Amino acid dipepetide frequency for Enterocytozoon hepatopenaei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.6AlaAla: 1.6 ± 0.065	0.7AlaCys: 0.7 ± 0.03	1.506AlaAsp: 1.506 ± 0.044	2.206AlaGlu: 2.206 ± 0.07	2.197AlaPhe: 2.197 ± 0.059	1.333AlaGly: 1.333 ± 0.057	0.588AlaHis: 0.588 ± 0.027	3.099AlaIle: 3.099 ± 0.068	3.11AlaLys: 3.11 ± 0.073	3.418AlaLeu: 3.418 ± 0.085	0.84AlaMet: 0.84 ± 0.034	2.244AlaAsn: 2.244 ± 0.061	0.825AlaPro: 0.825 ± 0.037	1.017AlaGln: 1.017 ± 0.042	1.041AlaArg: 1.041 ± 0.044	2.045AlaSer: 2.045 ± 0.062	1.703AlaThr: 1.703 ± 0.059	2.081AlaVal: 2.081 ± 0.065	0.209AlaTrp: 0.209 ± 0.019	1.583AlaTyr: 1.583 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.751CysAla: 0.751 ± 0.032	0.421CysCys: 0.421 ± 0.027	1.063CysAsp: 1.063 ± 0.036	1.2CysGlu: 1.2 ± 0.045	1.21CysPhe: 1.21 ± 0.04	0.908CysGly: 0.908 ± 0.039	0.248CysHis: 0.248 ± 0.019	1.751CysIle: 1.751 ± 0.049	2.023CysLys: 2.023 ± 0.054	1.79CysLeu: 1.79 ± 0.057	0.494CysMet: 0.494 ± 0.024	1.877CysAsn: 1.877 ± 0.08	0.397CysPro: 0.397 ± 0.025	0.378CysGln: 0.378 ± 0.024	0.553CysArg: 0.553 ± 0.027	1.272CysSer: 1.272 ± 0.037	0.874CysThr: 0.874 ± 0.038	1.107CysVal: 1.107 ± 0.04	0.088CysTrp: 0.088 ± 0.012	0.832CysTyr: 0.832 ± 0.035	0.0CysXaa: 0.0 ± 0.0
Asp	1.921AspAla: 1.921 ± 0.052	0.866AspCys: 0.866 ± 0.036	2.821AspAsp: 2.821 ± 0.069	3.869AspGlu: 3.869 ± 0.069	3.791AspPhe: 3.791 ± 0.085	1.921AspGly: 1.921 ± 0.07	0.672AspHis: 0.672 ± 0.031	5.414AspIle: 5.414 ± 0.112	5.442AspLys: 5.442 ± 0.102	4.809AspLeu: 4.809 ± 0.081	1.192AspMet: 1.192 ± 0.044	4.823AspAsn: 4.823 ± 0.157	1.007AspPro: 1.007 ± 0.038	1.065AspGln: 1.065 ± 0.04	1.337AspArg: 1.337 ± 0.051	3.276AspSer: 3.276 ± 0.061	2.352AspThr: 2.352 ± 0.05	3.013AspVal: 3.013 ± 0.065	0.256AspTrp: 0.256 ± 0.021	2.074AspTyr: 2.074 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	2.248GluAla: 2.248 ± 0.073	1.312GluCys: 1.312 ± 0.045	3.81GluAsp: 3.81 ± 0.078	7.692GluGlu: 7.692 ± 0.163	3.577GluPhe: 3.577 ± 0.066	2.397GluGly: 2.397 ± 0.063	1.207GluHis: 1.207 ± 0.039	7.772GluIle: 7.772 ± 0.142	9.388GluLys: 9.388 ± 0.168	5.508GluLeu: 5.508 ± 0.095	2.136GluMet: 2.136 ± 0.052	7.87GluAsn: 7.87 ± 0.12	1.057GluPro: 1.057 ± 0.036	2.124GluGln: 2.124 ± 0.061	2.255GluArg: 2.255 ± 0.055	4.008GluSer: 4.008 ± 0.088	3.632GluThr: 3.632 ± 0.08	3.283GluVal: 3.283 ± 0.08	0.394GluTrp: 0.394 ± 0.022	3.434GluTyr: 3.434 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	1.842PheAla: 1.842 ± 0.062	1.331PheCys: 1.331 ± 0.045	3.32PheAsp: 3.32 ± 0.071	3.961PheGlu: 3.961 ± 0.088	3.527PhePhe: 3.527 ± 0.097	2.051PheGly: 2.051 ± 0.069	0.678PheHis: 0.678 ± 0.034	5.787PheIle: 5.787 ± 0.089	5.753PheLys: 5.753 ± 0.097	6.668PheLeu: 6.668 ± 0.112	1.555PheMet: 1.555 ± 0.048	4.047PheAsn: 4.047 ± 0.08	0.96PhePro: 0.96 ± 0.043	1.047PheGln: 1.047 ± 0.039	1.334PheArg: 1.334 ± 0.046	3.995PheSer: 3.995 ± 0.079	3.087PheThr: 3.087 ± 0.065	3.566PheVal: 3.566 ± 0.068	0.305PheTrp: 0.305 ± 0.02	3.651PheTyr: 3.651 ± 0.076	0.0PheXaa: 0.0 ± 0.0
Gly	1.359GlyAla: 1.359 ± 0.043	0.719GlyCys: 0.719 ± 0.034	1.675GlyAsp: 1.675 ± 0.059	2.41GlyGlu: 2.41 ± 0.061	2.082GlyPhe: 2.082 ± 0.054	1.605GlyGly: 1.605 ± 0.064	0.651GlyHis: 0.651 ± 0.034	3.447GlyIle: 3.447 ± 0.082	4.088GlyLys: 4.088 ± 0.09	2.688GlyLeu: 2.688 ± 0.065	0.989GlyMet: 0.989 ± 0.039	2.685GlyAsn: 2.685 ± 0.076	0.639GlyPro: 0.639 ± 0.034	0.877GlyGln: 0.877 ± 0.031	1.146GlyArg: 1.146 ± 0.044	2.259GlySer: 2.259 ± 0.067	1.805GlyThr: 1.805 ± 0.064	2.096GlyVal: 2.096 ± 0.062	0.218GlyTrp: 0.218 ± 0.015	1.579GlyTyr: 1.579 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.645HisAla: 0.645 ± 0.031	0.31HisCys: 0.31 ± 0.02	0.762HisAsp: 0.762 ± 0.037	1.114HisGlu: 1.114 ± 0.042	1.106HisPhe: 1.106 ± 0.039	0.678HisGly: 0.678 ± 0.03	0.305HisHis: 0.305 ± 0.019	1.513HisIle: 1.513 ± 0.043	2.053HisLys: 2.053 ± 0.059	1.521HisLeu: 1.521 ± 0.047	0.441HisMet: 0.441 ± 0.026	1.737HisAsn: 1.737 ± 0.072	0.464HisPro: 0.464 ± 0.031	0.422HisGln: 0.422 ± 0.025	0.522HisArg: 0.522 ± 0.029	1.2HisSer: 1.2 ± 0.041	0.87HisThr: 0.87 ± 0.036	1.034HisVal: 1.034 ± 0.044	0.107HisTrp: 0.107 ± 0.011	0.672HisTyr: 0.672 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	2.859IleAla: 2.859 ± 0.063	2.239IleCys: 2.239 ± 0.071	4.902IleAsp: 4.902 ± 0.102	6.441IleGlu: 6.441 ± 0.107	5.883IlePhe: 5.883 ± 0.1	2.873IleGly: 2.873 ± 0.071	1.672IleHis: 1.672 ± 0.057	7.425IleIle: 7.425 ± 0.153	10.609IleLys: 10.609 ± 0.12	10.265IleLeu: 10.265 ± 0.196	1.721IleMet: 1.721 ± 0.049	8.862IleAsn: 8.862 ± 0.182	1.957IlePro: 1.957 ± 0.054	2.492IleGln: 2.492 ± 0.066	2.438IleArg: 2.438 ± 0.067	6.575IleSer: 6.575 ± 0.107	4.336IleThr: 4.336 ± 0.098	4.374IleVal: 4.374 ± 0.092	0.406IleTrp: 0.406 ± 0.025	4.773IleTyr: 4.773 ± 0.123	0.0IleXaa: 0.0 ± 0.0
Lys	3.186LysAla: 3.186 ± 0.07	1.873LysCys: 1.873 ± 0.058	5.292LysAsp: 5.292 ± 0.1	10.667LysGlu: 10.667 ± 0.173	4.228LysPhe: 4.228 ± 0.082	3.264LysGly: 3.264 ± 0.074	2.457LysHis: 2.457 ± 0.058	10.819LysIle: 10.819 ± 0.129	12.446LysLys: 12.446 ± 0.167	8.327LysLeu: 8.327 ± 0.108	2.97LysMet: 2.97 ± 0.064	11.413LysAsn: 11.413 ± 0.163	2.069LysPro: 2.069 ± 0.055	3.519LysGln: 3.519 ± 0.087	3.706LysArg: 3.706 ± 0.072	5.807LysSer: 5.807 ± 0.103	6.258LysThr: 6.258 ± 0.108	4.982LysVal: 4.982 ± 0.083	0.521LysTrp: 0.521 ± 0.029	5.834LysTyr: 5.834 ± 0.125	0.0LysXaa: 0.0 ± 0.0
Leu	2.691LeuAla: 2.691 ± 0.082	2.121LeuCys: 2.121 ± 0.057	4.296LeuAsp: 4.296 ± 0.082	6.421LeuGlu: 6.421 ± 0.124	5.932LeuPhe: 5.932 ± 0.11	3.043LeuGly: 3.043 ± 0.067	1.871LeuHis: 1.871 ± 0.058	6.774LeuIle: 6.774 ± 0.123	9.999LeuLys: 9.999 ± 0.147	8.749LeuLeu: 8.749 ± 0.13	1.896LeuMet: 1.896 ± 0.056	8.104LeuAsn: 8.104 ± 0.115	2.188LeuPro: 2.188 ± 0.054	2.72LeuGln: 2.72 ± 0.061	2.799LeuArg: 2.799 ± 0.06	6.327LeuSer: 6.327 ± 0.098	4.511LeuThr: 4.511 ± 0.119	4.429LeuVal: 4.429 ± 0.075	0.457LeuTrp: 0.457 ± 0.028	4.772LeuTyr: 4.772 ± 0.125	0.0LeuXaa: 0.0 ± 0.0
Met	0.945MetAla: 0.945 ± 0.033	0.487MetCys: 0.487 ± 0.025	1.333MetAsp: 1.333 ± 0.036	1.711MetGlu: 1.711 ± 0.048	1.718MetPhe: 1.718 ± 0.052	0.859MetGly: 0.859 ± 0.04	0.602MetHis: 0.602 ± 0.025	1.787MetIle: 1.787 ± 0.051	1.937MetLys: 1.937 ± 0.051	2.482MetLeu: 2.482 ± 0.054	0.428MetMet: 0.428 ± 0.025	1.423MetAsn: 1.423 ± 0.036	0.591MetPro: 0.591 ± 0.028	0.755MetGln: 0.755 ± 0.032	0.649MetArg: 0.649 ± 0.034	1.578MetSer: 1.578 ± 0.042	1.005MetThr: 1.005 ± 0.037	1.462MetVal: 1.462 ± 0.05	0.121MetTrp: 0.121 ± 0.013	1.075MetTyr: 1.075 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	2.838AsnAla: 2.838 ± 0.065	1.38AsnCys: 1.38 ± 0.047	5.192AsnAsp: 5.192 ± 0.125	5.74AsnGlu: 5.74 ± 0.115	4.378AsnPhe: 4.378 ± 0.089	2.793AsnGly: 2.793 ± 0.073	1.204AsnHis: 1.204 ± 0.041	11.998AsnIle: 11.998 ± 0.337	10.705AsnLys: 10.705 ± 0.151	7.597AsnLeu: 7.597 ± 0.126	1.833AsnMet: 1.833 ± 0.05	13.183AsnAsn: 13.183 ± 0.459	1.548AsnPro: 1.548 ± 0.055	2.028AsnGln: 2.028 ± 0.062	2.065AsnArg: 2.065 ± 0.063	6.758AsnSer: 6.758 ± 0.151	7.946AsnThr: 7.946 ± 0.266	4.425AsnVal: 4.425 ± 0.081	0.344AsnTrp: 0.344 ± 0.021	3.439AsnTyr: 3.439 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	0.789ProAla: 0.789 ± 0.037	0.371ProCys: 0.371 ± 0.025	0.891ProAsp: 0.891 ± 0.038	1.583ProGlu: 1.583 ± 0.047	1.345ProPhe: 1.345 ± 0.045	0.87ProGly: 0.87 ± 0.045	0.401ProHis: 0.401 ± 0.021	1.547ProIle: 1.547 ± 0.053	1.887ProLys: 1.887 ± 0.054	1.83ProLeu: 1.83 ± 0.06	0.415ProMet: 0.415 ± 0.024	1.377ProAsn: 1.377 ± 0.044	0.545ProPro: 0.545 ± 0.034	0.587ProGln: 0.587 ± 0.032	0.577ProArg: 0.577 ± 0.027	1.486ProSer: 1.486 ± 0.051	1.029ProThr: 1.029 ± 0.05	1.424ProVal: 1.424 ± 0.049	0.1ProTrp: 0.1 ± 0.012	0.929ProTyr: 0.929 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	0.829GlnAla: 0.829 ± 0.036	0.41GlnCys: 0.41 ± 0.023	1.034GlnAsp: 1.034 ± 0.042	2.132GlnGlu: 2.132 ± 0.067	1.25GlnPhe: 1.25 ± 0.046	0.867GlnGly: 0.867 ± 0.035	0.502GlnHis: 0.502 ± 0.023	2.685GlnIle: 2.685 ± 0.063	3.303GlnLys: 3.303 ± 0.069	2.136GlnLeu: 2.136 ± 0.059	0.842GlnMet: 0.842 ± 0.032	2.49GlnAsn: 2.49 ± 0.06	0.588GlnPro: 0.588 ± 0.029	1.056GlnGln: 1.056 ± 0.055	0.932GlnArg: 0.932 ± 0.037	1.393GlnSer: 1.393 ± 0.045	1.579GlnThr: 1.579 ± 0.052	1.221GlnVal: 1.221 ± 0.044	0.146GlnTrp: 0.146 ± 0.016	1.005GlnTyr: 1.005 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.065ArgAla: 1.065 ± 0.043	0.541ArgCys: 0.541 ± 0.032	1.281ArgAsp: 1.281 ± 0.043	2.37ArgGlu: 2.37 ± 0.071	1.513ArgPhe: 1.513 ± 0.044	1.028ArgGly: 1.028 ± 0.041	0.591ArgHis: 0.591 ± 0.029	2.734ArgIle: 2.734 ± 0.061	3.535ArgLys: 3.535 ± 0.082	2.317ArgLeu: 2.317 ± 0.055	0.778ArgMet: 0.778 ± 0.037	2.491ArgAsn: 2.491 ± 0.06	0.646ArgPro: 0.646 ± 0.035	0.807ArgGln: 0.807 ± 0.029	1.342ArgArg: 1.342 ± 0.078	1.423ArgSer: 1.423 ± 0.048	1.296ArgThr: 1.296 ± 0.04	1.442ArgVal: 1.442 ± 0.045	0.185ArgTrp: 0.185 ± 0.015	1.262ArgTyr: 1.262 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	2.128SerAla: 2.128 ± 0.066	1.152SerCys: 1.152 ± 0.041	3.577SerAsp: 3.577 ± 0.072	4.381SerGlu: 4.381 ± 0.08	4.293SerPhe: 4.293 ± 0.092	2.378SerGly: 2.378 ± 0.066	1.059SerHis: 1.059 ± 0.038	5.656SerIle: 5.656 ± 0.088	6.769SerLys: 6.769 ± 0.117	5.655SerLeu: 5.655 ± 0.092	1.3SerMet: 1.3 ± 0.04	6.719SerAsn: 6.719 ± 0.186	1.168SerPro: 1.168 ± 0.051	1.656SerGln: 1.656 ± 0.049	1.608SerArg: 1.608 ± 0.047	4.844SerSer: 4.844 ± 0.141	3.299SerThr: 3.299 ± 0.073	3.335SerVal: 3.335 ± 0.071	0.26SerTrp: 0.26 ± 0.018	2.6SerTyr: 2.6 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	1.925ThrAla: 1.925 ± 0.055	1.001ThrCys: 1.001 ± 0.038	2.973ThrAsp: 2.973 ± 0.07	3.822ThrGlu: 3.822 ± 0.089	2.931ThrPhe: 2.931 ± 0.065	2.174ThrGly: 2.174 ± 0.062	1.123ThrHis: 1.123 ± 0.039	4.193ThrIle: 4.193 ± 0.083	5.263ThrLys: 5.263 ± 0.09	4.557ThrLeu: 4.557 ± 0.094	0.897ThrMet: 0.897 ± 0.032	6.553ThrAsn: 6.553 ± 0.219	1.297ThrPro: 1.297 ± 0.05	1.567ThrGln: 1.567 ± 0.052	1.459ThrArg: 1.459 ± 0.062	3.176ThrSer: 3.176 ± 0.071	2.831ThrThr: 2.831 ± 0.079	2.85ThrVal: 2.85 ± 0.07	0.268ThrTrp: 0.268 ± 0.02	2.598ThrTyr: 2.598 ± 0.097	0.0ThrXaa: 0.0 ± 0.0
Val	1.818ValAla: 1.818 ± 0.049	1.163ValCys: 1.163 ± 0.041	3.02ValAsp: 3.02 ± 0.07	4.146ValGlu: 4.146 ± 0.099	4.116ValPhe: 4.116 ± 0.092	1.97ValGly: 1.97 ± 0.056	0.867ValHis: 0.867 ± 0.035	4.073ValIle: 4.073 ± 0.085	5.5ValLys: 5.5 ± 0.079	5.241ValLeu: 5.241 ± 0.086	1.064ValMet: 1.064 ± 0.045	3.623ValAsn: 3.623 ± 0.068	1.187ValPro: 1.187 ± 0.043	1.284ValGln: 1.284 ± 0.051	1.417ValArg: 1.417 ± 0.05	3.447ValSer: 3.447 ± 0.073	2.246ValThr: 2.246 ± 0.065	3.141ValVal: 3.141 ± 0.074	0.264ValTrp: 0.264 ± 0.018	2.538ValTyr: 2.538 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.217TrpAla: 0.217 ± 0.018	0.115TrpCys: 0.115 ± 0.013	0.247TrpAsp: 0.247 ± 0.02	0.328TrpGlu: 0.328 ± 0.024	0.378TrpPhe: 0.378 ± 0.023	0.21TrpGly: 0.21 ± 0.018	0.108TrpHis: 0.108 ± 0.011	0.441TrpIle: 0.441 ± 0.025	0.409TrpLys: 0.409 ± 0.024	0.446TrpLeu: 0.446 ± 0.027	0.117TrpMet: 0.117 ± 0.013	0.378TrpAsn: 0.378 ± 0.022	0.136TrpPro: 0.136 ± 0.014	0.108TrpGln: 0.108 ± 0.011	0.159TrpArg: 0.159 ± 0.017	0.325TrpSer: 0.325 ± 0.021	0.212TrpThr: 0.212 ± 0.018	0.283TrpVal: 0.283 ± 0.021	0.032TrpTrp: 0.032 ± 0.007	0.236TrpTyr: 0.236 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.69TyrAla: 1.69 ± 0.05	0.724TyrCys: 0.724 ± 0.036	2.925TyrAsp: 2.925 ± 0.078	2.909TyrGlu: 2.909 ± 0.068	3.013TyrPhe: 3.013 ± 0.069	1.798TyrGly: 1.798 ± 0.076	0.67TyrHis: 0.67 ± 0.03	4.186TyrIle: 4.186 ± 0.135	5.42TyrLys: 5.42 ± 0.101	4.095TyrLeu: 4.095 ± 0.087	1.038TyrMet: 1.038 ± 0.042	5.496TyrAsn: 5.496 ± 0.198	0.713TyrPro: 0.713 ± 0.039	0.891TyrGln: 0.891 ± 0.039	1.307TyrArg: 1.307 ± 0.039	2.642TyrSer: 2.642 ± 0.057	2.587TyrThr: 2.587 ± 0.062	2.577TyrVal: 2.577 ± 0.056	0.204TyrTrp: 0.204 ± 0.017	2.028TyrTyr: 2.028 ± 0.085	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2431 proteins (741464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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