Amino acid dipepetide frequency for Campylobacter phage CJIE4-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.247AlaAla: 1.247 ± 0.353
0.623AlaCys: 0.623 ± 0.268
2.048AlaAsp: 2.048 ± 0.362
3.383AlaGlu: 3.383 ± 0.711
4.363AlaPhe: 4.363 ± 0.69
2.849AlaGly: 2.849 ± 0.665
0.712AlaHis: 0.712 ± 0.255
3.918AlaIle: 3.918 ± 0.585
7.212AlaLys: 7.212 ± 0.851
8.548AlaLeu: 8.548 ± 1.092
1.425AlaMet: 1.425 ± 0.361
5.699AlaAsn: 5.699 ± 1.121
1.514AlaPro: 1.514 ± 0.38
2.048AlaGln: 2.048 ± 0.516
1.514AlaArg: 1.514 ± 0.494
4.452AlaSer: 4.452 ± 0.581
2.76AlaThr: 2.76 ± 0.591
1.603AlaVal: 1.603 ± 0.363
0.89AlaTrp: 0.89 ± 0.29
2.226AlaTyr: 2.226 ± 0.477
0.0AlaXaa: 0.0 ± 0.0
Cys
0.623CysAla: 0.623 ± 0.189
0.178CysCys: 0.178 ± 0.144
0.979CysAsp: 0.979 ± 0.328
0.979CysGlu: 0.979 ± 0.383
0.712CysPhe: 0.712 ± 0.276
0.623CysGly: 0.623 ± 0.292
0.089CysHis: 0.089 ± 0.089
0.623CysIle: 0.623 ± 0.278
1.247CysLys: 1.247 ± 0.394
1.158CysLeu: 1.158 ± 0.438
0.267CysMet: 0.267 ± 0.189
0.801CysAsn: 0.801 ± 0.255
0.356CysPro: 0.356 ± 0.191
0.089CysGln: 0.089 ± 0.072
0.0CysArg: 0.0 ± 0.0
0.979CysSer: 0.979 ± 0.342
0.267CysThr: 0.267 ± 0.161
0.534CysVal: 0.534 ± 0.24
0.0CysTrp: 0.0 ± 0.0
0.267CysTyr: 0.267 ± 0.202
0.0CysXaa: 0.0 ± 0.0
Asp
2.582AspAla: 2.582 ± 0.395
0.178AspCys: 0.178 ± 0.129
3.027AspAsp: 3.027 ± 0.605
6.055AspGlu: 6.055 ± 1.151
3.651AspPhe: 3.651 ± 0.581
2.493AspGly: 2.493 ± 0.476
0.445AspHis: 0.445 ± 0.213
3.562AspIle: 3.562 ± 0.371
6.411AspLys: 6.411 ± 0.752
5.609AspLeu: 5.609 ± 0.835
0.623AspMet: 0.623 ± 0.213
3.562AspAsn: 3.562 ± 0.64
0.89AspPro: 0.89 ± 0.278
0.623AspGln: 0.623 ± 0.206
1.068AspArg: 1.068 ± 0.378
1.514AspSer: 1.514 ± 0.336
2.582AspThr: 2.582 ± 0.456
2.315AspVal: 2.315 ± 0.422
0.356AspTrp: 0.356 ± 0.135
2.938AspTyr: 2.938 ± 0.56
0.0AspXaa: 0.0 ± 0.0
Glu
5.164GluAla: 5.164 ± 0.848
1.068GluCys: 1.068 ± 0.312
2.938GluAsp: 2.938 ± 0.658
8.103GluGlu: 8.103 ± 1.344
4.363GluPhe: 4.363 ± 0.689
1.781GluGly: 1.781 ± 0.431
0.712GluHis: 0.712 ± 0.249
8.103GluIle: 8.103 ± 1.033
11.664GluLys: 11.664 ± 1.129
11.041GluLeu: 11.041 ± 1.478
1.692GluMet: 1.692 ± 0.364
8.37GluAsn: 8.37 ± 0.82
1.068GluPro: 1.068 ± 0.346
4.363GluGln: 4.363 ± 0.639
2.938GluArg: 2.938 ± 0.58
4.63GluSer: 4.63 ± 0.773
2.404GluThr: 2.404 ± 0.549
4.274GluVal: 4.274 ± 0.528
0.534GluTrp: 0.534 ± 0.178
2.493GluTyr: 2.493 ± 0.44
0.0GluXaa: 0.0 ± 0.0
Phe
2.582PheAla: 2.582 ± 0.553
0.89PheCys: 0.89 ± 0.318
2.671PheAsp: 2.671 ± 0.52
4.452PheGlu: 4.452 ± 0.562
2.76PhePhe: 2.76 ± 0.893
2.404PheGly: 2.404 ± 0.448
0.623PheHis: 0.623 ± 0.254
4.363PheIle: 4.363 ± 0.826
7.123PheLys: 7.123 ± 0.84
6.233PheLeu: 6.233 ± 0.976
1.158PheMet: 1.158 ± 0.341
4.096PheAsn: 4.096 ± 0.606
0.534PhePro: 0.534 ± 0.232
1.336PheGln: 1.336 ± 0.274
1.336PheArg: 1.336 ± 0.381
3.294PheSer: 3.294 ± 0.726
2.582PheThr: 2.582 ± 0.53
2.315PheVal: 2.315 ± 0.723
0.178PheTrp: 0.178 ± 0.107
3.116PheTyr: 3.116 ± 0.765
0.0PheXaa: 0.0 ± 0.0
Gly
2.582GlyAla: 2.582 ± 0.766
0.623GlyCys: 0.623 ± 0.248
3.562GlyAsp: 3.562 ± 0.725
2.938GlyGlu: 2.938 ± 0.378
3.74GlyPhe: 3.74 ± 0.451
2.493GlyGly: 2.493 ± 0.747
0.267GlyHis: 0.267 ± 0.15
4.719GlyIle: 4.719 ± 0.62
4.452GlyLys: 4.452 ± 0.787
4.63GlyLeu: 4.63 ± 0.91
0.623GlyMet: 0.623 ± 0.223
3.116GlyAsn: 3.116 ± 0.58
0.0GlyPro: 0.0 ± 0.0
0.801GlyGln: 0.801 ± 0.272
0.0GlyArg: 0.0 ± 0.0
2.76GlySer: 2.76 ± 0.682
1.87GlyThr: 1.87 ± 0.531
2.938GlyVal: 2.938 ± 0.49
0.267GlyTrp: 0.267 ± 0.132
2.048GlyTyr: 2.048 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
0.356HisAla: 0.356 ± 0.161
0.178HisCys: 0.178 ± 0.141
0.178HisAsp: 0.178 ± 0.126
1.158HisGlu: 1.158 ± 0.415
1.068HisPhe: 1.068 ± 0.4
0.534HisGly: 0.534 ± 0.28
0.534HisHis: 0.534 ± 0.25
0.534HisIle: 0.534 ± 0.202
1.247HisLys: 1.247 ± 0.413
0.979HisLeu: 0.979 ± 0.223
0.178HisMet: 0.178 ± 0.112
0.623HisAsn: 0.623 ± 0.257
0.267HisPro: 0.267 ± 0.189
0.356HisGln: 0.356 ± 0.245
0.267HisArg: 0.267 ± 0.172
0.534HisSer: 0.534 ± 0.196
0.89HisThr: 0.89 ± 0.28
0.178HisVal: 0.178 ± 0.12
0.089HisTrp: 0.089 ± 0.08
0.356HisTyr: 0.356 ± 0.156
0.0HisXaa: 0.0 ± 0.0
Ile
5.52IleAla: 5.52 ± 0.568
0.445IleCys: 0.445 ± 0.195
4.719IleAsp: 4.719 ± 0.662
6.856IleGlu: 6.856 ± 0.716
3.651IlePhe: 3.651 ± 0.721
3.829IleGly: 3.829 ± 0.763
0.979IleHis: 0.979 ± 0.312
6.411IleIle: 6.411 ± 1.224
10.596IleLys: 10.596 ± 0.931
7.479IleLeu: 7.479 ± 1.093
1.514IleMet: 1.514 ± 0.304
7.034IleAsn: 7.034 ± 0.707
1.781IlePro: 1.781 ± 0.439
2.582IleGln: 2.582 ± 0.419
2.226IleArg: 2.226 ± 0.55
5.075IleSer: 5.075 ± 0.63
4.363IleThr: 4.363 ± 0.543
2.76IleVal: 2.76 ± 0.461
0.89IleTrp: 0.89 ± 0.329
2.671IleTyr: 2.671 ± 0.517
0.0IleXaa: 0.0 ± 0.0
Lys
8.548LysAla: 8.548 ± 0.984
1.247LysCys: 1.247 ± 0.415
6.767LysAsp: 6.767 ± 0.941
12.198LysGlu: 12.198 ± 1.049
3.562LysPhe: 3.562 ± 0.717
5.877LysGly: 5.877 ± 0.959
1.158LysHis: 1.158 ± 0.465
11.041LysIle: 11.041 ± 1.615
12.02LysLys: 12.02 ± 1.276
9.616LysLeu: 9.616 ± 0.996
2.582LysMet: 2.582 ± 0.432
10.507LysAsn: 10.507 ± 0.971
3.205LysPro: 3.205 ± 0.75
5.342LysGln: 5.342 ± 0.592
3.473LysArg: 3.473 ± 0.557
5.164LysSer: 5.164 ± 0.663
6.589LysThr: 6.589 ± 0.673
4.541LysVal: 4.541 ± 0.692
0.623LysTrp: 0.623 ± 0.198
3.562LysTyr: 3.562 ± 0.512
0.0LysXaa: 0.0 ± 0.0
Leu
5.877LeuAla: 5.877 ± 0.913
1.247LeuCys: 1.247 ± 0.393
3.562LeuAsp: 3.562 ± 0.548
11.664LeuGlu: 11.664 ± 1.448
4.719LeuPhe: 4.719 ± 0.697
5.609LeuGly: 5.609 ± 1.092
0.979LeuHis: 0.979 ± 0.285
5.966LeuIle: 5.966 ± 0.756
14.157LeuLys: 14.157 ± 1.16
5.966LeuLeu: 5.966 ± 0.737
2.849LeuMet: 2.849 ± 0.488
9.082LeuAsn: 9.082 ± 0.787
1.425LeuPro: 1.425 ± 0.327
3.027LeuGln: 3.027 ± 0.676
4.452LeuArg: 4.452 ± 0.509
9.349LeuSer: 9.349 ± 0.948
3.918LeuThr: 3.918 ± 0.499
3.829LeuVal: 3.829 ± 0.615
0.979LeuTrp: 0.979 ± 0.379
2.938LeuTyr: 2.938 ± 0.588
0.0LeuXaa: 0.0 ± 0.0
Met
0.89MetAla: 0.89 ± 0.236
0.089MetCys: 0.089 ± 0.076
1.158MetAsp: 1.158 ± 0.264
0.979MetGlu: 0.979 ± 0.279
0.801MetPhe: 0.801 ± 0.24
0.623MetGly: 0.623 ± 0.212
0.178MetHis: 0.178 ± 0.114
2.315MetIle: 2.315 ± 0.453
2.137MetLys: 2.137 ± 0.398
2.582MetLeu: 2.582 ± 0.566
0.178MetMet: 0.178 ± 0.13
1.158MetAsn: 1.158 ± 0.281
0.623MetPro: 0.623 ± 0.229
2.137MetGln: 2.137 ± 0.36
1.336MetArg: 1.336 ± 0.368
2.76MetSer: 2.76 ± 0.527
0.712MetThr: 0.712 ± 0.223
0.712MetVal: 0.712 ± 0.252
0.178MetTrp: 0.178 ± 0.129
0.445MetTyr: 0.445 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
6.411AsnAla: 6.411 ± 0.68
0.979AsnCys: 0.979 ± 0.355
5.164AsnAsp: 5.164 ± 0.545
8.103AsnGlu: 8.103 ± 1.018
2.849AsnPhe: 2.849 ± 0.466
4.096AsnGly: 4.096 ± 0.702
1.068AsnHis: 1.068 ± 0.268
7.212AsnIle: 7.212 ± 0.769
6.945AsnLys: 6.945 ± 0.676
8.993AsnLeu: 8.993 ± 0.846
1.781AsnMet: 1.781 ± 0.401
4.986AsnAsn: 4.986 ± 0.695
1.781AsnPro: 1.781 ± 0.445
3.651AsnGln: 3.651 ± 0.86
1.158AsnArg: 1.158 ± 0.271
5.609AsnSer: 5.609 ± 0.881
2.671AsnThr: 2.671 ± 0.465
2.404AsnVal: 2.404 ± 0.382
0.445AsnTrp: 0.445 ± 0.225
2.137AsnTyr: 2.137 ± 0.459
0.0AsnXaa: 0.0 ± 0.0
Pro
0.89ProAla: 0.89 ± 0.317
0.178ProCys: 0.178 ± 0.16
0.534ProAsp: 0.534 ± 0.23
1.068ProGlu: 1.068 ± 0.246
1.603ProPhe: 1.603 ± 0.357
0.356ProGly: 0.356 ± 0.161
0.445ProHis: 0.445 ± 0.223
1.336ProIle: 1.336 ± 0.372
2.048ProLys: 2.048 ± 0.557
1.959ProLeu: 1.959 ± 0.579
0.445ProMet: 0.445 ± 0.149
1.336ProAsn: 1.336 ± 0.362
0.356ProPro: 0.356 ± 0.181
1.692ProGln: 1.692 ± 0.454
0.623ProArg: 0.623 ± 0.28
1.603ProSer: 1.603 ± 0.486
1.514ProThr: 1.514 ± 0.357
0.801ProVal: 0.801 ± 0.279
0.089ProTrp: 0.089 ± 0.076
1.514ProTyr: 1.514 ± 0.343
0.0ProXaa: 0.0 ± 0.0
Gln
2.849GlnAla: 2.849 ± 0.679
0.356GlnCys: 0.356 ± 0.184
1.87GlnAsp: 1.87 ± 0.356
3.383GlnGlu: 3.383 ± 0.628
0.801GlnPhe: 0.801 ± 0.249
1.781GlnGly: 1.781 ± 0.371
0.267GlnHis: 0.267 ± 0.161
3.74GlnIle: 3.74 ± 0.553
4.719GlnLys: 4.719 ± 0.477
2.671GlnLeu: 2.671 ± 0.651
1.336GlnMet: 1.336 ± 0.435
3.651GlnAsn: 3.651 ± 0.675
0.178GlnPro: 0.178 ± 0.126
0.801GlnGln: 0.801 ± 0.262
1.336GlnArg: 1.336 ± 0.397
3.205GlnSer: 3.205 ± 0.568
2.137GlnThr: 2.137 ± 0.376
1.514GlnVal: 1.514 ± 0.361
0.089GlnTrp: 0.089 ± 0.097
1.158GlnTyr: 1.158 ± 0.312
0.0GlnXaa: 0.0 ± 0.0
Arg
1.692ArgAla: 1.692 ± 0.354
0.178ArgCys: 0.178 ± 0.145
1.068ArgAsp: 1.068 ± 0.304
2.671ArgGlu: 2.671 ± 0.599
1.692ArgPhe: 1.692 ± 0.45
0.712ArgGly: 0.712 ± 0.26
0.089ArgHis: 0.089 ± 0.08
2.137ArgIle: 2.137 ± 0.488
3.473ArgLys: 3.473 ± 0.53
3.473ArgLeu: 3.473 ± 0.633
0.801ArgMet: 0.801 ± 0.303
1.692ArgAsn: 1.692 ± 0.4
0.623ArgPro: 0.623 ± 0.174
1.068ArgGln: 1.068 ± 0.24
0.623ArgArg: 0.623 ± 0.212
1.603ArgSer: 1.603 ± 0.455
0.89ArgThr: 0.89 ± 0.258
1.692ArgVal: 1.692 ± 0.404
0.356ArgTrp: 0.356 ± 0.196
0.801ArgTyr: 0.801 ± 0.237
0.0ArgXaa: 0.0 ± 0.0
Ser
4.185SerAla: 4.185 ± 0.603
0.356SerCys: 0.356 ± 0.195
3.74SerAsp: 3.74 ± 0.47
4.719SerGlu: 4.719 ± 0.618
5.609SerPhe: 5.609 ± 1.025
2.938SerGly: 2.938 ± 0.416
0.178SerHis: 0.178 ± 0.112
5.52SerIle: 5.52 ± 0.776
7.835SerLys: 7.835 ± 0.734
7.746SerLeu: 7.746 ± 0.803
1.603SerMet: 1.603 ± 0.354
3.918SerAsn: 3.918 ± 0.699
1.781SerPro: 1.781 ± 0.377
2.315SerGln: 2.315 ± 0.367
1.336SerArg: 1.336 ± 0.424
5.164SerSer: 5.164 ± 1.222
3.383SerThr: 3.383 ± 0.559
2.938SerVal: 2.938 ± 0.622
0.534SerTrp: 0.534 ± 0.165
1.603SerTyr: 1.603 ± 0.374
0.0SerXaa: 0.0 ± 0.0
Thr
2.404ThrAla: 2.404 ± 0.52
0.445ThrCys: 0.445 ± 0.226
1.781ThrAsp: 1.781 ± 0.365
2.76ThrGlu: 2.76 ± 0.444
2.315ThrPhe: 2.315 ± 0.428
1.959ThrGly: 1.959 ± 0.461
1.068ThrHis: 1.068 ± 0.253
3.473ThrIle: 3.473 ± 0.528
5.164ThrLys: 5.164 ± 0.558
4.007ThrLeu: 4.007 ± 0.63
1.336ThrMet: 1.336 ± 0.306
4.096ThrAsn: 4.096 ± 0.592
1.514ThrPro: 1.514 ± 0.403
2.76ThrGln: 2.76 ± 0.468
0.979ThrArg: 0.979 ± 0.264
4.096ThrSer: 4.096 ± 0.558
2.849ThrThr: 2.849 ± 0.525
0.267ThrVal: 0.267 ± 0.151
0.623ThrTrp: 0.623 ± 0.206
2.048ThrTyr: 2.048 ± 0.422
0.0ThrXaa: 0.0 ± 0.0
Val
2.137ValAla: 2.137 ± 0.37
0.979ValCys: 0.979 ± 0.372
1.603ValAsp: 1.603 ± 0.36
2.315ValGlu: 2.315 ± 0.583
3.027ValPhe: 3.027 ± 0.755
1.781ValGly: 1.781 ± 0.4
0.178ValHis: 0.178 ± 0.121
2.76ValIle: 2.76 ± 0.516
4.096ValLys: 4.096 ± 0.564
5.253ValLeu: 5.253 ± 0.781
0.801ValMet: 0.801 ± 0.208
2.137ValAsn: 2.137 ± 0.308
1.425ValPro: 1.425 ± 0.427
0.979ValGln: 0.979 ± 0.346
0.89ValArg: 0.89 ± 0.291
3.74ValSer: 3.74 ± 0.649
1.336ValThr: 1.336 ± 0.37
2.404ValVal: 2.404 ± 0.482
0.623ValTrp: 0.623 ± 0.207
1.247ValTyr: 1.247 ± 0.379
0.0ValXaa: 0.0 ± 0.0
Trp
0.356TrpAla: 0.356 ± 0.135
0.089TrpCys: 0.089 ± 0.076
0.534TrpAsp: 0.534 ± 0.198
0.534TrpGlu: 0.534 ± 0.177
0.445TrpPhe: 0.445 ± 0.221
0.445TrpGly: 0.445 ± 0.211
0.267TrpHis: 0.267 ± 0.155
0.712TrpIle: 0.712 ± 0.199
0.801TrpLys: 0.801 ± 0.23
0.979TrpLeu: 0.979 ± 0.324
0.0TrpMet: 0.0 ± 0.0
0.712TrpAsn: 0.712 ± 0.326
0.0TrpPro: 0.0 ± 0.0
0.267TrpGln: 0.267 ± 0.13
0.267TrpArg: 0.267 ± 0.154
0.356TrpSer: 0.356 ± 0.18
0.534TrpThr: 0.534 ± 0.19
0.356TrpVal: 0.356 ± 0.264
0.267TrpTrp: 0.267 ± 0.159
0.267TrpTyr: 0.267 ± 0.11
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.137TyrAla: 2.137 ± 0.478
0.445TyrCys: 0.445 ± 0.204
2.582TyrAsp: 2.582 ± 0.524
3.383TyrGlu: 3.383 ± 0.354
2.315TyrPhe: 2.315 ± 0.588
1.247TyrGly: 1.247 ± 0.379
0.267TyrHis: 0.267 ± 0.148
2.938TyrIle: 2.938 ± 0.53
4.274TyrLys: 4.274 ± 0.719
2.671TyrLeu: 2.671 ± 0.647
0.712TyrMet: 0.712 ± 0.194
1.87TyrAsn: 1.87 ± 0.457
1.068TyrPro: 1.068 ± 0.369
1.603TyrGln: 1.603 ± 0.345
1.514TyrArg: 1.514 ± 0.444
1.603TyrSer: 1.603 ± 0.334
1.692TyrThr: 1.692 ± 0.346
1.336TyrVal: 1.336 ± 0.248
0.178TyrTrp: 0.178 ± 0.115
1.336TyrTyr: 1.336 ± 0.382
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (11232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski