Amino acid dipepetide frequency for Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.173AlaAla: 19.173 ± 0.179	1.129AlaCys: 1.129 ± 0.034	7.719AlaAsp: 7.719 ± 0.094	7.434AlaGlu: 7.434 ± 0.094	4.38AlaPhe: 4.38 ± 0.065	11.501AlaGly: 11.501 ± 0.114	2.4AlaHis: 2.4 ± 0.051	6.68AlaIle: 6.68 ± 0.077	3.888AlaLys: 3.888 ± 0.069	14.087AlaLeu: 14.087 ± 0.134	4.118AlaMet: 4.118 ± 0.07	3.017AlaAsn: 3.017 ± 0.056	6.347AlaPro: 6.347 ± 0.102	4.73AlaGln: 4.73 ± 0.066	10.008AlaArg: 10.008 ± 0.101	6.559AlaSer: 6.559 ± 0.082	6.145AlaThr: 6.145 ± 0.08	8.511AlaVal: 8.511 ± 0.097	1.582AlaTrp: 1.582 ± 0.035	2.641AlaTyr: 2.641 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.062CysAla: 1.062 ± 0.027	0.102CysCys: 0.102 ± 0.008	0.508CysAsp: 0.508 ± 0.021	0.407CysGlu: 0.407 ± 0.019	0.295CysPhe: 0.295 ± 0.016	0.883CysGly: 0.883 ± 0.029	0.226CysHis: 0.226 ± 0.018	0.392CysIle: 0.392 ± 0.019	0.164CysLys: 0.164 ± 0.01	0.705CysLeu: 0.705 ± 0.025	0.182CysMet: 0.182 ± 0.013	0.189CysAsn: 0.189 ± 0.014	0.492CysPro: 0.492 ± 0.024	0.202CysGln: 0.202 ± 0.013	0.631CysArg: 0.631 ± 0.022	0.454CysSer: 0.454 ± 0.02	0.368CysThr: 0.368 ± 0.016	0.553CysVal: 0.553 ± 0.021	0.123CysTrp: 0.123 ± 0.01	0.176CysTyr: 0.176 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.532AspAla: 7.532 ± 0.087	0.48AspCys: 0.48 ± 0.019	3.247AspAsp: 3.247 ± 0.069	3.298AspGlu: 3.298 ± 0.057	2.166AspPhe: 2.166 ± 0.039	5.748AspGly: 5.748 ± 0.113	1.441AspHis: 1.441 ± 0.041	3.078AspIle: 3.078 ± 0.054	1.595AspLys: 1.595 ± 0.04	5.856AspLeu: 5.856 ± 0.072	1.616AspMet: 1.616 ± 0.04	1.432AspAsn: 1.432 ± 0.033	3.681AspPro: 3.681 ± 0.056	1.781AspGln: 1.781 ± 0.034	5.141AspArg: 5.141 ± 0.081	2.409AspSer: 2.409 ± 0.045	2.246AspThr: 2.246 ± 0.061	3.917AspVal: 3.917 ± 0.055	1.083AspTrp: 1.083 ± 0.032	1.709AspTyr: 1.709 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.668GluAla: 7.668 ± 0.105	0.306GluCys: 0.306 ± 0.017	2.704GluAsp: 2.704 ± 0.048	3.245GluGlu: 3.245 ± 0.067	1.42GluPhe: 1.42 ± 0.036	4.714GluGly: 4.714 ± 0.07	1.052GluHis: 1.052 ± 0.031	2.886GluIle: 2.886 ± 0.054	2.095GluLys: 2.095 ± 0.04	4.852GluLeu: 4.852 ± 0.073	1.426GluMet: 1.426 ± 0.029	1.353GluAsn: 1.353 ± 0.032	2.436GluPro: 2.436 ± 0.043	2.085GluGln: 2.085 ± 0.034	5.073GluArg: 5.073 ± 0.074	2.367GluSer: 2.367 ± 0.047	2.89GluThr: 2.89 ± 0.051	3.29GluVal: 3.29 ± 0.053	0.722GluTrp: 0.722 ± 0.023	0.945GluTyr: 0.945 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.726PheAla: 4.726 ± 0.06	0.353PheCys: 0.353 ± 0.017	2.583PheAsp: 2.583 ± 0.051	1.905PheGlu: 1.905 ± 0.039	1.262PhePhe: 1.262 ± 0.036	3.57PheGly: 3.57 ± 0.053	0.773PheHis: 0.773 ± 0.026	1.487PheIle: 1.487 ± 0.036	0.821PheLys: 0.821 ± 0.026	3.24PheLeu: 3.24 ± 0.051	0.779PheMet: 0.779 ± 0.027	1.011PheAsn: 1.011 ± 0.029	1.549PhePro: 1.549 ± 0.036	0.961PheGln: 0.961 ± 0.027	2.407PheArg: 2.407 ± 0.045	2.086PheSer: 2.086 ± 0.044	1.961PheThr: 1.961 ± 0.042	2.369PheVal: 2.369 ± 0.039	0.514PheTrp: 0.514 ± 0.022	0.908PheTyr: 0.908 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.299GlyAla: 10.299 ± 0.109	0.815GlyCys: 0.815 ± 0.025	4.998GlyAsp: 4.998 ± 0.097	4.88GlyGlu: 4.88 ± 0.061	3.628GlyPhe: 3.628 ± 0.059	8.404GlyGly: 8.404 ± 0.14	1.993GlyHis: 1.993 ± 0.04	4.433GlyIle: 4.433 ± 0.064	3.271GlyLys: 3.271 ± 0.064	8.826GlyLeu: 8.826 ± 0.092	2.495GlyMet: 2.495 ± 0.047	2.426GlyAsn: 2.426 ± 0.066	3.772GlyPro: 3.772 ± 0.067	3.245GlyGln: 3.245 ± 0.054	7.063GlyArg: 7.063 ± 0.083	4.943GlySer: 4.943 ± 0.084	4.536GlyThr: 4.536 ± 0.077	6.059GlyVal: 6.059 ± 0.069	1.657GlyTrp: 1.657 ± 0.037	2.257GlyTyr: 2.257 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.488HisAla: 2.488 ± 0.048	0.225HisCys: 0.225 ± 0.014	1.346HisAsp: 1.346 ± 0.036	0.988HisGlu: 0.988 ± 0.031	0.881HisPhe: 0.881 ± 0.026	2.118HisGly: 2.118 ± 0.044	0.62HisHis: 0.62 ± 0.024	0.975HisIle: 0.975 ± 0.032	0.436HisLys: 0.436 ± 0.018	1.99HisLeu: 1.99 ± 0.042	0.537HisMet: 0.537 ± 0.023	0.453HisAsn: 0.453 ± 0.018	1.318HisPro: 1.318 ± 0.035	0.579HisGln: 0.579 ± 0.021	1.582HisArg: 1.582 ± 0.042	1.008HisSer: 1.008 ± 0.028	0.524HisThr: 0.524 ± 0.021	1.641HisVal: 1.641 ± 0.037	0.362HisTrp: 0.362 ± 0.017	0.621HisTyr: 0.621 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.667IleAla: 7.667 ± 0.089	0.444IleCys: 0.444 ± 0.018	3.854IleAsp: 3.854 ± 0.057	3.181IleGlu: 3.181 ± 0.06	1.747IlePhe: 1.747 ± 0.033	5.109IleGly: 5.109 ± 0.066	0.901IleHis: 0.901 ± 0.025	2.069IleIle: 2.069 ± 0.039	1.194IleLys: 1.194 ± 0.028	4.325IleLeu: 4.325 ± 0.068	0.975IleMet: 0.975 ± 0.03	1.3IleAsn: 1.3 ± 0.033	2.248IlePro: 2.248 ± 0.038	1.214IleGln: 1.214 ± 0.028	3.417IleArg: 3.417 ± 0.054	2.742IleSer: 2.742 ± 0.048	2.287IleThr: 2.287 ± 0.044	4.137IleVal: 4.137 ± 0.065	0.645IleTrp: 0.645 ± 0.024	0.993IleTyr: 0.993 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.198LysAla: 4.198 ± 0.067	0.165LysCys: 0.165 ± 0.011	1.592LysAsp: 1.592 ± 0.042	1.309LysGlu: 1.309 ± 0.037	0.792LysPhe: 0.792 ± 0.025	2.821LysGly: 2.821 ± 0.05	0.489LysHis: 0.489 ± 0.017	1.475LysIle: 1.475 ± 0.038	1.087LysLys: 1.087 ± 0.035	3.025LysLeu: 3.025 ± 0.054	0.781LysMet: 0.781 ± 0.026	0.69LysAsn: 0.69 ± 0.025	1.961LysPro: 1.961 ± 0.045	0.875LysGln: 0.875 ± 0.025	2.215LysArg: 2.215 ± 0.048	1.557LysSer: 1.557 ± 0.033	1.534LysThr: 1.534 ± 0.042	2.134LysVal: 2.134 ± 0.044	0.403LysTrp: 0.403 ± 0.017	0.541LysTyr: 0.541 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.881LeuAla: 13.881 ± 0.126	0.922LeuCys: 0.922 ± 0.027	6.061LeuAsp: 6.061 ± 0.071	4.689LeuGlu: 4.689 ± 0.08	3.779LeuPhe: 3.779 ± 0.059	8.306LeuGly: 8.306 ± 0.079	1.943LeuHis: 1.943 ± 0.035	4.942LeuIle: 4.942 ± 0.07	3.053LeuLys: 3.053 ± 0.053	9.927LeuLeu: 9.927 ± 0.128	2.283LeuMet: 2.283 ± 0.049	2.516LeuAsn: 2.516 ± 0.047	5.792LeuPro: 5.792 ± 0.076	2.512LeuGln: 2.512 ± 0.046	7.269LeuArg: 7.269 ± 0.097	6.453LeuSer: 6.453 ± 0.074	5.393LeuThr: 5.393 ± 0.061	6.796LeuVal: 6.796 ± 0.072	1.296LeuTrp: 1.296 ± 0.032	1.991LeuTyr: 1.991 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.635MetAla: 3.635 ± 0.064	0.142MetCys: 0.142 ± 0.011	1.224MetAsp: 1.224 ± 0.031	1.25MetGlu: 1.25 ± 0.038	0.671MetPhe: 0.671 ± 0.022	2.012MetGly: 2.012 ± 0.045	0.457MetHis: 0.457 ± 0.022	1.341MetIle: 1.341 ± 0.037	0.979MetLys: 0.979 ± 0.03	2.776MetLeu: 2.776 ± 0.048	0.725MetMet: 0.725 ± 0.024	0.741MetAsn: 0.741 ± 0.022	1.554MetPro: 1.554 ± 0.033	0.81MetGln: 0.81 ± 0.022	1.9MetArg: 1.9 ± 0.034	1.522MetSer: 1.522 ± 0.035	1.766MetThr: 1.766 ± 0.039	1.635MetVal: 1.635 ± 0.041	0.199MetTrp: 0.199 ± 0.011	0.226MetTyr: 0.226 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.27AsnAla: 3.27 ± 0.052	0.236AsnCys: 0.236 ± 0.014	1.454AsnAsp: 1.454 ± 0.049	1.118AsnGlu: 1.118 ± 0.031	0.932AsnPhe: 0.932 ± 0.028	2.632AsnGly: 2.632 ± 0.065	0.47AsnHis: 0.47 ± 0.019	1.337AsnIle: 1.337 ± 0.038	0.635AsnLys: 0.635 ± 0.025	2.473AsnLeu: 2.473 ± 0.048	0.578AsnMet: 0.578 ± 0.021	0.674AsnAsn: 0.674 ± 0.029	1.728AsnPro: 1.728 ± 0.038	0.806AsnGln: 0.806 ± 0.023	1.983AsnArg: 1.983 ± 0.035	1.317AsnSer: 1.317 ± 0.039	0.881AsnThr: 0.881 ± 0.029	1.82AsnVal: 1.82 ± 0.044	0.44AsnTrp: 0.44 ± 0.02	0.683AsnTyr: 0.683 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.129ProAla: 7.129 ± 0.094	