Amino acid dipepetide frequency for Flavobacterium akiainvivens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.98AlaAla: 6.98 ± 0.104	0.678AlaCys: 0.678 ± 0.028	4.471AlaAsp: 4.471 ± 0.059	5.215AlaGlu: 5.215 ± 0.074	3.83AlaPhe: 3.83 ± 0.065	5.797AlaGly: 5.797 ± 0.071	1.359AlaHis: 1.359 ± 0.038	5.358AlaIle: 5.358 ± 0.079	4.971AlaLys: 4.971 ± 0.082	7.596AlaLeu: 7.596 ± 0.083	1.731AlaMet: 1.731 ± 0.042	4.057AlaAsn: 4.057 ± 0.075	2.649AlaPro: 2.649 ± 0.06	3.491AlaGln: 3.491 ± 0.057	2.429AlaArg: 2.429 ± 0.053	4.283AlaSer: 4.283 ± 0.061	5.132AlaThr: 5.132 ± 0.12	5.37AlaVal: 5.37 ± 0.066	0.823AlaTrp: 0.823 ± 0.027	3.005AlaTyr: 3.005 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.539CysAla: 0.539 ± 0.022	0.099CysCys: 0.099 ± 0.009	0.412CysAsp: 0.412 ± 0.028	0.444CysGlu: 0.444 ± 0.023	0.396CysPhe: 0.396 ± 0.018	0.686CysGly: 0.686 ± 0.028	0.187CysHis: 0.187 ± 0.015	0.6CysIle: 0.6 ± 0.021	0.408CysLys: 0.408 ± 0.02	0.665CysLeu: 0.665 ± 0.023	0.165CysMet: 0.165 ± 0.011	0.434CysAsn: 0.434 ± 0.021	0.345CysPro: 0.345 ± 0.017	0.225CysGln: 0.225 ± 0.015	0.274CysArg: 0.274 ± 0.015	0.536CysSer: 0.536 ± 0.025	0.51CysThr: 0.51 ± 0.03	0.407CysVal: 0.407 ± 0.02	0.063CysTrp: 0.063 ± 0.007	0.335CysTyr: 0.335 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.474AspAla: 4.474 ± 0.069	0.414AspCys: 0.414 ± 0.021	2.87AspAsp: 2.87 ± 0.061	3.596AspGlu: 3.596 ± 0.056	3.419AspPhe: 3.419 ± 0.051	4.15AspGly: 4.15 ± 0.077	0.812AspHis: 0.812 ± 0.026	4.078AspIle: 4.078 ± 0.067	3.917AspLys: 3.917 ± 0.065	4.364AspLeu: 4.364 ± 0.063	1.235AspMet: 1.235 ± 0.037	3.174AspAsn: 3.174 ± 0.05	1.777AspPro: 1.777 ± 0.045	1.176AspGln: 1.176 ± 0.03	1.957AspArg: 1.957 ± 0.046	2.819AspSer: 2.819 ± 0.054	3.092AspThr: 3.092 ± 0.054	3.812AspVal: 3.812 ± 0.057	0.744AspTrp: 0.744 ± 0.026	2.753AspTyr: 2.753 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.243GluAla: 5.243 ± 0.088	0.366GluCys: 0.366 ± 0.02	3.163GluAsp: 3.163 ± 0.054	4.178GluGlu: 4.178 ± 0.069	2.611GluPhe: 2.611 ± 0.05	4.105GluGly: 4.105 ± 0.063	1.107GluHis: 1.107 ± 0.035	4.43GluIle: 4.43 ± 0.065	4.908GluLys: 4.908 ± 0.074	5.55GluLeu: 5.55 ± 0.068	1.587GluMet: 1.587 ± 0.034	3.707GluAsn: 3.707 ± 0.055	1.925GluPro: 1.925 ± 0.042	2.48GluGln: 2.48 ± 0.048	2.514GluArg: 2.514 ± 0.053	2.91GluSer: 2.91 ± 0.049	3.54GluThr: 3.54 ± 0.057	4.317GluVal: 4.317 ± 0.057	0.691GluTrp: 0.691 ± 0.027	2.595GluTyr: 2.595 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.665PheAla: 3.665 ± 0.066	0.441PheCys: 0.441 ± 0.018	3.092PheAsp: 3.092 ± 0.052	3.192PheGlu: 3.192 ± 0.052	2.372PhePhe: 2.372 ± 0.062	3.536PheGly: 3.536 ± 0.059	0.746PheHis: 0.746 ± 0.025	3.359PheIle: 3.359 ± 0.058	3.192PheLys: 3.192 ± 0.05	3.76PheLeu: 3.76 ± 0.062	1.179PheMet: 1.179 ± 0.034	2.999PheAsn: 2.999 ± 0.056	1.57PhePro: 1.57 ± 0.034	1.141PheGln: 1.141 ± 0.03	1.723PheArg: 1.723 ± 0.036	3.489PheSer: 3.489 ± 0.059	3.705PheThr: 3.705 ± 0.061	2.967PheVal: 2.967 ± 0.049	0.535PheTrp: 0.535 ± 0.023	2.137PheTyr: 2.137 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.065GlyAla: 5.065 ± 0.073	0.711GlyCys: 0.711 ± 0.034	3.433GlyAsp: 3.433 ± 0.05	3.718GlyGlu: 3.718 ± 0.059	3.811GlyPhe: 3.811 ± 0.057	5.025GlyGly: 5.025 ± 0.083	1.32GlyHis: 1.32 ± 0.033	5.301GlyIle: 5.301 ± 0.071	4.956GlyLys: 4.956 ± 0.082	6.163GlyLeu: 6.163 ± 0.083	1.675GlyMet: 1.675 ± 0.041	4.045GlyAsn: 4.045 ± 0.076	1.568GlyPro: 1.568 ± 0.044	2.475GlyGln: 2.475 ± 0.047	2.461GlyArg: 2.461 ± 0.049	4.329GlySer: 4.329 ± 0.078	4.939GlyThr: 4.939 ± 0.101	4.639GlyVal: 4.639 ± 0.063	0.941GlyTrp: 0.941 ± 0.035	3.282GlyTyr: 3.282 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.143HisAla: 1.143 ± 0.035	0.159HisCys: 0.159 ± 0.011	0.985HisAsp: 0.985 ± 0.03	1.021HisGlu: 1.021 ± 0.029	1.1HisPhe: 1.1 ± 0.03	1.188HisGly: 1.188 ± 0.03	0.495HisHis: 0.495 ± 0.02	1.438HisIle: 1.438 ± 0.035	1.134HisLys: 1.134 ± 0.031	1.689HisLeu: 1.689 ± 0.037	0.357HisMet: 0.357 ± 0.018	1.176HisAsn: 1.176 ± 0.029	0.897HisPro: 0.897 ± 0.031	0.583HisGln: 0.583 ± 0.023	0.727HisArg: 0.727 ± 0.023	1.028HisSer: 1.028 ± 0.029	1.125HisThr: 1.125 ± 0.032	0.91HisVal: 0.91 ± 0.029	0.219HisTrp: 0.219 ± 0.013	0.957HisTyr: 0.957 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.731IleAla: 5.731 ± 0.087	0.553IleCys: 0.553 ± 0.02	4.122IleAsp: 4.122 ± 0.064	4.447IleGlu: 4.447 ± 0.063	2.866IlePhe: 2.866 ± 0.058	4.28IleGly: 4.28 ± 0.061	1.159IleHis: 1.159 ± 0.034	4.845IleIle: 4.845 ± 0.078	4.73IleLys: 4.73 ± 0.065	5.641IleLeu: 5.641 ± 0.08	1.385IleMet: 1.385 ± 0.031	4.137IleAsn: 4.137 ± 0.066	2.941IlePro: 2.941 ± 0.048	2.139IleGln: 2.139 ± 0.04	2.344IleArg: 2.344 ± 0.043	4.475IleSer: 4.475 ± 0.063	5.123IleThr: 5.123 ± 0.068	4.265IleVal: 4.265 ± 0.072	0.629IleTrp: 0.629 ± 0.026	2.607IleTyr: 2.607 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.485LysAla: 5.485 ± 0.08	0.307LysCys: 0.307 ± 0.016	4.166LysAsp: 4.166 ± 0.072	4.944LysGlu: 4.944 ± 0.076	2.476LysPhe: 2.476 ± 0.042	4.402LysGly: 4.402 ± 0.076	1.24LysHis: 1.24 ± 0.032	4.615LysIle: 4.615 ± 0.07	5.753LysLys: 5.753 ± 0.087	5.766LysLeu: 5.766 ± 0.08	1.886LysMet: 1.886 ± 0.048	4.067LysAsn: 4.067 ± 0.064	2.613LysPro: 2.613 ± 0.047	2.756LysGln: 2.756 ± 0.058	2.443LysArg: 2.443 ± 0.045	3.471LysSer: 3.471 ± 0.054	4.184LysThr: 4.184 ± 0.066	4.356LysVal: 4.356 ± 0.078	0.763LysTrp: 0.763 ± 0.025	2.728LysTyr: 2.728 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.876LeuAla: 6.876 ± 0.08	0.77LeuCys: 0.77 ± 0.028	4.588LeuAsp: 4.588 ± 0.066	5.336LeuGlu: 5.336 ± 0.069	4.449LeuPhe: 4.449 ± 0.075	5.808LeuGly: 5.808 ± 0.081	1.731LeuHis: 1.731 ± 0.039	5.402LeuIle: 5.402 ± 0.091	6.711LeuLys: 6.711 ± 0.095	8.893LeuLeu: 8.893 ± 0.119	2.127LeuMet: 2.127 ± 0.04	4.952LeuAsn: 4.952 ± 0.074	3.977LeuPro: 3.977 ± 0.065	3.617LeuGln: 3.617 ± 0.061	3.275LeuArg: 3.275 ± 0.054	5.985LeuSer: 5.985 ± 0.078	5.552LeuThr: 5.552 ± 0.073	5.483LeuVal: 5.483 ± 0.065	0.877LeuTrp: 0.877 ± 0.029	3.556LeuTyr: 3.556 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.117MetAla: 2.117 ± 0.043	0.157MetCys: 0.157 ± 0.013	1.217MetAsp: 1.217 ± 0.03	1.461MetGlu: 1.461 ± 0.031	0.873MetPhe: 0.873 ± 0.031	1.605MetGly: 1.605 ± 0.041	0.433MetHis: 0.433 ± 0.017	1.163MetIle: 1.163 ± 0.031	2.096MetLys: 2.096 ± 0.039	2.113MetLeu: 2.113 ± 0.044	0.6MetMet: 0.6 ± 0.026	1.027MetAsn: 1.027 ± 0.028	1.058MetPro: 1.058 ± 0.026	0.969MetGln: 0.969 ± 0.029	0.885MetArg: 0.885 ± 0.026	1.304MetSer: 1.304 ± 0.035	1.106MetThr: 1.106 ± 0.03	1.509MetVal: 1.509 ± 0.032	0.192MetTrp: 0.192 ± 0.01	0.781MetTyr: 0.781 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.302AsnAla: 4.302 ± 0.062	0.404AsnCys: 0.404 ± 0.021	2.94AsnAsp: 2.94 ± 0.051	3.18AsnGlu: 3.18 ± 0.057	2.617AsnPhe: 2.617 ± 0.059	4.606AsnGly: 4.606 ± 0.084	1.044AsnHis: 1.044 ± 0.03	4.186AsnIle: 4.186 ± 0.06	3.277AsnLys: 3.277 ± 0.057	4.813AsnLeu: 4.813 ± 0.064	1.208AsnMet: 1.208 ± 0.034	3.631AsnAsn: 3.631 ± 0.076	2.981AsnPro: 2.981 ± 0.061	1.852AsnGln: 1.852 ± 0.039	2.264AsnArg: 2.264 ± 0.04	3.185AsnSer: 3.185 ± 0.058	3.783AsnThr: 3.783 ± 0.07	3.516AsnVal: 3.516 ± 0.06	0.708AsnTrp: 0.708 ± 0.026	2.659AsnTyr: 2.659 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	3.322ProAla: 3.322 ± 0.07	0.222ProCys: 0.222 ± 0.014	2.503ProAsp: 2.503 ± 0.055	3.054ProGlu: 3.054 ± 0.06	1.856ProPhe: 1.856 ± 0.043	2.848ProGly: 2.848 ± 0.058	0.732ProHis: 0.732 ± 0.026	2.094ProIle: 2.094 ± 0.038	2.255ProLys: 2.255 ± 0.045	3.282ProLeu: 3.282 ± 0.051	0.783ProMet: 0.783 ± 0.023	2.031ProAsn: 2.031 ± 0.043	0.983ProPro: 0.983 ± 0.033	1.724ProGln: 1.724 ± 0.045	1.009ProArg: 1.009 ± 0.03	1.893ProSer: 1.893 ± 0.04	2.04ProThr: 2.04 ± 0.044	3.377ProVal: 3.377 ± 0.059	0.388ProTrp: 0.388 ± 0.017	1.585ProTyr: 1.585 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.687GlnAla: 2.687 ± 0.051	0.204GlnCys: 0.204 ± 0.014	1.886GlnAsp: 1.886 ± 0.045	2.281GlnGlu: 2.281 ± 0.049	1.626GlnPhe: 1.626 ± 0.034	2.249GlnGly: 2.249 ± 0.04	0.758GlnHis: 0.758 ± 0.027	2.126GlnIle: 2.126 ± 0.041	2.71GlnLys: 2.71 ± 0.052	3.481GlnLeu: 3.481 ± 0.059	0.901GlnMet: 0.901 ± 0.028	2.204GlnAsn: 2.204 ± 0.043	1.551GlnPro: 1.551 ± 0.041	1.921GlnGln: 1.921 ± 0.051	1.382GlnArg: 1.382 ± 0.032	1.914GlnSer: 1.914 ± 0.04	2.101GlnThr: 2.101 ± 0.049	2.4GlnVal: 2.4 ± 0.044	0.448GlnTrp: 0.448 ± 0.023	1.698GlnTyr: 1.698 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.363ArgAla: 2.363 ± 0.046	0.215ArgCys: 0.215 ± 0.014	1.796ArgAsp: 1.796 ± 0.036	2.342ArgGlu: 2.342 ± 0.041	2.014ArgPhe: 2.014 ± 0.046	2.034ArgGly: 2.034 ± 0.051	0.745ArgHis: 0.745 ± 0.026	2.724ArgIle: 2.724 ± 0.048	2.573ArgLys: 2.573 ± 0.049	3.605ArgLeu: 3.605 ± 0.059	0.968ArgMet: 0.968 ± 0.026	2.065ArgAsn: 2.065 ± 0.041	1.254ArgPro: 1.254 ± 0.034	1.398ArgGln: 1.398 ± 0.036	1.532ArgArg: 1.532 ± 0.04	1.795ArgSer: 1.795 ± 0.037	1.905ArgThr: 1.905 ± 0.04	2.321ArgVal: 2.321 ± 0.042	0.412ArgTrp: 0.412 ± 0.02	1.68ArgTyr: 1.68 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.353SerAla: 4.353 ± 0.066	0.564SerCys: 0.564 ± 0.022	2.821SerAsp: 2.821 ± 0.048	3.12SerGlu: 3.12 ± 0.054	3.254SerPhe: 3.254 ± 0.06	4.625SerGly: 4.625 ± 0.07	1.107SerHis: 1.107 ± 0.031	4.05SerIle: 4.05 ± 0.064	3.437SerLys: 3.437 ± 0.057	5.645SerLeu: 5.645 ± 0.07	1.157SerMet: 1.157 ± 0.03	2.98SerAsn: 2.98 ± 0.052	2.299SerPro: 2.299 ± 0.045	2.077SerGln: 2.077 ± 0.044	2.173SerArg: 2.173 ± 0.049	3.199SerSer: 3.199 ± 0.068	3.358SerThr: 3.358 ± 0.065	4.088SerVal: 4.088 ± 0.058	0.682SerTrp: 0.682 ± 0.022	2.647SerTyr: 2.647 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	5.475ThrAla: 5.475 ± 0.099	0.372ThrCys: 0.372 ± 0.019	3.71ThrAsp: 3.71 ± 0.049	3.614ThrGlu: 3.614 ± 0.057	3.066ThrPhe: 3.066 ± 0.059	5.393ThrGly: 5.393 ± 0.089	1.122ThrHis: 1.122 ± 0.028	4.478ThrIle: 4.478 ± 0.07	3.3ThrLys: 3.3 ± 0.061	5.971ThrLeu: 5.971 ± 0.075	1.008ThrMet: 1.008 ± 0.03	3.069ThrAsn: 3.069 ± 0.064	3.109ThrPro: 3.109 ± 0.062	2.267ThrGln: 2.267 ± 0.048	1.906ThrArg: 1.906 ± 0.04	3.446ThrSer: 3.446 ± 0.066	4.219ThrThr: 4.219 ± 0.099	4.976ThrVal: 4.976 ± 0.097	0.651ThrTrp: 0.651 ± 0.026	2.701ThrTyr: 2.701 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.497ValAla: 5.497 ± 0.068	0.612ValCys: 0.612 ± 0.025	3.433ValAsp: 3.433 ± 0.059	3.8ValGlu: 3.8 ± 0.06	3.306ValPhe: 3.306 ± 0.054	3.894ValGly: 3.894 ± 0.063	1.14ValHis: 1.14 ± 0.036	4.636ValIle: 4.636 ± 0.068	4.543ValLys: 4.543 ± 0.069	6.199ValLeu: 6.199 ± 0.078	1.494ValMet: 1.494 ± 0.038	3.841ValAsn: 3.841 ± 0.064	2.556ValPro: 2.556 ± 0.047	2.223ValGln: 2.223 ± 0.043	2.195ValArg: 2.195 ± 0.044	4.308ValSer: 4.308 ± 0.066	4.748ValThr: 4.748 ± 0.086	4.854ValVal: 4.854 ± 0.078	0.697ValTrp: 0.697 ± 0.025	2.782ValTyr: 2.782 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.851TrpAla: 0.851 ± 0.033	0.108TrpCys: 0.108 ± 0.009	0.681TrpAsp: 0.681 ± 0.025	0.625TrpGlu: 0.625 ± 0.025	0.535TrpPhe: 0.535 ± 0.022	0.777TrpGly: 0.777 ± 0.029	0.269TrpHis: 0.269 ± 0.016	0.667TrpIle: 0.667 ± 0.022	0.722TrpLys: 0.722 ± 0.025	1.039TrpLeu: 1.039 ± 0.033	0.3TrpMet: 0.3 ± 0.014	0.717TrpAsn: 0.717 ± 0.027	0.312TrpPro: 0.312 ± 0.019	0.576TrpGln: 0.576 ± 0.02	0.403TrpArg: 0.403 ± 0.02	0.596TrpSer: 0.596 ± 0.026	0.575TrpThr: 0.575 ± 0.025	0.73TrpVal: 0.73 ± 0.027	0.146TrpTrp: 0.146 ± 0.013	0.51TrpTyr: 0.51 ± 0.022	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.058TyrAla: 3.058 ± 0.051	0.376TyrCys: 0.376 ± 0.02	2.345TyrAsp: 2.345 ± 0.047	2.36TyrGlu: 2.36 ± 0.047	2.324TyrPhe: 2.324 ± 0.051	2.846TyrGly: 2.846 ± 0.054	0.823TyrHis: 0.823 ± 0.025	2.874TyrIle: 2.874 ± 0.045	2.829TyrLys: 2.829 ± 0.056	3.731TyrLeu: 3.731 ± 0.058	0.918TyrMet: 0.918 ± 0.027	2.843TyrAsn: 2.843 ± 0.051	1.614TyrPro: 1.614 ± 0.036	1.438TyrGln: 1.438 ± 0.037	1.844TyrArg: 1.844 ± 0.042	2.671TyrSer: 2.671 ± 0.046	3.117TyrThr: 3.117 ± 0.057	2.459TyrVal: 2.459 ± 0.042	0.529TyrTrp: 0.529 ± 0.02	2.228TyrTyr: 2.228 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3833 proteins (1277701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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