Amino acid dipepetide frequency for Comamonadaceae bacterium OH2545_COT-014

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.402AlaAla: 23.402 ± 0.309	1.558AlaCys: 1.558 ± 0.039	6.748AlaAsp: 6.748 ± 0.094	7.054AlaGlu: 7.054 ± 0.093	4.262AlaPhe: 4.262 ± 0.077	11.846AlaGly: 11.846 ± 0.129	3.469AlaHis: 3.469 ± 0.074	4.785AlaIle: 4.785 ± 0.074	3.506AlaLys: 3.506 ± 0.082	18.462AlaLeu: 18.462 ± 0.242	3.473AlaMet: 3.473 ± 0.064	2.566AlaAsn: 2.566 ± 0.061	9.036AlaPro: 9.036 ± 0.156	7.169AlaGln: 7.169 ± 0.118	11.365AlaArg: 11.365 ± 0.148	7.288AlaSer: 7.288 ± 0.112	6.704AlaThr: 6.704 ± 0.087	9.225AlaVal: 9.225 ± 0.106	2.542AlaTrp: 2.542 ± 0.06	2.434AlaTyr: 2.434 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.232CysAla: 1.232 ± 0.042	0.105CysCys: 0.105 ± 0.011	0.524CysAsp: 0.524 ± 0.024	0.428CysGlu: 0.428 ± 0.025	0.274CysPhe: 0.274 ± 0.018	1.006CysGly: 1.006 ± 0.038	0.304CysHis: 0.304 ± 0.02	0.394CysIle: 0.394 ± 0.02	0.211CysLys: 0.211 ± 0.015	0.907CysLeu: 0.907 ± 0.036	0.214CysMet: 0.214 ± 0.015	0.228CysAsn: 0.228 ± 0.016	0.621CysPro: 0.621 ± 0.03	0.376CysGln: 0.376 ± 0.021	0.545CysArg: 0.545 ± 0.025	0.418CysSer: 0.418 ± 0.024	0.551CysThr: 0.551 ± 0.023	0.676CysVal: 0.676 ± 0.03	0.125CysTrp: 0.125 ± 0.011	0.189CysTyr: 0.189 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.668AspAla: 7.668 ± 0.108	0.432AspCys: 0.432 ± 0.024	2.444AspAsp: 2.444 ± 0.061	3.04AspGlu: 3.04 ± 0.072	1.909AspPhe: 1.909 ± 0.048	4.32AspGly: 4.32 ± 0.07	1.016AspHis: 1.016 ± 0.034	2.057AspIle: 2.057 ± 0.051	1.633AspLys: 1.633 ± 0.048	4.586AspLeu: 4.586 ± 0.078	1.287AspMet: 1.287 ± 0.035	1.043AspAsn: 1.043 ± 0.032	2.61AspPro: 2.61 ± 0.052	1.43AspGln: 1.43 ± 0.045	2.741AspArg: 2.741 ± 0.056	2.035AspSer: 2.035 ± 0.048	2.545AspThr: 2.545 ± 0.05	3.854AspVal: 3.854 ± 0.066	0.92AspTrp: 0.92 ± 0.036	1.294AspTyr: 1.294 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.104GluAla: 7.104 ± 0.103	0.367GluCys: 0.367 ± 0.023	2.066GluAsp: 2.066 ± 0.047	2.226GluGlu: 2.226 ± 0.058	1.429GluPhe: 1.429 ± 0.04	3.885GluGly: 3.885 ± 0.067	1.224GluHis: 1.224 ± 0.044	2.22GluIle: 2.22 ± 0.062	1.956GluLys: 1.956 ± 0.051	4.977GluLeu: 4.977 ± 0.078	1.194GluMet: 1.194 ± 0.037	1.189GluAsn: 1.189 ± 0.036	2.455GluPro: 2.455 ± 0.072	2.515GluGln: 2.515 ± 0.063	4.349GluArg: 4.349 ± 0.075	2.095GluSer: 2.095 ± 0.057	2.301GluThr: 2.301 ± 0.051	3.47GluVal: 3.47 ± 0.054	0.666GluTrp: 0.666 ± 0.026	0.984GluTyr: 0.984 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.079PheAla: 4.079 ± 0.067	0.371PheCys: 0.371 ± 0.023	2.315PheAsp: 2.315 ± 0.05	1.793PheGlu: 1.793 ± 0.048	1.304PhePhe: 1.304 ± 0.038	3.065PheGly: 3.065 ± 0.058	0.747PheHis: 0.747 ± 0.027	1.469PheIle: 1.469 ± 0.041	1.086PheLys: 1.086 ± 0.034	2.634PheLeu: 2.634 ± 0.063	0.869PheMet: 0.869 ± 0.033	0.983PheAsn: 0.983 ± 0.036	1.329PhePro: 1.329 ± 0.037	0.995PheGln: 0.995 ± 0.032	1.68PheArg: 1.68 ± 0.042	1.874PheSer: 1.874 ± 0.047	1.874PheThr: 1.874 ± 0.043	2.415PheVal: 2.415 ± 0.057	0.519PheTrp: 0.519 ± 0.024	0.771PheTyr: 0.771 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.722GlyAla: 10.722 ± 0.109	0.902GlyCys: 0.902 ± 0.031	3.851GlyAsp: 3.851 ± 0.066	4.313GlyGlu: 4.313 ± 0.08	3.048GlyPhe: 3.048 ± 0.063	7.504GlyGly: 7.504 ± 0.136	2.301GlyHis: 2.301 ± 0.052	3.402GlyIle: 3.402 ± 0.064	2.964GlyLys: 2.964 ± 0.068	9.091GlyLeu: 9.091 ± 0.13	2.386GlyMet: 2.386 ± 0.054	1.962GlyAsn: 1.962 ± 0.051	3.421GlyPro: 3.421 ± 0.064	4.493GlyGln: 4.493 ± 0.08	5.901GlyArg: 5.901 ± 0.087	4.164GlySer: 4.164 ± 0.068	3.95GlyThr: 3.95 ± 0.076	6.395GlyVal: 6.395 ± 0.094	1.703GlyTrp: 1.703 ± 0.051	2.075GlyTyr: 2.075 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	3.871HisAla: 3.871 ± 0.076	0.307HisCys: 0.307 ± 0.019	1.295HisAsp: 1.295 ± 0.044	1.282HisGlu: 1.282 ± 0.039	0.879HisPhe: 0.879 ± 0.029	2.523HisGly: 2.523 ± 0.06	0.639HisHis: 0.639 ± 0.03	1.021HisIle: 1.021 ± 0.031	0.549HisLys: 0.549 ± 0.024	2.468HisLeu: 2.468 ± 0.063	0.533HisMet: 0.533 ± 0.027	0.525HisAsn: 0.525 ± 0.028	1.669HisPro: 1.669 ± 0.043	0.887HisGln: 0.887 ± 0.037	1.61HisArg: 1.61 ± 0.044	1.01HisSer: 1.01 ± 0.034	1.303HisThr: 1.303 ± 0.041	1.804HisVal: 1.804 ± 0.041	0.533HisTrp: 0.533 ± 0.025	0.691HisTyr: 0.691 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.348IleAla: 5.348 ± 0.083	0.401IleCys: 0.401 ± 0.023	2.72IleAsp: 2.72 ± 0.057	2.717IleGlu: 2.717 ± 0.063	1.077IlePhe: 1.077 ± 0.045	3.52IleGly: 3.52 ± 0.075	0.867IleHis: 0.867 ± 0.035	1.435IleIle: 1.435 ± 0.046	1.333IleLys: 1.333 ± 0.045	2.682IleLeu: 2.682 ± 0.054	0.719IleMet: 0.719 ± 0.029	1.184IleAsn: 1.184 ± 0.037	1.593IlePro: 1.593 ± 0.05	1.277IleGln: 1.277 ± 0.035	2.328IleArg: 2.328 ± 0.05	2.066IleSer: 2.066 ± 0.052	2.371IleThr: 2.371 ± 0.053	2.895IleVal: 2.895 ± 0.068	0.454IleTrp: 0.454 ± 0.025	0.909IleTyr: 0.909 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.801LysAla: 3.801 ± 0.088	0.174LysCys: 0.174 ± 0.017	1.478LysAsp: 1.478 ± 0.051	1.438LysGlu: 1.438 ± 0.045	0.751LysPhe: 0.751 ± 0.028	2.329LysGly: 2.329 ± 0.06	0.593LysHis: 0.593 ± 0.025	1.213LysIle: 1.213 ± 0.041	1.436LysLys: 1.436 ± 0.055	2.992LysLeu: 2.992 ± 0.059	0.705LysMet: 0.705 ± 0.03	0.931LysAsn: 0.931 ± 0.035	1.904LysPro: 1.904 ± 0.055	1.098LysGln: 1.098 ± 0.038	1.942LysArg: 1.942 ± 0.048	1.432LysSer: 1.432 ± 0.042	1.804LysThr: 1.804 ± 0.051	2.084LysVal: 2.084 ± 0.056	0.323LysTrp: 0.323 ± 0.018	0.637LysTyr: 0.637 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	18.055LeuAla: 18.055 ± 0.21	0.98LeuCys: 0.98 ± 0.033	5.559LeuAsp: 5.559 ± 0.074	4.349LeuGlu: 4.349 ± 0.077	3.151LeuPhe: 3.151 ± 0.069	8.875LeuGly: 8.875 ± 0.115	3.032LeuHis: 3.032 ± 0.064	3.845LeuIle: 3.845 ± 0.071	3.289LeuLys: 3.289 ± 0.054	11.865LeuLeu: 11.865 ± 0.167	2.559LeuMet: 2.559 ± 0.056	2.515LeuAsn: 2.515 ± 0.053	7.369LeuPro: 7.369 ± 0.11	4.449LeuGln: 4.449 ± 0.077	8.046LeuArg: 8.046 ± 0.117	5.224LeuSer: 5.224 ± 0.085	5.376LeuThr: 5.376 ± 0.079	6.82LeuVal: 6.82 ± 0.104	1.653LeuTrp: 1.653 ± 0.048	2.061LeuTyr: 2.061 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.368MetAla: 3.368 ± 0.061	0.149MetCys: 0.149 ± 0.013	1.067MetAsp: 1.067 ± 0.036	0.954MetGlu: 0.954 ± 0.032	0.589MetPhe: 0.589 ± 0.028	1.9MetGly: 1.9 ± 0.051	0.618MetHis: 0.618 ± 0.026	0.788MetIle: 0.788 ± 0.029	0.903MetLys: 0.903 ± 0.027	2.593MetLeu: 2.593 ± 0.056	0.483MetMet: 0.483 ± 0.018	0.829MetAsn: 0.829 ± 0.032	1.654MetPro: 1.654 ± 0.04	1.201MetGln: 1.201 ± 0.036	1.749MetArg: 1.749 ± 0.049	1.327MetSer: 1.327 ± 0.041	1.441MetThr: 1.441 ± 0.035	1.516MetVal: 1.516 ± 0.043	0.167MetTrp: 0.167 ± 0.014	0.339MetTyr: 0.339 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.26AsnAla: 3.26 ± 0.065	0.245AsnCys: 0.245 ± 0.019	1.105AsnAsp: 1.105 ± 0.037	1.001AsnGlu: 1.001 ± 0.032	0.752AsnPhe: 0.752 ± 0.033	1.983AsnGly: 1.983 ± 0.055	0.533AsnHis: 0.533 ± 0.022	1.005AsnIle: 1.005 ± 0.039	0.701AsnLys: 0.701 ± 0.032	2.369AsnLeu: 2.369 ± 0.061	0.507AsnMet: 0.507 ± 0.031	0.665AsnAsn: 0.665 ± 0.035	1.85AsnPro: 1.85 ± 0.049	0.841AsnGln: 0.841 ± 0.028	1.474AsnArg: 1.474 ± 0.04	0.88AsnSer: 0.88 ± 0.037	1.332AsnThr: 1.332 ± 0.044	1.614AsnVal: 1.614 ± 0.049	0.366AsnTrp: 0.366 ± 0.019	0.612AsnTyr: 0.612 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	10.456ProAla: 10.456 ± 0.166	0.469ProCys: 0.469 ± 0.024	3.222ProAsp: 3.222 ± 0.068	3.482ProGlu: 3.482 ± 0.072	1.771ProPhe: 1.771 ± 0.046	5.558ProGly: 5.558 ± 0.087	1.449ProHis: 1.449 ± 0.039	1.637ProIle: 1.637 ± 0.049	1.269ProLys: 1.269 ± 0.041	6.082ProLeu: 6.082 ± 0.092	1.364ProMet: 1.364 ± 0.037	1.137ProAsn: 1.137 ± 0.038	4.478ProPro: 4.478 ± 0.112	2.501ProGln: 2.501 ± 0.055	3.661ProArg: 3.661 ± 0.072	2.732ProSer: 2.732 ± 0.054	2.333ProThr: 2.333 ± 0.055	4.606ProVal: 4.606 ± 0.083	0.959ProTrp: 0.959 ± 0.04	1.101ProTyr: 1.101 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	7.866GlnAla: 7.866 ± 0.121	0.348GlnCys: 0.348 ± 0.022	1.94GlnAsp: 1.94 ± 0.045	1.668GlnGlu: 1.668 ± 0.047	1.183GlnPhe: 1.183 ± 0.037	3.796GlnGly: 3.796 ± 0.068	1.162GlnHis: 1.162 ± 0.041	1.646GlnIle: 1.646 ± 0.039	1.166GlnLys: 1.166 ± 0.039	4.36GlnLeu: 4.36 ± 0.087	1.014GlnMet: 1.014 ± 0.036	0.859GlnAsn: 0.859 ± 0.03	3.052GlnPro: 3.052 ± 0.071	2.123GlnGln: 2.123 ± 0.054	3.812GlnArg: 3.812 ± 0.089	1.964GlnSer: 1.964 ± 0.047	2.151GlnThr: 2.151 ± 0.054	3.044GlnVal: 3.044 ± 0.063	0.886GlnTrp: 0.886 ± 0.031	0.793GlnTyr: 0.793 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	9.46ArgAla: 9.46 ± 0.124	0.615ArgCys: 0.615 ± 0.027	3.141ArgAsp: 3.141 ± 0.066	3.805ArgGlu: 3.805 ± 0.077	2.796ArgPhe: 2.796 ± 0.058	4.726ArgGly: 4.726 ± 0.082	2.38ArgHis: 2.38 ± 0.064	3.094ArgIle: 3.094 ± 0.063	1.715ArgLys: 1.715 ± 0.045	8.84ArgLeu: 8.84 ± 0.12	1.86ArgMet: 1.86 ± 0.043	1.512ArgAsn: 1.512 ± 0.039	4.176ArgPro: 4.176 ± 0.086	4.082ArgGln: 4.082 ± 0.075	5.568ArgArg: 5.568 ± 0.084	2.781ArgSer: 2.781 ± 0.061	3.153ArgThr: 3.153 ± 0.067	5.234ArgVal: 5.234 ± 0.081	1.366ArgTrp: 1.366 ± 0.038	1.841ArgTyr: 1.841 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.912SerAla: 6.912 ± 0.091	0.389SerCys: 0.389 ± 0.022	2.138SerAsp: 2.138 ± 0.049	2.072SerGlu: 2.072 ± 0.058	1.741SerPhe: 1.741 ± 0.047	4.98SerGly: 4.98 ± 0.081	1.225SerHis: 1.225 ± 0.039	1.817SerIle: 1.817 ± 0.048	1.157SerLys: 1.157 ± 0.036	4.852SerLeu: 4.852 ± 0.071	0.995SerMet: 0.995 ± 0.03	1.109SerAsn: 1.109 ± 0.036	2.828SerPro: 2.828 ± 0.066	1.791SerGln: 1.791 ± 0.047	3.159SerArg: 3.159 ± 0.064	2.407SerSer: 2.407 ± 0.062	2.319SerThr: 2.319 ± 0.055	3.316SerVal: 3.316 ± 0.055	0.633SerTrp: 0.633 ± 0.028	1.12SerTyr: 1.12 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.463ThrAla: 6.463 ± 0.101	0.418ThrCys: 0.418 ± 0.025	2.179ThrAsp: 2.179 ± 0.05	2.066ThrGlu: 2.066 ± 0.047	1.477ThrPhe: 1.477 ± 0.046	4.743ThrGly: 4.743 ± 0.076	1.254ThrHis: 1.254 ± 0.041	1.724ThrIle: 1.724 ± 0.046	0.991ThrLys: 0.991 ± 0.042	6.481ThrLeu: 6.481 ± 0.081	0.798ThrMet: 0.798 ± 0.03	1.018ThrAsn: 1.018 ± 0.039	4.076ThrPro: 4.076 ± 0.07	2.126ThrGln: 2.126 ± 0.047	3.622ThrArg: 3.622 ± 0.052	2.144ThrSer: 2.144 ± 0.052	2.398ThrThr: 2.398 ± 0.052	3.947ThrVal: 3.947 ± 0.074	0.62ThrTrp: 0.62 ± 0.022	0.959ThrTyr: 0.959 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.342ValAla: 9.342 ± 0.112	0.686ValCys: 0.686 ± 0.028	3.401ValAsp: 3.401 ± 0.061	3.418ValGlu: 3.418 ± 0.066	2.464ValPhe: 2.464 ± 0.054	4.947ValGly: 4.947 ± 0.092	1.673ValHis: 1.673 ± 0.044	3.119ValIle: 3.119 ± 0.069	2.168ValLys: 2.168 ± 0.058	7.982ValLeu: 7.982 ± 0.109	1.846ValMet: 1.846 ± 0.044	1.92ValAsn: 1.92 ± 0.054	4.046ValPro: 4.046 ± 0.077	3.412ValGln: 3.412 ± 0.072	5.282ValArg: 5.282 ± 0.074	3.481ValSer: 3.481 ± 0.064	3.853ValThr: 3.853 ± 0.066	5.121ValVal: 5.121 ± 0.087	0.986ValTrp: 0.986 ± 0.038	1.429ValTyr: 1.429 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.885TrpAla: 1.885 ± 0.059	0.18TrpCys: 0.18 ± 0.014	0.549TrpAsp: 0.549 ± 0.026	0.483TrpGlu: 0.483 ± 0.024	0.505TrpPhe: 0.505 ± 0.023	1.082TrpGly: 1.082 ± 0.038	0.464TrpHis: 0.464 ± 0.026	0.507TrpIle: 0.507 ± 0.024	0.366TrpLys: 0.366 ± 0.02	2.647TrpLeu: 2.647 ± 0.06	0.423TrpMet: 0.423 ± 0.021	0.349TrpAsn: 0.349 ± 0.021	1.015TrpPro: 1.015 ± 0.037	1.133TrpGln: 1.133 ± 0.038	1.706TrpArg: 1.706 ± 0.05	0.633TrpSer: 0.633 ± 0.023	0.598TrpThr: 0.598 ± 0.03	0.971TrpVal: 0.971 ± 0.038	0.3TrpTrp: 0.3 ± 0.019	0.254TrpTyr: 0.254 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.599TyrAla: 2.599 ± 0.058	0.234TyrCys: 0.234 ± 0.015	1.122TyrAsp: 1.122 ± 0.04	1.083TyrGlu: 1.083 ± 0.038	0.809TyrPhe: 0.809 ± 0.03	1.955TyrGly: 1.955 ± 0.054	0.447TyrHis: 0.447 ± 0.026	0.719TyrIle: 0.719 ± 0.03	0.665TyrLys: 0.665 ± 0.03	2.204TyrLeu: 2.204 ± 0.044	0.406TyrMet: 0.406 ± 0.018	0.57TyrAsn: 0.57 ± 0.028	1.082TyrPro: 1.082 ± 0.031	0.936TyrGln: 0.936 ± 0.033	1.608TyrArg: 1.608 ± 0.043	1.005TyrSer: 1.005 ± 0.033	1.147TyrThr: 1.147 ± 0.037	1.57TyrVal: 1.57 ± 0.039	0.33TyrTrp: 0.33 ± 0.02	0.532TyrTyr: 0.532 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2763 proteins (887405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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