Dracunculus medinensis (Guinea worm)

Taxonomy: cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Spirurina; Dracunculoidea; Dracunculidae; Dracunculus

Average proteome isoelectric point is 6.92

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 10868 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A0N4U5P7|A0A0N4U5P7_DRAME Homeobox domain-containing protein OS=Dracunculus medinensis OX=318479 GN=DME_LOCUS6544 PE=4 SV=1
MM1 pKa = 7.48SVFHH5 pKa = 7.23DD6 pKa = 4.45EE7 pKa = 4.72IEE9 pKa = 4.57IEE11 pKa = 4.18DD12 pKa = 3.94FEE14 pKa = 5.23FDD16 pKa = 4.24EE17 pKa = 4.52EE18 pKa = 4.35LQIYY22 pKa = 7.64TYY24 pKa = 10.23PCPCGDD30 pKa = 3.15RR31 pKa = 11.84FEE33 pKa = 4.95ISRR36 pKa = 11.84EE37 pKa = 3.79MLEE40 pKa = 4.08AGEE43 pKa = 5.74DD44 pKa = 3.32IATCPSCSLIVRR56 pKa = 11.84VIYY59 pKa = 10.85DD60 pKa = 3.44PDD62 pKa = 3.66VFIKK66 pKa = 11.0LEE68 pKa = 4.26TVEE71 pKa = 4.22SQPIKK76 pKa = 10.55EE77 pKa = 4.3ILADD81 pKa = 3.52

Molecular weight: 9.38 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A0N4UBT2|A0A0N4UBT2_DRAME BEACH domain-containing protein OS=Dracunculus medinensis OX=318479 GN=DME_LOCUS8568 PE=4 SV=2
MM1 pKa = 7.45WFSILFWTILLIGTSLSAPQLGPVIGGTGLGGWNRR36 pKa = 11.84GGWNNPGGWNRR47 pKa = 11.84GGWSNPGGWNRR58 pKa = 11.84GGWNNPGGWNRR69 pKa = 11.84GGWNNPGQWNNPGGWNRR86 pKa = 11.84RR87 pKa = 11.84GWNNPGGWNRR97 pKa = 11.84GGWNNPGQWNRR108 pKa = 11.84GGMNPLGWAQPALQNFLGG126 pKa = 3.9

Molecular weight: 13.73 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

10868

0

10868

4070558

31

6322

374.5

42.61

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.875 ± 0.02

2.386 ± 0.022

5.327 ± 0.02

6.348 ± 0.028

4.969 ± 0.018

5.006 ± 0.028

2.295 ± 0.011

7.491 ± 0.022

6.347 ± 0.024

9.406 ± 0.032

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.392 ± 0.011

5.551 ± 0.019

4.119 ± 0.028

3.828 ± 0.016

5.474 ± 0.018

8.124 ± 0.03

4.929 ± 0.017

5.6 ± 0.018

1.133 ± 0.008

3.4 ± 0.013
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski