Amino acid dipepetide frequency for Thottopalayam virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.969AlaAla: 2.969 ± 0.643
1.08AlaCys: 1.08 ± 1.139
2.429AlaAsp: 2.429 ± 0.71
4.588AlaGlu: 4.588 ± 0.06
1.619AlaPhe: 1.619 ± 0.191
2.969AlaGly: 2.969 ± 1.321
2.429AlaHis: 2.429 ± 0.7
1.619AlaIle: 1.619 ± 0.972
3.509AlaLys: 3.509 ± 1.686
5.938AlaLeu: 5.938 ± 1.903
1.619AlaMet: 1.619 ± 0.664
1.889AlaAsn: 1.889 ± 1.107
1.35AlaPro: 1.35 ± 0.236
2.969AlaGln: 2.969 ± 0.93
1.35AlaArg: 1.35 ± 0.284
4.049AlaSer: 4.049 ± 0.598
4.318AlaThr: 4.318 ± 1.266
3.779AlaVal: 3.779 ± 0.87
1.08AlaTrp: 1.08 ± 0.503
2.159AlaTyr: 2.159 ± 1.036
0.0AlaXaa: 0.0 ± 0.0
Cys
1.889CysAla: 1.889 ± 0.425
0.27CysCys: 0.27 ± 0.285
1.35CysAsp: 1.35 ± 0.746
1.35CysGlu: 1.35 ± 0.344
1.35CysPhe: 1.35 ± 0.284
0.81CysGly: 0.81 ± 0.436
0.54CysHis: 0.54 ± 0.165
1.619CysIle: 1.619 ± 0.496
1.619CysLys: 1.619 ± 0.873
2.969CysLeu: 2.969 ± 1.872
0.81CysMet: 0.81 ± 0.335
1.35CysAsn: 1.35 ± 1.002
1.889CysPro: 1.889 ± 1.717
0.27CysGln: 0.27 ± 0.285
0.81CysArg: 0.81 ± 0.854
1.08CysSer: 1.08 ± 0.718
2.429CysThr: 2.429 ± 1.309
2.699CysVal: 2.699 ± 1.258
0.27CysTrp: 0.27 ± 0.285
1.08CysTyr: 1.08 ± 0.718
0.0CysXaa: 0.0 ± 0.0
Asp
2.699AspAla: 2.699 ± 0.471
1.889AspCys: 1.889 ± 0.757
2.699AspAsp: 2.699 ± 0.832
1.619AspGlu: 1.619 ± 0.326
2.699AspPhe: 2.699 ± 1.59
2.699AspGly: 2.699 ± 0.579
1.35AspHis: 1.35 ± 0.344
4.049AspIle: 4.049 ± 1.03
4.318AspLys: 4.318 ± 0.661
5.938AspLeu: 5.938 ± 2.422
1.35AspMet: 1.35 ± 0.236
3.239AspAsn: 3.239 ± 0.395
3.239AspPro: 3.239 ± 0.202
3.509AspGln: 3.509 ± 1.121
2.429AspArg: 2.429 ± 0.448
2.699AspSer: 2.699 ± 0.811
2.699AspThr: 2.699 ± 0.567
3.239AspVal: 3.239 ± 0.382
1.35AspTrp: 1.35 ± 0.81
2.159AspTyr: 2.159 ± 1.007
0.0AspXaa: 0.0 ± 0.0
Glu
3.779GluAla: 3.779 ± 0.674
1.619GluCys: 1.619 ± 0.873
2.969GluAsp: 2.969 ± 1.07
3.239GluGlu: 3.239 ± 1.625
3.239GluPhe: 3.239 ± 1.542
3.509GluGly: 3.509 ± 0.248
1.619GluHis: 1.619 ± 0.585
4.858GluIle: 4.858 ± 0.977
5.128GluLys: 5.128 ± 1.897
5.398GluLeu: 5.398 ± 2.068
1.35GluMet: 1.35 ± 0.81
1.619GluAsn: 1.619 ± 0.496
2.429GluPro: 2.429 ± 0.71
1.35GluGln: 1.35 ± 0.81
2.699GluArg: 2.699 ± 0.579
3.239GluSer: 3.239 ± 1.061
4.318GluThr: 4.318 ± 0.862
3.509GluVal: 3.509 ± 0.711
1.35GluTrp: 1.35 ± 0.595
4.588GluTyr: 4.588 ± 1.093
0.0GluXaa: 0.0 ± 0.0
Phe
2.429PheAla: 2.429 ± 0.448
0.81PheCys: 0.81 ± 0.854
2.429PheAsp: 2.429 ± 0.7
3.239PheGlu: 3.239 ± 0.548
3.239PhePhe: 3.239 ± 0.716
1.35PheGly: 1.35 ± 0.595
1.35PheHis: 1.35 ± 0.284
3.779PheIle: 3.779 ± 1.478
5.128PheLys: 5.128 ± 1.15
3.509PheLeu: 3.509 ± 0.965
1.35PheMet: 1.35 ± 0.344
2.699PheAsn: 2.699 ± 0.483
1.35PhePro: 1.35 ± 0.284
1.889PheGln: 1.889 ± 0.083
2.969PheArg: 2.969 ± 0.321
5.128PheSer: 5.128 ± 1.055
2.429PheThr: 2.429 ± 0.92
0.54PheVal: 0.54 ± 0.165
0.54PheTrp: 0.54 ± 0.324
1.08PheTyr: 1.08 ± 0.24
0.0PheXaa: 0.0 ± 0.0
Gly
4.049GlyAla: 4.049 ± 1.548
1.08GlyCys: 1.08 ± 0.278
3.779GlyAsp: 3.779 ± 2.137
4.049GlyGlu: 4.049 ± 0.348
3.239GlyPhe: 3.239 ± 0.395
2.159GlyGly: 2.159 ± 0.264
1.889GlyHis: 1.889 ± 1.154
4.318GlyIle: 4.318 ± 0.774
3.779GlyLys: 3.779 ± 0.914
5.668GlyLeu: 5.668 ± 1.126
1.619GlyMet: 1.619 ± 0.742
3.239GlyAsn: 3.239 ± 0.967
0.54GlyPro: 0.54 ± 0.57
1.619GlyGln: 1.619 ± 1.405
1.35GlyArg: 1.35 ± 0.798
3.509GlySer: 3.509 ± 0.434
2.969GlyThr: 2.969 ± 0.533
3.239GlyVal: 3.239 ± 0.855
1.08GlyTrp: 1.08 ± 0.278
1.35GlyTyr: 1.35 ± 0.284
0.0GlyXaa: 0.0 ± 0.0
His
1.619HisAla: 1.619 ± 0.972
1.35HisCys: 1.35 ± 1.002
1.35HisAsp: 1.35 ± 0.284
1.889HisGlu: 1.889 ± 0.083
1.08HisPhe: 1.08 ± 0.503
1.35HisGly: 1.35 ± 0.595
0.27HisHis: 0.27 ± 0.162
1.35HisIle: 1.35 ± 0.746
1.619HisLys: 1.619 ± 1.011
2.429HisLeu: 2.429 ± 0.757
0.27HisMet: 0.27 ± 0.162
0.54HisAsn: 0.54 ± 0.324
0.81HisPro: 0.81 ± 0.486
1.08HisGln: 1.08 ± 0.278
0.54HisArg: 0.54 ± 0.165
2.429HisSer: 2.429 ± 1.309
1.889HisThr: 1.889 ± 0.757
1.08HisVal: 1.08 ± 0.278
0.54HisTrp: 0.54 ± 0.165
0.81HisTyr: 0.81 ± 0.436
0.0HisXaa: 0.0 ± 0.0
Ile
2.699IleAla: 2.699 ± 0.689
1.35IleCys: 1.35 ± 0.284
3.779IleAsp: 3.779 ± 1.127
5.668IleGlu: 5.668 ± 2.677
2.699IlePhe: 2.699 ± 1.078
2.699IleGly: 2.699 ± 0.826
2.159IleHis: 2.159 ± 0.264
4.858IleIle: 4.858 ± 0.975
6.478IleLys: 6.478 ± 1.529
5.398IleLeu: 5.398 ± 0.611
1.889IleMet: 1.889 ± 0.435
2.699IleAsn: 2.699 ± 0.579
4.318IlePro: 4.318 ± 0.108
4.318IleGln: 4.318 ± 0.774
2.699IleArg: 2.699 ± 0.483
7.018IleSer: 7.018 ± 1.554
4.588IleThr: 4.588 ± 0.998
2.969IleVal: 2.969 ± 0.585
0.81IleTrp: 0.81 ± 0.161
2.159IleTyr: 2.159 ± 0.899
0.0IleXaa: 0.0 ± 0.0
Lys
4.858LysAla: 4.858 ± 1.403
1.08LysCys: 1.08 ± 0.718
4.049LysAsp: 4.049 ± 0.707
3.779LysGlu: 3.779 ± 0.165
3.779LysPhe: 3.779 ± 0.849
4.318LysGly: 4.318 ± 1.64
1.619LysHis: 1.619 ± 0.323
6.208LysIle: 6.208 ± 0.841
5.128LysLys: 5.128 ± 1.706
7.557LysLeu: 7.557 ± 1.266
1.889LysMet: 1.889 ± 1.167
2.429LysAsn: 2.429 ± 0.594
2.429LysPro: 2.429 ± 0.543
3.509LysGln: 3.509 ± 0.777
2.969LysArg: 2.969 ± 0.236
5.668LysSer: 5.668 ± 0.705
4.049LysThr: 4.049 ± 1.082
4.858LysVal: 4.858 ± 0.504
0.27LysTrp: 0.27 ± 0.162
3.239LysTyr: 3.239 ± 1.659
0.0LysXaa: 0.0 ± 0.0
Leu
7.827LeuAla: 7.827 ± 0.708
1.619LeuCys: 1.619 ± 1.286
5.668LeuAsp: 5.668 ± 1.856
7.557LeuGlu: 7.557 ± 0.702
5.398LeuPhe: 5.398 ± 1.294
5.398LeuGly: 5.398 ± 0.313
0.81LeuHis: 0.81 ± 0.486
5.668LeuIle: 5.668 ± 1.85
6.748LeuLys: 6.748 ± 1.179
9.177LeuLeu: 9.177 ± 0.554
1.889LeuMet: 1.889 ± 0.832
4.858LeuAsn: 4.858 ± 0.654
3.239LeuPro: 3.239 ± 0.826
4.588LeuGln: 4.588 ± 0.493
4.318LeuArg: 4.318 ± 1.95
4.858LeuSer: 4.858 ± 0.654
5.128LeuThr: 5.128 ± 1.893
5.398LeuVal: 5.398 ± 1.159
0.81LeuTrp: 0.81 ± 0.161
4.588LeuTyr: 4.588 ± 0.493
0.0LeuXaa: 0.0 ± 0.0
Met
0.54MetAla: 0.54 ± 0.324
1.08MetCys: 1.08 ± 1.139
1.08MetAsp: 1.08 ± 0.72
1.08MetGlu: 1.08 ± 0.731
1.35MetPhe: 1.35 ± 0.606
1.08MetGly: 1.08 ± 0.72
0.81MetHis: 0.81 ± 0.486
1.889MetIle: 1.889 ± 0.806
1.619MetLys: 1.619 ± 0.581
2.699MetLeu: 2.699 ± 0.689
0.81MetMet: 0.81 ± 0.486
0.81MetAsn: 0.81 ± 0.436
0.54MetPro: 0.54 ± 0.165
1.619MetGln: 1.619 ± 0.326
0.54MetArg: 0.54 ± 0.165
1.619MetSer: 1.619 ± 0.326
3.239MetThr: 3.239 ± 0.721
0.81MetVal: 0.81 ± 0.436
0.54MetTrp: 0.54 ± 0.324
1.08MetTyr: 1.08 ± 0.278
0.0MetXaa: 0.0 ± 0.0
Asn
1.08AsnAla: 1.08 ± 0.487
1.35AsnCys: 1.35 ± 0.746
1.889AsnAsp: 1.889 ± 0.425
2.699AsnGlu: 2.699 ± 0.09
1.619AsnPhe: 1.619 ± 0.581
2.429AsnGly: 2.429 ± 0.976
0.27AsnHis: 0.27 ± 0.285
1.889AsnIle: 1.889 ± 0.425
4.049AsnLys: 4.049 ± 1.058
4.588AsnLeu: 4.588 ± 0.06
1.619AsnMet: 1.619 ± 0.323
1.08AsnAsn: 1.08 ± 0.648
3.239AsnPro: 3.239 ± 0.721
0.81AsnGln: 0.81 ± 0.335
1.619AsnArg: 1.619 ± 0.326
2.159AsnSer: 2.159 ± 0.696
2.969AsnThr: 2.969 ± 0.756
3.239AsnVal: 3.239 ± 0.202
1.35AsnTrp: 1.35 ± 0.344
1.889AsnTyr: 1.889 ± 0.457
0.0AsnXaa: 0.0 ± 0.0
Pro
1.889ProAla: 1.889 ± 0.806
0.81ProCys: 0.81 ± 0.161
3.779ProAsp: 3.779 ± 1.07
4.049ProGlu: 4.049 ± 1.03
0.81ProPhe: 0.81 ± 0.161
4.049ProGly: 4.049 ± 1.033
1.35ProHis: 1.35 ± 1.002
2.429ProIle: 2.429 ± 0.113
1.35ProLys: 1.35 ± 0.284
2.699ProLeu: 2.699 ± 0.09
1.08ProMet: 1.08 ± 0.278
1.35ProAsn: 1.35 ± 0.606
0.81ProPro: 0.81 ± 0.399
1.08ProGln: 1.08 ± 0.278
0.27ProArg: 0.27 ± 0.162
2.699ProSer: 2.699 ± 0.09
2.429ProThr: 2.429 ± 0.521
2.429ProVal: 2.429 ± 0.113
0.81ProTrp: 0.81 ± 0.335
1.08ProTyr: 1.08 ± 0.33
0.0ProXaa: 0.0 ± 0.0
Gln
3.779GlnAla: 3.779 ± 1.431
0.81GlnCys: 0.81 ± 0.335
1.889GlnAsp: 1.889 ± 0.593
2.699GlnGlu: 2.699 ± 0.811
0.81GlnPhe: 0.81 ± 0.161
3.239GlnGly: 3.239 ± 0.382
1.619GlnHis: 1.619 ± 0.797
2.969GlnIle: 2.969 ± 0.756
1.619GlnLys: 1.619 ± 0.67
2.969GlnLeu: 2.969 ± 1.005
0.54GlnMet: 0.54 ± 0.165
1.35GlnAsn: 1.35 ± 0.641
0.54GlnPro: 0.54 ± 0.57
1.889GlnGln: 1.889 ± 0.593
2.699GlnArg: 2.699 ± 0.397
3.239GlnSer: 3.239 ± 1.339
3.509GlnThr: 3.509 ± 0.997
2.429GlnVal: 2.429 ± 0.957
0.81GlnTrp: 0.81 ± 0.486
1.08GlnTyr: 1.08 ± 0.648
0.0GlnXaa: 0.0 ± 0.0
Arg
1.08ArgAla: 1.08 ± 0.278
1.08ArgCys: 1.08 ± 0.24
2.429ArgAsp: 2.429 ± 1.059
1.08ArgGlu: 1.08 ± 0.278
2.699ArgPhe: 2.699 ± 0.826
3.239ArgGly: 3.239 ± 0.855
1.35ArgHis: 1.35 ± 0.426
2.969ArgIle: 2.969 ± 0.682
2.429ArgLys: 2.429 ± 1.189
3.239ArgLeu: 3.239 ± 1.945
1.35ArgMet: 1.35 ± 0.236
1.889ArgAsn: 1.889 ± 0.875
0.54ArgPro: 0.54 ± 0.324
0.81ArgGln: 0.81 ± 0.824
1.35ArgArg: 1.35 ± 0.236
3.239ArgSer: 3.239 ± 0.202
2.429ArgThr: 2.429 ± 1.005
3.239ArgVal: 3.239 ± 0.202
0.81ArgTrp: 0.81 ± 0.161
2.429ArgTyr: 2.429 ± 0.324
0.0ArgXaa: 0.0 ± 0.0
Ser
2.429SerAla: 2.429 ± 0.113
2.159SerCys: 2.159 ± 1.129
3.509SerAsp: 3.509 ± 0.38
2.699SerGlu: 2.699 ± 0.09
3.239SerPhe: 3.239 ± 0.548
4.049SerGly: 4.049 ± 0.598
0.81SerHis: 0.81 ± 0.161
7.827SerIle: 7.827 ± 0.449
7.287SerLys: 7.287 ± 1.341
8.097SerLeu: 8.097 ± 0.225
1.619SerMet: 1.619 ± 0.191
2.699SerAsn: 2.699 ± 0.483
3.239SerPro: 3.239 ± 0.395
2.969SerGln: 2.969 ± 0.813
2.699SerArg: 2.699 ± 0.851
6.478SerSer: 6.478 ± 1.71
4.588SerThr: 4.588 ± 1.141
3.239SerVal: 3.239 ± 1.162
0.81SerTrp: 0.81 ± 0.436
2.429SerTyr: 2.429 ± 0.448
0.0SerXaa: 0.0 ± 0.0
Thr
3.509ThrAla: 3.509 ± 0.246
1.889ThrCys: 1.889 ± 1.154
3.239ThrAsp: 3.239 ± 2.155
4.858ThrGlu: 4.858 ± 0.648
2.699ThrPhe: 2.699 ± 0.579
2.429ThrGly: 2.429 ± 0.113
1.35ThrHis: 1.35 ± 1.002
3.509ThrIle: 3.509 ± 1.248
4.049ThrLys: 4.049 ± 1.398
5.398ThrLeu: 5.398 ± 1.19
1.35ThrMet: 1.35 ± 0.344
2.969ThrAsn: 2.969 ± 0.682
2.429ThrPro: 2.429 ± 0.881
2.159ThrGln: 2.159 ± 0.955
3.239ThrArg: 3.239 ± 0.721
5.668ThrSer: 5.668 ± 1.936
3.509ThrThr: 3.509 ± 1.679
6.478ThrVal: 6.478 ± 0.939
0.81ThrTrp: 0.81 ± 0.854
1.619ThrTyr: 1.619 ± 0.323
0.0ThrXaa: 0.0 ± 0.0
Val
2.159ValAla: 2.159 ± 0.604
2.699ValCys: 2.699 ± 0.826
5.398ValAsp: 5.398 ± 0.761
2.969ValGlu: 2.969 ± 0.236
2.699ValPhe: 2.699 ± 0.826
2.159ValGly: 2.159 ± 0.661
1.619ValHis: 1.619 ± 1.286
6.478ValIle: 6.478 ± 1.896
4.049ValLys: 4.049 ± 0.509
5.938ValLeu: 5.938 ± 0.473
1.08ValMet: 1.08 ± 0.503
1.619ValAsn: 1.619 ± 0.742
2.429ValPro: 2.429 ± 0.324
2.429ValGln: 2.429 ± 0.484
2.969ValArg: 2.969 ± 1.501
3.509ValSer: 3.509 ± 0.977
3.779ValThr: 3.779 ± 0.743
2.429ValVal: 2.429 ± 0.521
1.08ValTrp: 1.08 ± 0.718
2.699ValTyr: 2.699 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
1.619TrpAla: 1.619 ± 0.323
0.27TrpCys: 0.27 ± 0.285
0.27TrpAsp: 0.27 ± 0.162
0.54TrpGlu: 0.54 ± 0.324
1.08TrpPhe: 1.08 ± 0.278
1.889TrpGly: 1.889 ± 0.424
0.54TrpHis: 0.54 ± 0.324
0.27TrpIle: 0.27 ± 0.285
1.35TrpLys: 1.35 ± 0.284
2.159TrpLeu: 2.159 ± 0.264
0.27TrpMet: 0.27 ± 0.285
0.54TrpAsn: 0.54 ± 0.57
0.54TrpPro: 0.54 ± 0.365
0.27TrpGln: 0.27 ± 0.162
0.54TrpArg: 0.54 ± 0.165
1.35TrpSer: 1.35 ± 0.81
0.27TrpThr: 0.27 ± 0.285
1.35TrpVal: 1.35 ± 0.284
0.0TrpTrp: 0.0 ± 0.0
0.81TrpTyr: 0.81 ± 0.436
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.81TyrAla: 0.81 ± 0.486
2.159TyrCys: 2.159 ± 1.129
1.889TyrAsp: 1.889 ± 0.739
2.159TyrGlu: 2.159 ± 0.899
1.889TyrPhe: 1.889 ± 0.457
2.699TyrGly: 2.699 ± 0.826
0.54TyrHis: 0.54 ± 0.165
2.699TyrIle: 2.699 ± 0.982
2.429TyrLys: 2.429 ± 0.324
4.049TyrLeu: 4.049 ± 0.707
0.81TyrMet: 0.81 ± 0.405
2.969TyrAsn: 2.969 ± 0.236
1.35TyrPro: 1.35 ± 0.284
1.35TyrGln: 1.35 ± 0.344
1.619TyrArg: 1.619 ± 0.191
3.239TyrSer: 3.239 ± 0.645
1.619TyrThr: 1.619 ± 0.496
3.239TyrVal: 3.239 ± 0.804
0.81TyrTrp: 0.81 ± 0.486
1.08TyrTyr: 1.08 ± 0.648
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski