Amino acid dipepetide frequency for Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf spot fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.721AlaAla: 9.721 ± 0.067	0.991AlaCys: 0.991 ± 0.016	4.209AlaAsp: 4.209 ± 0.031	5.436AlaGlu: 5.436 ± 0.046	3.169AlaPhe: 3.169 ± 0.029	6.088AlaGly: 6.088 ± 0.047	1.714AlaHis: 1.714 ± 0.019	4.291AlaIle: 4.291 ± 0.032	4.464AlaLys: 4.464 ± 0.036	7.728AlaLeu: 7.728 ± 0.047	1.972AlaMet: 1.972 ± 0.022	2.947AlaAsn: 2.947 ± 0.029	5.229AlaPro: 5.229 ± 0.043	3.415AlaGln: 3.415 ± 0.03	5.189AlaArg: 5.189 ± 0.04	7.586AlaSer: 7.586 ± 0.051	5.394AlaThr: 5.394 ± 0.039	5.225AlaVal: 5.225 ± 0.034	1.076AlaTrp: 1.076 ± 0.015	2.105AlaTyr: 2.105 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.012	0.219CysCys: 0.219 ± 0.007	0.595CysAsp: 0.595 ± 0.011	0.594CysGlu: 0.594 ± 0.013	0.517CysPhe: 0.517 ± 0.009	0.907CysGly: 0.907 ± 0.016	0.302CysHis: 0.302 ± 0.008	0.631CysIle: 0.631 ± 0.014	0.547CysLys: 0.547 ± 0.013	1.138CysLeu: 1.138 ± 0.018	0.247CysMet: 0.247 ± 0.007	0.415CysAsn: 0.415 ± 0.01	0.648CysPro: 0.648 ± 0.013	0.407CysGln: 0.407 ± 0.008	0.712CysArg: 0.712 ± 0.014	0.909CysSer: 0.909 ± 0.014	0.683CysThr: 0.683 ± 0.013	0.727CysVal: 0.727 ± 0.013	0.2CysTrp: 0.2 ± 0.007	0.355CysTyr: 0.355 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.59AspAla: 4.59 ± 0.032	0.616AspCys: 0.616 ± 0.013	4.14AspAsp: 4.14 ± 0.042	4.497AspGlu: 4.497 ± 0.041	2.188AspPhe: 2.188 ± 0.02	4.15AspGly: 4.15 ± 0.032	1.193AspHis: 1.193 ± 0.017	2.825AspIle: 2.825 ± 0.027	2.264AspLys: 2.264 ± 0.024	4.984AspLeu: 4.984 ± 0.033	1.227AspMet: 1.227 ± 0.015	1.749AspAsn: 1.749 ± 0.022	3.247AspPro: 3.247 ± 0.026	1.778AspGln: 1.778 ± 0.019	3.029AspArg: 3.029 ± 0.029	4.138AspSer: 4.138 ± 0.039	2.78AspThr: 2.78 ± 0.023	3.456AspVal: 3.456 ± 0.023	0.79AspTrp: 0.79 ± 0.014	1.47AspTyr: 1.47 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.567GluAla: 5.567 ± 0.044	0.608GluCys: 0.608 ± 0.012	4.408GluAsp: 4.408 ± 0.038	6.146GluGlu: 6.146 ± 0.067	1.934GluPhe: 1.934 ± 0.018	4.184GluGly: 4.184 ± 0.03	1.299GluHis: 1.299 ± 0.016	3.217GluIle: 3.217 ± 0.031	4.159GluLys: 4.159 ± 0.038	5.101GluLeu: 5.101 ± 0.034	1.586GluMet: 1.586 ± 0.02	2.317GluAsn: 2.317 ± 0.023	2.826GluPro: 2.826 ± 0.033	2.349GluGln: 2.349 ± 0.026	4.204GluArg: 4.204 ± 0.038	4.39GluSer: 4.39 ± 0.039	3.318GluThr: 3.318 ± 0.029	3.743GluVal: 3.743 ± 0.03	0.837GluTrp: 0.837 ± 0.015	1.625GluTyr: 1.625 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.11PheAla: 3.11 ± 0.03	0.525PheCys: 0.525 ± 0.012	2.141PheAsp: 2.141 ± 0.019	2.165PheGlu: 2.165 ± 0.023	1.517PhePhe: 1.517 ± 0.022	2.803PheGly: 2.803 ± 0.03	0.815PheHis: 0.815 ± 0.013	1.686PheIle: 1.686 ± 0.024	1.669PheLys: 1.669 ± 0.019	3.281PheLeu: 3.281 ± 0.032	0.761PheMet: 0.761 ± 0.011	1.428PheAsn: 1.428 ± 0.016	1.936PhePro: 1.936 ± 0.019	1.341PheGln: 1.341 ± 0.018	1.891PheArg: 1.891 ± 0.019	3.033PheSer: 3.033 ± 0.026	2.133PheThr: 2.133 ± 0.024	2.301PheVal: 2.301 ± 0.024	0.574PheTrp: 0.574 ± 0.013	1.054PheTyr: 1.054 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.386GlyAla: 5.386 ± 0.042	0.831GlyCys: 0.831 ± 0.012	3.717GlyAsp: 3.717 ± 0.031	4.073GlyGlu: 4.073 ± 0.039	2.78GlyPhe: 2.78 ± 0.029	6.537GlyGly: 6.537 ± 0.062	1.582GlyHis: 1.582 ± 0.02	3.463GlyIle: 3.463 ± 0.029	3.75GlyLys: 3.75 ± 0.034	5.992GlyLeu: 5.992 ± 0.04	1.697GlyMet: 1.697 ± 0.021	2.665GlyAsn: 2.665 ± 0.031	3.537GlyPro: 3.537 ± 0.032	2.429GlyGln: 2.429 ± 0.025	4.401GlyArg: 4.401 ± 0.036	5.955GlySer: 5.955 ± 0.036	4.005GlyThr: 4.005 ± 0.031	4.346GlyVal: 4.346 ± 0.036	1.125GlyTrp: 1.125 ± 0.017	2.085GlyTyr: 2.085 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.768HisAla: 1.768 ± 0.021	0.308HisCys: 0.308 ± 0.007	1.198HisAsp: 1.198 ± 0.015	1.276HisGlu: 1.276 ± 0.016	0.84HisPhe: 0.84 ± 0.014	1.618HisGly: 1.618 ± 0.02	0.837HisHis: 0.837 ± 0.016	1.087HisIle: 1.087 ± 0.018	0.912HisLys: 0.912 ± 0.012	2.081HisLeu: 2.081 ± 0.023	0.464HisMet: 0.464 ± 0.009	0.786HisAsn: 0.786 ± 0.013	1.635HisPro: 1.635 ± 0.02	0.961HisGln: 0.961 ± 0.014	1.429HisArg: 1.429 ± 0.018	1.803HisSer: 1.803 ± 0.023	1.236HisThr: 1.236 ± 0.019	1.317HisVal: 1.317 ± 0.019	0.28HisTrp: 0.28 ± 0.007	0.625HisTyr: 0.625 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.156IleAla: 4.156 ± 0.035	0.693IleCys: 0.693 ± 0.012	2.812IleAsp: 2.812 ± 0.021	2.926IleGlu: 2.926 ± 0.031	1.934IlePhe: 1.934 ± 0.023	3.06IleGly: 3.06 ± 0.026	1.118IleHis: 1.118 ± 0.014	2.428IleIle: 2.428 ± 0.028	2.412IleLys: 2.412 ± 0.025	4.452IleLeu: 4.452 ± 0.035	1.019IleMet: 1.019 ± 0.014	1.797IleAsn: 1.797 ± 0.021	3.133IlePro: 3.133 ± 0.029	1.831IleGln: 1.831 ± 0.018	2.792IleArg: 2.792 ± 0.024	4.005IleSer: 4.005 ± 0.03	2.871IleThr: 2.871 ± 0.026	2.992IleVal: 2.992 ± 0.024	0.65IleTrp: 0.65 ± 0.013	1.333IleTyr: 1.333 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.778LysAla: 4.778 ± 0.043	0.522LysCys: 0.522 ± 0.012	2.861LysAsp: 2.861 ± 0.031	3.826LysGlu: 3.826 ± 0.042	1.554LysPhe: 1.554 ± 0.017	3.293LysGly: 3.293 ± 0.03	1.131LysHis: 1.131 ± 0.015	2.534LysIle: 2.534 ± 0.018	4.025LysLys: 4.025 ± 0.06	4.213LysLeu: 4.213 ± 0.04	1.171LysMet: 1.171 ± 0.016	1.903LysAsn: 1.903 ± 0.02	2.893LysPro: 2.893 ± 0.029	1.906LysGln: 1.906 ± 0.021	3.673LysArg: 3.673 ± 0.036	3.975LysSer: 3.975 ± 0.036	3.006LysThr: 3.006 ± 0.027	2.993LysVal: 2.993 ± 0.029	0.659LysTrp: 0.659 ± 0.013	1.352LysTyr: 1.352 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.822LeuAla: 7.822 ± 0.049	1.081LeuCys: 1.081 ± 0.014	4.873LeuAsp: 4.873 ± 0.037	5.405LeuGlu: 5.405 ± 0.045	3.147LeuPhe: 3.147 ± 0.033	5.8LeuGly: 5.8 ± 0.039	1.99LeuHis: 1.99 ± 0.022	3.81LeuIle: 3.81 ± 0.036	4.55LeuLys: 4.55 ± 0.04	8.05LeuLeu: 8.05 ± 0.054	1.772LeuMet: 1.772 ± 0.02	3.1LeuAsn: 3.1 ± 0.027	5.569LeuPro: 5.569 ± 0.04	3.603LeuGln: 3.603 ± 0.031	5.641LeuArg: 5.641 ± 0.039	7.108LeuSer: 7.108 ± 0.047	4.745LeuThr: 4.745 ± 0.034	5.215LeuVal: 5.215 ± 0.04	1.087LeuTrp: 1.087 ± 0.019	2.196LeuTyr: 2.196 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.235MetAla: 2.235 ± 0.02	0.222MetCys: 0.222 ± 0.007	1.254MetAsp: 1.254 ± 0.017	1.351MetGlu: 1.351 ± 0.018	0.733MetPhe: 0.733 ± 0.014	1.57MetGly: 1.57 ± 0.022	0.463MetHis: 0.463 ± 0.011	0.996MetIle: 0.996 ± 0.016	1.109MetLys: 1.109 ± 0.015	1.826MetLeu: 1.826 ± 0.022	0.583MetMet: 0.583 ± 0.015	0.833MetAsn: 0.833 ± 0.014	1.295MetPro: 1.295 ± 0.017	0.893MetGln: 0.893 ± 0.015	1.293MetArg: 1.293 ± 0.016	1.93MetSer: 1.93 ± 0.023	1.248MetThr: 1.248 ± 0.017	1.318MetVal: 1.318 ± 0.017	0.247MetTrp: 0.247 ± 0.007	0.512MetTyr: 0.512 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.053AsnAla: 3.053 ± 0.028	0.454AsnCys: 0.454 ± 0.01	1.878AsnAsp: 1.878 ± 0.02	1.965AsnGlu: 1.965 ± 0.024	1.413AsnPhe: 1.413 ± 0.018	3.01AsnGly: 3.01 ± 0.029	0.831AsnHis: 0.831 ± 0.014	1.968AsnIle: 1.968 ± 0.021	1.625AsnLys: 1.625 ± 0.022	3.193AsnLeu: 3.193 ± 0.029	0.835AsnMet: 0.835 ± 0.013	1.544AsnAsn: 1.544 ± 0.024	2.52AsnPro: 2.52 ± 0.023	1.31AsnGln: 1.31 ± 0.021	1.966AsnArg: 1.966 ± 0.02	2.949AsnSer: 2.949 ± 0.027	2.233AsnThr: 2.233 ± 0.022	2.189AsnVal: 2.189 ± 0.024	0.505AsnTrp: 0.505 ± 0.011	1.042AsnTyr: 1.042 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.797ProAla: 5.797 ± 0.049	0.508ProCys: 0.508 ± 0.011	3.022ProAsp: 3.022 ± 0.025	3.749ProGlu: 3.749 ± 0.034	2.078ProPhe: 2.078 ± 0.02	4.122ProGly: 4.122 ± 0.04	1.279ProHis: 1.279 ± 0.017	2.634ProIle: 2.634 ± 0.026	2.95ProLys: 2.95 ± 0.031	4.832ProLeu: 4.832 ± 0.036	1.102ProMet: 1.102 ± 0.02	2.242ProAsn: 2.242 ± 0.024	5.71ProPro: 5.71 ± 0.064	2.473ProGln: 2.473 ± 0.036	3.734ProArg: 3.734 ± 0.034	6.329ProSer: 6.329 ± 0.053	4.175ProThr: 4.175 ± 0.034	3.711ProVal: 3.711 ± 0.028	0.646ProTrp: 0.646 ± 0.01	1.453ProTyr: 1.453 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.484GlnAla: 3.484 ± 0.028	0.389GlnCys: 0.389 ± 0.009	1.975GlnAsp: 1.975 ± 0.022	2.359GlnGlu: 2.359 ± 0.024	1.205GlnPhe: 1.205 ± 0.017	2.315GlnGly: 2.315 ± 0.027	1.052GlnHis: 1.052 ± 0.017	1.868GlnIle: 1.868 ± 0.021	2.08GlnLys: 2.08 ± 0.023	3.185GlnLeu: 3.185 ± 0.028	0.912GlnMet: 0.912 ± 0.016	1.567GlnAsn: 1.567 ± 0.02	2.476GlnPro: 2.476 ± 0.028	2.534GlnGln: 2.534 ± 0.067	2.595GlnArg: 2.595 ± 0.024	3.069GlnSer: 3.069 ± 0.031	2.175GlnThr: 2.175 ± 0.024	2.103GlnVal: 2.103 ± 0.021	0.478GlnTrp: 0.478 ± 0.01	1.098GlnTyr: 1.098 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.02ArgAla: 5.02 ± 0.042	0.725ArgCys: 0.725 ± 0.014	3.304ArgAsp: 3.304 ± 0.027	4.179ArgGlu: 4.179 ± 0.037	2.068ArgPhe: 2.068 ± 0.021	4.135ArgGly: 4.135 ± 0.041	1.466ArgHis: 1.466 ± 0.018	2.948ArgIle: 2.948 ± 0.033	3.807ArgLys: 3.807 ± 0.031	5.249ArgLeu: 5.249 ± 0.035	1.366ArgMet: 1.366 ± 0.018	2.322ArgAsn: 2.322 ± 0.022	3.668ArgPro: 3.668 ± 0.032	2.501ArgGln: 2.501 ± 0.026	5.234ArgArg: 5.234 ± 0.048	5.11ArgSer: 5.11 ± 0.046	3.316ArgThr: 3.316 ± 0.026	3.313ArgVal: 3.313 ± 0.027	0.846ArgTrp: 0.846 ± 0.013	1.611ArgTyr: 1.611 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.965SerAla: 6.965 ± 0.04	0.89SerCys: 0.89 ± 0.015	4.069SerAsp: 4.069 ± 0.035	4.368SerGlu: 4.368 ± 0.039	3.056SerPhe: 3.056 ± 0.028	5.728SerGly: 5.728 ± 0.035	1.905SerHis: 1.905 ± 0.023	4.122SerIle: 4.122 ± 0.033	4.161SerLys: 4.161 ± 0.035	7.176SerLeu: 7.176 ± 0.045	1.754SerMet: 1.754 ± 0.021	3.085SerAsn: 3.085 ± 0.03	6.073SerPro: 6.073 ± 0.061	3.31SerGln: 3.31 ± 0.03	5.32SerArg: 5.32 ± 0.04	9.579SerSer: 9.579 ± 0.09	5.789SerThr: 5.789 ± 0.049	4.457SerVal: 4.457 ± 0.035	1.037SerTrp: 1.037 ± 0.017	2.039SerTyr: 2.039 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.231ThrAla: 5.231 ± 0.035	0.703ThrCys: 0.703 ± 0.014	2.739ThrAsp: 2.739 ± 0.026	3.047ThrGlu: 3.047 ± 0.027	2.221ThrPhe: 2.221 ± 0.025	4.127ThrGly: 4.127 ± 0.036	1.236ThrHis: 1.236 ± 0.016	3.085ThrIle: 3.085 ± 0.028	2.794ThrLys: 2.794 ± 0.026	5.122ThrLeu: 5.122 ± 0.039	1.201ThrMet: 1.201 ± 0.018	2.105ThrAsn: 2.105 ± 0.023	4.55ThrPro: 4.55 ± 0.047	2.081ThrGln: 2.081 ± 0.023	3.282ThrArg: 3.282 ± 0.027	5.558ThrSer: 5.558 ± 0.047	4.402ThrThr: 4.402 ± 0.036	3.465ThrVal: 3.465 ± 0.029	0.754ThrTrp: 0.754 ± 0.013	1.574ThrTyr: 1.574 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.294ValAla: 5.294 ± 0.035	0.747ValCys: 0.747 ± 0.012	3.538ValAsp: 3.538 ± 0.03	4.08ValGlu: 4.08 ± 0.03	2.246ValPhe: 2.246 ± 0.025	4.015ValGly: 4.015 ± 0.033	1.248ValHis: 1.248 ± 0.016	2.793ValIle: 2.793 ± 0.028	3.061ValLys: 3.061 ± 0.029	5.306ValLeu: 5.306 ± 0.037	1.299ValMet: 1.299 ± 0.017	2.064ValAsn: 2.064 ± 0.019	3.612ValPro: 3.612 ± 0.031	2.229ValGln: 2.229 ± 0.021	3.398ValArg: 3.398 ± 0.026	4.511ValSer: 4.511 ± 0.034	3.35ValThr: 3.35 ± 0.027	4.256ValVal: 4.256 ± 0.038	0.8ValTrp: 0.8 ± 0.015	1.587ValTyr: 1.587 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.035TrpAla: 1.035 ± 0.015	0.178TrpCys: 0.178 ± 0.006	0.817TrpAsp: 0.817 ± 0.015	0.832TrpGlu: 0.832 ± 0.014	0.474TrpPhe: 0.474 ± 0.011	0.883TrpGly: 0.883 ± 0.016	0.299TrpHis: 0.299 ± 0.009	0.692TrpIle: 0.692 ± 0.014	0.782TrpLys: 0.782 ± 0.013	1.174TrpLeu: 1.174 ± 0.015	0.372TrpMet: 0.372 ± 0.009	0.561TrpAsn: 0.561 ± 0.011	0.545TrpPro: 0.545 ± 0.01	0.493TrpGln: 0.493 ± 0.01	0.855TrpArg: 0.855 ± 0.014	0.946TrpSer: 0.946 ± 0.015	0.841TrpThr: 0.841 ± 0.013	0.803TrpVal: 0.803 ± 0.013	0.26TrpTrp: 0.26 ± 0.007	0.381TrpTyr: 0.381 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.02	0.411TyrCys: 0.411 ± 0.01	1.56TyrAsp: 1.56 ± 0.02	1.545TyrGlu: 1.545 ± 0.017	1.091TyrPhe: 1.091 ± 0.015	2.014TyrGly: 2.014 ± 0.021	0.699TyrHis: 0.699 ± 0.012	1.336TyrIle: 1.336 ± 0.017	1.148TyrLys: 1.148 ± 0.015	2.481TyrLeu: 2.481 ± 0.027	0.572TyrMet: 0.572 ± 0.01	1.054TyrAsn: 1.054 ± 0.017	1.444TyrPro: 1.444 ± 0.02	1.073TyrGln: 1.073 ± 0.019	1.55TyrArg: 1.55 ± 0.018	1.998TyrSer: 1.998 ± 0.022	1.578TyrThr: 1.578 ± 0.019	1.504TyrVal: 1.504 ± 0.018	0.37TyrTrp: 0.37 ± 0.009	0.913TyrTyr: 0.913 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10037 proteins (4975927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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