Amino acid dipepetide frequency for Dietzia sp. UCD-THP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.783AlaAla: 18.783 ± 0.218
1.026AlaCys: 1.026 ± 0.034
8.483AlaAsp: 8.483 ± 0.106
8.421AlaGlu: 8.421 ± 0.087
3.262AlaPhe: 3.262 ± 0.057
13.239AlaGly: 13.239 ± 0.119
2.587AlaHis: 2.587 ± 0.052
4.385AlaIle: 4.385 ± 0.072
2.062AlaLys: 2.062 ± 0.053
12.702AlaLeu: 12.702 ± 0.134
2.73AlaMet: 2.73 ± 0.05
1.877AlaAsn: 1.877 ± 0.045
6.386AlaPro: 6.386 ± 0.098
3.332AlaGln: 3.332 ± 0.063
9.678AlaArg: 9.678 ± 0.104
6.361AlaSer: 6.361 ± 0.082
7.348AlaThr: 7.348 ± 0.08
11.981AlaVal: 11.981 ± 0.129
1.625AlaTrp: 1.625 ± 0.038
2.163AlaTyr: 2.163 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.007CysAla: 1.007 ± 0.033
0.078CysCys: 0.078 ± 0.008
0.512CysAsp: 0.512 ± 0.019
0.4CysGlu: 0.4 ± 0.021
0.192CysPhe: 0.192 ± 0.014
0.881CysGly: 0.881 ± 0.028
0.188CysHis: 0.188 ± 0.014
0.24CysIle: 0.24 ± 0.013
0.106CysLys: 0.106 ± 0.01
0.646CysLeu: 0.646 ± 0.023
0.127CysMet: 0.127 ± 0.011
0.122CysAsn: 0.122 ± 0.009
0.476CysPro: 0.476 ± 0.024
0.17CysGln: 0.17 ± 0.012
0.578CysArg: 0.578 ± 0.024
0.461CysSer: 0.461 ± 0.02
0.519CysThr: 0.519 ± 0.024
0.619CysVal: 0.619 ± 0.024
0.081CysTrp: 0.081 ± 0.009
0.131CysTyr: 0.131 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.081AspAla: 8.081 ± 0.097
0.418AspCys: 0.418 ± 0.02
4.67AspAsp: 4.67 ± 0.076
4.492AspGlu: 4.492 ± 0.068
1.639AspPhe: 1.639 ± 0.044
6.445AspGly: 6.445 ± 0.086
1.661AspHis: 1.661 ± 0.037
2.072AspIle: 2.072 ± 0.045
1.018AspLys: 1.018 ± 0.033
6.959AspLeu: 6.959 ± 0.09
1.006AspMet: 1.006 ± 0.033
0.866AspAsn: 0.866 ± 0.028
5.218AspPro: 5.218 ± 0.078
1.78AspGln: 1.78 ± 0.042
5.509AspArg: 5.509 ± 0.075
3.326AspSer: 3.326 ± 0.062
3.454AspThr: 3.454 ± 0.06
5.323AspVal: 5.323 ± 0.068
0.937AspTrp: 0.937 ± 0.03
1.269AspTyr: 1.269 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.034GluAla: 7.034 ± 0.091
0.38GluCys: 0.38 ± 0.018
3.154GluAsp: 3.154 ± 0.054
3.178GluGlu: 3.178 ± 0.063
1.882GluPhe: 1.882 ± 0.039
4.545GluGly: 4.545 ± 0.071
1.479GluHis: 1.479 ± 0.034
2.936GluIle: 2.936 ± 0.055
1.404GluLys: 1.404 ± 0.037
6.478GluLeu: 6.478 ± 0.082
1.198GluMet: 1.198 ± 0.032
1.177GluAsn: 1.177 ± 0.034
3.094GluPro: 3.094 ± 0.064
2.191GluGln: 2.191 ± 0.049
4.846GluArg: 4.846 ± 0.085
3.076GluSer: 3.076 ± 0.056
3.041GluThr: 3.041 ± 0.052
5.451GluVal: 5.451 ± 0.071
0.891GluTrp: 0.891 ± 0.034
1.212GluTyr: 1.212 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.546PheAla: 3.546 ± 0.062
0.287PheCys: 0.287 ± 0.017
2.101PheAsp: 2.101 ± 0.042
1.419PheGlu: 1.419 ± 0.04
0.843PhePhe: 0.843 ± 0.031
3.08PheGly: 3.08 ± 0.059
0.642PheHis: 0.642 ± 0.025
0.894PheIle: 0.894 ± 0.03
0.38PheLys: 0.38 ± 0.019
2.67PheLeu: 2.67 ± 0.051
0.426PheMet: 0.426 ± 0.021
0.546PheAsn: 0.546 ± 0.025
1.36PhePro: 1.36 ± 0.038
0.607PheGln: 0.607 ± 0.025
1.778PheArg: 1.778 ± 0.042
1.625PheSer: 1.625 ± 0.042
1.891PheThr: 1.891 ± 0.045
2.435PheVal: 2.435 ± 0.054
0.408PheTrp: 0.408 ± 0.019
0.632PheTyr: 0.632 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.937GlyAla: 10.937 ± 0.127
0.773GlyCys: 0.773 ± 0.025
5.553GlyAsp: 5.553 ± 0.081
5.34GlyGlu: 5.34 ± 0.081
2.942GlyPhe: 2.942 ± 0.06
8.774GlyGly: 8.774 ± 0.135
2.175GlyHis: 2.175 ± 0.049
4.084GlyIle: 4.084 ± 0.067
1.895GlyLys: 1.895 ± 0.051
9.157GlyLeu: 9.157 ± 0.09
2.366GlyMet: 2.366 ± 0.049
1.633GlyAsn: 1.633 ± 0.044
5.241GlyPro: 5.241 ± 0.071
2.724GlyGln: 2.724 ± 0.053
7.696GlyArg: 7.696 ± 0.09
6.174GlySer: 6.174 ± 0.125
5.862GlyThr: 5.862 ± 0.074
8.478GlyVal: 8.478 ± 0.097
1.583GlyTrp: 1.583 ± 0.038
2.122GlyTyr: 2.122 ± 0.044
0.001GlyXaa: 0.001 ± 0.001
His
2.428HisAla: 2.428 ± 0.049
0.187HisCys: 0.187 ± 0.013
1.386HisAsp: 1.386 ± 0.038
1.168HisGlu: 1.168 ± 0.034
0.583HisPhe: 0.583 ± 0.023
2.193HisGly: 2.193 ± 0.046
0.743HisHis: 0.743 ± 0.027
0.696HisIle: 0.696 ± 0.027
0.308HisLys: 0.308 ± 0.016
2.367HisLeu: 2.367 ± 0.051
0.351HisMet: 0.351 ± 0.016
0.383HisAsn: 0.383 ± 0.018
1.628HisPro: 1.628 ± 0.041
0.578HisGln: 0.578 ± 0.027
1.965HisArg: 1.965 ± 0.042
1.222HisSer: 1.222 ± 0.033
1.227HisThr: 1.227 ± 0.032
1.785HisVal: 1.785 ± 0.036
0.304HisTrp: 0.304 ± 0.017
0.462HisTyr: 0.462 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.415IleAla: 5.415 ± 0.072
0.341IleCys: 0.341 ± 0.02
3.098IleAsp: 3.098 ± 0.048
2.403IleGlu: 2.403 ± 0.051
0.823IlePhe: 0.823 ± 0.034
4.001IleGly: 4.001 ± 0.065
0.786IleHis: 0.786 ± 0.027
1.413IleIle: 1.413 ± 0.043
0.658IleLys: 0.658 ± 0.026
3.227IleLeu: 3.227 ± 0.062
0.612IleMet: 0.612 ± 0.023
0.89IleAsn: 0.89 ± 0.031
2.253IlePro: 2.253 ± 0.044
0.814IleGln: 0.814 ± 0.026
2.68IleArg: 2.68 ± 0.047
2.106IleSer: 2.106 ± 0.045
2.478IleThr: 2.478 ± 0.051
3.56IleVal: 3.56 ± 0.065
0.407IleTrp: 0.407 ± 0.022
0.673IleTyr: 0.673 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.157LysAla: 2.157 ± 0.053
0.09LysCys: 0.09 ± 0.008
0.986LysAsp: 0.986 ± 0.031
0.848LysGlu: 0.848 ± 0.031
0.434LysPhe: 0.434 ± 0.019
1.478LysGly: 1.478 ± 0.043
0.365LysHis: 0.365 ± 0.019
0.879LysIle: 0.879 ± 0.028
0.659LysLys: 0.659 ± 0.036
1.442LysLeu: 1.442 ± 0.038
0.403LysMet: 0.403 ± 0.02
0.435LysAsn: 0.435 ± 0.022
0.919LysPro: 0.919 ± 0.036
0.503LysGln: 0.503 ± 0.021
1.22LysArg: 1.22 ± 0.035
1.078LysSer: 1.078 ± 0.032
1.135LysThr: 1.135 ± 0.036
1.659LysVal: 1.659 ± 0.039
0.227LysTrp: 0.227 ± 0.016
0.412LysTyr: 0.412 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.16LeuAla: 14.16 ± 0.143
0.801LeuCys: 0.801 ± 0.026
7.021LeuAsp: 7.021 ± 0.099
5.265LeuGlu: 5.265 ± 0.068
2.485LeuPhe: 2.485 ± 0.058
9.335LeuGly: 9.335 ± 0.096
1.962LeuHis: 1.962 ± 0.048
3.382LeuIle: 3.382 ± 0.07
1.468LeuLys: 1.468 ± 0.041
9.342LeuLeu: 9.342 ± 0.121
1.66LeuMet: 1.66 ± 0.036
1.477LeuAsn: 1.477 ± 0.033
5.586LeuPro: 5.586 ± 0.076
2.024LeuGln: 2.024 ± 0.047
7.505LeuArg: 7.505 ± 0.086
5.386LeuSer: 5.386 ± 0.073
6.21LeuThr: 6.21 ± 0.069
9.322LeuVal: 9.322 ± 0.108
1.131LeuTrp: 1.131 ± 0.034
1.559LeuTyr: 1.559 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.52MetAla: 2.52 ± 0.052
0.161MetCys: 0.161 ± 0.013
1.07MetAsp: 1.07 ± 0.027
0.857MetGlu: 0.857 ± 0.028
0.557MetPhe: 0.557 ± 0.023
1.634MetGly: 1.634 ± 0.041
0.363MetHis: 0.363 ± 0.019
0.934MetIle: 0.934 ± 0.029
0.378MetLys: 0.378 ± 0.021
2.01MetLeu: 2.01 ± 0.041
0.414MetMet: 0.414 ± 0.021
0.469MetAsn: 0.469 ± 0.022
1.102MetPro: 1.102 ± 0.028
0.462MetGln: 0.462 ± 0.02
1.508MetArg: 1.508 ± 0.041
1.577MetSer: 1.577 ± 0.038
1.937MetThr: 1.937 ± 0.039
1.634MetVal: 1.634 ± 0.044
0.241MetTrp: 0.241 ± 0.016
0.318MetTyr: 0.318 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.024AsnAla: 2.024 ± 0.046
0.168AsnCys: 0.168 ± 0.014
0.983AsnAsp: 0.983 ± 0.032
0.853AsnGlu: 0.853 ± 0.032
0.454AsnPhe: 0.454 ± 0.021
1.647AsnGly: 1.647 ± 0.041
0.375AsnHis: 0.375 ± 0.018
0.737AsnIle: 0.737 ± 0.027
0.376AsnLys: 0.376 ± 0.019
1.659AsnLeu: 1.659 ± 0.04
0.342AsnMet: 0.342 ± 0.017
0.407AsnAsn: 0.407 ± 0.02
1.467AsnPro: 1.467 ± 0.043
0.511AsnGln: 0.511 ± 0.022
1.285AsnArg: 1.285 ± 0.038
0.971AsnSer: 0.971 ± 0.031
1.026AsnThr: 1.026 ± 0.031
1.313AsnVal: 1.313 ± 0.033
0.28AsnTrp: 0.28 ± 0.017
0.402AsnTyr: 0.402 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
7.61ProAla: 7.61 ± 0.101
0.308ProCys: 0.308 ± 0.016
4.666ProAsp: 4.666 ± 0.07
4.356ProGlu: 4.356 ± 0.068
1.547ProPhe: 1.547 ± 0.041
6.628ProGly: 6.628 ± 0.092
1.228ProHis: 1.228 ± 0.035
1.667ProIle: 1.667 ± 0.037
0.848ProLys: 0.848 ± 0.03
4.767ProLeu: 4.767 ± 0.067
1.064ProMet: 1.064 ± 0.028
0.84ProAsn: 0.84 ± 0.027
2.877ProPro: 2.877 ± 0.066
1.338ProGln: 1.338 ± 0.035
3.888ProArg: 3.888 ± 0.061
3.077ProSer: 3.077 ± 0.059
3.545ProThr: 3.545 ± 0.051
5.567ProVal: 5.567 ± 0.07
0.889ProTrp: 0.889 ± 0.026
1.005ProTyr: 1.005 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.183GlnAla: 3.183 ± 0.06
0.165GlnCys: 0.165 ± 0.012
1.293GlnAsp: 1.293 ± 0.037
1.231GlnGlu: 1.231 ± 0.033
0.782GlnPhe: 0.782 ± 0.025
1.969GlnGly: 1.969 ± 0.052
0.584GlnHis: 0.584 ± 0.026
1.37GlnIle: 1.37 ± 0.035
0.557GlnLys: 0.557 ± 0.022
2.685GlnLeu: 2.685 ± 0.053
0.621GlnMet: 0.621 ± 0.026
0.54GlnAsn: 0.54 ± 0.021
1.376GlnPro: 1.376 ± 0.041
0.992GlnGln: 0.992 ± 0.042
2.09GlnArg: 2.09 ± 0.044
1.393GlnSer: 1.393 ± 0.038
1.374GlnThr: 1.374 ± 0.038
2.361GlnVal: 2.361 ± 0.05
0.499GlnTrp: 0.499 ± 0.019
0.555GlnTyr: 0.555 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.022ArgAla: 9.022 ± 0.11
0.543ArgCys: 0.543 ± 0.022
4.696ArgAsp: 4.696 ± 0.075
4.703ArgGlu: 4.703 ± 0.065
2.399ArgPhe: 2.399 ± 0.051
6.011ArgGly: 6.011 ± 0.079
1.874ArgHis: 1.874 ± 0.044
3.555ArgIle: 3.555 ± 0.056
1.42ArgLys: 1.42 ± 0.034
7.526ArgLeu: 7.526 ± 0.094
1.962ArgMet: 1.962 ± 0.043
1.337ArgAsn: 1.337 ± 0.033
4.396ArgPro: 4.396 ± 0.068
2.098ArgGln: 2.098 ± 0.043
7.556ArgArg: 7.556 ± 0.121
4.516ArgSer: 4.516 ± 0.072
4.672ArgThr: 4.672 ± 0.072
6.365ArgVal: 6.365 ± 0.072
1.343ArgTrp: 1.343 ± 0.037
1.675ArgTyr: 1.675 ± 0.039
0.001ArgXaa: 0.001 ± 0.001
Ser
7.237SerAla: 7.237 ± 0.081
0.384SerCys: 0.384 ± 0.019
3.607SerAsp: 3.607 ± 0.062
3.108SerGlu: 3.108 ± 0.056
1.475SerPhe: 1.475 ± 0.036
6.486SerGly: 6.486 ± 0.085
1.084SerHis: 1.084 ± 0.03
2.061SerIle: 2.061 ± 0.047
0.972SerLys: 0.972 ± 0.028
5.05SerLeu: 5.05 ± 0.087
1.345SerMet: 1.345 ± 0.04
0.908SerAsn: 0.908 ± 0.03
3.362SerPro: 3.362 ± 0.053
1.339SerGln: 1.339 ± 0.034
4.122SerArg: 4.122 ± 0.061
3.305SerSer: 3.305 ± 0.069
3.709SerThr: 3.709 ± 0.06
4.819SerVal: 4.819 ± 0.069
0.844SerTrp: 0.844 ± 0.025
1.017SerTyr: 1.017 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
7.863ThrAla: 7.863 ± 0.087
0.432ThrCys: 0.432 ± 0.021
3.992ThrAsp: 3.992 ± 0.062
3.437ThrGlu: 3.437 ± 0.053
1.616ThrPhe: 1.616 ± 0.042
6.608ThrGly: 6.608 ± 0.08
1.2ThrHis: 1.2 ± 0.034
2.357ThrIle: 2.357 ± 0.047
0.905ThrLys: 0.905 ± 0.033
5.541ThrLeu: 5.541 ± 0.069
1.191ThrMet: 1.191 ± 0.035
0.991ThrAsn: 0.991 ± 0.034
4.066ThrPro: 4.066 ± 0.06
1.29ThrGln: 1.29 ± 0.033
4.339ThrArg: 4.339 ± 0.077
3.461ThrSer: 3.461 ± 0.063
4.284ThrThr: 4.284 ± 0.072
6.112ThrVal: 6.112 ± 0.086
0.885ThrTrp: 0.885 ± 0.029
1.222ThrTyr: 1.222 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
11.624ValAla: 11.624 ± 0.115
0.685ValCys: 0.685 ± 0.025
6.823ValAsp: 6.823 ± 0.08
5.423ValGlu: 5.423 ± 0.065
2.493ValPhe: 2.493 ± 0.057
7.66ValGly: 7.66 ± 0.087
1.975ValHis: 1.975 ± 0.047
3.701ValIle: 3.701 ± 0.057
1.287ValLys: 1.287 ± 0.042
9.287ValLeu: 9.287 ± 0.101
1.692ValMet: 1.692 ± 0.045
1.651ValAsn: 1.651 ± 0.042
5.156ValPro: 5.156 ± 0.075
1.874ValGln: 1.874 ± 0.039
6.522ValArg: 6.522 ± 0.079
4.928ValSer: 4.928 ± 0.078
5.995ValThr: 5.995 ± 0.075
9.855ValVal: 9.855 ± 0.135
1.118ValTrp: 1.118 ± 0.033
1.505ValTyr: 1.505 ± 0.039
0.002ValXaa: 0.002 ± 0.001
Trp
1.671TrpAla: 1.671 ± 0.04
0.134TrpCys: 0.134 ± 0.012
0.81TrpAsp: 0.81 ± 0.03
0.708TrpGlu: 0.708 ± 0.024
0.516TrpPhe: 0.516 ± 0.02
1.009TrpGly: 1.009 ± 0.032
0.321TrpHis: 0.321 ± 0.019
0.654TrpIle: 0.654 ± 0.025
0.288TrpLys: 0.288 ± 0.017
1.478TrpLeu: 1.478 ± 0.041
0.34TrpMet: 0.34 ± 0.018
0.359TrpAsn: 0.359 ± 0.021
0.734TrpPro: 0.734 ± 0.023
0.453TrpGln: 0.453 ± 0.022
1.203TrpArg: 1.203 ± 0.033
0.963TrpSer: 0.963 ± 0.03
0.971TrpThr: 0.971 ± 0.028
1.071TrpVal: 1.071 ± 0.03
0.353TrpTrp: 0.353 ± 0.019
0.331TrpTyr: 0.331 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.129TyrAla: 2.129 ± 0.042
0.17TyrCys: 0.17 ± 0.012
1.238TyrAsp: 1.238 ± 0.036
1.038TyrGlu: 1.038 ± 0.032
0.646TyrPhe: 0.646 ± 0.026
1.89TyrGly: 1.89 ± 0.042
0.373TyrHis: 0.373 ± 0.019
0.622TyrIle: 0.622 ± 0.021
0.34TyrLys: 0.34 ± 0.017
2.091TyrLeu: 2.091 ± 0.046
0.296TyrMet: 0.296 ± 0.016
0.371TyrAsn: 0.371 ± 0.018
1.017TyrPro: 1.017 ± 0.031
0.54TyrGln: 0.54 ± 0.02
1.697TyrArg: 1.697 ± 0.044
1.228TyrSer: 1.228 ± 0.039
1.116TyrThr: 1.116 ± 0.031
1.542TyrVal: 1.542 ± 0.039
0.323TyrTrp: 0.323 ± 0.018
0.401TyrTyr: 0.401 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.001
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 3489 proteins (1118474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski