Amino acid dipepetide frequency for Bifidobacterium catulorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.796AlaAla: 13.796 ± 0.233
0.966AlaCys: 0.966 ± 0.038
7.983AlaAsp: 7.983 ± 0.145
6.144AlaGlu: 6.144 ± 0.13
3.444AlaPhe: 3.444 ± 0.074
9.18AlaGly: 9.18 ± 0.134
2.084AlaHis: 2.084 ± 0.057
5.666AlaIle: 5.666 ± 0.096
4.881AlaLys: 4.881 ± 0.127
9.642AlaLeu: 9.642 ± 0.127
3.175AlaMet: 3.175 ± 0.064
3.387AlaAsn: 3.387 ± 0.081
4.077AlaPro: 4.077 ± 0.102
3.626AlaGln: 3.626 ± 0.096
6.514AlaArg: 6.514 ± 0.118
6.318AlaSer: 6.318 ± 0.116
6.031AlaThr: 6.031 ± 0.112
9.048AlaVal: 9.048 ± 0.13
1.351AlaTrp: 1.351 ± 0.049
2.835AlaTyr: 2.835 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.032CysAla: 1.032 ± 0.043
0.123CysCys: 0.123 ± 0.014
0.552CysAsp: 0.552 ± 0.032
0.47CysGlu: 0.47 ± 0.024
0.296CysPhe: 0.296 ± 0.021
1.043CysGly: 1.043 ± 0.043
0.197CysHis: 0.197 ± 0.018
0.429CysIle: 0.429 ± 0.026
0.206CysLys: 0.206 ± 0.018
0.753CysLeu: 0.753 ± 0.033
0.212CysMet: 0.212 ± 0.016
0.235CysAsn: 0.235 ± 0.017
0.442CysPro: 0.442 ± 0.028
0.194CysGln: 0.194 ± 0.016
0.617CysArg: 0.617 ± 0.032
0.523CysSer: 0.523 ± 0.028
0.467CysThr: 0.467 ± 0.028
0.77CysVal: 0.77 ± 0.032
0.098CysTrp: 0.098 ± 0.011
0.216CysTyr: 0.216 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
8.226AspAla: 8.226 ± 0.14
0.538AspCys: 0.538 ± 0.028
5.899AspAsp: 5.899 ± 0.138
4.811AspGlu: 4.811 ± 0.089
2.311AspPhe: 2.311 ± 0.059
6.991AspGly: 6.991 ± 0.135
1.385AspHis: 1.385 ± 0.043
3.442AspIle: 3.442 ± 0.074
2.356AspLys: 2.356 ± 0.074
5.441AspLeu: 5.441 ± 0.091
1.625AspMet: 1.625 ± 0.047
1.826AspAsn: 1.826 ± 0.06
3.607AspPro: 3.607 ± 0.062
1.632AspGln: 1.632 ± 0.05
4.06AspArg: 4.06 ± 0.085
3.504AspSer: 3.504 ± 0.077
3.387AspThr: 3.387 ± 0.074
5.736AspVal: 5.736 ± 0.094
0.936AspTrp: 0.936 ± 0.039
2.014AspTyr: 2.014 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
5.812GluAla: 5.812 ± 0.11
0.467GluCys: 0.467 ± 0.027
3.136GluAsp: 3.136 ± 0.077
3.186GluGlu: 3.186 ± 0.088
1.879GluPhe: 1.879 ± 0.049
3.922GluGly: 3.922 ± 0.077
1.543GluHis: 1.543 ± 0.049
2.742GluIle: 2.742 ± 0.066
2.316GluLys: 2.316 ± 0.065
5.078GluLeu: 5.078 ± 0.088
1.366GluMet: 1.366 ± 0.04
1.803GluAsn: 1.803 ± 0.055
2.509GluPro: 2.509 ± 0.066
2.212GluGln: 2.212 ± 0.062
4.538GluArg: 4.538 ± 0.108
3.36GluSer: 3.36 ± 0.06
3.25GluThr: 3.25 ± 0.072
3.373GluVal: 3.373 ± 0.086
0.68GluTrp: 0.68 ± 0.032
1.706GluTyr: 1.706 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.823PheAla: 3.823 ± 0.088
0.355PheCys: 0.355 ± 0.022
2.722PheAsp: 2.722 ± 0.065
1.683PheGlu: 1.683 ± 0.054
1.192PhePhe: 1.192 ± 0.048
3.354PheGly: 3.354 ± 0.075
0.718PheHis: 0.718 ± 0.028
1.681PheIle: 1.681 ± 0.051
1.042PheLys: 1.042 ± 0.039
2.73PheLeu: 2.73 ± 0.072
0.724PheMet: 0.724 ± 0.032
1.169PheAsn: 1.169 ± 0.042
1.42PhePro: 1.42 ± 0.04
0.84PheGln: 0.84 ± 0.035
1.8PheArg: 1.8 ± 0.052
2.196PheSer: 2.196 ± 0.062
2.27PheThr: 2.27 ± 0.089
2.744PheVal: 2.744 ± 0.073
0.403PheTrp: 0.403 ± 0.027
0.839PheTyr: 0.839 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.882GlyAla: 7.882 ± 0.112
0.772GlyCys: 0.772 ± 0.036
5.255GlyAsp: 5.255 ± 0.096
4.683GlyGlu: 4.683 ± 0.092
3.252GlyPhe: 3.252 ± 0.071
7.007GlyGly: 7.007 ± 0.13
1.836GlyHis: 1.836 ± 0.052
4.728GlyIle: 4.728 ± 0.096
3.933GlyLys: 3.933 ± 0.095
7.227GlyLeu: 7.227 ± 0.123
2.279GlyMet: 2.279 ± 0.056
2.928GlyAsn: 2.928 ± 0.079
2.798GlyPro: 2.798 ± 0.071
2.312GlyGln: 2.312 ± 0.057
5.859GlyArg: 5.859 ± 0.112
5.145GlySer: 5.145 ± 0.115
5.374GlyThr: 5.374 ± 0.114
6.941GlyVal: 6.941 ± 0.1
1.183GlyTrp: 1.183 ± 0.042
2.704GlyTyr: 2.704 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.202HisAla: 2.202 ± 0.059
0.188HisCys: 0.188 ± 0.016
1.774HisAsp: 1.774 ± 0.048
1.2HisGlu: 1.2 ± 0.042
0.591HisPhe: 0.591 ± 0.031
2.003HisGly: 2.003 ± 0.049
0.553HisHis: 0.553 ± 0.033
1.136HisIle: 1.136 ± 0.046
0.574HisLys: 0.574 ± 0.026
1.591HisLeu: 1.591 ± 0.048
0.516HisMet: 0.516 ± 0.027
0.6HisAsn: 0.6 ± 0.027
1.344HisPro: 1.344 ± 0.045
0.531HisGln: 0.531 ± 0.027
1.55HisArg: 1.55 ± 0.051
0.994HisSer: 0.994 ± 0.035
1.176HisThr: 1.176 ± 0.043
1.792HisVal: 1.792 ± 0.055
0.287HisTrp: 0.287 ± 0.02
0.627HisTyr: 0.627 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.308IleAla: 6.308 ± 0.111
0.556IleCys: 0.556 ± 0.03
4.269IleAsp: 4.269 ± 0.077
2.976IleGlu: 2.976 ± 0.08
1.408IlePhe: 1.408 ± 0.047
4.785IleGly: 4.785 ± 0.089
1.02IleHis: 1.02 ± 0.043
2.868IleIle: 2.868 ± 0.078
1.643IleLys: 1.643 ± 0.051
3.804IleLeu: 3.804 ± 0.095
1.187IleMet: 1.187 ± 0.038
1.597IleAsn: 1.597 ± 0.052
2.712IlePro: 2.712 ± 0.064
1.244IleGln: 1.244 ± 0.042
3.316IleArg: 3.316 ± 0.078
2.935IleSer: 2.935 ± 0.068
3.274IleThr: 3.274 ± 0.07
4.728IleVal: 4.728 ± 0.093
0.564IleTrp: 0.564 ± 0.031
1.094IleTyr: 1.094 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.035LysAla: 5.035 ± 0.134
0.173LysCys: 0.173 ± 0.014
2.557LysAsp: 2.557 ± 0.088
2.171LysGlu: 2.171 ± 0.06
0.89LysPhe: 0.89 ± 0.038
2.854LysGly: 2.854 ± 0.073
0.787LysHis: 0.787 ± 0.035
1.775LysIle: 1.775 ± 0.052
1.744LysLys: 1.744 ± 0.067
2.894LysLeu: 2.894 ± 0.078
0.789LysMet: 0.789 ± 0.03
1.405LysAsn: 1.405 ± 0.055
2.274LysPro: 2.274 ± 0.058
1.267LysGln: 1.267 ± 0.045
2.438LysArg: 2.438 ± 0.058
2.258LysSer: 2.258 ± 0.062
2.905LysThr: 2.905 ± 0.091
2.886LysVal: 2.886 ± 0.079
0.385LysTrp: 0.385 ± 0.023
1.078LysTyr: 1.078 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
10.061LeuAla: 10.061 ± 0.138
0.893LeuCys: 0.893 ± 0.036
6.282LeuAsp: 6.282 ± 0.104
4.202LeuGlu: 4.202 ± 0.083
2.946LeuPhe: 2.946 ± 0.074
7.236LeuGly: 7.236 ± 0.108
1.811LeuHis: 1.811 ± 0.052
4.262LeuIle: 4.262 ± 0.092
3.357LeuLys: 3.357 ± 0.08
7.655LeuLeu: 7.655 ± 0.143
2.271LeuMet: 2.271 ± 0.065
2.772LeuAsn: 2.772 ± 0.061
4.489LeuPro: 4.489 ± 0.096
2.068LeuGln: 2.068 ± 0.052
5.684LeuArg: 5.684 ± 0.095
5.216LeuSer: 5.216 ± 0.097
5.397LeuThr: 5.397 ± 0.089
6.413LeuVal: 6.413 ± 0.119
1.0LeuTrp: 1.0 ± 0.042
1.99LeuTyr: 1.99 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.895MetAla: 2.895 ± 0.078
0.232MetCys: 0.232 ± 0.018
1.465MetAsp: 1.465 ± 0.048
1.151MetGlu: 1.151 ± 0.045
0.867MetPhe: 0.867 ± 0.036
1.841MetGly: 1.841 ± 0.048
0.526MetHis: 0.526 ± 0.026
1.295MetIle: 1.295 ± 0.044
0.895MetLys: 0.895 ± 0.039
2.501MetLeu: 2.501 ± 0.067
0.72MetMet: 0.72 ± 0.032
0.957MetAsn: 0.957 ± 0.034
1.478MetPro: 1.478 ± 0.045
0.777MetGln: 0.777 ± 0.031
1.819MetArg: 1.819 ± 0.046
1.62MetSer: 1.62 ± 0.048
2.095MetThr: 2.095 ± 0.055
1.827MetVal: 1.827 ± 0.048
0.277MetTrp: 0.277 ± 0.019
0.544MetTyr: 0.544 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.698AsnAla: 3.698 ± 0.088
0.234AsnCys: 0.234 ± 0.017
2.372AsnAsp: 2.372 ± 0.064
1.717AsnGlu: 1.717 ± 0.052
0.873AsnPhe: 0.873 ± 0.037
3.466AsnGly: 3.466 ± 0.11
0.65AsnHis: 0.65 ± 0.033
1.562AsnIle: 1.562 ± 0.052
1.058AsnLys: 1.058 ± 0.042
2.569AsnLeu: 2.569 ± 0.07
0.732AsnMet: 0.732 ± 0.031
1.084AsnAsn: 1.084 ± 0.052
2.191AsnPro: 2.191 ± 0.06
0.919AsnGln: 0.919 ± 0.032
2.012AsnArg: 2.012 ± 0.05
1.571AsnSer: 1.571 ± 0.056
1.999AsnThr: 1.999 ± 0.063
2.57AsnVal: 2.57 ± 0.06
0.408AsnTrp: 0.408 ± 0.025
0.785AsnTyr: 0.785 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
5.0ProAla: 5.0 ± 0.119
0.366ProCys: 0.366 ± 0.022
3.577ProAsp: 3.577 ± 0.059
3.383ProGlu: 3.383 ± 0.077
1.557ProPhe: 1.557 ± 0.045
3.749ProGly: 3.749 ± 0.08
1.016ProHis: 1.016 ± 0.034
2.18ProIle: 2.18 ± 0.055
1.919ProLys: 1.919 ± 0.061
3.813ProLeu: 3.813 ± 0.084
1.138ProMet: 1.138 ± 0.04
1.575ProAsn: 1.575 ± 0.056
1.424ProPro: 1.424 ± 0.054
1.632ProGln: 1.632 ± 0.057
2.671ProArg: 2.671 ± 0.081
2.987ProSer: 2.987 ± 0.074
2.913ProThr: 2.913 ± 0.076
4.022ProVal: 4.022 ± 0.077
0.68ProTrp: 0.68 ± 0.034
1.344ProTyr: 1.344 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.406GlnAla: 3.406 ± 0.096
0.272GlnCys: 0.272 ± 0.018
1.505GlnAsp: 1.505 ± 0.045
1.254GlnGlu: 1.254 ± 0.045
0.93GlnPhe: 0.93 ± 0.035
2.115GlnGly: 2.115 ± 0.058
0.601GlnHis: 0.601 ± 0.029
1.719GlnIle: 1.719 ± 0.053
1.108GlnLys: 1.108 ± 0.04
2.888GlnLeu: 2.888 ± 0.075
0.783GlnMet: 0.783 ± 0.03
0.926GlnAsn: 0.926 ± 0.035
1.398GlnPro: 1.398 ± 0.05
1.356GlnGln: 1.356 ± 0.052
2.218GlnArg: 2.218 ± 0.06
1.863GlnSer: 1.863 ± 0.064
1.836GlnThr: 1.836 ± 0.055
2.105GlnVal: 2.105 ± 0.052
0.524GlnTrp: 0.524 ± 0.025
0.986GlnTyr: 0.986 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.46ArgAla: 5.46 ± 0.103
0.58ArgCys: 0.58 ± 0.031
4.085ArgAsp: 4.085 ± 0.091
3.824ArgGlu: 3.824 ± 0.077
2.595ArgPhe: 2.595 ± 0.06
4.383ArgGly: 4.383 ± 0.108
1.696ArgHis: 1.696 ± 0.048
4.045ArgIle: 4.045 ± 0.076
2.651ArgLys: 2.651 ± 0.062
6.139ArgLeu: 6.139 ± 0.112
2.079ArgMet: 2.079 ± 0.059
2.311ArgAsn: 2.311 ± 0.063
3.024ArgPro: 3.024 ± 0.072
2.288ArgGln: 2.288 ± 0.058
6.304ArgArg: 6.304 ± 0.142
3.66ArgSer: 3.66 ± 0.082
3.661ArgThr: 3.661 ± 0.085
4.254ArgVal: 4.254 ± 0.091
0.953ArgTrp: 0.953 ± 0.039
2.02ArgTyr: 2.02 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.188SerAla: 6.188 ± 0.112
0.496SerCys: 0.496 ± 0.028
3.875SerAsp: 3.875 ± 0.077
2.913SerGlu: 2.913 ± 0.062
2.009SerPhe: 2.009 ± 0.058
5.694SerGly: 5.694 ± 0.102
1.263SerHis: 1.263 ± 0.041
3.054SerIle: 3.054 ± 0.063
2.106SerLys: 2.106 ± 0.058
5.136SerLeu: 5.136 ± 0.092
1.609SerMet: 1.609 ± 0.054
1.882SerAsn: 1.882 ± 0.062
2.66SerPro: 2.66 ± 0.067
1.946SerGln: 1.946 ± 0.056
3.783SerArg: 3.783 ± 0.081
4.235SerSer: 4.235 ± 0.127
3.507SerThr: 3.507 ± 0.089
4.533SerVal: 4.533 ± 0.087
0.774SerTrp: 0.774 ± 0.036
1.58SerTyr: 1.58 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
6.588ThrAla: 6.588 ± 0.117
0.427ThrCys: 0.427 ± 0.023
4.045ThrAsp: 4.045 ± 0.094
2.682ThrGlu: 2.682 ± 0.066
2.204ThrPhe: 2.204 ± 0.078
5.483ThrGly: 5.483 ± 0.093
1.179ThrHis: 1.179 ± 0.041
3.44ThrIle: 3.44 ± 0.075
2.264ThrLys: 2.264 ± 0.071
5.586ThrLeu: 5.586 ± 0.112
1.531ThrMet: 1.531 ± 0.052
1.95ThrAsn: 1.95 ± 0.06
3.406ThrPro: 3.406 ± 0.07
1.689ThrGln: 1.689 ± 0.046
3.123ThrArg: 3.123 ± 0.07
3.413ThrSer: 3.413 ± 0.081
3.804ThrThr: 3.804 ± 0.091
5.69ThrVal: 5.69 ± 0.126
0.787ThrTrp: 0.787 ± 0.039
1.703ThrTyr: 1.703 ± 0.074
0.0ThrXaa: 0.0 ± 0.0
Val
8.482ValAla: 8.482 ± 0.129
0.834ValCys: 0.834 ± 0.039
5.475ValAsp: 5.475 ± 0.107
4.312ValGlu: 4.312 ± 0.086
2.942ValPhe: 2.942 ± 0.077
5.543ValGly: 5.543 ± 0.109
1.519ValHis: 1.519 ± 0.05
4.481ValIle: 4.481 ± 0.074
3.097ValLys: 3.097 ± 0.089
6.923ValLeu: 6.923 ± 0.129
2.023ValMet: 2.023 ± 0.059
2.692ValAsn: 2.692 ± 0.064
3.991ValPro: 3.991 ± 0.082
1.907ValGln: 1.907 ± 0.052
4.783ValArg: 4.783 ± 0.095
5.048ValSer: 5.048 ± 0.096
5.272ValThr: 5.272 ± 0.132
6.921ValVal: 6.921 ± 0.141
0.97ValTrp: 0.97 ± 0.043
1.95ValTyr: 1.95 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
1.14TrpAla: 1.14 ± 0.042
0.145TrpCys: 0.145 ± 0.014
0.754TrpAsp: 0.754 ± 0.039
0.552TrpGlu: 0.552 ± 0.023
0.548TrpPhe: 0.548 ± 0.027
0.884TrpGly: 0.884 ± 0.037
0.331TrpHis: 0.331 ± 0.021
0.645TrpIle: 0.645 ± 0.035
0.579TrpLys: 0.579 ± 0.029
1.271TrpLeu: 1.271 ± 0.045
0.432TrpMet: 0.432 ± 0.023
0.556TrpAsn: 0.556 ± 0.032
0.482TrpPro: 0.482 ± 0.026
0.507TrpGln: 0.507 ± 0.029
1.011TrpArg: 1.011 ± 0.044
0.833TrpSer: 0.833 ± 0.034
0.798TrpThr: 0.798 ± 0.036
0.789TrpVal: 0.789 ± 0.035
0.232TrpTrp: 0.232 ± 0.02
0.381TrpTyr: 0.381 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.112TyrAla: 3.112 ± 0.07
0.258TyrCys: 0.258 ± 0.02
2.146TyrAsp: 2.146 ± 0.06
1.565TyrGlu: 1.565 ± 0.04
0.97TyrPhe: 0.97 ± 0.04
2.562TyrGly: 2.562 ± 0.076
0.516TyrHis: 0.516 ± 0.028
1.136TyrIle: 1.136 ± 0.044
0.837TyrLys: 0.837 ± 0.038
2.365TyrLeu: 2.365 ± 0.059
0.591TyrMet: 0.591 ± 0.028
0.817TyrAsn: 0.817 ± 0.033
1.218TyrPro: 1.218 ± 0.047
0.845TyrGln: 0.845 ± 0.036
1.912TyrArg: 1.912 ± 0.049
1.566TyrSer: 1.566 ± 0.053
1.58TyrThr: 1.58 ± 0.062
2.021TyrVal: 2.021 ± 0.056
0.376TyrTrp: 0.376 ± 0.024
0.81TyrTyr: 0.81 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2008 proteins (732220 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski