Amino acid dipepetide frequency for Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.907AlaAla: 11.907 ± 0.147
1.332AlaCys: 1.332 ± 0.034
5.65AlaAsp: 5.65 ± 0.074
6.511AlaGlu: 6.511 ± 0.083
3.428AlaPhe: 3.428 ± 0.057
8.77AlaGly: 8.77 ± 0.099
2.155AlaHis: 2.155 ± 0.047
5.733AlaIle: 5.733 ± 0.079
4.149AlaLys: 4.149 ± 0.069
13.207AlaLeu: 13.207 ± 0.118
3.187AlaMet: 3.187 ± 0.051
3.143AlaAsn: 3.143 ± 0.061
4.385AlaPro: 4.385 ± 0.072
4.528AlaGln: 4.528 ± 0.06
6.666AlaArg: 6.666 ± 0.083
5.877AlaSer: 5.877 ± 0.074
4.739AlaThr: 4.739 ± 0.069
6.688AlaVal: 6.688 ± 0.079
1.427AlaTrp: 1.427 ± 0.038
2.252AlaTyr: 2.252 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.049CysAla: 1.049 ± 0.029
0.199CysCys: 0.199 ± 0.015
0.656CysAsp: 0.656 ± 0.021
0.66CysGlu: 0.66 ± 0.025
0.454CysPhe: 0.454 ± 0.019
1.068CysGly: 1.068 ± 0.032
0.424CysHis: 0.424 ± 0.025
0.5CysIle: 0.5 ± 0.019
0.347CysLys: 0.347 ± 0.015
1.181CysLeu: 1.181 ± 0.028
0.228CysMet: 0.228 ± 0.012
0.318CysAsn: 0.318 ± 0.016
0.573CysPro: 0.573 ± 0.022
0.555CysGln: 0.555 ± 0.021
0.75CysArg: 0.75 ± 0.026
0.67CysSer: 0.67 ± 0.023
0.496CysThr: 0.496 ± 0.021
0.638CysVal: 0.638 ± 0.025
0.216CysTrp: 0.216 ± 0.014
0.345CysTyr: 0.345 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.944AspAla: 4.944 ± 0.062
0.562AspCys: 0.562 ± 0.024
2.518AspAsp: 2.518 ± 0.048
3.803AspGlu: 3.803 ± 0.065
1.989AspPhe: 1.989 ± 0.04
4.37AspGly: 4.37 ± 0.107
1.206AspHis: 1.206 ± 0.032
2.785AspIle: 2.785 ± 0.053
2.386AspLys: 2.386 ± 0.045
5.549AspLeu: 5.549 ± 0.065
1.277AspMet: 1.277 ± 0.034
1.737AspAsn: 1.737 ± 0.043
2.623AspPro: 2.623 ± 0.046
2.045AspGln: 2.045 ± 0.041
2.701AspArg: 2.701 ± 0.051
2.511AspSer: 2.511 ± 0.045
2.244AspThr: 2.244 ± 0.049
3.163AspVal: 3.163 ± 0.052
0.905AspTrp: 0.905 ± 0.027
1.822AspTyr: 1.822 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
6.184GluAla: 6.184 ± 0.08
0.514GluCys: 0.514 ± 0.021
2.097GluAsp: 2.097 ± 0.047
3.315GluGlu: 3.315 ± 0.063
1.919GluPhe: 1.919 ± 0.037
4.155GluGly: 4.155 ± 0.057
1.407GluHis: 1.407 ± 0.032
2.86GluIle: 2.86 ± 0.061
2.168GluLys: 2.168 ± 0.044
7.55GluLeu: 7.55 ± 0.093
1.589GluMet: 1.589 ± 0.037
1.465GluAsn: 1.465 ± 0.037
2.518GluPro: 2.518 ± 0.045
4.62GluGln: 4.62 ± 0.077
4.309GluArg: 4.309 ± 0.074
2.727GluSer: 2.727 ± 0.045
2.507GluThr: 2.507 ± 0.074
4.248GluVal: 4.248 ± 0.062
0.819GluTrp: 0.819 ± 0.025
1.343GluTyr: 1.343 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.769PheAla: 3.769 ± 0.061
0.498PheCys: 0.498 ± 0.017
2.358PheAsp: 2.358 ± 0.039
2.099PheGlu: 2.099 ± 0.046
1.469PhePhe: 1.469 ± 0.036
3.231PheGly: 3.231 ± 0.054
0.814PheHis: 0.814 ± 0.024
2.07PheIle: 2.07 ± 0.046
1.403PheLys: 1.403 ± 0.033
3.216PheLeu: 3.216 ± 0.059
0.91PheMet: 0.91 ± 0.026
1.517PheAsn: 1.517 ± 0.033
1.371PhePro: 1.371 ± 0.036
1.111PheGln: 1.111 ± 0.03
1.633PheArg: 1.633 ± 0.034
2.503PheSer: 2.503 ± 0.043
2.004PheThr: 2.004 ± 0.039
2.519PheVal: 2.519 ± 0.051
0.553PheTrp: 0.553 ± 0.022
1.144PheTyr: 1.144 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.186GlyAla: 7.186 ± 0.115
1.045GlyCys: 1.045 ± 0.03
3.902GlyAsp: 3.902 ± 0.067
5.189GlyGlu: 5.189 ± 0.07
3.313GlyPhe: 3.313 ± 0.052
5.788GlyGly: 5.788 ± 0.09
1.909GlyHis: 1.909 ± 0.044
4.611GlyIle: 4.611 ± 0.069
3.94GlyLys: 3.94 ± 0.055
8.964GlyLeu: 8.964 ± 0.118
2.497GlyMet: 2.497 ± 0.05
2.611GlyAsn: 2.611 ± 0.068
2.461GlyPro: 2.461 ± 0.042
3.836GlyGln: 3.836 ± 0.064
4.573GlyArg: 4.573 ± 0.066
4.593GlySer: 4.593 ± 0.096
3.618GlyThr: 3.618 ± 0.098
5.676GlyVal: 5.676 ± 0.086
1.459GlyTrp: 1.459 ± 0.034
2.539GlyTyr: 2.539 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.995HisAla: 1.995 ± 0.042
0.385HisCys: 0.385 ± 0.017
1.189HisAsp: 1.189 ± 0.03
1.198HisGlu: 1.198 ± 0.032
1.071HisPhe: 1.071 ± 0.025
2.015HisGly: 2.015 ± 0.04
0.84HisHis: 0.84 ± 0.035
1.129HisIle: 1.129 ± 0.028
0.837HisLys: 0.837 ± 0.021
2.555HisLeu: 2.555 ± 0.048
0.497HisMet: 0.497 ± 0.019
0.697HisAsn: 0.697 ± 0.021
1.553HisPro: 1.553 ± 0.032
1.371HisGln: 1.371 ± 0.033
1.277HisArg: 1.277 ± 0.036
1.261HisSer: 1.261 ± 0.032
1.04HisThr: 1.04 ± 0.034
1.153HisVal: 1.153 ± 0.03
0.463HisTrp: 0.463 ± 0.02
0.887HisTyr: 0.887 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.6IleAla: 5.6 ± 0.08
0.629IleCys: 0.629 ± 0.019
3.056IleAsp: 3.056 ± 0.05
3.346IleGlu: 3.346 ± 0.056
1.616IlePhe: 1.616 ± 0.04
4.398IleGly: 4.398 ± 0.063
1.157IleHis: 1.157 ± 0.032
2.37IleIle: 2.37 ± 0.048
2.253IleLys: 2.253 ± 0.051
4.562IleLeu: 4.562 ± 0.062
1.125IleMet: 1.125 ± 0.035
2.003IleAsn: 2.003 ± 0.046
2.445IlePro: 2.445 ± 0.048
1.67IleGln: 1.67 ± 0.037
2.97IleArg: 2.97 ± 0.053
3.27IleSer: 3.27 ± 0.049
2.822IleThr: 2.822 ± 0.084
3.028IleVal: 3.028 ± 0.055
0.612IleTrp: 0.612 ± 0.024
1.294IleTyr: 1.294 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.309LysAla: 4.309 ± 0.073
0.236LysCys: 0.236 ± 0.014
1.778LysAsp: 1.778 ± 0.037
2.472LysGlu: 2.472 ± 0.052
1.033LysPhe: 1.033 ± 0.037
3.141LysGly: 3.141 ± 0.055
0.713LysHis: 0.713 ± 0.023
1.755LysIle: 1.755 ± 0.047
1.54LysLys: 1.54 ± 0.048
4.271LysLeu: 4.271 ± 0.062
0.953LysMet: 0.953 ± 0.029
1.064LysAsn: 1.064 ± 0.029
2.113LysPro: 2.113 ± 0.041
2.101LysGln: 2.101 ± 0.042
2.238LysArg: 2.238 ± 0.045
2.091LysSer: 2.091 ± 0.043
1.799LysThr: 1.799 ± 0.036
3.148LysVal: 3.148 ± 0.066
0.409LysTrp: 0.409 ± 0.016
0.835LysTyr: 0.835 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.328LeuAla: 15.328 ± 0.141
1.497LeuCys: 1.497 ± 0.036
6.322LeuAsp: 6.322 ± 0.07
5.95LeuGlu: 5.95 ± 0.084
4.385LeuPhe: 4.385 ± 0.069
9.603LeuGly: 9.603 ± 0.114
2.41LeuHis: 2.41 ± 0.043
5.579LeuIle: 5.579 ± 0.077
4.502LeuLys: 4.502 ± 0.067
15.235LeuLeu: 15.235 ± 0.201
3.032LeuMet: 3.032 ± 0.051
3.472LeuAsn: 3.472 ± 0.049
6.364LeuPro: 6.364 ± 0.073
4.721LeuGln: 4.721 ± 0.066
6.161LeuArg: 6.161 ± 0.09
7.125LeuSer: 7.125 ± 0.083
6.58LeuThr: 6.58 ± 0.097
8.467LeuVal: 8.467 ± 0.095
1.514LeuTrp: 1.514 ± 0.046
2.625LeuTyr: 2.625 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.041MetAla: 3.041 ± 0.059
0.18MetCys: 0.18 ± 0.011
1.222MetAsp: 1.222 ± 0.033
1.288MetGlu: 1.288 ± 0.031
0.721MetPhe: 0.721 ± 0.025
2.074MetGly: 2.074 ± 0.049
0.476MetHis: 0.476 ± 0.019
1.223MetIle: 1.223 ± 0.033
1.179MetLys: 1.179 ± 0.031
3.032MetLeu: 3.032 ± 0.053
0.767MetMet: 0.767 ± 0.028
0.928MetAsn: 0.928 ± 0.024
1.296MetPro: 1.296 ± 0.032
1.14MetGln: 1.14 ± 0.032
1.285MetArg: 1.285 ± 0.027
1.815MetSer: 1.815 ± 0.037
1.626MetThr: 1.626 ± 0.032
1.989MetVal: 1.989 ± 0.04
0.215MetTrp: 0.215 ± 0.013
0.396MetTyr: 0.396 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.672AsnAla: 2.672 ± 0.048
0.307AsnCys: 0.307 ± 0.015
1.523AsnAsp: 1.523 ± 0.048
1.638AsnGlu: 1.638 ± 0.043
1.04AsnPhe: 1.04 ± 0.031
2.57AsnGly: 2.57 ± 0.062
0.713AsnHis: 0.713 ± 0.022
1.578AsnIle: 1.578 ± 0.04
1.279AsnLys: 1.279 ± 0.033
3.419AsnLeu: 3.419 ± 0.051
0.763AsnMet: 0.763 ± 0.026
1.08AsnAsn: 1.08 ± 0.031
2.031AsnPro: 2.031 ± 0.042
1.604AsnGln: 1.604 ± 0.037
1.881AsnArg: 1.881 ± 0.04
1.565AsnSer: 1.565 ± 0.047
1.52AsnThr: 1.52 ± 0.039
1.817AsnVal: 1.817 ± 0.051
0.524AsnTrp: 0.524 ± 0.021
0.871AsnTyr: 0.871 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.884ProAla: 5.884 ± 0.089
0.476ProCys: 0.476 ± 0.023
2.877ProAsp: 2.877 ± 0.043
3.194ProGlu: 3.194 ± 0.047
1.886ProPhe: 1.886 ± 0.04
3.473ProGly: 3.473 ± 0.055
1.123ProHis: 1.123 ± 0.03
2.104ProIle: 2.104 ± 0.038
1.483ProLys: 1.483 ± 0.031
6.051ProLeu: 6.051 ± 0.074
1.238ProMet: 1.238 ± 0.029
1.201ProAsn: 1.201 ± 0.033
1.737ProPro: 1.737 ± 0.042
2.017ProGln: 2.017 ± 0.04
2.288ProArg: 2.288 ± 0.042
2.341ProSer: 2.341 ± 0.043
2.303ProThr: 2.303 ± 0.04
3.755ProVal: 3.755 ± 0.06
0.768ProTrp: 0.768 ± 0.024
1.251ProTyr: 1.251 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
5.741GlnAla: 5.741 ± 0.078
0.393GlnCys: 0.393 ± 0.015
2.118GlnAsp: 2.118 ± 0.04
2.475GlnGlu: 2.475 ± 0.044
1.489GlnPhe: 1.489 ± 0.033
4.165GlnGly: 4.165 ± 0.066
1.249GlnHis: 1.249 ± 0.035
2.229GlnIle: 2.229 ± 0.045
1.414GlnLys: 1.414 ± 0.036
6.274GlnLeu: 6.274 ± 0.081
1.147GlnMet: 1.147 ± 0.029
1.055GlnAsn: 1.055 ± 0.031
2.497GlnPro: 2.497 ± 0.046
3.653GlnGln: 3.653 ± 0.078
2.853GlnArg: 2.853 ± 0.054
2.542GlnSer: 2.542 ± 0.043
2.152GlnThr: 2.152 ± 0.049
3.465GlnVal: 3.465 ± 0.057
0.82GlnTrp: 0.82 ± 0.029
1.063GlnTyr: 1.063 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
5.242ArgAla: 5.242 ± 0.066
0.634ArgCys: 0.634 ± 0.021
2.976ArgAsp: 2.976 ± 0.044
3.778ArgGlu: 3.778 ± 0.064
2.611ArgPhe: 2.611 ± 0.043
3.544ArgGly: 3.544 ± 0.058
1.851ArgHis: 1.851 ± 0.039
3.337ArgIle: 3.337 ± 0.049
1.97ArgLys: 1.97 ± 0.044
7.911ArgLeu: 7.911 ± 0.093
1.419ArgMet: 1.419 ± 0.036
1.662ArgAsn: 1.662 ± 0.041
2.529ArgPro: 2.529 ± 0.043
3.454ArgGln: 3.454 ± 0.059
3.717ArgArg: 3.717 ± 0.064
2.837ArgSer: 2.837 ± 0.049
2.447ArgThr: 2.447 ± 0.042
4.055ArgVal: 4.055 ± 0.053
1.018ArgTrp: 1.018 ± 0.031
2.022ArgTyr: 2.022 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.476SerAla: 5.476 ± 0.082
0.638SerCys: 0.638 ± 0.023
2.801SerAsp: 2.801 ± 0.058
3.117SerGlu: 3.117 ± 0.051
2.207SerPhe: 2.207 ± 0.042
5.07SerGly: 5.07 ± 0.073
1.462SerHis: 1.462 ± 0.032
2.487SerIle: 2.487 ± 0.049
1.975SerLys: 1.975 ± 0.044
7.088SerLeu: 7.088 ± 0.088
1.346SerMet: 1.346 ± 0.027
1.629SerAsn: 1.629 ± 0.046
2.652SerPro: 2.652 ± 0.054
2.676SerGln: 2.676 ± 0.049
3.742SerArg: 3.742 ± 0.056
3.294SerSer: 3.294 ± 0.065
2.508SerThr: 2.508 ± 0.044
3.597SerVal: 3.597 ± 0.07
0.929SerTrp: 0.929 ± 0.029
1.549SerTyr: 1.549 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.626ThrAla: 4.626 ± 0.067
0.463ThrCys: 0.463 ± 0.019
2.41ThrAsp: 2.41 ± 0.047
2.399ThrGlu: 2.399 ± 0.069
1.661ThrPhe: 1.661 ± 0.038
4.129ThrGly: 4.129 ± 0.093
1.11ThrHis: 1.11 ± 0.028
2.444ThrIle: 2.444 ± 0.076
1.33ThrLys: 1.33 ± 0.038
7.317ThrLeu: 7.317 ± 0.102
1.044ThrMet: 1.044 ± 0.028
1.333ThrAsn: 1.333 ± 0.036
3.104ThrPro: 3.104 ± 0.044
1.985ThrGln: 1.985 ± 0.04
3.007ThrArg: 3.007 ± 0.045
2.572ThrSer: 2.572 ± 0.045
2.366ThrThr: 2.366 ± 0.054
3.272ThrVal: 3.272 ± 0.077
0.523ThrTrp: 0.523 ± 0.02
1.095ThrTyr: 1.095 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
7.493ValAla: 7.493 ± 0.091
0.794ValCys: 0.794 ± 0.023
3.727ValAsp: 3.727 ± 0.088
4.122ValGlu: 4.122 ± 0.056
2.271ValPhe: 2.271 ± 0.042
5.026ValGly: 5.026 ± 0.069
1.245ValHis: 1.245 ± 0.031
3.824ValIle: 3.824 ± 0.063
2.703ValLys: 2.703 ± 0.056
7.534ValLeu: 7.534 ± 0.094
1.982ValMet: 1.982 ± 0.04
2.302ValAsn: 2.302 ± 0.048
3.04ValPro: 3.04 ± 0.044
2.512ValGln: 2.512 ± 0.044
3.868ValArg: 3.868 ± 0.062
4.397ValSer: 4.397 ± 0.062
3.849ValThr: 3.849 ± 0.09
5.122ValVal: 5.122 ± 0.076
0.844ValTrp: 0.844 ± 0.025
1.617ValTyr: 1.617 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.066TrpAla: 1.066 ± 0.028
0.192TrpCys: 0.192 ± 0.011
0.606TrpAsp: 0.606 ± 0.023
0.541TrpGlu: 0.541 ± 0.018
0.58TrpPhe: 0.58 ± 0.024
0.914TrpGly: 0.914 ± 0.032
0.468TrpHis: 0.468 ± 0.019
0.586TrpIle: 0.586 ± 0.021
0.332TrpLys: 0.332 ± 0.017
2.584TrpLeu: 2.584 ± 0.06
0.344TrpMet: 0.344 ± 0.016
0.369TrpAsn: 0.369 ± 0.016
0.759TrpPro: 0.759 ± 0.027
1.452TrpGln: 1.452 ± 0.042
1.066TrpArg: 1.066 ± 0.03
0.824TrpSer: 0.824 ± 0.026
0.5TrpThr: 0.5 ± 0.025
0.903TrpVal: 0.903 ± 0.028
0.276TrpTrp: 0.276 ± 0.014
0.36TrpTyr: 0.36 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.218TyrAla: 2.218 ± 0.041
0.352TyrCys: 0.352 ± 0.016
1.351TyrAsp: 1.351 ± 0.037
1.219TyrGlu: 1.219 ± 0.03
1.05TyrPhe: 1.05 ± 0.033
2.207TyrGly: 2.207 ± 0.047
0.684TyrHis: 0.684 ± 0.019
1.023TyrIle: 1.023 ± 0.028
0.813TyrLys: 0.813 ± 0.024
3.375TyrLeu: 3.375 ± 0.056
0.548TyrMet: 0.548 ± 0.019
0.805TyrAsn: 0.805 ± 0.034
1.4TyrPro: 1.4 ± 0.033
1.741TyrGln: 1.741 ± 0.037
2.027TyrArg: 2.027 ± 0.039
1.427TyrSer: 1.427 ± 0.034
1.071TyrThr: 1.071 ± 0.029
1.57TyrVal: 1.57 ± 0.036
0.427TyrTrp: 0.427 ± 0.018
0.792TyrTyr: 0.792 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4121 proteins (1379394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski