Amino acid dipepetide frequency for Aeromonas phage LAh1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.094AlaAla: 16.094 ± 2.205
0.924AlaCys: 0.924 ± 0.301
5.852AlaAsp: 5.852 ± 0.604
9.01AlaGlu: 9.01 ± 1.289
2.772AlaPhe: 2.772 ± 0.503
9.857AlaGly: 9.857 ± 0.788
1.694AlaHis: 1.694 ± 0.368
4.62AlaIle: 4.62 ± 0.565
5.852AlaLys: 5.852 ± 0.826
11.166AlaLeu: 11.166 ± 1.183
3.234AlaMet: 3.234 ± 0.514
4.004AlaAsn: 4.004 ± 0.637
3.311AlaPro: 3.311 ± 0.501
6.16AlaGln: 6.16 ± 1.116
6.006AlaArg: 6.006 ± 0.756
5.159AlaSer: 5.159 ± 0.47
7.008AlaThr: 7.008 ± 0.982
6.623AlaVal: 6.623 ± 0.986
1.078AlaTrp: 1.078 ± 0.3
3.619AlaTyr: 3.619 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
1.001CysAla: 1.001 ± 0.305
0.385CysCys: 0.385 ± 0.222
0.462CysAsp: 0.462 ± 0.229
0.539CysGlu: 0.539 ± 0.201
0.385CysPhe: 0.385 ± 0.137
1.463CysGly: 1.463 ± 0.422
0.385CysHis: 0.385 ± 0.178
0.616CysIle: 0.616 ± 0.231
0.616CysLys: 0.616 ± 0.219
0.693CysLeu: 0.693 ± 0.276
0.539CysMet: 0.539 ± 0.197
0.231CysAsn: 0.231 ± 0.114
0.693CysPro: 0.693 ± 0.221
0.308CysGln: 0.308 ± 0.135
0.693CysArg: 0.693 ± 0.221
0.77CysSer: 0.77 ± 0.284
0.924CysThr: 0.924 ± 0.337
0.847CysVal: 0.847 ± 0.214
0.077CysTrp: 0.077 ± 0.07
0.462CysTyr: 0.462 ± 0.204
0.0CysXaa: 0.0 ± 0.0
Asp
6.006AspAla: 6.006 ± 0.552
0.924AspCys: 0.924 ± 0.264
4.543AspAsp: 4.543 ± 0.634
3.927AspGlu: 3.927 ± 0.436
3.003AspPhe: 3.003 ± 0.446
4.389AspGly: 4.389 ± 0.713
1.001AspHis: 1.001 ± 0.305
3.234AspIle: 3.234 ± 0.441
3.465AspLys: 3.465 ± 0.471
4.928AspLeu: 4.928 ± 0.645
2.079AspMet: 2.079 ± 0.489
1.54AspAsn: 1.54 ± 0.353
2.002AspPro: 2.002 ± 0.372
2.002AspGln: 2.002 ± 0.278
3.311AspArg: 3.311 ± 0.408
3.619AspSer: 3.619 ± 0.431
2.849AspThr: 2.849 ± 0.517
3.388AspVal: 3.388 ± 0.437
0.924AspTrp: 0.924 ± 0.272
2.233AspTyr: 2.233 ± 0.465
0.0AspXaa: 0.0 ± 0.0
Glu
7.393GluAla: 7.393 ± 0.789
0.693GluCys: 0.693 ± 0.245
3.465GluAsp: 3.465 ± 0.647
3.773GluGlu: 3.773 ± 0.533
2.002GluPhe: 2.002 ± 0.412
3.85GluGly: 3.85 ± 0.587
1.617GluHis: 1.617 ± 0.34
1.155GluIle: 1.155 ± 0.303
3.465GluLys: 3.465 ± 0.578
6.7GluLeu: 6.7 ± 0.771
1.078GluMet: 1.078 ± 0.261
1.386GluAsn: 1.386 ± 0.302
1.463GluPro: 1.463 ± 0.303
4.158GluGln: 4.158 ± 0.758
3.388GluArg: 3.388 ± 0.542
3.157GluSer: 3.157 ± 0.444
3.696GluThr: 3.696 ± 0.427
4.235GluVal: 4.235 ± 0.549
1.001GluTrp: 1.001 ± 0.229
1.771GluTyr: 1.771 ± 0.319
0.0GluXaa: 0.0 ± 0.0
Phe
2.772PheAla: 2.772 ± 0.412
0.385PheCys: 0.385 ± 0.172
3.003PheAsp: 3.003 ± 0.454
1.694PheGlu: 1.694 ± 0.336
0.924PhePhe: 0.924 ± 0.251
2.926PheGly: 2.926 ± 0.419
0.231PheHis: 0.231 ± 0.141
2.233PheIle: 2.233 ± 0.467
2.156PheLys: 2.156 ± 0.427
2.464PheLeu: 2.464 ± 0.48
1.54PheMet: 1.54 ± 0.255
1.54PheAsn: 1.54 ± 0.321
1.078PhePro: 1.078 ± 0.244
1.771PheGln: 1.771 ± 0.351
1.617PheArg: 1.617 ± 0.291
1.617PheSer: 1.617 ± 0.254
1.309PheThr: 1.309 ± 0.309
2.156PheVal: 2.156 ± 0.341
0.385PheTrp: 0.385 ± 0.17
1.232PheTyr: 1.232 ± 0.288
0.0PheXaa: 0.0 ± 0.0
Gly
7.701GlyAla: 7.701 ± 0.982
1.463GlyCys: 1.463 ± 0.434
5.313GlyAsp: 5.313 ± 0.69
3.311GlyGlu: 3.311 ± 0.457
3.311GlyPhe: 3.311 ± 0.545
7.085GlyGly: 7.085 ± 1.414
1.54GlyHis: 1.54 ± 0.363
3.696GlyIle: 3.696 ± 0.509
4.928GlyLys: 4.928 ± 0.559
6.314GlyLeu: 6.314 ± 0.823
1.617GlyMet: 1.617 ± 0.401
3.003GlyAsn: 3.003 ± 0.554
2.233GlyPro: 2.233 ± 0.366
2.926GlyGln: 2.926 ± 0.447
4.851GlyArg: 4.851 ± 0.549
4.697GlySer: 4.697 ± 0.774
5.236GlyThr: 5.236 ± 0.756
5.159GlyVal: 5.159 ± 0.566
1.54GlyTrp: 1.54 ± 0.31
3.157GlyTyr: 3.157 ± 0.554
0.0GlyXaa: 0.0 ± 0.0
His
1.232HisAla: 1.232 ± 0.386
0.308HisCys: 0.308 ± 0.227
1.155HisAsp: 1.155 ± 0.261
1.232HisGlu: 1.232 ± 0.352
0.693HisPhe: 0.693 ± 0.165
2.156HisGly: 2.156 ± 0.451
0.539HisHis: 0.539 ± 0.232
0.924HisIle: 0.924 ± 0.278
0.77HisLys: 0.77 ± 0.266
1.001HisLeu: 1.001 ± 0.23
0.693HisMet: 0.693 ± 0.258
1.001HisAsn: 1.001 ± 0.283
1.463HisPro: 1.463 ± 0.33
0.77HisGln: 0.77 ± 0.219
2.002HisArg: 2.002 ± 0.542
1.386HisSer: 1.386 ± 0.329
1.155HisThr: 1.155 ± 0.315
1.463HisVal: 1.463 ± 0.339
0.154HisTrp: 0.154 ± 0.105
1.078HisTyr: 1.078 ± 0.347
0.0HisXaa: 0.0 ± 0.0
Ile
5.313IleAla: 5.313 ± 0.611
0.385IleCys: 0.385 ± 0.144
2.695IleAsp: 2.695 ± 0.402
2.079IleGlu: 2.079 ± 0.36
0.924IlePhe: 0.924 ± 0.296
3.927IleGly: 3.927 ± 0.711
1.386IleHis: 1.386 ± 0.308
1.771IleIle: 1.771 ± 0.342
2.079IleLys: 2.079 ± 0.483
3.08IleLeu: 3.08 ± 0.586
1.463IleMet: 1.463 ± 0.323
1.848IleAsn: 1.848 ± 0.476
1.694IlePro: 1.694 ± 0.295
1.771IleGln: 1.771 ± 0.326
2.618IleArg: 2.618 ± 0.318
2.079IleSer: 2.079 ± 0.379
2.618IleThr: 2.618 ± 0.466
2.464IleVal: 2.464 ± 0.466
0.308IleTrp: 0.308 ± 0.158
1.309IleTyr: 1.309 ± 0.304
0.0IleXaa: 0.0 ± 0.0
Lys
8.317LysAla: 8.317 ± 0.845
0.308LysCys: 0.308 ± 0.143
3.465LysAsp: 3.465 ± 0.446
4.466LysGlu: 4.466 ± 0.594
1.309LysPhe: 1.309 ± 0.293
3.465LysGly: 3.465 ± 0.574
1.155LysHis: 1.155 ± 0.304
1.771LysIle: 1.771 ± 0.357
2.772LysLys: 2.772 ± 0.503
5.698LysLeu: 5.698 ± 0.697
1.848LysMet: 1.848 ± 0.487
2.002LysAsn: 2.002 ± 0.35
2.695LysPro: 2.695 ± 0.56
2.772LysGln: 2.772 ± 0.575
3.388LysArg: 3.388 ± 0.386
2.695LysSer: 2.695 ± 0.407
2.618LysThr: 2.618 ± 0.414
3.311LysVal: 3.311 ± 0.445
1.463LysTrp: 1.463 ± 0.379
1.848LysTyr: 1.848 ± 0.315
0.0LysXaa: 0.0 ± 0.0
Leu
8.933LeuAla: 8.933 ± 0.912
1.309LeuCys: 1.309 ± 0.411
6.006LeuAsp: 6.006 ± 0.509
4.389LeuGlu: 4.389 ± 0.592
3.08LeuPhe: 3.08 ± 0.399
6.083LeuGly: 6.083 ± 0.709
2.156LeuHis: 2.156 ± 0.435
3.311LeuIle: 3.311 ± 0.577
5.159LeuLys: 5.159 ± 0.48
6.854LeuLeu: 6.854 ± 0.734
3.157LeuMet: 3.157 ± 0.467
3.927LeuAsn: 3.927 ± 0.468
4.543LeuPro: 4.543 ± 0.698
4.004LeuGln: 4.004 ± 0.578
4.389LeuArg: 4.389 ± 0.658
5.929LeuSer: 5.929 ± 0.581
5.544LeuThr: 5.544 ± 0.811
5.621LeuVal: 5.621 ± 0.872
0.924LeuTrp: 0.924 ± 0.331
2.618LeuTyr: 2.618 ± 0.39
0.0LeuXaa: 0.0 ± 0.0
Met
4.389MetAla: 4.389 ± 0.587
0.462MetCys: 0.462 ± 0.201
2.156MetAsp: 2.156 ± 0.412
1.463MetGlu: 1.463 ± 0.297
0.847MetPhe: 0.847 ± 0.303
1.463MetGly: 1.463 ± 0.372
0.693MetHis: 0.693 ± 0.294
0.847MetIle: 0.847 ± 0.211
2.156MetLys: 2.156 ± 0.472
3.311MetLeu: 3.311 ± 0.459
0.847MetMet: 0.847 ± 0.243
1.848MetAsn: 1.848 ± 0.435
1.309MetPro: 1.309 ± 0.306
1.694MetGln: 1.694 ± 0.508
1.694MetArg: 1.694 ± 0.338
1.925MetSer: 1.925 ± 0.403
1.309MetThr: 1.309 ± 0.343
1.848MetVal: 1.848 ± 0.47
0.154MetTrp: 0.154 ± 0.12
0.539MetTyr: 0.539 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
4.697AsnAla: 4.697 ± 0.706
0.308AsnCys: 0.308 ± 0.169
2.002AsnAsp: 2.002 ± 0.52
1.694AsnGlu: 1.694 ± 0.35
1.001AsnPhe: 1.001 ± 0.282
4.543AsnGly: 4.543 ± 0.674
1.155AsnHis: 1.155 ± 0.339
1.309AsnIle: 1.309 ± 0.238
2.541AsnLys: 2.541 ± 0.381
2.772AsnLeu: 2.772 ± 0.455
1.386AsnMet: 1.386 ± 0.357
1.54AsnAsn: 1.54 ± 0.334
2.31AsnPro: 2.31 ± 0.288
1.54AsnGln: 1.54 ± 0.297
2.849AsnArg: 2.849 ± 0.496
2.002AsnSer: 2.002 ± 0.356
1.925AsnThr: 1.925 ± 0.365
2.541AsnVal: 2.541 ± 0.46
0.539AsnTrp: 0.539 ± 0.155
1.078AsnTyr: 1.078 ± 0.341
0.0AsnXaa: 0.0 ± 0.0
Pro
5.39ProAla: 5.39 ± 0.794
0.539ProCys: 0.539 ± 0.185
2.849ProAsp: 2.849 ± 0.399
3.927ProGlu: 3.927 ± 0.603
1.309ProPhe: 1.309 ± 0.347
3.311ProGly: 3.311 ± 0.495
0.539ProHis: 0.539 ± 0.272
1.617ProIle: 1.617 ± 0.281
2.156ProLys: 2.156 ± 0.386
2.772ProLeu: 2.772 ± 0.417
1.078ProMet: 1.078 ± 0.36
1.848ProAsn: 1.848 ± 0.359
1.54ProPro: 1.54 ± 0.469
1.155ProGln: 1.155 ± 0.268
1.463ProArg: 1.463 ± 0.32
2.002ProSer: 2.002 ± 0.452
1.309ProThr: 1.309 ± 0.262
2.695ProVal: 2.695 ± 0.537
0.385ProTrp: 0.385 ± 0.228
1.232ProTyr: 1.232 ± 0.388
0.0ProXaa: 0.0 ± 0.0
Gln
6.314GlnAla: 6.314 ± 0.839
0.693GlnCys: 0.693 ± 0.233
1.54GlnAsp: 1.54 ± 0.335
2.464GlnGlu: 2.464 ± 0.413
1.771GlnPhe: 1.771 ± 0.324
3.465GlnGly: 3.465 ± 0.585
0.847GlnHis: 0.847 ± 0.258
1.925GlnIle: 1.925 ± 0.352
2.541GlnLys: 2.541 ± 0.452
5.005GlnLeu: 5.005 ± 0.736
1.54GlnMet: 1.54 ± 0.268
1.617GlnAsn: 1.617 ± 0.369
1.617GlnPro: 1.617 ± 0.301
3.388GlnGln: 3.388 ± 0.627
2.695GlnArg: 2.695 ± 0.41
2.541GlnSer: 2.541 ± 0.628
2.618GlnThr: 2.618 ± 0.546
2.31GlnVal: 2.31 ± 0.366
0.462GlnTrp: 0.462 ± 0.194
1.925GlnTyr: 1.925 ± 0.427
0.0GlnXaa: 0.0 ± 0.0
Arg
6.006ArgAla: 6.006 ± 0.817
0.693ArgCys: 0.693 ± 0.289
3.157ArgAsp: 3.157 ± 0.533
3.619ArgGlu: 3.619 ± 0.404
1.771ArgPhe: 1.771 ± 0.448
3.696ArgGly: 3.696 ± 0.612
1.232ArgHis: 1.232 ± 0.246
2.926ArgIle: 2.926 ± 0.675
3.465ArgLys: 3.465 ± 0.623
5.775ArgLeu: 5.775 ± 0.648
2.233ArgMet: 2.233 ± 0.501
3.157ArgAsn: 3.157 ± 0.417
1.848ArgPro: 1.848 ± 0.43
2.849ArgGln: 2.849 ± 0.526
3.465ArgArg: 3.465 ± 0.543
2.233ArgSer: 2.233 ± 0.359
2.772ArgThr: 2.772 ± 0.513
3.003ArgVal: 3.003 ± 0.588
1.694ArgTrp: 1.694 ± 0.391
2.079ArgTyr: 2.079 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
5.852SerAla: 5.852 ± 0.619
0.616SerCys: 0.616 ± 0.232
2.31SerAsp: 2.31 ± 0.331
2.464SerGlu: 2.464 ± 0.507
1.463SerPhe: 1.463 ± 0.219
4.543SerGly: 4.543 ± 0.55
0.539SerHis: 0.539 ± 0.238
2.618SerIle: 2.618 ± 0.354
3.619SerLys: 3.619 ± 0.486
4.158SerLeu: 4.158 ± 0.572
1.54SerMet: 1.54 ± 0.289
2.464SerAsn: 2.464 ± 0.504
2.079SerPro: 2.079 ± 0.376
3.003SerGln: 3.003 ± 0.507
3.465SerArg: 3.465 ± 0.584
3.157SerSer: 3.157 ± 0.456
3.773SerThr: 3.773 ± 0.68
3.542SerVal: 3.542 ± 0.447
0.924SerTrp: 0.924 ± 0.308
1.309SerTyr: 1.309 ± 0.277
0.0SerXaa: 0.0 ± 0.0
Thr
6.083ThrAla: 6.083 ± 0.849
0.385ThrCys: 0.385 ± 0.175
3.157ThrAsp: 3.157 ± 0.496
3.234ThrGlu: 3.234 ± 0.505
1.925ThrPhe: 1.925 ± 0.422
4.543ThrGly: 4.543 ± 0.488
0.924ThrHis: 0.924 ± 0.311
2.464ThrIle: 2.464 ± 0.48
4.081ThrLys: 4.081 ± 0.45
5.005ThrLeu: 5.005 ± 0.675
1.925ThrMet: 1.925 ± 0.418
1.617ThrAsn: 1.617 ± 0.394
2.772ThrPro: 2.772 ± 0.379
1.771ThrGln: 1.771 ± 0.438
3.157ThrArg: 3.157 ± 0.436
3.619ThrSer: 3.619 ± 0.502
4.081ThrThr: 4.081 ± 0.74
4.004ThrVal: 4.004 ± 0.469
0.539ThrTrp: 0.539 ± 0.188
2.233ThrTyr: 2.233 ± 0.514
0.0ThrXaa: 0.0 ± 0.0
Val
6.469ValAla: 6.469 ± 0.566
0.693ValCys: 0.693 ± 0.219
2.926ValAsp: 2.926 ± 0.526
3.927ValGlu: 3.927 ± 0.606
2.464ValPhe: 2.464 ± 0.374
4.774ValGly: 4.774 ± 0.647
2.233ValHis: 2.233 ± 0.487
2.772ValIle: 2.772 ± 0.532
3.388ValLys: 3.388 ± 0.477
5.082ValLeu: 5.082 ± 0.598
1.925ValMet: 1.925 ± 0.357
2.772ValAsn: 2.772 ± 0.373
2.695ValPro: 2.695 ± 0.576
2.926ValGln: 2.926 ± 0.517
3.773ValArg: 3.773 ± 0.49
2.772ValSer: 2.772 ± 0.311
4.389ValThr: 4.389 ± 0.619
5.005ValVal: 5.005 ± 0.651
0.693ValTrp: 0.693 ± 0.231
1.155ValTyr: 1.155 ± 0.324
0.0ValXaa: 0.0 ± 0.0
Trp
1.617TrpAla: 1.617 ± 0.248
0.231TrpCys: 0.231 ± 0.125
1.078TrpAsp: 1.078 ± 0.341
0.539TrpGlu: 0.539 ± 0.182
1.232TrpPhe: 1.232 ± 0.262
1.001TrpGly: 1.001 ± 0.284
0.231TrpHis: 0.231 ± 0.141
0.077TrpIle: 0.077 ± 0.067
0.308TrpLys: 0.308 ± 0.123
2.079TrpLeu: 2.079 ± 0.477
0.462TrpMet: 0.462 ± 0.155
0.693TrpAsn: 0.693 ± 0.226
0.462TrpPro: 0.462 ± 0.221
0.462TrpGln: 0.462 ± 0.184
0.693TrpArg: 0.693 ± 0.188
0.385TrpSer: 0.385 ± 0.134
0.77TrpThr: 0.77 ± 0.242
0.693TrpVal: 0.693 ± 0.304
0.539TrpTrp: 0.539 ± 0.253
0.539TrpTyr: 0.539 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.541TyrAla: 2.541 ± 0.452
0.385TyrCys: 0.385 ± 0.162
2.233TyrAsp: 2.233 ± 0.532
1.694TyrGlu: 1.694 ± 0.464
0.847TyrPhe: 0.847 ± 0.255
2.541TyrGly: 2.541 ± 0.453
1.078TyrHis: 1.078 ± 0.308
1.925TyrIle: 1.925 ± 0.46
1.848TyrLys: 1.848 ± 0.337
3.08TyrLeu: 3.08 ± 0.746
0.693TyrMet: 0.693 ± 0.226
1.694TyrAsn: 1.694 ± 0.31
1.309TyrPro: 1.309 ± 0.355
1.848TyrGln: 1.848 ± 0.334
2.156TyrArg: 2.156 ± 0.397
1.694TyrSer: 1.694 ± 0.32
1.617TyrThr: 1.617 ± 0.323
1.925TyrVal: 1.925 ± 0.36
0.308TyrTrp: 0.308 ± 0.14
0.539TyrTyr: 0.539 ± 0.201
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (12987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski