Amino acid dipepetide frequency for Rhodoferax fermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.071AlaAla: 15.071 ± 0.154
1.332AlaCys: 1.332 ± 0.035
5.937AlaAsp: 5.937 ± 0.066
5.8AlaGlu: 5.8 ± 0.069
3.938AlaPhe: 3.938 ± 0.062
8.674AlaGly: 8.674 ± 0.101
2.552AlaHis: 2.552 ± 0.042
5.122AlaIle: 5.122 ± 0.064
4.657AlaLys: 4.657 ± 0.083
14.604AlaLeu: 14.604 ± 0.118
3.41AlaMet: 3.41 ± 0.053
3.298AlaAsn: 3.298 ± 0.054
5.172AlaPro: 5.172 ± 0.069
6.592AlaGln: 6.592 ± 0.089
7.142AlaArg: 7.142 ± 0.092
6.965AlaSer: 6.965 ± 0.095
5.945AlaThr: 5.945 ± 0.07
8.485AlaVal: 8.485 ± 0.078
1.784AlaTrp: 1.784 ± 0.039
2.565AlaTyr: 2.565 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.137CysAla: 1.137 ± 0.027
0.139CysCys: 0.139 ± 0.011
0.559CysAsp: 0.559 ± 0.02
0.54CysGlu: 0.54 ± 0.021
0.346CysPhe: 0.346 ± 0.016
0.972CysGly: 0.972 ± 0.034
0.292CysHis: 0.292 ± 0.015
0.438CysIle: 0.438 ± 0.018
0.307CysLys: 0.307 ± 0.016
0.968CysLeu: 0.968 ± 0.031
0.205CysMet: 0.205 ± 0.014
0.291CysAsn: 0.291 ± 0.013
0.571CysPro: 0.571 ± 0.027
0.431CysGln: 0.431 ± 0.018
0.515CysArg: 0.515 ± 0.02
0.544CysSer: 0.544 ± 0.021
0.473CysThr: 0.473 ± 0.017
0.789CysVal: 0.789 ± 0.026
0.151CysTrp: 0.151 ± 0.01
0.236CysTyr: 0.236 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.248AspAla: 6.248 ± 0.071
0.486AspCys: 0.486 ± 0.021
2.642AspAsp: 2.642 ± 0.052
3.029AspGlu: 3.029 ± 0.053
2.133AspPhe: 2.133 ± 0.042
4.027AspGly: 4.027 ± 0.061
1.175AspHis: 1.175 ± 0.034
2.731AspIle: 2.731 ± 0.045
2.157AspLys: 2.157 ± 0.044
5.57AspLeu: 5.57 ± 0.077
1.301AspMet: 1.301 ± 0.033
1.459AspAsn: 1.459 ± 0.029
2.603AspPro: 2.603 ± 0.047
2.031AspGln: 2.031 ± 0.04
2.733AspArg: 2.733 ± 0.047
2.5AspSer: 2.5 ± 0.048
2.745AspThr: 2.745 ± 0.05
3.936AspVal: 3.936 ± 0.064
0.954AspTrp: 0.954 ± 0.028
1.434AspTyr: 1.434 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
6.103GluAla: 6.103 ± 0.081
0.389GluCys: 0.389 ± 0.019
2.193GluAsp: 2.193 ± 0.047
2.31GluGlu: 2.31 ± 0.045
1.81GluPhe: 1.81 ± 0.038
3.173GluGly: 3.173 ± 0.052
1.292GluHis: 1.292 ± 0.035
2.632GluIle: 2.632 ± 0.048
1.952GluLys: 1.952 ± 0.044
6.067GluLeu: 6.067 ± 0.069
1.299GluMet: 1.299 ± 0.03
1.361GluAsn: 1.361 ± 0.036
2.388GluPro: 2.388 ± 0.047
2.721GluGln: 2.721 ± 0.048
3.784GluArg: 3.784 ± 0.053
2.634GluSer: 2.634 ± 0.051
2.462GluThr: 2.462 ± 0.046
4.262GluVal: 4.262 ± 0.062
0.628GluTrp: 0.628 ± 0.025
0.977GluTyr: 0.977 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.01PheAla: 4.01 ± 0.058
0.441PheCys: 0.441 ± 0.019
2.468PheAsp: 2.468 ± 0.036
2.335PheGlu: 2.335 ± 0.045
1.42PhePhe: 1.42 ± 0.035
3.273PheGly: 3.273 ± 0.06
0.685PheHis: 0.685 ± 0.022
1.542PheIle: 1.542 ± 0.034
1.579PheLys: 1.579 ± 0.034
3.196PheLeu: 3.196 ± 0.058
0.839PheMet: 0.839 ± 0.027
1.185PheAsn: 1.185 ± 0.032
1.41PhePro: 1.41 ± 0.037
1.157PheGln: 1.157 ± 0.032
1.564PheArg: 1.564 ± 0.039
2.332PheSer: 2.332 ± 0.039
1.941PheThr: 1.941 ± 0.038
2.978PheVal: 2.978 ± 0.052
0.563PheTrp: 0.563 ± 0.022
0.963PheTyr: 0.963 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.825GlyAla: 7.825 ± 0.09
0.945GlyCys: 0.945 ± 0.033
3.661GlyAsp: 3.661 ± 0.059
3.894GlyGlu: 3.894 ± 0.059
3.166GlyPhe: 3.166 ± 0.057
5.872GlyGly: 5.872 ± 0.089
1.884GlyHis: 1.884 ± 0.04
3.861GlyIle: 3.861 ± 0.058
3.38GlyLys: 3.38 ± 0.059
9.238GlyLeu: 9.238 ± 0.107
2.073GlyMet: 2.073 ± 0.038
2.035GlyAsn: 2.035 ± 0.042
2.708GlyPro: 2.708 ± 0.051
3.942GlyGln: 3.942 ± 0.056
4.399GlyArg: 4.399 ± 0.062
4.365GlySer: 4.365 ± 0.073
3.864GlyThr: 3.864 ± 0.058
6.439GlyVal: 6.439 ± 0.081
1.308GlyTrp: 1.308 ± 0.033
2.079GlyTyr: 2.079 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.523HisAla: 2.523 ± 0.044
0.306HisCys: 0.306 ± 0.014
1.18HisAsp: 1.18 ± 0.03
1.071HisGlu: 1.071 ± 0.031
0.97HisPhe: 0.97 ± 0.03
1.955HisGly: 1.955 ± 0.037
0.71HisHis: 0.71 ± 0.027
1.172HisIle: 1.172 ± 0.029
0.728HisLys: 0.728 ± 0.026
2.431HisLeu: 2.431 ± 0.048
0.549HisMet: 0.549 ± 0.018
0.651HisAsn: 0.651 ± 0.024
1.463HisPro: 1.463 ± 0.036
1.013HisGln: 1.013 ± 0.03
1.302HisArg: 1.302 ± 0.031
1.17HisSer: 1.17 ± 0.031
1.262HisThr: 1.262 ± 0.035
1.507HisVal: 1.507 ± 0.035
0.453HisTrp: 0.453 ± 0.019
0.602HisTyr: 0.602 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.374IleAla: 5.374 ± 0.068
0.504IleCys: 0.504 ± 0.021
2.925IleAsp: 2.925 ± 0.048
2.954IleGlu: 2.954 ± 0.052
1.401IlePhe: 1.401 ± 0.033
3.886IleGly: 3.886 ± 0.059
1.025IleHis: 1.025 ± 0.031
1.725IleIle: 1.725 ± 0.041
1.962IleLys: 1.962 ± 0.04
3.703IleLeu: 3.703 ± 0.052
0.858IleMet: 0.858 ± 0.026
1.774IleAsn: 1.774 ± 0.04
2.015IlePro: 2.015 ± 0.044
1.698IleGln: 1.698 ± 0.033
2.554IleArg: 2.554 ± 0.048
2.982IleSer: 2.982 ± 0.05
2.948IleThr: 2.948 ± 0.052
3.209IleVal: 3.209 ± 0.044
0.546IleTrp: 0.546 ± 0.023
1.069IleTyr: 1.069 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.417LysAla: 4.417 ± 0.074
0.219LysCys: 0.219 ± 0.014
1.922LysAsp: 1.922 ± 0.045
1.719LysGlu: 1.719 ± 0.043
1.097LysPhe: 1.097 ± 0.03
2.723LysGly: 2.723 ± 0.046
0.891LysHis: 0.891 ± 0.028
1.798LysIle: 1.798 ± 0.041
1.762LysLys: 1.762 ± 0.051
4.284LysLeu: 4.284 ± 0.064
0.972LysMet: 0.972 ± 0.029
1.257LysAsn: 1.257 ± 0.033
2.236LysPro: 2.236 ± 0.045
1.556LysGln: 1.556 ± 0.036
2.462LysArg: 2.462 ± 0.044
2.128LysSer: 2.128 ± 0.044
2.428LysThr: 2.428 ± 0.053
2.863LysVal: 2.863 ± 0.05
0.381LysTrp: 0.381 ± 0.017
0.76LysTyr: 0.76 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.869LeuAla: 14.869 ± 0.148
1.156LeuCys: 1.156 ± 0.03
6.067LeuAsp: 6.067 ± 0.078
5.208LeuGlu: 5.208 ± 0.068
3.616LeuPhe: 3.616 ± 0.055
8.991LeuGly: 8.991 ± 0.094
2.368LeuHis: 2.368 ± 0.046
4.876LeuIle: 4.876 ± 0.063
4.245LeuLys: 4.245 ± 0.064
12.366LeuLeu: 12.366 ± 0.145
2.968LeuMet: 2.968 ± 0.046
3.115LeuAsn: 3.115 ± 0.049
6.152LeuPro: 6.152 ± 0.07
5.091LeuGln: 5.091 ± 0.075
6.87LeuArg: 6.87 ± 0.066
7.243LeuSer: 7.243 ± 0.09
5.929LeuThr: 5.929 ± 0.074
8.512LeuVal: 8.512 ± 0.089
1.458LeuTrp: 1.458 ± 0.045
2.11LeuTyr: 2.11 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.223MetAla: 3.223 ± 0.052
0.193MetCys: 0.193 ± 0.012
1.232MetAsp: 1.232 ± 0.03
1.027MetGlu: 1.027 ± 0.029
0.784MetPhe: 0.784 ± 0.027
2.01MetGly: 2.01 ± 0.039
0.537MetHis: 0.537 ± 0.019
0.973MetIle: 0.973 ± 0.029
1.084MetLys: 1.084 ± 0.03
2.879MetLeu: 2.879 ± 0.043
0.659MetMet: 0.659 ± 0.025
0.939MetAsn: 0.939 ± 0.028
1.435MetPro: 1.435 ± 0.032
1.153MetGln: 1.153 ± 0.028
1.532MetArg: 1.532 ± 0.034
1.716MetSer: 1.716 ± 0.037
1.602MetThr: 1.602 ± 0.033
2.027MetVal: 2.027 ± 0.045
0.226MetTrp: 0.226 ± 0.011
0.405MetTyr: 0.405 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.338AsnAla: 3.338 ± 0.058
0.293AsnCys: 0.293 ± 0.014
1.499AsnAsp: 1.499 ± 0.041
1.286AsnGlu: 1.286 ± 0.031
1.059AsnPhe: 1.059 ± 0.028
2.153AsnGly: 2.153 ± 0.041
0.649AsnHis: 0.649 ± 0.022
1.437AsnIle: 1.437 ± 0.039
1.084AsnLys: 1.084 ± 0.029
3.001AsnLeu: 3.001 ± 0.053
0.705AsnMet: 0.705 ± 0.024
0.912AsnAsn: 0.912 ± 0.032
1.983AsnPro: 1.983 ± 0.038
1.262AsnGln: 1.262 ± 0.033
1.607AsnArg: 1.607 ± 0.033
1.521AsnSer: 1.521 ± 0.035
1.81AsnThr: 1.81 ± 0.042
1.947AsnVal: 1.947 ± 0.043
0.441AsnTrp: 0.441 ± 0.017
0.77AsnTyr: 0.77 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.816ProAla: 5.816 ± 0.075
0.379ProCys: 0.379 ± 0.017
3.043ProAsp: 3.043 ± 0.055
3.243ProGlu: 3.243 ± 0.053
1.712ProPhe: 1.712 ± 0.036
4.058ProGly: 4.058 ± 0.06
1.039ProHis: 1.039 ± 0.025
1.955ProIle: 1.955 ± 0.042
1.79ProLys: 1.79 ± 0.044
5.135ProLeu: 5.135 ± 0.062
1.34ProMet: 1.34 ± 0.034
1.393ProAsn: 1.393 ± 0.036
2.232ProPro: 2.232 ± 0.041
2.323ProGln: 2.323 ± 0.043
2.308ProArg: 2.308 ± 0.046
2.855ProSer: 2.855 ± 0.05
2.789ProThr: 2.789 ± 0.05
4.137ProVal: 4.137 ± 0.06
0.761ProTrp: 0.761 ± 0.027
1.127ProTyr: 1.127 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
6.856GlnAla: 6.856 ± 0.094
0.309GlnCys: 0.309 ± 0.016
2.054GlnAsp: 2.054 ± 0.041
1.847GlnGlu: 1.847 ± 0.041
1.444GlnPhe: 1.444 ± 0.032
3.377GlnGly: 3.377 ± 0.057
1.273GlnHis: 1.273 ± 0.034
2.107GlnIle: 2.107 ± 0.043
1.453GlnLys: 1.453 ± 0.033
5.207GlnLeu: 5.207 ± 0.07
1.153GlnMet: 1.153 ± 0.029
1.157GlnAsn: 1.157 ± 0.027
2.384GlnPro: 2.384 ± 0.053
2.474GlnGln: 2.474 ± 0.056
3.579GlnArg: 3.579 ± 0.058
2.402GlnSer: 2.402 ± 0.044
2.604GlnThr: 2.604 ± 0.046
3.624GlnVal: 3.624 ± 0.051
0.662GlnTrp: 0.662 ± 0.025
0.813GlnTyr: 0.813 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.337ArgAla: 6.337 ± 0.075
0.572ArgCys: 0.572 ± 0.022
3.163ArgAsp: 3.163 ± 0.043
3.348ArgGlu: 3.348 ± 0.053
2.475ArgPhe: 2.475 ± 0.045
3.717ArgGly: 3.717 ± 0.055
1.569ArgHis: 1.569 ± 0.031
2.911ArgIle: 2.911 ± 0.055
2.053ArgLys: 2.053 ± 0.038
7.317ArgLeu: 7.317 ± 0.085
1.585ArgMet: 1.585 ± 0.036
1.616ArgAsn: 1.616 ± 0.041
2.578ArgPro: 2.578 ± 0.05
3.111ArgGln: 3.111 ± 0.056
3.779ArgArg: 3.779 ± 0.064
3.376ArgSer: 3.376 ± 0.053
2.791ArgThr: 2.791 ± 0.049
4.698ArgVal: 4.698 ± 0.066
1.054ArgTrp: 1.054 ± 0.032
1.586ArgTyr: 1.586 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.848SerAla: 6.848 ± 0.069
0.519SerCys: 0.519 ± 0.019
2.882SerAsp: 2.882 ± 0.052
2.77SerGlu: 2.77 ± 0.046
2.301SerPhe: 2.301 ± 0.041
5.151SerGly: 5.151 ± 0.08
1.367SerHis: 1.367 ± 0.037
2.577SerIle: 2.577 ± 0.046
2.033SerLys: 2.033 ± 0.043
6.447SerLeu: 6.447 ± 0.077
1.475SerMet: 1.475 ± 0.034
1.599SerAsn: 1.599 ± 0.036
2.992SerPro: 2.992 ± 0.051
2.537SerGln: 2.537 ± 0.046
3.264SerArg: 3.264 ± 0.052
3.522SerSer: 3.522 ± 0.062
3.286SerThr: 3.286 ± 0.05
4.282SerVal: 4.282 ± 0.059
0.82SerTrp: 0.82 ± 0.027
1.402SerTyr: 1.402 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.826ThrAla: 5.826 ± 0.072
0.442ThrCys: 0.442 ± 0.017
2.721ThrAsp: 2.721 ± 0.046
2.725ThrGlu: 2.725 ± 0.049
1.686ThrPhe: 1.686 ± 0.035
4.526ThrGly: 4.526 ± 0.062
1.308ThrHis: 1.308 ± 0.033
2.075ThrIle: 2.075 ± 0.04
1.588ThrLys: 1.588 ± 0.037
6.801ThrLeu: 6.801 ± 0.08
1.163ThrMet: 1.163 ± 0.033
1.336ThrAsn: 1.336 ± 0.036
3.625ThrPro: 3.625 ± 0.054
2.655ThrGln: 2.655 ± 0.054
3.171ThrArg: 3.171 ± 0.056
3.122ThrSer: 3.122 ± 0.055
2.965ThrThr: 2.965 ± 0.052
4.289ThrVal: 4.289 ± 0.06
0.725ThrTrp: 0.725 ± 0.022
1.14ThrTyr: 1.14 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.372ValAla: 9.372 ± 0.094
0.845ValCys: 0.845 ± 0.028
4.057ValAsp: 4.057 ± 0.058
3.721ValGlu: 3.721 ± 0.058
2.98ValPhe: 2.98 ± 0.049
5.547ValGly: 5.547 ± 0.079
1.538ValHis: 1.538 ± 0.031
3.696ValIle: 3.696 ± 0.057
2.832ValLys: 2.832 ± 0.052
9.128ValLeu: 9.128 ± 0.094
2.181ValMet: 2.181 ± 0.042
2.304ValAsn: 2.304 ± 0.047
3.615ValPro: 3.615 ± 0.051
3.102ValGln: 3.102 ± 0.043
4.441ValArg: 4.441 ± 0.059
4.615ValSer: 4.615 ± 0.074
4.192ValThr: 4.192 ± 0.063
6.608ValVal: 6.608 ± 0.085
1.047ValTrp: 1.047 ± 0.032
1.569ValTyr: 1.569 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.384TrpAla: 1.384 ± 0.034
0.183TrpCys: 0.183 ± 0.012
0.619TrpAsp: 0.619 ± 0.022
0.515TrpGlu: 0.515 ± 0.02
0.541TrpPhe: 0.541 ± 0.021
0.946TrpGly: 0.946 ± 0.027
0.384TrpHis: 0.384 ± 0.018
0.612TrpIle: 0.612 ± 0.02
0.431TrpLys: 0.431 ± 0.019
2.26TrpLeu: 2.26 ± 0.054
0.433TrpMet: 0.433 ± 0.02
0.378TrpAsn: 0.378 ± 0.019
0.716TrpPro: 0.716 ± 0.028
0.91TrpGln: 0.91 ± 0.028
1.139TrpArg: 1.139 ± 0.032
0.79TrpSer: 0.79 ± 0.028
0.657TrpThr: 0.657 ± 0.023
1.167TrpVal: 1.167 ± 0.032
0.284TrpTrp: 0.284 ± 0.018
0.283TrpTyr: 0.283 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.463TyrAla: 2.463 ± 0.049
0.252TyrCys: 0.252 ± 0.014
1.07TyrAsp: 1.07 ± 0.028
1.096TyrGlu: 1.096 ± 0.031
1.0TyrPhe: 1.0 ± 0.028
1.906TyrGly: 1.906 ± 0.037
0.48TyrHis: 0.48 ± 0.021
0.873TyrIle: 0.873 ± 0.027
0.797TyrLys: 0.797 ± 0.027
2.609TyrLeu: 2.609 ± 0.045
0.471TyrMet: 0.471 ± 0.02
0.698TyrAsn: 0.698 ± 0.024
1.16TyrPro: 1.16 ± 0.025
1.021TyrGln: 1.021 ± 0.025
1.49TyrArg: 1.49 ± 0.034
1.289TyrSer: 1.289 ± 0.032
1.198TyrThr: 1.198 ± 0.029
1.634TyrVal: 1.634 ± 0.035
0.385TyrTrp: 0.385 ± 0.02
0.561TyrTyr: 0.561 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3985 proteins (1303039 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski