	1.885GluLys: 1.885 ± 0.041	5.554GluLeu: 5.554 ± 0.072	1.311GluMet: 1.311 ± 0.03	1.196GluAsn: 1.196 ± 0.033	2.554GluPro: 2.554 ± 0.047	2.254GluGln: 2.254 ± 0.046	4.58GluArg: 4.58 ± 0.073	2.493GluSer: 2.493 ± 0.045	2.575GluThr: 2.575 ± 0.046	4.094GluVal: 4.094 ± 0.063	0.789GluTrp: 0.789 ± 0.029	1.016GluTyr: 1.016 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.531PheAla: 4.531 ± 0.066	0.422PheCys: 0.422 ± 0.017	2.686PheAsp: 2.686 ± 0.052	2.163PheGlu: 2.163 ± 0.039	1.44PhePhe: 1.44 ± 0.042	3.729PheGly: 3.729 ± 0.057	0.791PheHis: 0.791 ± 0.026	1.592PheIle: 1.592 ± 0.041	1.196PheLys: 1.196 ± 0.036	2.95PheLeu: 2.95 ± 0.055	0.862PheMet: 0.862 ± 0.028	1.129PheAsn: 1.129 ± 0.032	1.59PhePro: 1.59 ± 0.035	1.027PheGln: 1.027 ± 0.027	1.975PheArg: 1.975 ± 0.042	2.104PheSer: 2.104 ± 0.046	1.986PheThr: 1.986 ± 0.042	2.955PheVal: 2.955 ± 0.054	0.58PheTrp: 0.58 ± 0.022	0.852PheTyr: 0.852 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.015GlyAla: 10.015 ± 0.107	0.962GlyCys: 0.962 ± 0.034	4.138GlyAsp: 4.138 ± 0.058	4.429GlyGlu: 4.429 ± 0.065	3.501GlyPhe: 3.501 ± 0.055	7.379GlyGly: 7.379 ± 0.115	1.917GlyHis: 1.917 ± 0.042	4.252GlyIle: 4.252 ± 0.066	3.418GlyLys: 3.418 ± 0.06	8.922GlyLeu: 8.922 ± 0.094	2.444GlyMet: 2.444 ± 0.046	2.226GlyAsn: 2.226 ± 0.049	3.273GlyPro: 3.273 ± 0.062	3.131GlyGln: 3.131 ± 0.052	5.508GlyArg: 5.508 ± 0.067	4.585GlySer: 4.585 ± 0.067	4.7GlyThr: 4.7 ± 0.08	6.74GlyVal: 6.74 ± 0.078	1.491GlyTrp: 1.491 ± 0.036	2.351GlyTyr: 2.351 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.908HisAla: 2.908 ± 0.054	0.286HisCys: 0.286 ± 0.016	1.222HisAsp: 1.222 ± 0.038	1.134HisGlu: 1.134 ± 0.033	0.888HisPhe: 0.888 ± 0.028	2.212HisGly: 2.212 ± 0.042	0.619HisHis: 0.619 ± 0.025	0.949HisIle: 0.949 ± 0.027	0.603HisLys: 0.603 ± 0.026	2.096HisLeu: 2.096 ± 0.045	0.505HisMet: 0.505 ± 0.018	0.524HisAsn: 0.524 ± 0.022	1.446HisPro: 1.446 ± 0.039	0.611HisGln: 0.611 ± 0.026	1.529HisArg: 1.529 ± 0.043	0.991HisSer: 0.991 ± 0.033	1.095HisThr: 1.095 ± 0.029	1.603HisVal: 1.603 ± 0.035	0.411HisTrp: 0.411 ± 0.02	0.628HisTyr: 0.628 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.697IleAla: 6.697 ± 0.078	0.413IleCys: 0.413 ± 0.018	3.233IleAsp: 3.233 ± 0.057	3.085IleGlu: 3.085 ± 0.051	1.329IlePhe: 1.329 ± 0.036	4.645IleGly: 4.645 ± 0.067	0.876IleHis: 0.876 ± 0.028	1.443IleIle: 1.443 ± 0.042	1.465IleLys: 1.465 ± 0.039	3.165IleLeu: 3.165 ± 0.061	0.796IleMet: 0.796 ± 0.026	1.339IleAsn: 1.339 ± 0.03	2.111IlePro: 2.111 ± 0.046	1.175IleGln: 1.175 ± 0.035	2.471IleArg: 2.471 ± 0.05	2.269IleSer: 2.269 ± 0.045	2.496IleThr: 2.496 ± 0.044	3.837IleVal: 3.837 ± 0.077	0.513IleTrp: 0.513 ± 0.024	0.994IleTyr: 0.994 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.124LysAla: 4.124 ± 0.077	0.134LysCys: 0.134 ± 0.01	1.678LysAsp: 1.678 ± 0.043	1.51LysGlu: 1.51 ± 0.035	0.983LysPhe: 0.983 ± 0.029	2.605LysGly: 2.605 ± 0.051	0.664LysHis: 0.664 ± 0.022	1.509LysIle: 1.509 ± 0.034	1.486LysLys: 1.486 ± 0.051	3.81LysLeu: 3.81 ± 0.06	0.834LysMet: 0.834 ± 0.027	0.917LysAsn: 0.917 ± 0.03	2.178LysPro: 2.178 ± 0.047	1.173LysGln: 1.173 ± 0.03	2.195LysArg: 2.195 ± 0.046	1.751LysSer: 1.751 ± 0.043	2.042LysThr: 2.042 ± 0.047	2.673LysVal: 2.673 ± 0.057	0.365LysTrp: 0.365 ± 0.018	0.684LysTyr: 0.684 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.507LeuAla: 14.507 ± 0.14	0.953LeuCys: 0.953 ± 0.03	5.695LeuAsp: 5.695 ± 0.078	4.979LeuGlu: 4.979 ± 0.063	3.56LeuPhe: 3.56 ± 0.069	8.749LeuGly: 8.749 ± 0.091	2.357LeuHis: 2.357 ± 0.05	4.355LeuIle: 4.355 ± 0.075	3.594LeuLys: 3.594 ± 0.062	10.947LeuLeu: 10.947 ± 0.137	2.626LeuMet: 2.626 ± 0.051	2.655LeuAsn: 2.655 ± 0.049	5.989LeuPro: 5.989 ± 0.072	4.08LeuGln: 4.08 ± 0.061	7.451LeuArg: 7.451 ± 0.087	5.739LeuSer: 5.739 ± 0.069	5.287LeuThr: 5.287 ± 0.075	7.989LeuVal: 7.989 ± 0.101	1.371LeuTrp: 1.371 ± 0.035	1.992LeuTyr: 1.992 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.21MetAla: 3.21 ± 0.055	0.195MetCys: 0.195 ± 0.013	1.11MetAsp: 1.11 ± 0.031	1.059MetGlu: 1.059 ± 0.028	0.816MetPhe: 0.816 ± 0.026	1.928MetGly: 1.928 ± 0.047	0.578MetHis: 0.578 ± 0.022	1.002MetIle: 1.002 ± 0.034	1.137MetLys: 1.137 ± 0.034	2.778MetLeu: 2.778 ± 0.055	0.61MetMet: 0.61 ± 0.025	0.898MetAsn: 0.898 ± 0.027	1.623MetPro: 1.623 ± 0.034	1.096MetGln: 1.096 ± 0.029	1.813MetArg: 1.813 ± 0.039	1.608MetSer: 1.608 ± 0.037	1.652MetThr: 1.652 ± 0.039	1.891MetVal: 1.891 ± 0.041	0.238MetTrp: 0.238 ± 0.014	0.388MetTyr: 0.388 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.428AsnAla: 3.428 ± 0.049	0.267AsnCys: 0.267 ± 0.015	1.321AsnAsp: 1.321 ± 0.029	1.205AsnGlu: 1.205 ± 0.032	1.017AsnPhe: 1.017 ± 0.031	2.208AsnGly: 2.208 ± 0.043	0.53AsnHis: 0.53 ± 0.023	1.206AsnIle: 1.206 ± 0.03	0.817AsnLys: 0.817 ± 0.03	2.566AsnLeu: 2.566 ± 0.046	0.605AsnMet: 0.605 ± 0.021	0.754AsnAsn: 0.754 ± 0.029	1.829AsnPro: 1.829 ± 0.04	0.792AsnGln: 0.792 ± 0.024	1.568AsnArg: 1.568 ± 0.037	1.165AsnSer: 1.165 ± 0.029	1.386AsnThr: 1.386 ± 0.036	2.047AsnVal: 2.047 ± 0.043	0.413AsnTrp: 0.413 ± 0.018	0.674AsnTyr: 0.674 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.265ProAla: 7.265 ± 0.091	0.339ProCys: 0.339 ± 0.016	3.177ProAsp: 3.177 ± 0.051	3.301ProGlu: 3.301 ± 0.054	1.935ProPhe: 1.935 ± 0.04	4.758ProGly: 4.758 ± 0.062	1.158ProHis: 1.158 ± 0.029	2.003ProIle: 2.003 ± 0.042	1.624ProLys: 1.624 ± 0.041	5.282ProLeu: 5.282 ± 0.059	1.416ProMet: 1.416 ± 0.032	1.39ProAsn: 1.39 ± 0.037	2.883ProPro: 2.883 ± 0.069	1.895ProGln: 1.895 ± 0.044	3.058ProArg: 3.058 ± 0.065	2.667ProSer: 2.667 ± 0.048	2.695ProThr: 2.695 ± 0.047	4.465ProVal: 4.465 ± 0.065	0.816ProTrp: 0.816 ± 0.025	1.177ProTyr: 1.177 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.781GlnAla: 4.781 ± 0.068	0.31GlnCys: 0.31 ± 0.016	1.444GlnAsp: 1.444 ± 0.03	1.372GlnGlu: 1.372 ± 0.039	1.206GlnPhe: 1.206 ± 0.026	2.732GlnGly: 2.732 ± 0.05	0.926GlnHis: 0.926 ± 0.025	1.66GlnIle: 1.66 ± 0.039	1.192GlnLys: 1.192 ± 0.031	4.012GlnLeu: 4.012 ± 0.058	0.926GlnMet: 0.926 ± 0.027	0.818GlnAsn: 0.818 ± 0.025	2.203GlnPro: 2.203 ± 0.045	1.778GlnGln: 1.778 ± 0.041	3.262GlnArg: 3.262 ± 0.057	1.845GlnSer: 1.845 ± 0.042	1.845GlnThr: 1.845 ± 0.042	2.745GlnVal: 2.745 ± 0.052	0.641GlnTrp: 0.641 ± 0.026	0.726GlnTyr: 0.726 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.123ArgAla: 8.123 ± 0.107	0.606ArgCys: 0.606 ± 0.024	3.7ArgAsp: 3.7 ± 0.059	4.185ArgGlu: 4.185 ± 0.06	2.891ArgPhe: 2.891 ± 0.056	4.852ArgGly: 4.852 ± 0.065	1.707ArgHis: 1.707 ± 0.044	3.495ArgIle: 3.495 ± 0.054	2.211ArgLys: 2.211 ± 0.045	7.248ArgLeu: 7.248 ± 0.093	1.969ArgMet: 1.969 ± 0.043	1.85ArgAsn: 1.85 ± 0.04	3.187ArgPro: 3.187 ± 0.053	2.525ArgGln: 2.525 ± 0.049	4.975ArgArg: 4.975 ± 0.077	3.406ArgSer: 3.406 ± 0.064	3.411ArgThr: 3.411 ± 0.049	5.162ArgVal: 5.162 ± 0.069	1.193ArgTrp: 1.193 ± 0.036	1.826ArgTyr: 1.826 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.426SerAla: 6.426 ± 0.078	0.441SerCys: 0.441 ± 0.027	2.569SerAsp: 2.569 ± 0.045	2.359SerGlu: 2.359 ± 0.042	2.141SerPhe: 2.141 ± 0.038	5.078SerGly: 5.078 ± 0.076	1.147SerHis: 1.147 ± 0.033	2.332SerIle: 2.332 ± 0.048	1.588SerLys: 1.588 ± 0.033	5.112SerLeu: 5.112 ± 0.075	1.349SerMet: 1.349 ± 0.032	1.354SerAsn: 1.354 ± 0.034	2.836SerPro: 2.836 ± 0.044	1.703SerGln: 1.703 ± 0.035	3.362SerArg: 3.362 ± 0.055	2.861SerSer: 2.861 ± 0.049	2.897SerThr: 2.897 ± 0.053	3.924SerVal: 3.924 ± 0.055	0.672SerTrp: 0.672 ± 0.024	1.262SerTyr: 1.262 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.332ThrAla: 6.332 ± 0.083	0.418ThrCys: 0.418 ± 0.023	2.527ThrAsp: 2.527 ± 0.048	2.395ThrGlu: 2.395 ± 0.05	1.803ThrPhe: 1.803 ± 0.038	4.798ThrGly: 4.798 ± 0.068	1.175ThrHis: 1.175 ± 0.034	2.28ThrIle: 2.28 ± 0.057	1.322ThrLys: 1.322 ± 0.033	6.493ThrLeu: 6.493 ± 0.087	1.196ThrMet: 1.196 ± 0.035	1.165ThrAsn: 1.165 ± 0.033	3.617ThrPro: 3.617 ± 0.055	1.846ThrGln: 1.846 ± 0.04	3.435ThrArg: 3.435 ± 0.064	2.693ThrSer: 2.693 ± 0.057	2.866ThrThr: 2.866 ± 0.07	4.486ThrVal: 4.486 ± 0.061	0.737ThrTrp: 0.737 ± 0.026	1.05ThrTyr: 1.05 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.093ValAla: 10.093 ± 0.109	0.723ValCys: 0.723 ± 0.026	4.251ValAsp: 4.251 ± 0.061	4.161ValGlu: 4.161 ± 0.067	2.904ValPhe: 2.904 ± 0.053	5.87ValGly: 5.87 ± 0.084	1.618ValHis: 1.618 ± 0.041	3.671ValIle: 3.671 ± 0.058	2.667ValLys: 2.667 ± 0.053	8.44ValLeu: 8.44 ± 0.09	2.097ValMet: 2.097 ± 0.044	2.058ValAsn: 2.058 ± 0.044	4.249ValPro: 4.249 ± 0.06	2.785ValGln: 2.785 ± 0.056	5.294ValArg: 5.294 ± 0.077	3.994ValSer: 3.994 ± 0.061	4.285ValThr: 4.285 ± 0.065	6.536ValVal: 6.536 ± 0.084	1.003ValTrp: 1.003 ± 0.026	1.549ValTyr: 1.549 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.415TrpAla: 1.415 ± 0.033	0.179TrpCys: 0.179 ± 0.013	0.613TrpAsp: 0.613 ± 0.023	0.513TrpGlu: 0.513 ± 0.019	0.601TrpPhe: 0.601 ± 0.025	1.026TrpGly: 1.026 ± 0.032	0.396TrpHis: 0.396 ± 0.019	0.717TrpIle: 0.717 ± 0.027	0.503TrpLys: 0.503 ± 0.019	2.102TrpLeu: 2.102 ± 0.048	0.436TrpMet: 0.436 ± 0.022	0.442TrpAsn: 0.442 ± 0.019	0.767TrpPro: 0.767 ± 0.028	0.729TrpGln: 0.729 ± 0.027	1.267TrpArg: 1.267 ± 0.036	0.794TrpSer: 0.794 ± 0.03	0.736TrpThr: 0.736 ± 0.028	1.027TrpVal: 1.027 ± 0.029	0.278TrpTrp: 0.278 ± 0.019	0.326TrpTyr: 0.326 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.677TyrAla: 2.677 ± 0.047	0.258TyrCys: 0.258 ± 0.015	1.211TyrAsp: 1.211 ± 0.032	1.168TyrGlu: 1.168 ± 0.03	0.935TyrPhe: 0.935 ± 0.03	2.041TyrGly: 2.041 ± 0.046	0.429TyrHis: 0.429 ± 0.018	0.814TyrIle: 0.814 ± 0.022	0.747TyrLys: 0.747 ± 0.025	2.346TyrLeu: 2.346 ± 0.045	0.443TyrMet: 0.443 ± 0.021	0.627TyrAsn: 0.627 ± 0.024	1.124TyrPro: 1.124 ± 0.035	0.745TyrGln: 0.745 ± 0.027	1.609TyrArg: 1.609 ± 0.033	1.133TyrSer: 1.133 ± 0.037	1.212TyrThr: 1.212 ± 0.033	1.643TyrVal: 1.643 ± 0.036	0.379TyrTrp: 0.379 ± 0.02	0.595TyrTyr: 0.595 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4285 proteins (1217634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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