Amino acid dipepetide frequency for Streptomyces yanglinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.121AlaAla: 24.121 ± 0.144	1.059AlaCys: 1.059 ± 0.02	8.669AlaAsp: 8.669 ± 0.061	8.25AlaGlu: 8.25 ± 0.08	3.517AlaPhe: 3.517 ± 0.037	14.634AlaGly: 14.634 ± 0.093	3.031AlaHis: 3.031 ± 0.038	3.47AlaIle: 3.47 ± 0.04	2.516AlaLys: 2.516 ± 0.041	14.448AlaLeu: 14.448 ± 0.089	2.486AlaMet: 2.486 ± 0.028	2.061AlaAsn: 2.061 ± 0.03	7.95AlaPro: 7.95 ± 0.071	3.913AlaGln: 3.913 ± 0.048	10.518AlaArg: 10.518 ± 0.092	6.362AlaSer: 6.362 ± 0.053	7.735AlaThr: 7.735 ± 0.065	12.585AlaVal: 12.585 ± 0.082	1.883AlaTrp: 1.883 ± 0.03	2.736AlaTyr: 2.736 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.048CysAla: 1.048 ± 0.021	0.098CysCys: 0.098 ± 0.006	0.432CysAsp: 0.432 ± 0.013	0.351CysGlu: 0.351 ± 0.011	0.201CysPhe: 0.201 ± 0.008	0.984CysGly: 0.984 ± 0.018	0.187CysHis: 0.187 ± 0.008	0.152CysIle: 0.152 ± 0.008	0.095CysLys: 0.095 ± 0.007	0.73CysLeu: 0.73 ± 0.018	0.115CysMet: 0.115 ± 0.007	0.141CysAsn: 0.141 ± 0.007	0.436CysPro: 0.436 ± 0.014	0.149CysGln: 0.149 ± 0.007	0.568CysArg: 0.568 ± 0.014	0.458CysSer: 0.458 ± 0.012	0.5CysThr: 0.5 ± 0.015	0.631CysVal: 0.631 ± 0.015	0.134CysTrp: 0.134 ± 0.008	0.148CysTyr: 0.148 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.001AspAla: 8.001 ± 0.061	0.389AspCys: 0.389 ± 0.013	3.586AspAsp: 3.586 ± 0.043	3.327AspGlu: 3.327 ± 0.038	1.641AspPhe: 1.641 ± 0.028	6.705AspGly: 6.705 ± 0.067	1.476AspHis: 1.476 ± 0.025	1.813AspIle: 1.813 ± 0.027	0.922AspLys: 0.922 ± 0.018	6.356AspLeu: 6.356 ± 0.052	0.763AspMet: 0.763 ± 0.015	0.987AspAsn: 0.987 ± 0.021	4.916AspPro: 4.916 ± 0.048	1.641AspGln: 1.641 ± 0.025	4.947AspArg: 4.947 ± 0.051	2.657AspSer: 2.657 ± 0.031	3.396AspThr: 3.396 ± 0.038	4.727AspVal: 4.727 ± 0.042	1.013AspTrp: 1.013 ± 0.021	1.131AspTyr: 1.131 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.515GluAla: 6.515 ± 0.072	0.308GluCys: 0.308 ± 0.011	2.526GluAsp: 2.526 ± 0.036	2.997GluGlu: 2.997 ± 0.051	1.36GluPhe: 1.36 ± 0.026	3.836GluGly: 3.836 ± 0.047	1.393GluHis: 1.393 ± 0.025	1.903GluIle: 1.903 ± 0.026	0.989GluLys: 0.989 ± 0.022	6.059GluLeu: 6.059 ± 0.071	0.809GluMet: 0.809 ± 0.019	0.853GluAsn: 0.853 ± 0.019	3.34GluPro: 3.34 ± 0.039	2.148GluGln: 2.148 ± 0.031	4.849GluArg: 4.849 ± 0.058	2.383GluSer: 2.383 ± 0.03	2.433GluThr: 2.433 ± 0.03	4.233GluVal: 4.233 ± 0.048	0.69GluTrp: 0.69 ± 0.017	0.971GluTyr: 0.971 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.745PheAla: 3.745 ± 0.038	0.25PheCys: 0.25 ± 0.009	1.99PheAsp: 1.99 ± 0.028	1.243PheGlu: 1.243 ± 0.023	0.832PhePhe: 0.832 ± 0.018	3.04PheGly: 3.04 ± 0.038	0.65PheHis: 0.65 ± 0.015	0.611PheIle: 0.611 ± 0.017	0.399PheLys: 0.399 ± 0.014	2.459PheLeu: 2.459 ± 0.034	0.362PheMet: 0.362 ± 0.012	0.531PheAsn: 0.531 ± 0.013	1.416PhePro: 1.416 ± 0.024	0.682PheGln: 0.682 ± 0.016	1.802PheArg: 1.802 ± 0.028	1.473PheSer: 1.473 ± 0.026	2.075PheThr: 2.075 ± 0.031	2.155PheVal: 2.155 ± 0.028	0.422PheTrp: 0.422 ± 0.012	0.563PheTyr: 0.563 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.202GlyAla: 12.202 ± 0.088	0.876GlyCys: 0.876 ± 0.021	5.37GlyAsp: 5.37 ± 0.053	4.735GlyGlu: 4.735 ± 0.045	2.864GlyPhe: 2.864 ± 0.035	9.919GlyGly: 9.919 ± 0.093	2.39GlyHis: 2.39 ± 0.03	3.328GlyIle: 3.328 ± 0.042	2.161GlyLys: 2.161 ± 0.031	9.256GlyLeu: 9.256 ± 0.06	1.967GlyMet: 1.967 ± 0.027	1.867GlyAsn: 1.867 ± 0.033	5.883GlyPro: 5.883 ± 0.057	2.782GlyGln: 2.782 ± 0.036	7.92GlyArg: 7.92 ± 0.065	6.273GlySer: 6.273 ± 0.071	7.244GlyThr: 7.244 ± 0.071	7.501GlyVal: 7.501 ± 0.059	1.805GlyTrp: 1.805 ± 0.028	2.513GlyTyr: 2.513 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.898HisAla: 2.898 ± 0.027	0.184HisCys: 0.184 ± 0.008	1.439HisAsp: 1.439 ± 0.022	1.11HisGlu: 1.11 ± 0.022	0.658HisPhe: 0.658 ± 0.017	2.492HisGly: 2.492 ± 0.033	0.725HisHis: 0.725 ± 0.019	0.637HisIle: 0.637 ± 0.017	0.285HisLys: 0.285 ± 0.01	2.467HisLeu: 2.467 ± 0.03	0.325HisMet: 0.325 ± 0.011	0.343HisAsn: 0.343 ± 0.012	1.951HisPro: 1.951 ± 0.033	0.682HisGln: 0.682 ± 0.016	2.055HisArg: 2.055 ± 0.032	1.029HisSer: 1.029 ± 0.02	1.338HisThr: 1.338 ± 0.022	1.717HisVal: 1.717 ± 0.027	0.391HisTrp: 0.391 ± 0.013	0.502HisTyr: 0.502 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.55IleAla: 4.55 ± 0.045	0.262IleCys: 0.262 ± 0.009	2.199IleAsp: 2.199 ± 0.031	1.706IleGlu: 1.706 ± 0.031	0.649IlePhe: 0.649 ± 0.018	3.599IleGly: 3.599 ± 0.042	0.587IleHis: 0.587 ± 0.015	0.796IleIle: 0.796 ± 0.021	0.594IleLys: 0.594 ± 0.015	2.197IleLeu: 2.197 ± 0.034	0.403IleMet: 0.403 ± 0.013	0.66IleAsn: 0.66 ± 0.018	1.648IlePro: 1.648 ± 0.028	0.679IleGln: 0.679 ± 0.018	2.125IleArg: 2.125 ± 0.027	1.688IleSer: 1.688 ± 0.029	2.193IleThr: 2.193 ± 0.034	2.475IleVal: 2.475 ± 0.033	0.341IleTrp: 0.341 ± 0.011	0.519IleTyr: 0.519 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.472LysAla: 2.472 ± 0.036	0.102LysCys: 0.102 ± 0.006	1.12LysAsp: 1.12 ± 0.026	0.857LysGlu: 0.857 ± 0.019	0.367LysPhe: 0.367 ± 0.011	1.55LysGly: 1.55 ± 0.033	0.367LysHis: 0.367 ± 0.013	0.685LysIle: 0.685 ± 0.016	0.622LysLys: 0.622 ± 0.02	1.639LysLeu: 1.639 ± 0.027	0.31LysMet: 0.31 ± 0.011	0.434LysAsn: 0.434 ± 0.015	1.127LysPro: 1.127 ± 0.022	0.621LysGln: 0.621 ± 0.017	1.144LysArg: 1.144 ± 0.02	1.047LysSer: 1.047 ± 0.023	1.029LysThr: 1.029 ± 0.024	1.665LysVal: 1.665 ± 0.032	0.239LysTrp: 0.239 ± 0.011	0.37LysTyr: 0.37 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.483LeuAla: 15.483 ± 0.11	0.794LeuCys: 0.794 ± 0.016	6.736LeuAsp: 6.736 ± 0.058	4.096LeuGlu: 4.096 ± 0.044	2.523LeuPhe: 2.523 ± 0.037	9.028LeuGly: 9.028 ± 0.063	2.343LeuHis: 2.343 ± 0.032	2.966LeuIle: 2.966 ± 0.042	1.58LeuLys: 1.58 ± 0.028	10.98LeuLeu: 10.98 ± 0.097	1.518LeuMet: 1.518 ± 0.025	1.645LeuAsn: 1.645 ± 0.024	6.696LeuPro: 6.696 ± 0.06	2.141LeuGln: 2.141 ± 0.03	8.517LeuArg: 8.517 ± 0.078	5.298LeuSer: 5.298 ± 0.049	6.695LeuThr: 6.695 ± 0.053	8.649LeuVal: 8.649 ± 0.071	1.251LeuTrp: 1.251 ± 0.023	1.825LeuTyr: 1.825 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.181MetAla: 2.181 ± 0.029	0.125MetCys: 0.125 ± 0.007	0.888MetAsp: 0.888 ± 0.019	0.646MetGlu: 0.646 ± 0.017	0.429MetPhe: 0.429 ± 0.013	1.25MetGly: 1.25 ± 0.024	0.344MetHis: 0.344 ± 0.012	0.587MetIle: 0.587 ± 0.014	0.364MetLys: 0.364 ± 0.012	1.609MetLeu: 1.609 ± 0.027	0.273MetMet: 0.273 ± 0.011	0.435MetAsn: 0.435 ± 0.013	1.105MetPro: 1.105 ± 0.02	0.427MetGln: 0.427 ± 0.013	1.382MetArg: 1.382 ± 0.025	1.274MetSer: 1.274 ± 0.022	1.45MetThr: 1.45 ± 0.024	1.29MetVal: 1.29 ± 0.02	0.205MetTrp: 0.205 ± 0.008	0.31MetTyr: 0.31 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.215AsnAla: 2.215 ± 0.033	0.16AsnCys: 0.16 ± 0.008	0.958AsnAsp: 0.958 ± 0.02	0.708AsnGlu: 0.708 ± 0.018	0.495AsnPhe: 0.495 ± 0.014	2.115AsnGly: 2.115 ± 0.036	0.386AsnHis: 0.386 ± 0.013	0.604AsnIle: 0.604 ± 0.018	0.34AsnLys: 0.34 ± 0.012	1.669AsnLeu: 1.669 ± 0.027	0.284AsnMet: 0.284 ± 0.011	0.43AsnAsn: 0.43 ± 0.015	1.361AsnPro: 1.361 ± 0.026	0.532AsnGln: 0.532 ± 0.015	1.18AsnArg: 1.18 ± 0.02	1.045AsnSer: 1.045 ± 0.022	1.159AsnThr: 1.159 ± 0.028	1.377AsnVal: 1.377 ± 0.027	0.311AsnTrp: 0.311 ± 0.013	0.423AsnTyr: 0.423 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.116ProAla: 10.116 ± 0.077	0.331ProCys: 0.331 ± 0.01	4.781ProAsp: 4.781 ± 0.059	3.931ProGlu: 3.931 ± 0.049	1.528ProPhe: 1.528 ± 0.026	7.383ProGly: 7.383 ± 0.056	1.438ProHis: 1.438 ± 0.023	1.349ProIle: 1.349 ± 0.023	1.036ProLys: 1.036 ± 0.019	5.428ProLeu: 5.428 ± 0.048	0.99ProMet: 0.99 ± 0.02	0.945ProAsn: 0.945 ± 0.021	4.165ProPro: 4.165 ± 0.066	1.906ProGln: 1.906 ± 0.038	4.119ProArg: 4.119 ± 0.049	3.637ProSer: 3.637 ± 0.043	3.371ProThr: 3.371 ± 0.041	5.453ProVal: 5.453 ± 0.051	0.913ProTrp: 0.913 ± 0.021	1.433ProTyr: 1.433 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.841GlnAla: 3.841 ± 0.043	0.173GlnCys: 0.173 ± 0.008	1.561GlnAsp: 1.561 ± 0.025	1.366GlnGlu: 1.366 ± 0.024	0.704GlnPhe: 0.704 ± 0.018	2.371GlnGly: 2.371 ± 0.037	0.688GlnHis: 0.688 ± 0.015	1.037GlnIle: 1.037 ± 0.023	0.503GlnLys: 0.503 ± 0.015	2.926GlnLeu: 2.926 ± 0.033	0.473GlnMet: 0.473 ± 0.013	0.555GlnAsn: 0.555 ± 0.015	1.879GlnPro: 1.879 ± 0.038	1.368GlnGln: 1.368 ± 0.033	2.306GlnArg: 2.306 ± 0.034	1.35GlnSer: 1.35 ± 0.027	1.384GlnThr: 1.384 ± 0.027	2.591GlnVal: 2.591 ± 0.034	0.504GlnTrp: 0.504 ± 0.015	0.625GlnTyr: 0.625 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.076ArgAla: 10.076 ± 0.087	0.539ArgCys: 0.539 ± 0.015	4.099ArgAsp: 4.099 ± 0.049	4.249ArgGlu: 4.249 ± 0.056	2.246ArgPhe: 2.246 ± 0.028	5.822ArgGly: 5.822 ± 0.05	2.082ArgHis: 2.082 ± 0.028	3.128ArgIle: 3.128 ± 0.037	1.359ArgLys: 1.359 ± 0.026	8.574ArgLeu: 8.574 ± 0.083	1.696ArgMet: 1.696 ± 0.025	1.299ArgAsn: 1.299 ± 0.023	5.118ArgPro: 5.118 ± 0.052	2.318ArgGln: 2.318 ± 0.028	7.608ArgArg: 7.608 ± 0.08	4.066ArgSer: 4.066 ± 0.041	5.392ArgThr: 5.392 ± 0.047	5.797ArgVal: 5.797 ± 0.053	1.343ArgTrp: 1.343 ± 0.02	1.779ArgTyr: 1.779 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.495SerAla: 7.495 ± 0.066	0.413SerCys: 0.413 ± 0.013	2.932SerAsp: 2.932 ± 0.044	2.155SerGlu: 2.155 ± 0.029	1.543SerPhe: 1.543 ± 0.029	6.782SerGly: 6.782 ± 0.068	1.077SerHis: 1.077 ± 0.019	1.43SerIle: 1.43 ± 0.025	0.884SerLys: 0.884 ± 0.022	4.796SerLeu: 4.796 ± 0.045	1.033SerMet: 1.033 ± 0.02	0.974SerAsn: 0.974 ± 0.023	3.383SerPro: 3.383 ± 0.037	1.311SerGln: 1.311 ± 0.026	3.644SerArg: 3.644 ± 0.044	3.398SerSer: 3.398 ± 0.057	3.659SerThr: 3.659 ± 0.048	4.36SerVal: 4.36 ± 0.038	0.919SerTrp: 0.919 ± 0.02	1.31SerTyr: 1.31 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.579ThrAla: 9.579 ± 0.078	0.461ThrCys: 0.461 ± 0.014	3.705ThrAsp: 3.705 ± 0.046	2.815ThrGlu: 2.815 ± 0.039	1.682ThrPhe: 1.682 ± 0.026	7.318ThrGly: 7.318 ± 0.069	1.221ThrHis: 1.221 ± 0.023	1.651ThrIle: 1.651 ± 0.032	1.04ThrLys: 1.04 ± 0.022	5.839ThrLeu: 5.839 ± 0.043	0.913ThrMet: 0.913 ± 0.018	1.056ThrAsn: 1.056 ± 0.026	4.267ThrPro: 4.267 ± 0.05	1.435ThrGln: 1.435 ± 0.027	3.944ThrArg: 3.944 ± 0.041	3.668ThrSer: 3.668 ± 0.05	4.138ThrThr: 4.138 ± 0.071	6.247ThrVal: 6.247 ± 0.06	0.963ThrTrp: 0.963 ± 0.022	1.384ThrTyr: 1.384 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.006ValAla: 11.006 ± 0.069	0.726ValCys: 0.726 ± 0.019	5.027ValAsp: 5.027 ± 0.047	4.315ValGlu: 4.315 ± 0.046	2.341ValPhe: 2.341 ± 0.035	6.674ValGly: 6.674 ± 0.056	2.022ValHis: 2.022 ± 0.029	2.714ValIle: 2.714 ± 0.036	1.453ValLys: 1.453 ± 0.029	9.505ValLeu: 9.505 ± 0.08	1.33ValMet: 1.33 ± 0.025	1.67ValAsn: 1.67 ± 0.025	5.573ValPro: 5.573 ± 0.044	2.103ValGln: 2.103 ± 0.027	6.903ValArg: 6.903 ± 0.061	4.303ValSer: 4.303 ± 0.047	5.684ValThr: 5.684 ± 0.061	7.925ValVal: 7.925 ± 0.07	1.128ValTrp: 1.128 ± 0.023	1.583ValTyr: 1.583 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.634TrpAla: 1.634 ± 0.027	0.139TrpCys: 0.139 ± 0.007	0.837TrpAsp: 0.837 ± 0.021	0.676TrpGlu: 0.676 ± 0.018	0.484TrpPhe: 0.484 ± 0.013	1.052TrpGly: 1.052 ± 0.019	0.389TrpHis: 0.389 ± 0.012	0.552TrpIle: 0.552 ± 0.014	0.307TrpLys: 0.307 ± 0.012	1.691TrpLeu: 1.691 ± 0.026	0.289TrpMet: 0.289 ± 0.011	0.439TrpAsn: 0.439 ± 0.013	0.825TrpPro: 0.825 ± 0.017	0.673TrpGln: 0.673 ± 0.016	1.276TrpArg: 1.276 ± 0.021	1.083TrpSer: 1.083 ± 0.02	1.15TrpThr: 1.15 ± 0.021	0.939TrpVal: 0.939 ± 0.021	0.344TrpTrp: 0.344 ± 0.012	0.386TrpTyr: 0.386 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.763TyrAla: 2.763 ± 0.032	0.17TyrCys: 0.17 ± 0.009	1.538TyrAsp: 1.538 ± 0.031	1.065TyrGlu: 1.065 ± 0.02	0.636TyrPhe: 0.636 ± 0.014	2.304TyrGly: 2.304 ± 0.033	0.432TyrHis: 0.432 ± 0.012	0.454TyrIle: 0.454 ± 0.014	0.317TyrLys: 0.317 ± 0.011	2.132TyrLeu: 2.132 ± 0.033	0.234TyrMet: 0.234 ± 0.008	0.426TyrAsn: 0.426 ± 0.013	1.215TyrPro: 1.215 ± 0.022	0.696TyrGln: 0.696 ± 0.017	1.786TyrArg: 1.786 ± 0.026	1.005TyrSer: 1.005 ± 0.022	1.301TyrThr: 1.301 ± 0.026	1.67TyrVal: 1.67 ± 0.025	0.366TyrTrp: 0.366 ± 0.011	0.466TyrTyr: 0.466 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8055 proteins (2771259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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