Amino acid dipepetide frequency for Thalassococcus halodurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.165AlaAla: 14.165 ± 0.168	1.041AlaCys: 1.041 ± 0.032	7.001AlaAsp: 7.001 ± 0.072	7.853AlaGlu: 7.853 ± 0.099	4.248AlaPhe: 4.248 ± 0.066	9.375AlaGly: 9.375 ± 0.099	2.088AlaHis: 2.088 ± 0.046	5.983AlaIle: 5.983 ± 0.072	4.563AlaLys: 4.563 ± 0.07	12.477AlaLeu: 12.477 ± 0.139	3.673AlaMet: 3.673 ± 0.057	2.974AlaAsn: 2.974 ± 0.055	4.993AlaPro: 4.993 ± 0.075	4.331AlaGln: 4.331 ± 0.066	7.098AlaArg: 7.098 ± 0.077	5.762AlaSer: 5.762 ± 0.083	5.873AlaThr: 5.873 ± 0.07	7.808AlaVal: 7.808 ± 0.094	1.325AlaTrp: 1.325 ± 0.032	2.52AlaTyr: 2.52 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.993CysAla: 0.993 ± 0.031	0.111CysCys: 0.111 ± 0.01	0.679CysAsp: 0.679 ± 0.028	0.452CysGlu: 0.452 ± 0.02	0.354CysPhe: 0.354 ± 0.018	0.919CysGly: 0.919 ± 0.027	0.294CysHis: 0.294 ± 0.019	0.437CysIle: 0.437 ± 0.018	0.244CysLys: 0.244 ± 0.015	0.841CysLeu: 0.841 ± 0.028	0.172CysMet: 0.172 ± 0.011	0.212CysAsn: 0.212 ± 0.013	0.506CysPro: 0.506 ± 0.023	0.245CysGln: 0.245 ± 0.015	0.476CysArg: 0.476 ± 0.019	0.498CysSer: 0.498 ± 0.022	0.465CysThr: 0.465 ± 0.021	0.651CysVal: 0.651 ± 0.024	0.1CysTrp: 0.1 ± 0.008	0.219CysTyr: 0.219 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.552AspAla: 7.552 ± 0.092	0.566AspCys: 0.566 ± 0.023	3.982AspAsp: 3.982 ± 0.087	3.825AspGlu: 3.825 ± 0.063	2.423AspPhe: 2.423 ± 0.048	5.841AspGly: 5.841 ± 0.104	1.458AspHis: 1.458 ± 0.038	3.516AspIle: 3.516 ± 0.055	2.045AspLys: 2.045 ± 0.045	6.555AspLeu: 6.555 ± 0.081	1.822AspMet: 1.822 ± 0.034	1.484AspAsn: 1.484 ± 0.039	3.578AspPro: 3.578 ± 0.055	2.35AspGln: 2.35 ± 0.048	4.122AspArg: 4.122 ± 0.067	2.38AspSer: 2.38 ± 0.052	3.409AspThr: 3.409 ± 0.061	4.75AspVal: 4.75 ± 0.062	1.179AspTrp: 1.179 ± 0.034	1.595AspTyr: 1.595 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.571GluAla: 7.571 ± 0.085	0.4GluCys: 0.4 ± 0.019	3.689GluAsp: 3.689 ± 0.063	3.86GluGlu: 3.86 ± 0.082	1.993GluPhe: 1.993 ± 0.044	4.803GluGly: 4.803 ± 0.072	1.147GluHis: 1.147 ± 0.03	3.63GluIle: 3.63 ± 0.067	2.702GluLys: 2.702 ± 0.052	5.381GluLeu: 5.381 ± 0.076	1.921GluMet: 1.921 ± 0.043	2.153GluAsn: 2.153 ± 0.039	2.51GluPro: 2.51 ± 0.058	2.188GluGln: 2.188 ± 0.039	3.999GluArg: 3.999 ± 0.069	2.284GluSer: 2.284 ± 0.043	4.039GluThr: 4.039 ± 0.067	4.311GluVal: 4.311 ± 0.072	0.763GluTrp: 0.763 ± 0.026	1.193GluTyr: 1.193 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.414PheAla: 4.414 ± 0.063	0.429PheCys: 0.429 ± 0.018	3.038PheAsp: 3.038 ± 0.053	2.383PheGlu: 2.383 ± 0.046	1.527PhePhe: 1.527 ± 0.041	3.83PheGly: 3.83 ± 0.064	0.769PheHis: 0.769 ± 0.03	1.727PheIle: 1.727 ± 0.042	1.144PheLys: 1.144 ± 0.035	3.547PheLeu: 3.547 ± 0.071	0.929PheMet: 0.929 ± 0.028	1.173PheAsn: 1.173 ± 0.032	1.507PhePro: 1.507 ± 0.038	1.179PheGln: 1.179 ± 0.031	2.097PheArg: 2.097 ± 0.043	2.224PheSer: 2.224 ± 0.049	2.106PheThr: 2.106 ± 0.044	2.843PheVal: 2.843 ± 0.049	0.576PheTrp: 0.576 ± 0.022	1.012PheTyr: 1.012 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.983GlyAla: 8.983 ± 0.101	0.852GlyCys: 0.852 ± 0.031	5.04GlyAsp: 5.04 ± 0.083	4.557GlyGlu: 4.557 ± 0.069	3.703GlyPhe: 3.703 ± 0.053	6.846GlyGly: 6.846 ± 0.109	1.86GlyHis: 1.86 ± 0.042	4.538GlyIle: 4.538 ± 0.082	3.35GlyLys: 3.35 ± 0.059	8.63GlyLeu: 8.63 ± 0.087	2.462GlyMet: 2.462 ± 0.05	2.236GlyAsn: 2.236 ± 0.058	3.41GlyPro: 3.41 ± 0.053	3.288GlyGln: 3.288 ± 0.059	5.077GlyArg: 5.077 ± 0.078	4.257GlySer: 4.257 ± 0.078	4.708GlyThr: 4.708 ± 0.079	6.353GlyVal: 6.353 ± 0.086	1.287GlyTrp: 1.287 ± 0.035	2.313GlyTyr: 2.313 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.083HisAla: 2.083 ± 0.048	0.228HisCys: 0.228 ± 0.012	1.251HisAsp: 1.251 ± 0.039	1.023HisGlu: 1.023 ± 0.03	0.857HisPhe: 0.857 ± 0.026	1.836HisGly: 1.836 ± 0.039	0.551HisHis: 0.551 ± 0.027	1.028HisIle: 1.028 ± 0.032	0.624HisLys: 0.624 ± 0.021	2.032HisLeu: 2.032 ± 0.048	0.547HisMet: 0.547 ± 0.022	0.507HisAsn: 0.507 ± 0.02	1.298HisPro: 1.298 ± 0.035	0.626HisGln: 0.626 ± 0.023	1.159HisArg: 1.159 ± 0.031	0.989HisSer: 0.989 ± 0.029	0.871HisThr: 0.871 ± 0.027	1.507HisVal: 1.507 ± 0.038	0.348HisTrp: 0.348 ± 0.018	0.533HisTyr: 0.533 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.004IleAla: 7.004 ± 0.076	0.63IleCys: 0.63 ± 0.023	3.767IleAsp: 3.767 ± 0.065	3.8IleGlu: 3.8 ± 0.062	1.874IlePhe: 1.874 ± 0.037	4.777IleGly: 4.777 ± 0.062	0.956IleHis: 0.956 ± 0.033	2.507IleIle: 2.507 ± 0.056	1.806IleLys: 1.806 ± 0.039	4.965IleLeu: 4.965 ± 0.068	1.214IleMet: 1.214 ± 0.033	1.549IleAsn: 1.549 ± 0.04	2.403IlePro: 2.403 ± 0.043	1.47IleGln: 1.47 ± 0.036	3.146IleArg: 3.146 ± 0.051	3.241IleSer: 3.241 ± 0.051	3.16IleThr: 3.16 ± 0.053	3.874IleVal: 3.874 ± 0.067	0.723IleTrp: 0.723 ± 0.025	1.223IleTyr: 1.223 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.566LysAla: 4.566 ± 0.065	0.2LysCys: 0.2 ± 0.012	2.223LysAsp: 2.223 ± 0.049	1.959LysGlu: 1.959 ± 0.056	1.095LysPhe: 1.095 ± 0.031	3.05LysGly: 3.05 ± 0.054	0.706LysHis: 0.706 ± 0.024	2.012LysIle: 2.012 ± 0.044	1.551LysLys: 1.551 ± 0.05	3.469LysLeu: 3.469 ± 0.053	1.012LysMet: 1.012 ± 0.029	1.103LysAsn: 1.103 ± 0.03	2.029LysPro: 2.029 ± 0.053	1.12LysGln: 1.12 ± 0.034	2.465LysArg: 2.465 ± 0.059	2.23LysSer: 2.23 ± 0.047	2.367LysThr: 2.367 ± 0.042	2.635LysVal: 2.635 ± 0.059	0.432LysTrp: 0.432 ± 0.018	0.752LysTyr: 0.752 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.361LeuAla: 11.361 ± 0.122	0.914LeuCys: 0.914 ± 0.031	6.065LeuAsp: 6.065 ± 0.076	5.483LeuGlu: 5.483 ± 0.075	3.649LeuPhe: 3.649 ± 0.063	8.019LeuGly: 8.019 ± 0.087	1.756LeuHis: 1.756 ± 0.042	5.395LeuIle: 5.395 ± 0.084	3.668LeuLys: 3.668 ± 0.057	8.444LeuLeu: 8.444 ± 0.121	2.718LeuMet: 2.718 ± 0.058	3.06LeuAsn: 3.06 ± 0.054	5.219LeuPro: 5.219 ± 0.077	2.782LeuGln: 2.782 ± 0.051	6.271LeuArg: 6.271 ± 0.091	6.978LeuSer: 6.978 ± 0.09	6.115LeuThr: 6.115 ± 0.082	6.606LeuVal: 6.606 ± 0.079	1.273LeuTrp: 1.273 ± 0.038	1.979LeuTyr: 1.979 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.409MetAla: 3.409 ± 0.048	0.234MetCys: 0.234 ± 0.013	1.569MetAsp: 1.569 ± 0.035	1.346MetGlu: 1.346 ± 0.037	0.924MetPhe: 0.924 ± 0.027	2.326MetGly: 2.326 ± 0.048	0.49MetHis: 0.49 ± 0.021	1.658MetIle: 1.658 ± 0.038	1.258MetLys: 1.258 ± 0.035	2.552MetLeu: 2.552 ± 0.048	0.828MetMet: 0.828 ± 0.027	0.896MetAsn: 0.896 ± 0.028	1.494MetPro: 1.494 ± 0.037	0.983MetGln: 0.983 ± 0.032	1.798MetArg: 1.798 ± 0.036	1.862MetSer: 1.862 ± 0.042	2.159MetThr: 2.159 ± 0.043	1.9MetVal: 1.9 ± 0.05	0.248MetTrp: 0.248 ± 0.016	0.364MetTyr: 0.364 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.484AsnAla: 3.484 ± 0.057	0.311AsnCys: 0.311 ± 0.017	1.843AsnAsp: 1.843 ± 0.055	1.424AsnGlu: 1.424 ± 0.032	1.083AsnPhe: 1.083 ± 0.033	2.734AsnGly: 2.734 ± 0.064	0.551AsnHis: 0.551 ± 0.022	1.588AsnIle: 1.588 ± 0.039	0.823AsnLys: 0.823 ± 0.024	2.768AsnLeu: 2.768 ± 0.059	0.803AsnMet: 0.803 ± 0.027	0.801AsnAsn: 0.801 ± 0.032	1.927AsnPro: 1.927 ± 0.043	0.843AsnGln: 0.843 ± 0.025	1.826AsnArg: 1.826 ± 0.038	1.422AsnSer: 1.422 ± 0.033	1.488AsnThr: 1.488 ± 0.042	2.064AsnVal: 2.064 ± 0.042	0.468AsnTrp: 0.468 ± 0.02	0.715AsnTyr: 0.715 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.021ProAla: 5.021 ± 0.069	0.356ProCys: 0.356 ± 0.018	4.144ProAsp: 4.144 ± 0.07	4.193ProGlu: 4.193 ± 0.067	1.958ProPhe: 1.958 ± 0.039	3.327ProGly: 3.327 ± 0.048	0.991ProHis: 0.991 ± 0.027	2.343ProIle: 2.343 ± 0.048	1.977ProLys: 1.977 ± 0.053	4.338ProLeu: 4.338 ± 0.063	1.329ProMet: 1.329 ± 0.034	1.52ProAsn: 1.52 ± 0.032	1.87ProPro: 1.87 ± 0.048	1.573ProGln: 1.573 ± 0.038	2.496ProArg: 2.496 ± 0.056	2.613ProSer: 2.613 ± 0.048	2.513ProThr: 2.513 ± 0.05	3.998ProVal: 3.998 ± 0.06	0.635ProTrp: 0.635 ± 0.026	1.095ProTyr: 1.095 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.94GlnAla: 3.94 ± 0.056	0.215GlnCys: 0.215 ± 0.013	1.877GlnAsp: 1.877 ± 0.037	1.782GlnGlu: 1.782 ± 0.035	1.179GlnPhe: 1.179 ± 0.029	2.596GlnGly: 2.596 ± 0.052	0.606GlnHis: 0.606 ± 0.021	2.231GlnIle: 2.231 ± 0.044	1.317GlnLys: 1.317 ± 0.031	2.993GlnLeu: 2.993 ± 0.056	1.087GlnMet: 1.087 ± 0.034	1.108GlnAsn: 1.108 ± 0.033	1.652GlnPro: 1.652 ± 0.042	1.148GlnGln: 1.148 ± 0.036	2.101GlnArg: 2.101 ± 0.043	2.074GlnSer: 2.074 ± 0.045	2.027GlnThr: 2.027 ± 0.041	2.483GlnVal: 2.483 ± 0.049	0.393GlnTrp: 0.393 ± 0.017	0.627GlnTyr: 0.627 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.816ArgAla: 6.816 ± 0.087	0.427ArgCys: 0.427 ± 0.018	4.08ArgAsp: 4.08 ± 0.073	3.584ArgGlu: 3.584 ± 0.065	2.591ArgPhe: 2.591 ± 0.05	4.03ArgGly: 4.03 ± 0.063	1.358ArgHis: 1.358 ± 0.038	3.738ArgIle: 3.738 ± 0.061	2.522ArgLys: 2.522 ± 0.045	6.424ArgLeu: 6.424 ± 0.089	1.801ArgMet: 1.801 ± 0.041	1.826ArgAsn: 1.826 ± 0.038	2.797ArgPro: 2.797 ± 0.055	2.176ArgGln: 2.176 ± 0.043	4.162ArgArg: 4.162 ± 0.066	3.125ArgSer: 3.125 ± 0.057	2.818ArgThr: 2.818 ± 0.045	4.372ArgVal: 4.372 ± 0.068	0.825ArgTrp: 0.825 ± 0.028	1.463ArgTyr: 1.463 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.841SerAla: 5.841 ± 0.07	0.418SerCys: 0.418 ± 0.019	3.746SerAsp: 3.746 ± 0.062	3.355SerGlu: 3.355 ± 0.05	2.358SerPhe: 2.358 ± 0.046	5.448SerGly: 5.448 ± 0.083	1.073SerHis: 1.073 ± 0.027	2.741SerIle: 2.741 ± 0.057	1.908SerLys: 1.908 ± 0.041	5.243SerLeu: 5.243 ± 0.076	1.542SerMet: 1.542 ± 0.034	1.633SerAsn: 1.633 ± 0.038	2.438SerPro: 2.438 ± 0.046	1.77SerGln: 1.77 ± 0.039	3.089SerArg: 3.089 ± 0.058	2.875SerSer: 2.875 ± 0.061	2.707SerThr: 2.707 ± 0.051	4.13SerVal: 4.13 ± 0.062	0.679SerTrp: 0.679 ± 0.023	1.409SerTyr: 1.409 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.042ThrAla: 6.042 ± 0.073	0.507ThrCys: 0.507 ± 0.024	3.61ThrAsp: 3.61 ± 0.072	3.248ThrGlu: 3.248 ± 0.063	2.141ThrPhe: 2.141 ± 0.045	5.445ThrGly: 5.445 ± 0.083	1.101ThrHis: 1.101 ± 0.029	2.927ThrIle: 2.927 ± 0.057	1.783ThrLys: 1.783 ± 0.038	5.993ThrLeu: 5.993 ± 0.073	1.33ThrMet: 1.33 ± 0.032	1.545ThrAsn: 1.545 ± 0.041	3.403ThrPro: 3.403 ± 0.061	1.845ThrGln: 1.845 ± 0.041	3.241ThrArg: 3.241 ± 0.056	2.936ThrSer: 2.936 ± 0.05	2.937ThrThr: 2.937 ± 0.065	4.542ThrVal: 4.542 ± 0.074	0.676ThrTrp: 0.676 ± 0.023	1.351ThrTyr: 1.351 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.23ValAla: 8.23 ± 0.096	0.64ValCys: 0.64 ± 0.024	4.319ValAsp: 4.319 ± 0.074	4.466ValGlu: 4.466 ± 0.069	2.983ValPhe: 2.983 ± 0.052	5.366ValGly: 5.366 ± 0.07	1.289ValHis: 1.289 ± 0.036	4.329ValIle: 4.329 ± 0.063	2.463ValLys: 2.463 ± 0.045	7.336ValLeu: 7.336 ± 0.093	2.192ValMet: 2.192 ± 0.045	2.101ValAsn: 2.101 ± 0.045	3.527ValPro: 3.527 ± 0.056	2.232ValGln: 2.232 ± 0.044	3.919ValArg: 3.919 ± 0.056	4.6ValSer: 4.6 ± 0.066	4.88ValThr: 4.88 ± 0.076	5.594ValVal: 5.594 ± 0.083	0.955ValTrp: 0.955 ± 0.029	1.52ValTyr: 1.52 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.277TrpAla: 1.277 ± 0.036	0.129TrpCys: 0.129 ± 0.011	0.787TrpAsp: 0.787 ± 0.023	0.604TrpGlu: 0.604 ± 0.023	0.537TrpPhe: 0.537 ± 0.022	1.016TrpGly: 1.016 ± 0.027	0.331TrpHis: 0.331 ± 0.017	0.745TrpIle: 0.745 ± 0.026	0.523TrpLys: 0.523 ± 0.02	1.487TrpLeu: 1.487 ± 0.043	0.433TrpMet: 0.433 ± 0.02	0.449TrpAsn: 0.449 ± 0.019	0.669TrpPro: 0.669 ± 0.022	0.516TrpGln: 0.516 ± 0.019	0.973TrpArg: 0.973 ± 0.029	0.801TrpSer: 0.801 ± 0.026	0.787TrpThr: 0.787 ± 0.024	0.916TrpVal: 0.916 ± 0.034	0.193TrpTrp: 0.193 ± 0.013	0.264TrpTyr: 0.264 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.397TyrAla: 2.397 ± 0.039	0.259TyrCys: 0.259 ± 0.016	1.721TyrAsp: 1.721 ± 0.038	1.343TyrGlu: 1.343 ± 0.037	0.979TyrPhe: 0.979 ± 0.03	2.164TyrGly: 2.164 ± 0.05	0.522TyrHis: 0.522 ± 0.021	1.018TyrIle: 1.018 ± 0.029	0.709TyrLys: 0.709 ± 0.027	2.281TyrLeu: 2.281 ± 0.045	0.483TyrMet: 0.483 ± 0.021	0.639TyrAsn: 0.639 ± 0.024	1.058TyrPro: 1.058 ± 0.025	0.77TyrGln: 0.77 ± 0.026	1.418TyrArg: 1.418 ± 0.035	1.252TyrSer: 1.252 ± 0.036	1.174TyrThr: 1.174 ± 0.037	1.603TyrVal: 1.603 ± 0.039	0.358TyrTrp: 0.358 ± 0.017	0.626TyrTyr: 0.626 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3829 proteins (1203994 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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