0.363ProCys: 0.363 ± 0.018	3.776ProAsp: 3.776 ± 0.056	3.309ProGlu: 3.309 ± 0.056	1.929ProPhe: 1.929 ± 0.036	4.827ProGly: 4.827 ± 0.07	1.071ProHis: 1.071 ± 0.026	2.439ProIle: 2.439 ± 0.042	1.41ProLys: 1.41 ± 0.036	5.109ProLeu: 5.109 ± 0.064	1.342ProMet: 1.342 ± 0.031	1.253ProAsn: 1.253 ± 0.034	2.997ProPro: 2.997 ± 0.064	1.735ProGln: 1.735 ± 0.038	3.213ProArg: 3.213 ± 0.057	2.866ProSer: 2.866 ± 0.051	2.53ProThr: 2.53 ± 0.051	4.369ProVal: 4.369 ± 0.073	0.722ProTrp: 0.722 ± 0.024	1.079ProTyr: 1.079 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.564GlnAla: 4.564 ± 0.063	0.242GlnCys: 0.242 ± 0.014	1.521GlnAsp: 1.521 ± 0.033	1.444GlnGlu: 1.444 ± 0.036	1.008GlnPhe: 1.008 ± 0.029	2.708GlnGly: 2.708 ± 0.045	0.611GlnHis: 0.611 ± 0.021	1.848GlnIle: 1.848 ± 0.044	0.923GlnLys: 0.923 ± 0.031	3.033GlnLeu: 3.033 ± 0.053	0.87GlnMet: 0.87 ± 0.026	0.787GlnAsn: 0.787 ± 0.026	1.929GlnPro: 1.929 ± 0.045	1.256GlnGln: 1.256 ± 0.035	2.615GlnArg: 2.615 ± 0.045	1.775GlnSer: 1.775 ± 0.036	1.518GlnThr: 1.518 ± 0.034	2.299GlnVal: 2.299 ± 0.045	0.498GlnTrp: 0.498 ± 0.02	0.643GlnTyr: 0.643 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.932ArgAla: 8.932 ± 0.097	0.53ArgCys: 0.53 ± 0.021	4.409ArgAsp: 4.409 ± 0.065	4.084ArgGlu: 4.084 ± 0.069	3.197ArgPhe: 3.197 ± 0.055	5.263ArgGly: 5.263 ± 0.069	2.002ArgHis: 2.002 ± 0.044	4.408ArgIle: 4.408 ± 0.067	2.331ArgLys: 2.331 ± 0.045	8.744ArgLeu: 8.744 ± 0.11	2.054ArgMet: 2.054 ± 0.038	1.996ArgAsn: 1.996 ± 0.037	4.102ArgPro: 4.102 ± 0.06	2.856ArgGln: 2.856 ± 0.049	6.423ArgArg: 6.423 ± 0.086	4.0ArgSer: 4.0 ± 0.062	3.508ArgThr: 3.508 ± 0.059	4.646ArgVal: 4.646 ± 0.061	1.257ArgTrp: 1.257 ± 0.034	1.899ArgTyr: 1.899 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.536SerAla: 6.536 ± 0.075	0.478SerCys: 0.478 ± 0.022	3.141SerAsp: 3.141 ± 0.056	2.436SerGlu: 2.436 ± 0.039	2.272SerPhe: 2.272 ± 0.044	5.598SerGly: 5.598 ± 0.081	1.077SerHis: 1.077 ± 0.028	2.805SerIle: 2.805 ± 0.055	1.396SerLys: 1.396 ± 0.036	5.309SerLeu: 5.309 ± 0.062	1.284SerMet: 1.284 ± 0.032	1.377SerAsn: 1.377 ± 0.03	2.915SerPro: 2.915 ± 0.048	1.576SerGln: 1.576 ± 0.038	3.847SerArg: 3.847 ± 0.06	2.869SerSer: 2.869 ± 0.058	2.598SerThr: 2.598 ± 0.055	3.703SerVal: 3.703 ± 0.054	0.823SerTrp: 0.823 ± 0.028	1.413SerTyr: 1.413 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.004ThrAla: 6.004 ± 0.081	0.366ThrCys: 0.366 ± 0.016	2.753ThrAsp: 2.753 ± 0.05	2.189ThrGlu: 2.189 ± 0.042	1.569ThrPhe: 1.569 ± 0.035	5.117ThrGly: 5.117 ± 0.079	0.929ThrHis: 0.929 ± 0.026	2.751ThrIle: 2.751 ± 0.059	1.15ThrLys: 1.15 ± 0.035	5.608ThrLeu: 5.608 ± 0.07	1.064ThrMet: 1.064 ± 0.032	1.187ThrAsn: 1.187 ± 0.033	3.177ThrPro: 3.177 ± 0.057	1.439ThrGln: 1.439 ± 0.035	3.258ThrArg: 3.258 ± 0.047	2.479ThrSer: 2.479 ± 0.05	2.385ThrThr: 2.385 ± 0.045	4.009ThrVal: 4.009 ± 0.06	0.511ThrTrp: 0.511 ± 0.019	1.051ThrTyr: 1.051 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.232ValAla: 9.232 ± 0.09	0.479ValCys: 0.479 ± 0.02	4.309ValAsp: 4.309 ± 0.059	4.615ValGlu: 4.615 ± 0.067	1.974ValPhe: 1.974 ± 0.04	5.583ValGly: 5.583 ± 0.072	1.391ValHis: 1.391 ± 0.036	3.562ValIle: 3.562 ± 0.051	2.159ValLys: 2.159 ± 0.039	6.064ValLeu: 6.064 ± 0.068	1.607ValMet: 1.607 ± 0.039	1.985ValAsn: 1.985 ± 0.041	3.714ValPro: 3.714 ± 0.056	2.158ValGln: 2.158 ± 0.042	5.148ValArg: 5.148 ± 0.064	3.872ValSer: 3.872 ± 0.058	4.207ValThr: 4.207 ± 0.072	4.912ValVal: 4.912 ± 0.074	0.768ValTrp: 0.768 ± 0.026	1.352ValTyr: 1.352 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.407TrpAla: 1.407 ± 0.03	0.106TrpCys: 0.106 ± 0.009	0.717TrpAsp: 0.717 ± 0.03	0.591TrpGlu: 0.591 ± 0.021	0.552TrpPhe: 0.552 ± 0.02	0.967TrpGly: 0.967 ± 0.027	0.327TrpHis: 0.327 ± 0.016	0.711TrpIle: 0.711 ± 0.024	0.5TrpLys: 0.5 ± 0.023	1.762TrpLeu: 1.762 ± 0.039	0.381TrpMet: 0.381 ± 0.018	0.482TrpAsn: 0.482 ± 0.022	0.723TrpPro: 0.723 ± 0.027	0.578TrpGln: 0.578 ± 0.021	1.393TrpArg: 1.393 ± 0.033	0.92TrpSer: 0.92 ± 0.027	0.816TrpThr: 0.816 ± 0.025	0.753TrpVal: 0.753 ± 0.023	0.253TrpTrp: 0.253 ± 0.015	0.272TrpTyr: 0.272 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.053	0.231TyrCys: 0.231 ± 0.016	1.538TyrAsp: 1.538 ± 0.038	1.158TyrGlu: 1.158 ± 0.031	0.811TyrPhe: 0.811 ± 0.025	2.122TyrGly: 2.122 ± 0.046	0.522TyrHis: 0.522 ± 0.02	0.828TyrIle: 0.828 ± 0.028	0.557TyrLys: 0.557 ± 0.024	2.095TyrLeu: 2.095 ± 0.042	0.467TyrMet: 0.467 ± 0.018	0.599TyrAsn: 0.599 ± 0.026	1.033TyrPro: 1.033 ± 0.028	0.693TyrGln: 0.693 ± 0.025	2.054TyrArg: 2.054 ± 0.045	1.254TyrSer: 1.254 ± 0.034	0.904TyrThr: 0.904 ± 0.03	1.535TyrVal: 1.535 ± 0.033	0.352TyrTrp: 0.352 ± 0.016	0.617TyrTyr: 0.617 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4347 proteins (1313854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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