Amino acid dipepetide frequency for Aquabacterium pictum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.844AlaAla: 23.844 ± 0.203	1.354AlaCys: 1.354 ± 0.03	8.522AlaAsp: 8.522 ± 0.077	6.975AlaGlu: 6.975 ± 0.072	3.83AlaPhe: 3.83 ± 0.053	13.356AlaGly: 13.356 ± 0.127	2.872AlaHis: 2.872 ± 0.049	4.789AlaIle: 4.789 ± 0.05	3.264AlaLys: 3.264 ± 0.065	17.948AlaLeu: 17.948 ± 0.203	3.683AlaMet: 3.683 ± 0.051	2.728AlaAsn: 2.728 ± 0.05	7.699AlaPro: 7.699 ± 0.097	6.774AlaGln: 6.774 ± 0.093	10.045AlaArg: 10.045 ± 0.099	6.822AlaSer: 6.822 ± 0.072	7.386AlaThr: 7.386 ± 0.078	10.365AlaVal: 10.365 ± 0.087	2.511AlaTrp: 2.511 ± 0.044	2.274AlaTyr: 2.274 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.202CysAla: 1.202 ± 0.026	0.114CysCys: 0.114 ± 0.009	0.527CysAsp: 0.527 ± 0.015	0.391CysGlu: 0.391 ± 0.016	0.313CysPhe: 0.313 ± 0.012	0.945CysGly: 0.945 ± 0.026	0.275CysHis: 0.275 ± 0.012	0.351CysIle: 0.351 ± 0.015	0.169CysLys: 0.169 ± 0.009	0.819CysLeu: 0.819 ± 0.022	0.175CysMet: 0.175 ± 0.01	0.22CysAsn: 0.22 ± 0.012	0.488CysPro: 0.488 ± 0.017	0.316CysGln: 0.316 ± 0.014	0.603CysArg: 0.603 ± 0.019	0.511CysSer: 0.511 ± 0.016	0.512CysThr: 0.512 ± 0.015	0.638CysVal: 0.638 ± 0.02	0.141CysTrp: 0.141 ± 0.009	0.165CysTyr: 0.165 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.432AspAla: 8.432 ± 0.079	0.458AspCys: 0.458 ± 0.016	3.257AspAsp: 3.257 ± 0.045	2.712AspGlu: 2.712 ± 0.045	1.872AspPhe: 1.872 ± 0.032	5.496AspGly: 5.496 ± 0.068	1.245AspHis: 1.245 ± 0.03	2.119AspIle: 2.119 ± 0.042	1.39AspLys: 1.39 ± 0.034	5.866AspLeu: 5.866 ± 0.073	1.063AspMet: 1.063 ± 0.025	1.155AspAsn: 1.155 ± 0.026	3.082AspPro: 3.082 ± 0.04	1.871AspGln: 1.871 ± 0.044	3.598AspArg: 3.598 ± 0.046	2.412AspSer: 2.412 ± 0.048	2.689AspThr: 2.689 ± 0.044	3.74AspVal: 3.74 ± 0.05	1.062AspTrp: 1.062 ± 0.022	1.075AspTyr: 1.075 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.675GluAla: 6.675 ± 0.08	0.303GluCys: 0.303 ± 0.014	1.716GluAsp: 1.716 ± 0.036	1.508GluGlu: 1.508 ± 0.037	1.406GluPhe: 1.406 ± 0.03	3.052GluGly: 3.052 ± 0.046	1.02GluHis: 1.02 ± 0.025	1.956GluIle: 1.956 ± 0.041	1.127GluLys: 1.127 ± 0.035	4.972GluLeu: 4.972 ± 0.065	0.94GluMet: 0.94 ± 0.027	0.86GluAsn: 0.86 ± 0.022	2.36GluPro: 2.36 ± 0.042	2.149GluGln: 2.149 ± 0.044	3.953GluArg: 3.953 ± 0.055	1.792GluSer: 1.792 ± 0.033	2.139GluThr: 2.139 ± 0.037	3.402GluVal: 3.402 ± 0.05	0.527GluTrp: 0.527 ± 0.017	0.681GluTyr: 0.681 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.908PheAla: 3.908 ± 0.049	0.357PheCys: 0.357 ± 0.013	2.475PheAsp: 2.475 ± 0.04	1.599PheGlu: 1.599 ± 0.033	1.098PhePhe: 1.098 ± 0.029	3.218PheGly: 3.218 ± 0.047	0.698PheHis: 0.698 ± 0.021	1.361PheIle: 1.361 ± 0.032	0.959PheLys: 0.959 ± 0.025	2.539PheLeu: 2.539 ± 0.041	0.663PheMet: 0.663 ± 0.021	1.054PheAsn: 1.054 ± 0.028	1.281PhePro: 1.281 ± 0.027	1.098PheGln: 1.098 ± 0.024	1.735PheArg: 1.735 ± 0.033	1.912PheSer: 1.912 ± 0.034	1.909PheThr: 1.909 ± 0.031	2.273PheVal: 2.273 ± 0.041	0.468PheTrp: 0.468 ± 0.015	0.712PheTyr: 0.712 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.72GlyAla: 10.72 ± 0.101	0.971GlyCys: 0.971 ± 0.023	4.351GlyAsp: 4.351 ± 0.055	3.767GlyGlu: 3.767 ± 0.04	3.199GlyPhe: 3.199 ± 0.041	7.88GlyGly: 7.88 ± 0.109	2.182GlyHis: 2.182 ± 0.032	3.556GlyIle: 3.556 ± 0.053	2.609GlyLys: 2.609 ± 0.053	10.39GlyLeu: 10.39 ± 0.103	2.262GlyMet: 2.262 ± 0.039	1.985GlyAsn: 1.985 ± 0.039	3.887GlyPro: 3.887 ± 0.047	4.103GlyGln: 4.103 ± 0.048	6.222GlyArg: 6.222 ± 0.067	4.961GlySer: 4.961 ± 0.078	4.982GlyThr: 4.982 ± 0.089	6.486GlyVal: 6.486 ± 0.062	1.73GlyTrp: 1.73 ± 0.037	1.98GlyTyr: 1.98 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.185HisAla: 3.185 ± 0.048	0.295HisCys: 0.295 ± 0.012	1.202HisAsp: 1.202 ± 0.027	0.873HisGlu: 0.873 ± 0.024	0.821HisPhe: 0.821 ± 0.023	2.42HisGly: 2.42 ± 0.038	0.705HisHis: 0.705 ± 0.023	0.808HisIle: 0.808 ± 0.021	0.459HisLys: 0.459 ± 0.017	2.491HisLeu: 2.491 ± 0.044	0.416HisMet: 0.416 ± 0.014	0.442HisAsn: 0.442 ± 0.017	1.645HisPro: 1.645 ± 0.03	0.878HisGln: 0.878 ± 0.023	1.669HisArg: 1.669 ± 0.036	0.949HisSer: 0.949 ± 0.023	1.155HisThr: 1.155 ± 0.026	1.431HisVal: 1.431 ± 0.026	0.462HisTrp: 0.462 ± 0.016	0.543HisTyr: 0.543 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.337IleAla: 5.337 ± 0.06	0.325IleCys: 0.325 ± 0.013	2.994IleAsp: 2.994 ± 0.043	2.2IleGlu: 2.2 ± 0.04	0.96IlePhe: 0.96 ± 0.025	3.861IleGly: 3.861 ± 0.051	0.73IleHis: 0.73 ± 0.022	1.063IleIle: 1.063 ± 0.032	1.021IleLys: 1.021 ± 0.03	2.601IleLeu: 2.601 ± 0.046	0.534IleMet: 0.534 ± 0.019	1.129IleAsn: 1.129 ± 0.031	1.724IlePro: 1.724 ± 0.034	1.124IleGln: 1.124 ± 0.025	2.191IleArg: 2.191 ± 0.038	1.834IleSer: 1.834 ± 0.031	2.599IleThr: 2.599 ± 0.045	2.833IleVal: 2.833 ± 0.045	0.362IleTrp: 0.362 ± 0.015	0.645IleTyr: 0.645 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.398LysAla: 3.398 ± 0.056	0.114LysCys: 0.114 ± 0.008	1.274LysAsp: 1.274 ± 0.033	0.918LysGlu: 0.918 ± 0.029	0.693LysPhe: 0.693 ± 0.022	1.886LysGly: 1.886 ± 0.041	0.508LysHis: 0.508 ± 0.019	1.035LysIle: 1.035 ± 0.029	0.982LysLys: 0.982 ± 0.038	2.85LysLeu: 2.85 ± 0.049	0.587LysMet: 0.587 ± 0.021	0.638LysAsn: 0.638 ± 0.023	1.844LysPro: 1.844 ± 0.039	0.93LysGln: 0.93 ± 0.027	1.686LysArg: 1.686 ± 0.038	1.228LysSer: 1.228 ± 0.028	1.518LysThr: 1.518 ± 0.035	2.028LysVal: 2.028 ± 0.049	0.266LysTrp: 0.266 ± 0.012	0.466LysTyr: 0.466 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	18.668LeuAla: 18.668 ± 0.164	1.016LeuCys: 1.016 ± 0.026	6.224LeuAsp: 6.224 ± 0.066	4.138LeuGlu: 4.138 ± 0.051	3.151LeuPhe: 3.151 ± 0.044	9.554LeuGly: 9.554 ± 0.09	2.586LeuHis: 2.586 ± 0.041	3.452LeuIle: 3.452 ± 0.046	2.892LeuLys: 2.892 ± 0.049	12.868LeuLeu: 12.868 ± 0.129	2.304LeuMet: 2.304 ± 0.04	2.414LeuAsn: 2.414 ± 0.048	7.392LeuPro: 7.392 ± 0.09	5.937LeuGln: 5.937 ± 0.073	8.752LeuArg: 8.752 ± 0.082	5.534LeuSer: 5.534 ± 0.085	5.355LeuThr: 5.355 ± 0.126	8.928LeuVal: 8.928 ± 0.085	1.513LeuTrp: 1.513 ± 0.035	1.831LeuTyr: 1.831 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.349MetAla: 3.349 ± 0.056	0.142MetCys: 0.142 ± 0.008	1.063MetAsp: 1.063 ± 0.027	0.733MetGlu: 0.733 ± 0.02	0.573MetPhe: 0.573 ± 0.016	1.734MetGly: 1.734 ± 0.03	0.527MetHis: 0.527 ± 0.017	0.7MetIle: 0.7 ± 0.02	0.725MetLys: 0.725 ± 0.022	2.525MetLeu: 2.525 ± 0.04	0.438MetMet: 0.438 ± 0.017	0.655MetAsn: 0.655 ± 0.021	1.522MetPro: 1.522 ± 0.031	0.998MetGln: 0.998 ± 0.028	1.547MetArg: 1.547 ± 0.028	1.229MetSer: 1.229 ± 0.025	1.442MetThr: 1.442 ± 0.029	1.734MetVal: 1.734 ± 0.031	0.18MetTrp: 0.18 ± 0.011	0.284MetTyr: 0.284 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.049	0.217AsnCys: 0.217 ± 0.009	1.116AsnAsp: 1.116 ± 0.029	0.863AsnGlu: 0.863 ± 0.022	0.773AsnPhe: 0.773 ± 0.023	2.04AsnGly: 2.04 ± 0.044	0.477AsnHis: 0.477 ± 0.016	0.921AsnIle: 0.921 ± 0.022	0.593AsnLys: 0.593 ± 0.021	2.52AsnLeu: 2.52 ± 0.04	0.439AsnMet: 0.439 ± 0.016	0.619AsnAsn: 0.619 ± 0.024	1.69AsnPro: 1.69 ± 0.033	0.833AsnGln: 0.833 ± 0.024	1.521AsnArg: 1.521 ± 0.032	0.934AsnSer: 0.934 ± 0.024	1.281AsnThr: 1.281 ± 0.031	1.51AsnVal: 1.51 ± 0.031	0.319AsnTrp: 0.319 ± 0.014	0.465AsnTyr: 0.465 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	9.82ProAla: 9.82 ± 0.107	0.367ProCys: 0.367 ± 0.015	3.498ProAsp: 3.498 ± 0.045	2.874ProGlu: 2.874 ± 0.045	1.72ProPhe: 1.72 ± 0.033	5.863ProGly: 5.863 ± 0.065	1.128ProHis: 1.128 ± 0.024	1.632ProIle: 1.632 ± 0.03	1.32ProLys: 1.32 ± 0.029	6.212ProLeu: 6.212 ± 0.066	1.337ProMet: 1.337 ± 0.031	1.082ProAsn: 1.082 ± 0.025	3.684ProPro: 3.684 ± 0.07	2.366ProGln: 2.366 ± 0.034	3.316ProArg: 3.316 ± 0.05	2.485ProSer: 2.485 ± 0.039	2.855ProThr: 2.855 ± 0.063	4.745ProVal: 4.745 ± 0.059	0.941ProTrp: 0.941 ± 0.025	0.994ProTyr: 0.994 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	7.712GlnAla: 7.712 ± 0.088	0.289GlnCys: 0.289 ± 0.014	1.561GlnAsp: 1.561 ± 0.031	1.176GlnGlu: 1.176 ± 0.028	1.231GlnPhe: 1.231 ± 0.029	3.469GlnGly: 3.469 ± 0.041	1.121GlnHis: 1.121 ± 0.028	1.621GlnIle: 1.621 ± 0.064	0.827GlnLys: 0.827 ± 0.022	5.114GlnLeu: 5.114 ± 0.132	0.918GlnMet: 0.918 ± 0.023	0.637GlnAsn: 0.637 ± 0.022	3.24GlnPro: 3.24 ± 0.043	2.47GlnGln: 2.47 ± 0.041	4.476GlnArg: 4.476 ± 0.056	1.674GlnSer: 1.674 ± 0.027	1.931GlnThr: 1.931 ± 0.032	3.731GlnVal: 3.731 ± 0.06	0.709GlnTrp: 0.709 ± 0.02	0.594GlnTyr: 0.594 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.937ArgAla: 8.937 ± 0.08	0.672ArgCys: 0.672 ± 0.019	3.557ArgAsp: 3.557 ± 0.046	3.207ArgGlu: 3.207 ± 0.051	2.728ArgPhe: 2.728 ± 0.043	4.965ArgGly: 4.965 ± 0.054	2.139ArgHis: 2.139 ± 0.039	3.045ArgIle: 3.045 ± 0.041	1.543ArgLys: 1.543 ± 0.035	9.233ArgLeu: 9.233 ± 0.09	1.825ArgMet: 1.825 ± 0.031	1.534ArgAsn: 1.534 ± 0.033	3.864ArgPro: 3.864 ± 0.053	3.739ArgGln: 3.739 ± 0.044	5.663ArgArg: 5.663 ± 0.07	3.595ArgSer: 3.595 ± 0.051	3.189ArgThr: 3.189 ± 0.043	5.089ArgVal: 5.089 ± 0.057	1.449ArgTrp: 1.449 ± 0.027	1.496ArgTyr: 1.496 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.078	0.391SerCys: 0.391 ± 0.015	2.391SerAsp: 2.391 ± 0.044	1.812SerGlu: 1.812 ± 0.039	1.861SerPhe: 1.861 ± 0.035	4.985SerGly: 4.985 ± 0.067	1.115SerHis: 1.115 ± 0.026	1.891SerIle: 1.891 ± 0.036	1.127SerLys: 1.127 ± 0.029	5.433SerLeu: 5.433 ± 0.069	1.042SerMet: 1.042 ± 0.027	1.147SerAsn: 1.147 ± 0.026	2.705SerPro: 2.705 ± 0.039	1.825SerGln: 1.825 ± 0.038	3.161SerArg: 3.161 ± 0.047	2.459SerSer: 2.459 ± 0.056	2.844SerThr: 2.844 ± 0.071	3.576SerVal: 3.576 ± 0.049	0.659SerTrp: 0.659 ± 0.02	0.989SerTyr: 0.989 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.265ThrAla: 7.265 ± 0.104	0.402ThrCys: 0.402 ± 0.017	2.797ThrAsp: 2.797 ± 0.055	2.202ThrGlu: 2.202 ± 0.035	1.408ThrPhe: 1.408 ± 0.029	5.104ThrGly: 5.104 ± 0.079	1.052ThrHis: 1.052 ± 0.02	1.838ThrIle: 1.838 ± 0.035	1.035ThrLys: 1.035 ± 0.028	6.775ThrLeu: 6.775 ± 0.106	1.032ThrMet: 1.032 ± 0.026	1.049ThrAsn: 1.049 ± 0.026	3.877ThrPro: 3.877 ± 0.056	1.819ThrGln: 1.819 ± 0.048	3.226ThrArg: 3.226 ± 0.04	2.425ThrSer: 2.425 ± 0.059	3.145ThrThr: 3.145 ± 0.08	4.552ThrVal: 4.552 ± 0.061	0.766ThrTrp: 0.766 ± 0.02	0.91ThrTyr: 0.91 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.797ValAla: 10.797 ± 0.091	0.715ValCys: 0.715 ± 0.019	4.336ValAsp: 4.336 ± 0.054	3.336ValGlu: 3.336 ± 0.047	2.443ValPhe: 2.443 ± 0.042	5.671ValGly: 5.671 ± 0.059	1.691ValHis: 1.691 ± 0.032	2.756ValIle: 2.756 ± 0.046	1.909ValLys: 1.909 ± 0.043	9.03ValLeu: 9.03 ± 0.086	1.702ValMet: 1.702 ± 0.031	1.892ValAsn: 1.892 ± 0.04	4.411ValPro: 4.411 ± 0.062	3.531ValGln: 3.531 ± 0.049	5.208ValArg: 5.208 ± 0.059	3.669ValSer: 3.669 ± 0.05	3.85ValThr: 3.85 ± 0.066	6.615ValVal: 6.615 ± 0.07	1.062ValTrp: 1.062 ± 0.026	1.389ValTyr: 1.389 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.815TrpAla: 1.815 ± 0.034	0.186TrpCys: 0.186 ± 0.01	0.68TrpAsp: 0.68 ± 0.018	0.451TrpGlu: 0.451 ± 0.016	0.529TrpPhe: 0.529 ± 0.016	1.046TrpGly: 1.046 ± 0.024	0.405TrpHis: 0.405 ± 0.014	0.527TrpIle: 0.527 ± 0.019	0.38TrpLys: 0.38 ± 0.016	2.367TrpLeu: 2.367 ± 0.043	0.41TrpMet: 0.41 ± 0.016	0.379TrpAsn: 0.379 ± 0.015	0.918TrpPro: 0.918 ± 0.025	1.001TrpGln: 1.001 ± 0.026	1.461TrpArg: 1.461 ± 0.03	0.721TrpSer: 0.721 ± 0.017	0.763TrpThr: 0.763 ± 0.024	1.123TrpVal: 1.123 ± 0.026	0.333TrpTrp: 0.333 ± 0.014	0.27TrpTyr: 0.27 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.321TyrAla: 2.321 ± 0.036	0.187TyrCys: 0.187 ± 0.011	1.055TyrAsp: 1.055 ± 0.023	0.804TyrGlu: 0.804 ± 0.02	0.709TyrPhe: 0.709 ± 0.025	1.677TyrGly: 1.677 ± 0.031	0.372TyrHis: 0.372 ± 0.015	0.646TyrIle: 0.646 ± 0.022	0.517TyrLys: 0.517 ± 0.018	1.955TyrLeu: 1.955 ± 0.036	0.331TyrMet: 0.331 ± 0.014	0.504TyrAsn: 0.504 ± 0.017	0.925TyrPro: 0.925 ± 0.023	0.739TyrGln: 0.739 ± 0.022	1.431TyrArg: 1.431 ± 0.029	0.93TyrSer: 0.93 ± 0.026	1.139TyrThr: 1.139 ± 0.034	1.216TyrVal: 1.216 ± 0.029	0.304TyrTrp: 0.304 ± 0.013	0.401TyrTyr: 0.401 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5458 proteins (1884430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---