Amino acid dipepetide frequency for Streptococcus satellite phage Javan9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.8AlaCys: 0.8 ± 0.385
3.467AlaAsp: 3.467 ± 1.19
3.733AlaGlu: 3.733 ± 0.96
2.933AlaPhe: 2.933 ± 0.746
1.067AlaGly: 1.067 ± 0.523
0.0AlaHis: 0.0 ± 0.0
6.667AlaIle: 6.667 ± 0.858
4.533AlaLys: 4.533 ± 0.848
4.267AlaLeu: 4.267 ± 1.047
1.067AlaMet: 1.067 ± 0.467
4.267AlaAsn: 4.267 ± 0.971
1.867AlaPro: 1.867 ± 0.594
1.6AlaGln: 1.6 ± 0.686
2.4AlaArg: 2.4 ± 0.76
2.4AlaSer: 2.4 ± 0.775
3.733AlaThr: 3.733 ± 0.989
2.667AlaVal: 2.667 ± 0.924
1.333AlaTrp: 1.333 ± 0.768
2.667AlaTyr: 2.667 ± 0.703
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.533CysAsp: 0.533 ± 0.361
0.267CysGlu: 0.267 ± 0.247
0.0CysPhe: 0.0 ± 0.0
0.533CysGly: 0.533 ± 0.366
0.533CysHis: 0.533 ± 0.356
0.0CysIle: 0.0 ± 0.0
0.267CysLys: 0.267 ± 0.22
1.067CysLeu: 1.067 ± 0.481
0.0CysMet: 0.0 ± 0.0
1.067CysAsn: 1.067 ± 0.482
0.267CysPro: 0.267 ± 0.247
0.533CysGln: 0.533 ± 0.493
0.8CysArg: 0.8 ± 0.4
0.533CysSer: 0.533 ± 0.43
0.0CysThr: 0.0 ± 0.0
0.267CysVal: 0.267 ± 0.254
0.0CysTrp: 0.0 ± 0.0
0.533CysTyr: 0.533 ± 0.52
0.0CysXaa: 0.0 ± 0.0
Asp
0.533AspAla: 0.533 ± 0.399
0.8AspCys: 0.8 ± 0.386
2.4AspAsp: 2.4 ± 0.698
4.0AspGlu: 4.0 ± 1.011
5.333AspPhe: 5.333 ± 1.184
1.6AspGly: 1.6 ± 0.472
1.067AspHis: 1.067 ± 0.458
5.067AspIle: 5.067 ± 1.262
6.4AspLys: 6.4 ± 1.566
5.867AspLeu: 5.867 ± 0.818
2.4AspMet: 2.4 ± 0.891
2.133AspAsn: 2.133 ± 0.762
1.6AspPro: 1.6 ± 0.57
1.067AspGln: 1.067 ± 0.425
4.0AspArg: 4.0 ± 0.589
2.133AspSer: 2.133 ± 0.616
2.933AspThr: 2.933 ± 0.998
1.867AspVal: 1.867 ± 0.771
0.8AspTrp: 0.8 ± 0.379
3.733AspTyr: 3.733 ± 1.219
0.0AspXaa: 0.0 ± 0.0
Glu
6.4GluAla: 6.4 ± 0.869
0.267GluCys: 0.267 ± 0.247
4.8GluAsp: 4.8 ± 1.168
5.6GluGlu: 5.6 ± 1.42
1.867GluPhe: 1.867 ± 0.507
2.933GluGly: 2.933 ± 0.662
2.4GluHis: 2.4 ± 0.798
5.867GluIle: 5.867 ± 0.98
7.733GluLys: 7.733 ± 1.106
11.467GluLeu: 11.467 ± 1.752
2.133GluMet: 2.133 ± 0.846
4.267GluAsn: 4.267 ± 0.893
1.067GluPro: 1.067 ± 0.414
4.533GluGln: 4.533 ± 1.16
4.267GluArg: 4.267 ± 0.851
3.467GluSer: 3.467 ± 1.199
5.333GluThr: 5.333 ± 0.794
4.0GluVal: 4.0 ± 1.354
0.533GluTrp: 0.533 ± 0.299
3.733GluTyr: 3.733 ± 1.0
0.0GluXaa: 0.0 ± 0.0
Phe
2.133PheAla: 2.133 ± 0.579
0.267PheCys: 0.267 ± 0.22
3.2PheAsp: 3.2 ± 1.225
4.0PheGlu: 4.0 ± 0.807
1.6PhePhe: 1.6 ± 0.598
2.4PheGly: 2.4 ± 0.854
1.067PheHis: 1.067 ± 0.405
4.267PheIle: 4.267 ± 1.154
4.267PheLys: 4.267 ± 0.716
3.733PheLeu: 3.733 ± 0.724
0.0PheMet: 0.0 ± 0.0
5.067PheAsn: 5.067 ± 0.877
0.533PhePro: 0.533 ± 0.359
1.333PheGln: 1.333 ± 0.5
2.933PheArg: 2.933 ± 0.874
3.733PheSer: 3.733 ± 0.877
1.6PheThr: 1.6 ± 0.874
1.6PheVal: 1.6 ± 0.615
0.533PheTrp: 0.533 ± 0.299
2.667PheTyr: 2.667 ± 0.631
0.0PheXaa: 0.0 ± 0.0
Gly
2.933GlyAla: 2.933 ± 1.036
0.533GlyCys: 0.533 ± 0.403
2.133GlyAsp: 2.133 ± 1.079
3.467GlyGlu: 3.467 ± 0.944
2.667GlyPhe: 2.667 ± 0.836
1.067GlyGly: 1.067 ± 0.457
0.533GlyHis: 0.533 ± 0.347
2.933GlyIle: 2.933 ± 0.689
4.267GlyLys: 4.267 ± 0.992
5.333GlyLeu: 5.333 ± 1.283
0.8GlyMet: 0.8 ± 0.411
1.6GlyAsn: 1.6 ± 0.918
1.067GlyPro: 1.067 ± 0.583
1.067GlyGln: 1.067 ± 0.597
1.867GlyArg: 1.867 ± 0.646
1.6GlySer: 1.6 ± 0.566
2.667GlyThr: 2.667 ± 0.753
1.6GlyVal: 1.6 ± 0.544
0.533GlyTrp: 0.533 ± 0.439
3.2GlyTyr: 3.2 ± 1.115
0.0GlyXaa: 0.0 ± 0.0
His
1.6HisAla: 1.6 ± 0.702
0.0HisCys: 0.0 ± 0.0
0.8HisAsp: 0.8 ± 0.411
0.533HisGlu: 0.533 ± 0.312
1.867HisPhe: 1.867 ± 0.533
1.067HisGly: 1.067 ± 0.502
0.0HisHis: 0.0 ± 0.0
1.6HisIle: 1.6 ± 0.741
2.133HisLys: 2.133 ± 0.785
2.133HisLeu: 2.133 ± 0.651
0.0HisMet: 0.0 ± 0.0
0.533HisAsn: 0.533 ± 0.31
0.0HisPro: 0.0 ± 0.0
1.6HisGln: 1.6 ± 0.742
0.267HisArg: 0.267 ± 0.285
1.067HisSer: 1.067 ± 0.357
1.6HisThr: 1.6 ± 0.572
0.533HisVal: 0.533 ± 0.359
0.533HisTrp: 0.533 ± 0.493
2.667HisTyr: 2.667 ± 0.754
0.0HisXaa: 0.0 ± 0.0
Ile
4.0IleAla: 4.0 ± 1.127
0.8IleCys: 0.8 ± 0.407
4.8IleAsp: 4.8 ± 0.812
6.667IleGlu: 6.667 ± 1.28
3.467IlePhe: 3.467 ± 0.916
3.2IleGly: 3.2 ± 0.781
1.333IleHis: 1.333 ± 0.607
5.333IleIle: 5.333 ± 1.328
10.133IleLys: 10.133 ± 1.354
3.733IleLeu: 3.733 ± 0.724
1.333IleMet: 1.333 ± 0.788
4.0IleAsn: 4.0 ± 1.116
2.933IlePro: 2.933 ± 0.733
2.133IleGln: 2.133 ± 0.995
2.4IleArg: 2.4 ± 0.756
4.267IleSer: 4.267 ± 1.176
6.133IleThr: 6.133 ± 1.0
2.933IleVal: 2.933 ± 0.672
0.0IleTrp: 0.0 ± 0.0
5.067IleTyr: 5.067 ± 0.864
0.0IleXaa: 0.0 ± 0.0
Lys
6.4LysAla: 6.4 ± 1.54
0.533LysCys: 0.533 ± 0.366
4.0LysAsp: 4.0 ± 1.148
8.533LysGlu: 8.533 ± 1.475
3.733LysPhe: 3.733 ± 0.931
4.533LysGly: 4.533 ± 1.059
2.667LysHis: 2.667 ± 0.73
5.6LysIle: 5.6 ± 1.326
7.733LysLys: 7.733 ± 1.604
7.467LysLeu: 7.467 ± 1.265
2.4LysMet: 2.4 ± 0.724
4.8LysAsn: 4.8 ± 1.054
6.133LysPro: 6.133 ± 1.408
4.0LysGln: 4.0 ± 1.198
5.867LysArg: 5.867 ± 1.161
6.133LysSer: 6.133 ± 1.548
4.533LysThr: 4.533 ± 1.111
4.8LysVal: 4.8 ± 0.816
0.8LysTrp: 0.8 ± 0.55
4.8LysTyr: 4.8 ± 1.248
0.0LysXaa: 0.0 ± 0.0
Leu
4.8LeuAla: 4.8 ± 1.449
0.533LeuCys: 0.533 ± 0.392
6.933LeuAsp: 6.933 ± 1.268
10.667LeuGlu: 10.667 ± 2.352
6.133LeuPhe: 6.133 ± 1.164
4.0LeuGly: 4.0 ± 1.064
1.067LeuHis: 1.067 ± 0.476
5.6LeuIle: 5.6 ± 1.435
8.8LeuLys: 8.8 ± 1.654
7.2LeuLeu: 7.2 ± 1.374
3.2LeuMet: 3.2 ± 0.831
6.133LeuAsn: 6.133 ± 1.599
2.667LeuPro: 2.667 ± 0.939
2.4LeuGln: 2.4 ± 0.877
2.667LeuArg: 2.667 ± 0.719
7.467LeuSer: 7.467 ± 1.264
5.6LeuThr: 5.6 ± 1.024
5.067LeuVal: 5.067 ± 1.026
0.533LeuTrp: 0.533 ± 0.341
3.467LeuTyr: 3.467 ± 0.671
0.0LeuXaa: 0.0 ± 0.0
Met
1.333MetAla: 1.333 ± 0.637
0.0MetCys: 0.0 ± 0.0
1.333MetAsp: 1.333 ± 0.562
1.067MetGlu: 1.067 ± 0.352
0.267MetPhe: 0.267 ± 0.332
1.333MetGly: 1.333 ± 0.529
0.0MetHis: 0.0 ± 0.0
2.133MetIle: 2.133 ± 0.716
1.333MetLys: 1.333 ± 0.477
3.467MetLeu: 3.467 ± 0.833
0.267MetMet: 0.267 ± 0.264
1.867MetAsn: 1.867 ± 0.772
0.267MetPro: 0.267 ± 0.22
0.267MetGln: 0.267 ± 0.279
1.067MetArg: 1.067 ± 0.436
1.067MetSer: 1.067 ± 0.49
2.4MetThr: 2.4 ± 0.915
1.067MetVal: 1.067 ± 0.447
0.0MetTrp: 0.0 ± 0.0
0.533MetTyr: 0.533 ± 0.411
0.0MetXaa: 0.0 ± 0.0
Asn
4.533AsnAla: 4.533 ± 0.926
0.267AsnCys: 0.267 ± 0.26
2.667AsnAsp: 2.667 ± 0.776
4.267AsnGlu: 4.267 ± 0.988
1.067AsnPhe: 1.067 ± 0.476
3.733AsnGly: 3.733 ± 1.023
1.867AsnHis: 1.867 ± 0.692
5.067AsnIle: 5.067 ± 1.141
5.867AsnLys: 5.867 ± 0.843
5.333AsnLeu: 5.333 ± 1.243
1.333AsnMet: 1.333 ± 0.777
2.667AsnAsn: 2.667 ± 0.851
2.933AsnPro: 2.933 ± 0.681
3.2AsnGln: 3.2 ± 0.857
3.2AsnArg: 3.2 ± 0.63
2.4AsnSer: 2.4 ± 0.582
2.4AsnThr: 2.4 ± 1.155
3.467AsnVal: 3.467 ± 0.979
0.267AsnTrp: 0.267 ± 0.279
2.4AsnTyr: 2.4 ± 0.69
0.0AsnXaa: 0.0 ± 0.0
Pro
1.333ProAla: 1.333 ± 0.43
0.267ProCys: 0.267 ± 0.332
1.867ProAsp: 1.867 ± 0.511
3.2ProGlu: 3.2 ± 1.049
1.6ProPhe: 1.6 ± 0.651
0.267ProGly: 0.267 ± 0.247
0.267ProHis: 0.267 ± 0.26
1.067ProIle: 1.067 ± 0.644
5.067ProLys: 5.067 ± 1.259
3.733ProLeu: 3.733 ± 0.898
0.533ProMet: 0.533 ± 0.328
2.4ProAsn: 2.4 ± 1.062
1.333ProPro: 1.333 ± 0.49
1.067ProGln: 1.067 ± 0.67
2.667ProArg: 2.667 ± 0.824
1.867ProSer: 1.867 ± 0.639
1.333ProThr: 1.333 ± 0.497
2.133ProVal: 2.133 ± 0.917
0.267ProTrp: 0.267 ± 0.22
1.333ProTyr: 1.333 ± 0.538
0.0ProXaa: 0.0 ± 0.0
Gln
2.933GlnAla: 2.933 ± 0.548
0.0GlnCys: 0.0 ± 0.0
1.6GlnAsp: 1.6 ± 0.709
5.067GlnGlu: 5.067 ± 1.323
1.067GlnPhe: 1.067 ± 0.447
1.333GlnGly: 1.333 ± 0.491
0.533GlnHis: 0.533 ± 0.41
2.133GlnIle: 2.133 ± 0.607
2.4GlnLys: 2.4 ± 0.738
4.8GlnLeu: 4.8 ± 1.198
0.267GlnMet: 0.267 ± 0.27
2.4GlnAsn: 2.4 ± 0.83
1.333GlnPro: 1.333 ± 0.52
1.867GlnGln: 1.867 ± 0.482
2.4GlnArg: 2.4 ± 0.64
2.4GlnSer: 2.4 ± 0.867
1.867GlnThr: 1.867 ± 0.547
2.133GlnVal: 2.133 ± 0.692
0.8GlnTrp: 0.8 ± 0.51
1.6GlnTyr: 1.6 ± 0.844
0.0GlnXaa: 0.0 ± 0.0
Arg
1.6ArgAla: 1.6 ± 0.675
0.267ArgCys: 0.267 ± 0.247
1.867ArgAsp: 1.867 ± 0.721
4.0ArgGlu: 4.0 ± 1.115
2.133ArgPhe: 2.133 ± 0.509
2.4ArgGly: 2.4 ± 1.138
2.133ArgHis: 2.133 ± 0.767
4.533ArgIle: 4.533 ± 0.978
2.933ArgLys: 2.933 ± 0.743
5.867ArgLeu: 5.867 ± 1.443
0.267ArgMet: 0.267 ± 0.241
4.0ArgAsn: 4.0 ± 1.098
1.333ArgPro: 1.333 ± 0.535
2.4ArgGln: 2.4 ± 0.728
1.867ArgArg: 1.867 ± 0.596
1.867ArgSer: 1.867 ± 0.593
3.467ArgThr: 3.467 ± 1.271
4.267ArgVal: 4.267 ± 0.824
0.533ArgTrp: 0.533 ± 0.381
2.933ArgTyr: 2.933 ± 0.861
0.0ArgXaa: 0.0 ± 0.0
Ser
2.4SerAla: 2.4 ± 0.939
0.267SerCys: 0.267 ± 0.247
4.533SerAsp: 4.533 ± 0.961
5.867SerGlu: 5.867 ± 1.459
2.933SerPhe: 2.933 ± 0.514
1.6SerGly: 1.6 ± 0.607
1.067SerHis: 1.067 ± 0.426
5.067SerIle: 5.067 ± 1.128
5.6SerLys: 5.6 ± 1.3
4.0SerLeu: 4.0 ± 0.853
1.6SerMet: 1.6 ± 0.796
2.133SerAsn: 2.133 ± 0.561
1.333SerPro: 1.333 ± 0.454
3.2SerGln: 3.2 ± 1.059
1.867SerArg: 1.867 ± 0.644
2.667SerSer: 2.667 ± 0.944
2.933SerThr: 2.933 ± 0.831
2.933SerVal: 2.933 ± 0.927
0.533SerTrp: 0.533 ± 0.342
3.733SerTyr: 3.733 ± 1.076
0.0SerXaa: 0.0 ± 0.0
Thr
4.533ThrAla: 4.533 ± 1.191
0.267ThrCys: 0.267 ± 0.26
3.2ThrAsp: 3.2 ± 0.978
3.733ThrGlu: 3.733 ± 0.759
2.933ThrPhe: 2.933 ± 1.457
4.0ThrGly: 4.0 ± 0.971
1.867ThrHis: 1.867 ± 0.655
4.533ThrIle: 4.533 ± 1.073
4.267ThrLys: 4.267 ± 1.325
5.867ThrLeu: 5.867 ± 1.105
1.067ThrMet: 1.067 ± 0.532
2.4ThrAsn: 2.4 ± 0.969
2.933ThrPro: 2.933 ± 0.695
2.4ThrGln: 2.4 ± 0.647
3.467ThrArg: 3.467 ± 0.709
2.4ThrSer: 2.4 ± 0.632
1.867ThrThr: 1.867 ± 0.679
2.933ThrVal: 2.933 ± 1.345
0.533ThrTrp: 0.533 ± 0.32
2.4ThrTyr: 2.4 ± 0.803
0.0ThrXaa: 0.0 ± 0.0
Val
2.133ValAla: 2.133 ± 0.701
0.533ValCys: 0.533 ± 0.312
1.867ValAsp: 1.867 ± 0.66
3.733ValGlu: 3.733 ± 1.26
2.667ValPhe: 2.667 ± 0.706
2.133ValGly: 2.133 ± 0.642
0.8ValHis: 0.8 ± 0.567
4.0ValIle: 4.0 ± 1.124
4.8ValLys: 4.8 ± 0.922
4.8ValLeu: 4.8 ± 1.148
1.067ValMet: 1.067 ± 0.615
2.933ValAsn: 2.933 ± 0.799
1.867ValPro: 1.867 ± 0.956
1.6ValGln: 1.6 ± 0.72
1.6ValArg: 1.6 ± 0.58
4.267ValSer: 4.267 ± 1.011
5.6ValThr: 5.6 ± 1.168
3.2ValVal: 3.2 ± 0.905
0.267ValTrp: 0.267 ± 0.239
1.067ValTyr: 1.067 ± 0.575
0.0ValXaa: 0.0 ± 0.0
Trp
0.267TrpAla: 0.267 ± 0.241
0.0TrpCys: 0.0 ± 0.0
0.8TrpAsp: 0.8 ± 0.516
1.333TrpGlu: 1.333 ± 0.514
0.267TrpPhe: 0.267 ± 0.27
0.0TrpGly: 0.0 ± 0.0
0.267TrpHis: 0.267 ± 0.22
0.533TrpIle: 0.533 ± 0.303
0.8TrpLys: 0.8 ± 0.4
1.067TrpLeu: 1.067 ± 0.447
0.0TrpMet: 0.0 ± 0.0
0.267TrpAsn: 0.267 ± 0.241
0.267TrpPro: 0.267 ± 0.22
0.267TrpGln: 0.267 ± 0.22
0.8TrpArg: 0.8 ± 0.413
0.8TrpSer: 0.8 ± 0.376
0.0TrpThr: 0.0 ± 0.0
1.067TrpVal: 1.067 ± 0.441
0.533TrpTrp: 0.533 ± 0.359
0.267TrpTyr: 0.267 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.867TyrAla: 1.867 ± 0.659
0.8TyrCys: 0.8 ± 0.387
2.933TyrAsp: 2.933 ± 0.695
2.933TyrGlu: 2.933 ± 0.81
2.4TyrPhe: 2.4 ± 0.909
2.667TyrGly: 2.667 ± 0.832
1.067TyrHis: 1.067 ± 0.455
2.667TyrIle: 2.667 ± 0.83
6.133TyrLys: 6.133 ± 1.447
3.733TyrLeu: 3.733 ± 0.841
1.067TyrMet: 1.067 ± 0.596
4.0TyrAsn: 4.0 ± 1.034
1.867TyrPro: 1.867 ± 0.763
2.4TyrGln: 2.4 ± 0.764
4.267TyrArg: 4.267 ± 1.294
3.733TyrSer: 3.733 ± 1.166
1.6TyrThr: 1.6 ± 0.565
2.4TyrVal: 2.4 ± 0.632
0.267TyrTrp: 0.267 ± 0.247
2.133TyrTyr: 2.133 ± 0.958
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski