Amino acid dipepetide frequency for Pseudoroseicyclus sp. CLL3-39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.246AlaAla: 20.246 ± 0.225	1.031AlaCys: 1.031 ± 0.031	6.808AlaAsp: 6.808 ± 0.086	11.235AlaGlu: 11.235 ± 0.17	4.452AlaPhe: 4.452 ± 0.073	12.656AlaGly: 12.656 ± 0.146	2.343AlaHis: 2.343 ± 0.043	5.801AlaIle: 5.801 ± 0.077	2.878AlaLys: 2.878 ± 0.06	15.489AlaLeu: 15.489 ± 0.165	3.848AlaMet: 3.848 ± 0.067	2.332AlaAsn: 2.332 ± 0.051	7.45AlaPro: 7.45 ± 0.131	3.892AlaGln: 3.892 ± 0.071	10.189AlaArg: 10.189 ± 0.141	5.791AlaSer: 5.791 ± 0.077	5.885AlaThr: 5.885 ± 0.077	8.323AlaVal: 8.323 ± 0.086	1.668AlaTrp: 1.668 ± 0.038	2.513AlaTyr: 2.513 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.956CysAla: 0.956 ± 0.034	0.103CysCys: 0.103 ± 0.011	0.544CysAsp: 0.544 ± 0.021	0.418CysGlu: 0.418 ± 0.02	0.294CysPhe: 0.294 ± 0.018	0.881CysGly: 0.881 ± 0.033	0.244CysHis: 0.244 ± 0.015	0.348CysIle: 0.348 ± 0.017	0.117CysLys: 0.117 ± 0.011	0.832CysLeu: 0.832 ± 0.028	0.139CysMet: 0.139 ± 0.011	0.162CysAsn: 0.162 ± 0.012	0.487CysPro: 0.487 ± 0.022	0.191CysGln: 0.191 ± 0.013	0.576CysArg: 0.576 ± 0.025	0.389CysSer: 0.389 ± 0.019	0.419CysThr: 0.419 ± 0.02	0.456CysVal: 0.456 ± 0.021	0.117CysTrp: 0.117 ± 0.011	0.183CysTyr: 0.183 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.624AspAla: 6.624 ± 0.094	0.446AspCys: 0.446 ± 0.021	3.088AspAsp: 3.088 ± 0.077	3.854AspGlu: 3.854 ± 0.067	2.114AspPhe: 2.114 ± 0.042	5.351AspGly: 5.351 ± 0.08	1.189AspHis: 1.189 ± 0.033	2.851AspIle: 2.851 ± 0.056	1.27AspLys: 1.27 ± 0.042	5.915AspLeu: 5.915 ± 0.084	1.512AspMet: 1.512 ± 0.039	1.046AspAsn: 1.046 ± 0.035	3.48AspPro: 3.48 ± 0.062	1.325AspGln: 1.325 ± 0.038	3.786AspArg: 3.786 ± 0.06	2.051AspSer: 2.051 ± 0.048	2.3AspThr: 2.3 ± 0.053	3.993AspVal: 3.993 ± 0.054	1.176AspTrp: 1.176 ± 0.032	1.45AspTyr: 1.45 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	11.03GluAla: 11.03 ± 0.154	0.317GluCys: 0.317 ± 0.018	3.563GluAsp: 3.563 ± 0.065	5.532GluGlu: 5.532 ± 0.097	1.628GluPhe: 1.628 ± 0.036	6.646GluGly: 6.646 ± 0.085	1.215GluHis: 1.215 ± 0.036	3.569GluIle: 3.569 ± 0.062	1.666GluLys: 1.666 ± 0.049	6.096GluLeu: 6.096 ± 0.076	2.086GluMet: 2.086 ± 0.048	1.463GluAsn: 1.463 ± 0.041	3.411GluPro: 3.411 ± 0.057	1.887GluGln: 1.887 ± 0.042	5.222GluArg: 5.222 ± 0.074	2.648GluSer: 2.648 ± 0.051	3.886GluThr: 3.886 ± 0.053	5.231GluVal: 5.231 ± 0.071	0.829GluTrp: 0.829 ± 0.03	1.004GluTyr: 1.004 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.483PheAla: 4.483 ± 0.06	0.364PheCys: 0.364 ± 0.017	2.518PheAsp: 2.518 ± 0.054	2.237PheGlu: 2.237 ± 0.043	1.338PhePhe: 1.338 ± 0.044	3.639PheGly: 3.639 ± 0.061	0.73PheHis: 0.73 ± 0.028	1.518PheIle: 1.518 ± 0.037	0.608PheLys: 0.608 ± 0.024	3.428PheLeu: 3.428 ± 0.071	0.691PheMet: 0.691 ± 0.027	0.855PheAsn: 0.855 ± 0.032	1.562PhePro: 1.562 ± 0.039	0.927PheGln: 0.927 ± 0.027	2.299PheArg: 2.299 ± 0.048	2.038PheSer: 2.038 ± 0.047	2.027PheThr: 2.027 ± 0.04	2.422PheVal: 2.422 ± 0.05	0.567PheTrp: 0.567 ± 0.022	0.915PheTyr: 0.915 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.438GlyAla: 11.438 ± 0.124	0.842GlyCys: 0.842 ± 0.027	4.756GlyAsp: 4.756 ± 0.08	6.474GlyGlu: 6.474 ± 0.081	3.541GlyPhe: 3.541 ± 0.054	8.527GlyGly: 8.527 ± 0.13	2.047GlyHis: 2.047 ± 0.047	4.263GlyIle: 4.263 ± 0.069	2.488GlyLys: 2.488 ± 0.057	10.14GlyLeu: 10.14 ± 0.101	2.591GlyMet: 2.591 ± 0.049	1.869GlyAsn: 1.869 ± 0.059	4.653GlyPro: 4.653 ± 0.07	3.192GlyGln: 3.192 ± 0.067	7.02GlyArg: 7.02 ± 0.085	4.267GlySer: 4.267 ± 0.066	4.958GlyThr: 4.958 ± 0.08	6.047GlyVal: 6.047 ± 0.072	1.714GlyTrp: 1.714 ± 0.041	2.196GlyTyr: 2.196 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.41HisAla: 2.41 ± 0.05	0.216HisCys: 0.216 ± 0.015	1.259HisAsp: 1.259 ± 0.04	1.205HisGlu: 1.205 ± 0.031	0.814HisPhe: 0.814 ± 0.026	1.944HisGly: 1.944 ± 0.044	0.577HisHis: 0.577 ± 0.024	0.865HisIle: 0.865 ± 0.027	0.423HisLys: 0.423 ± 0.018	2.107HisLeu: 2.107 ± 0.046	0.497HisMet: 0.497 ± 0.02	0.384HisAsn: 0.384 ± 0.017	1.368HisPro: 1.368 ± 0.034	0.488HisGln: 0.488 ± 0.021	1.426HisArg: 1.426 ± 0.037	0.861HisSer: 0.861 ± 0.029	0.689HisThr: 0.689 ± 0.027	1.499HisVal: 1.499 ± 0.036	0.347HisTrp: 0.347 ± 0.02	0.557HisTyr: 0.557 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.684IleAla: 6.684 ± 0.079	0.528IleCys: 0.528 ± 0.024	3.103IleAsp: 3.103 ± 0.059	3.349IleGlu: 3.349 ± 0.056	1.783IlePhe: 1.783 ± 0.035	4.803IleGly: 4.803 ± 0.066	0.867IleHis: 0.867 ± 0.032	1.89IleIle: 1.89 ± 0.054	0.872IleLys: 0.872 ± 0.032	4.564IleLeu: 4.564 ± 0.069	0.916IleMet: 0.916 ± 0.032	1.084IleAsn: 1.084 ± 0.031	2.18IlePro: 2.18 ± 0.043	0.97IleGln: 0.97 ± 0.027	3.026IleArg: 3.026 ± 0.049	2.556IleSer: 2.556 ± 0.05	2.552IleThr: 2.552 ± 0.052	3.608IleVal: 3.608 ± 0.065	0.68IleTrp: 0.68 ± 0.028	1.078IleTyr: 1.078 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.077LysAla: 3.077 ± 0.065	0.123LysCys: 0.123 ± 0.01	1.304LysAsp: 1.304 ± 0.038	1.376LysGlu: 1.376 ± 0.045	0.592LysPhe: 0.592 ± 0.021	2.151LysGly: 2.151 ± 0.051	0.432LysHis: 0.432 ± 0.021	1.139LysIle: 1.139 ± 0.037	0.764LysLys: 0.764 ± 0.031	2.357LysLeu: 2.357 ± 0.052	0.617LysMet: 0.617 ± 0.026	0.494LysAsn: 0.494 ± 0.022	1.341LysPro: 1.341 ± 0.037	0.56LysGln: 0.56 ± 0.027	1.693LysArg: 1.693 ± 0.045	1.31LysSer: 1.31 ± 0.043	1.309LysThr: 1.309 ± 0.034	1.852LysVal: 1.852 ± 0.05	0.27LysTrp: 0.27 ± 0.018	0.43LysTyr: 0.43 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.329LeuAla: 15.329 ± 0.159	0.886LeuCys: 0.886 ± 0.034	5.464LeuAsp: 5.464 ± 0.076	5.869LeuGlu: 5.869 ± 0.069	3.62LeuPhe: 3.62 ± 0.067	9.298LeuGly: 9.298 ± 0.096	1.927LeuHis: 1.927 ± 0.046	4.887LeuIle: 4.887 ± 0.075	2.657LeuLys: 2.657 ± 0.06	9.724LeuLeu: 9.724 ± 0.148	2.614LeuMet: 2.614 ± 0.048	2.134LeuAsn: 2.134 ± 0.045	6.358LeuPro: 6.358 ± 0.108	2.662LeuGln: 2.662 ± 0.046	7.342LeuArg: 7.342 ± 0.091	6.669LeuSer: 6.669 ± 0.088	6.39LeuThr: 6.39 ± 0.082	7.293LeuVal: 7.293 ± 0.089	1.519LeuTrp: 1.519 ± 0.041	2.11LeuTyr: 2.11 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.596MetAla: 3.596 ± 0.064	0.139MetCys: 0.139 ± 0.01	1.348MetAsp: 1.348 ± 0.033	1.634MetGlu: 1.634 ± 0.034	0.638MetPhe: 0.638 ± 0.025	2.231MetGly: 2.231 ± 0.049	0.428MetHis: 0.428 ± 0.018	1.302MetIle: 1.302 ± 0.032	0.771MetLys: 0.771 ± 0.028	2.58MetLeu: 2.58 ± 0.049	0.702MetMet: 0.702 ± 0.025	0.657MetAsn: 0.657 ± 0.025	1.594MetPro: 1.594 ± 0.037	0.853MetGln: 0.853 ± 0.028	1.957MetArg: 1.957 ± 0.039	1.693MetSer: 1.693 ± 0.04	1.866MetThr: 1.866 ± 0.042	1.745MetVal: 1.745 ± 0.036	0.236MetTrp: 0.236 ± 0.014	0.309MetTyr: 0.309 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.674AsnAla: 2.674 ± 0.055	0.214AsnCys: 0.214 ± 0.014	1.161AsnAsp: 1.161 ± 0.044	1.017AsnGlu: 1.017 ± 0.034	0.836AsnPhe: 0.836 ± 0.029	1.873AsnGly: 1.873 ± 0.045	0.43AsnHis: 0.43 ± 0.018	1.109AsnIle: 1.109 ± 0.027	0.418AsnLys: 0.418 ± 0.021	2.185AsnLeu: 2.185 ± 0.053	0.564AsnMet: 0.564 ± 0.023	0.504AsnAsn: 0.504 ± 0.023	1.602AsnPro: 1.602 ± 0.038	0.521AsnGln: 0.521 ± 0.024	1.396AsnArg: 1.396 ± 0.036	0.951AsnSer: 0.951 ± 0.029	0.982AsnThr: 0.982 ± 0.032	1.613AsnVal: 1.613 ± 0.039	0.331AsnTrp: 0.331 ± 0.016	0.558AsnTyr: 0.558 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.542ProAla: 7.542 ± 0.118	0.339ProCys: 0.339 ± 0.018	3.471ProAsp: 3.471 ± 0.061	5.291ProGlu: 5.291 ± 0.09	2.046ProPhe: 2.046 ± 0.043	5.784ProGly: 5.784 ± 0.083	1.106ProHis: 1.106 ± 0.033	2.033ProIle: 2.033 ± 0.043	1.359ProLys: 1.359 ± 0.034	5.401ProLeu: 5.401 ± 0.073	1.293ProMet: 1.293 ± 0.034	1.117ProAsn: 1.117 ± 0.033	3.313ProPro: 3.313 ± 0.073	1.644ProGln: 1.644 ± 0.04	3.348ProArg: 3.348 ± 0.06	2.648ProSer: 2.648 ± 0.056	2.404ProThr: 2.404 ± 0.048	4.464ProVal: 4.464 ± 0.058	0.819ProTrp: 0.819 ± 0.033	1.171ProTyr: 1.171 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.592GlnAla: 3.592 ± 0.062	0.165GlnCys: 0.165 ± 0.011	1.399GlnAsp: 1.399 ± 0.036	1.753GlnGlu: 1.753 ± 0.038	0.821GlnPhe: 0.821 ± 0.027	2.438GlnGly: 2.438 ± 0.05	0.5GlnHis: 0.5 ± 0.02	1.678GlnIle: 1.678 ± 0.039	0.738GlnLys: 0.738 ± 0.026	2.765GlnLeu: 2.765 ± 0.053	0.945GlnMet: 0.945 ± 0.034	0.668GlnAsn: 0.668 ± 0.029	1.601GlnPro: 1.601 ± 0.039	0.899GlnGln: 0.899 ± 0.035	2.123GlnArg: 2.123 ± 0.043	1.49GlnSer: 1.49 ± 0.035	1.537GlnThr: 1.537 ± 0.036	2.218GlnVal: 2.218 ± 0.044	0.345GlnTrp: 0.345 ± 0.016	0.505GlnTyr: 0.505 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.558ArgAla: 9.558 ± 0.111	0.441ArgCys: 0.441 ± 0.02	3.688ArgAsp: 3.688 ± 0.069	4.57ArgGlu: 4.57 ± 0.068	2.658ArgPhe: 2.658 ± 0.048	5.277ArgGly: 5.277 ± 0.072	1.698ArgHis: 1.698 ± 0.038	3.62ArgIle: 3.62 ± 0.056	1.706ArgLys: 1.706 ± 0.044	8.751ArgLeu: 8.751 ± 0.114	1.946ArgMet: 1.946 ± 0.042	1.473ArgAsn: 1.473 ± 0.039	4.164ArgPro: 4.164 ± 0.07	2.421ArgGln: 2.421 ± 0.049	6.05ArgArg: 6.05 ± 0.087	3.183ArgSer: 3.183 ± 0.051	2.956ArgThr: 2.956 ± 0.055	4.752ArgVal: 4.752 ± 0.066	1.059ArgTrp: 1.059 ± 0.03	1.6ArgTyr: 1.6 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.026SerAla: 6.026 ± 0.081	0.385SerCys: 0.385 ± 0.02	2.772SerAsp: 2.772 ± 0.057	2.956SerGlu: 2.956 ± 0.054	2.152SerPhe: 2.152 ± 0.045	5.416SerGly: 5.416 ± 0.067	1.063SerHis: 1.063 ± 0.031	2.22SerIle: 2.22 ± 0.051	1.031SerLys: 1.031 ± 0.032	5.163SerLeu: 5.163 ± 0.074	1.246SerMet: 1.246 ± 0.035	1.037SerAsn: 1.037 ± 0.03	2.848SerPro: 2.848 ± 0.056	1.318SerGln: 1.318 ± 0.035	3.475SerArg: 3.475 ± 0.061	2.428SerSer: 2.428 ± 0.056	2.283SerThr: 2.283 ± 0.045	3.426SerVal: 3.426 ± 0.063	0.742SerTrp: 0.742 ± 0.026	1.265SerTyr: 1.265 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.356ThrAla: 6.356 ± 0.084	0.429ThrCys: 0.429 ± 0.019	2.722ThrAsp: 2.722 ± 0.054	3.129ThrGlu: 3.129 ± 0.055	2.037ThrPhe: 2.037 ± 0.045	5.6ThrGly: 5.6 ± 0.068	1.039ThrHis: 1.039 ± 0.028	2.617ThrIle: 2.617 ± 0.052	1.061ThrLys: 1.061 ± 0.037	5.757ThrLeu: 5.757 ± 0.076	1.267ThrMet: 1.267 ± 0.031	1.083ThrAsn: 1.083 ± 0.032	3.343ThrPro: 3.343 ± 0.061	1.297ThrGln: 1.297 ± 0.034	3.436ThrArg: 3.436 ± 0.055	2.545ThrSer: 2.545 ± 0.054	2.584ThrThr: 2.584 ± 0.054	3.517ThrVal: 3.517 ± 0.063	0.718ThrTrp: 0.718 ± 0.026	1.207ThrTyr: 1.207 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.116ValAla: 9.116 ± 0.085	0.526ValCys: 0.526 ± 0.02	3.636ValAsp: 3.636 ± 0.055	4.794ValGlu: 4.794 ± 0.066	2.435ValPhe: 2.435 ± 0.048	5.257ValGly: 5.257 ± 0.058	1.247ValHis: 1.247 ± 0.034	3.904ValIle: 3.904 ± 0.073	1.611ValLys: 1.611 ± 0.049	7.423ValLeu: 7.423 ± 0.097	1.982ValMet: 1.982 ± 0.043	1.661ValAsn: 1.661 ± 0.039	3.851ValPro: 3.851 ± 0.061	1.865ValGln: 1.865 ± 0.039	4.363ValArg: 4.363 ± 0.063	3.914ValSer: 3.914 ± 0.057	4.987ValThr: 4.987 ± 0.075	5.052ValVal: 5.052 ± 0.081	0.954ValTrp: 0.954 ± 0.024	1.338ValTyr: 1.338 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.576TrpAla: 1.576 ± 0.036	0.135TrpCys: 0.135 ± 0.01	0.778TrpAsp: 0.778 ± 0.027	0.838TrpGlu: 0.838 ± 0.031	0.526TrpPhe: 0.526 ± 0.022	1.12TrpGly: 1.12 ± 0.037	0.365TrpHis: 0.365 ± 0.017	0.636TrpIle: 0.636 ± 0.027	0.328TrpLys: 0.328 ± 0.019	1.855TrpLeu: 1.855 ± 0.046	0.388TrpMet: 0.388 ± 0.021	0.374TrpAsn: 0.374 ± 0.02	0.846TrpPro: 0.846 ± 0.03	0.666TrpGln: 0.666 ± 0.024	1.276TrpArg: 1.276 ± 0.037	0.785TrpSer: 0.785 ± 0.027	0.723TrpThr: 0.723 ± 0.029	0.934TrpVal: 0.934 ± 0.03	0.257TrpTrp: 0.257 ± 0.015	0.305TrpTyr: 0.305 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.517TyrAla: 2.517 ± 0.051	0.228TyrCys: 0.228 ± 0.013	1.442TyrAsp: 1.442 ± 0.038	1.396TyrGlu: 1.396 ± 0.042	0.844TyrPhe: 0.844 ± 0.025	2.133TyrGly: 2.133 ± 0.047	0.487TyrHis: 0.487 ± 0.022	0.845TyrIle: 0.845 ± 0.031	0.429TyrLys: 0.429 ± 0.02	2.219TyrLeu: 2.219 ± 0.046	0.434TyrMet: 0.434 ± 0.02	0.539TyrAsn: 0.539 ± 0.02	1.137TyrPro: 1.137 ± 0.029	0.602TyrGln: 0.602 ± 0.023	1.565TyrArg: 1.565 ± 0.035	1.037TyrSer: 1.037 ± 0.032	1.008TyrThr: 1.008 ± 0.031	1.469TyrVal: 1.469 ± 0.04	0.364TyrTrp: 0.364 ± 0.02	0.535TyrTyr: 0.535 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3556 proteins (1122436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---