Amino acid dipepetide frequency for Hydrocarboniphaga daqingensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.447AlaAla: 18.447 ± 0.182	1.204AlaCys: 1.204 ± 0.034	7.912AlaAsp: 7.912 ± 0.093	6.507AlaGlu: 6.507 ± 0.09	3.601AlaPhe: 3.601 ± 0.067	10.357AlaGly: 10.357 ± 0.134	2.356AlaHis: 2.356 ± 0.048	5.498AlaIle: 5.498 ± 0.072	2.93AlaLys: 2.93 ± 0.059	14.174AlaLeu: 14.174 ± 0.148	2.959AlaMet: 2.959 ± 0.055	2.799AlaAsn: 2.799 ± 0.068	6.456AlaPro: 6.456 ± 0.102	5.179AlaGln: 5.179 ± 0.075	9.058AlaArg: 9.058 ± 0.104	7.039AlaSer: 7.039 ± 0.087	6.399AlaThr: 6.399 ± 0.101	8.791AlaVal: 8.791 ± 0.099	1.594AlaTrp: 1.594 ± 0.045	2.824AlaTyr: 2.824 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.032	0.12CysCys: 0.12 ± 0.011	0.531CysAsp: 0.531 ± 0.021	0.469CysGlu: 0.469 ± 0.021	0.286CysPhe: 0.286 ± 0.018	0.916CysGly: 0.916 ± 0.028	0.238CysHis: 0.238 ± 0.013	0.414CysIle: 0.414 ± 0.023	0.2CysLys: 0.2 ± 0.014	0.796CysLeu: 0.796 ± 0.026	0.154CysMet: 0.154 ± 0.011	0.239CysAsn: 0.239 ± 0.015	0.497CysPro: 0.497 ± 0.028	0.283CysGln: 0.283 ± 0.015	0.604CysArg: 0.604 ± 0.026	0.555CysSer: 0.555 ± 0.024	0.448CysThr: 0.448 ± 0.022	0.699CysVal: 0.699 ± 0.026	0.129CysTrp: 0.129 ± 0.01	0.225CysTyr: 0.225 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.541AspAla: 8.541 ± 0.112	0.463AspCys: 0.463 ± 0.018	3.767AspAsp: 3.767 ± 0.077	3.403AspGlu: 3.403 ± 0.067	2.124AspPhe: 2.124 ± 0.052	5.672AspGly: 5.672 ± 0.08	1.244AspHis: 1.244 ± 0.037	2.563AspIle: 2.563 ± 0.052	1.489AspLys: 1.489 ± 0.041	6.012AspLeu: 6.012 ± 0.08	1.028AspMet: 1.028 ± 0.031	1.389AspAsn: 1.389 ± 0.039	3.303AspPro: 3.303 ± 0.059	2.028AspGln: 2.028 ± 0.044	4.365AspArg: 4.365 ± 0.062	2.682AspSer: 2.682 ± 0.065	2.979AspThr: 2.979 ± 0.081	4.402AspVal: 4.402 ± 0.07	0.947AspTrp: 0.947 ± 0.033	1.756AspTyr: 1.756 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.266GluAla: 6.266 ± 0.087	0.363GluCys: 0.363 ± 0.018	1.995GluAsp: 1.995 ± 0.037	1.88GluGlu: 1.88 ± 0.052	1.666GluPhe: 1.666 ± 0.041	3.126GluGly: 3.126 ± 0.06	1.227GluHis: 1.227 ± 0.035	2.495GluIle: 2.495 ± 0.055	1.353GluLys: 1.353 ± 0.041	5.819GluLeu: 5.819 ± 0.091	1.015GluMet: 1.015 ± 0.032	1.089GluAsn: 1.089 ± 0.035	2.694GluPro: 2.694 ± 0.054	2.665GluGln: 2.665 ± 0.057	4.697GluArg: 4.697 ± 0.078	2.662GluSer: 2.662 ± 0.047	2.413GluThr: 2.413 ± 0.047	3.36GluVal: 3.36 ± 0.059	0.603GluTrp: 0.603 ± 0.024	1.228GluTyr: 1.228 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.762PheAla: 3.762 ± 0.059	0.353PheCys: 0.353 ± 0.017	2.637PheAsp: 2.637 ± 0.045	1.858PheGlu: 1.858 ± 0.039	1.176PhePhe: 1.176 ± 0.039	3.186PheGly: 3.186 ± 0.059	0.68PheHis: 0.68 ± 0.029	1.406PheIle: 1.406 ± 0.037	1.019PheLys: 1.019 ± 0.03	2.629PheLeu: 2.629 ± 0.05	0.69PheMet: 0.69 ± 0.025	1.181PheAsn: 1.181 ± 0.037	1.383PhePro: 1.383 ± 0.041	1.041PheGln: 1.041 ± 0.031	1.997PheArg: 1.997 ± 0.043	1.99PheSer: 1.99 ± 0.049	1.823PheThr: 1.823 ± 0.042	2.721PheVal: 2.721 ± 0.048	0.468PheTrp: 0.468 ± 0.022	0.904PheTyr: 0.904 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.084GlyAla: 9.084 ± 0.134	0.841GlyCys: 0.841 ± 0.028	4.853GlyAsp: 4.853 ± 0.094	4.097GlyGlu: 4.097 ± 0.062	3.096GlyPhe: 3.096 ± 0.06	7.046GlyGly: 7.046 ± 0.128	1.815GlyHis: 1.815 ± 0.042	4.048GlyIle: 4.048 ± 0.071	2.709GlyLys: 2.709 ± 0.057	8.875GlyLeu: 8.875 ± 0.104	1.897GlyMet: 1.897 ± 0.042	2.288GlyAsn: 2.288 ± 0.101	3.071GlyPro: 3.071 ± 0.068	2.919GlyGln: 2.919 ± 0.051	5.864GlyArg: 5.864 ± 0.08	5.067GlySer: 5.067 ± 0.1	4.23GlyThr: 4.23 ± 0.079	6.4GlyVal: 6.4 ± 0.076	1.382GlyTrp: 1.382 ± 0.038	2.5GlyTyr: 2.5 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.379HisAla: 2.379 ± 0.05	0.249HisCys: 0.249 ± 0.015	1.279HisAsp: 1.279 ± 0.034	1.015HisGlu: 1.015 ± 0.034	0.817HisPhe: 0.817 ± 0.029	1.855HisGly: 1.855 ± 0.046	0.68HisHis: 0.68 ± 0.029	0.77HisIle: 0.77 ± 0.025	0.5HisLys: 0.5 ± 0.022	2.225HisLeu: 2.225 ± 0.048	0.399HisMet: 0.399 ± 0.018	0.484HisAsn: 0.484 ± 0.021	1.298HisPro: 1.298 ± 0.038	0.818HisGln: 0.818 ± 0.028	1.691HisArg: 1.691 ± 0.046	0.996HisSer: 0.996 ± 0.028	0.843HisThr: 0.843 ± 0.025	1.351HisVal: 1.351 ± 0.034	0.438HisTrp: 0.438 ± 0.02	0.665HisTyr: 0.665 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.676IleAla: 6.676 ± 0.079	0.407IleCys: 0.407 ± 0.019	3.817IleAsp: 3.817 ± 0.065	3.203IleGlu: 3.203 ± 0.064	1.181IlePhe: 1.181 ± 0.037	4.796IleGly: 4.796 ± 0.064	0.873IleHis: 0.873 ± 0.028	1.58IleIle: 1.58 ± 0.046	1.508IleLys: 1.508 ± 0.044	2.869IleLeu: 2.869 ± 0.052	0.638IleMet: 0.638 ± 0.028	1.487IleAsn: 1.487 ± 0.042	2.091IlePro: 2.091 ± 0.047	1.326IleGln: 1.326 ± 0.033	2.913IleArg: 2.913 ± 0.049	2.394IleSer: 2.394 ± 0.05	2.467IleThr: 2.467 ± 0.056	3.882IleVal: 3.882 ± 0.067	0.516IleTrp: 0.516 ± 0.022	1.036IleTyr: 1.036 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.28LysAla: 3.28 ± 0.062	0.152LysCys: 0.152 ± 0.012	1.316LysAsp: 1.316 ± 0.04	1.052LysGlu: 1.052 ± 0.034	0.747LysPhe: 0.747 ± 0.025	1.938LysGly: 1.938 ± 0.058	0.48LysHis: 0.48 ± 0.023	1.308LysIle: 1.308 ± 0.038	1.072LysLys: 1.072 ± 0.038	3.472LysLeu: 3.472 ± 0.059	0.606LysMet: 0.606 ± 0.028	0.755LysAsn: 0.755 ± 0.028	1.994LysPro: 1.994 ± 0.049	1.098LysGln: 1.098 ± 0.036	2.008LysArg: 2.008 ± 0.045	1.45LysSer: 1.45 ± 0.038	1.664LysThr: 1.664 ± 0.042	2.005LysVal: 2.005 ± 0.051	0.245LysTrp: 0.245 ± 0.014	0.531LysTyr: 0.531 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.589LeuAla: 13.589 ± 0.143	1.042LeuCys: 1.042 ± 0.031	6.678LeuAsp: 6.678 ± 0.078	4.575LeuGlu: 4.575 ± 0.08	3.29LeuPhe: 3.29 ± 0.059	8.169LeuGly: 8.169 ± 0.108	2.265LeuHis: 2.265 ± 0.047	5.061LeuIle: 5.061 ± 0.076	3.311LeuLys: 3.311 ± 0.063	12.367LeuLeu: 12.367 ± 0.176	2.583LeuMet: 2.583 ± 0.052	2.799LeuAsn: 2.799 ± 0.059	6.462LeuPro: 6.462 ± 0.084	4.598LeuGln: 4.598 ± 0.071	8.782LeuArg: 8.782 ± 0.112	6.917LeuSer: 6.917 ± 0.084	5.564LeuThr: 5.564 ± 0.087	7.235LeuVal: 7.235 ± 0.084	1.305LeuTrp: 1.305 ± 0.037	2.447LeuTyr: 2.447 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.619MetAla: 2.619 ± 0.044	0.141MetCys: 0.141 ± 0.01	0.979MetAsp: 0.979 ± 0.03	0.846MetGlu: 0.846 ± 0.031	0.619MetPhe: 0.619 ± 0.022	1.354MetGly: 1.354 ± 0.031	0.413MetHis: 0.413 ± 0.021	1.009MetIle: 1.009 ± 0.032	0.819MetLys: 0.819 ± 0.026	2.561MetLeu: 2.561 ± 0.05	0.513MetMet: 0.513 ± 0.026	0.722MetAsn: 0.722 ± 0.023	1.507MetPro: 1.507 ± 0.039	0.997MetGln: 0.997 ± 0.027	1.689MetArg: 1.689 ± 0.032	1.649MetSer: 1.649 ± 0.033	1.451MetThr: 1.451 ± 0.037	1.303MetVal: 1.303 ± 0.037	0.164MetTrp: 0.164 ± 0.014	0.337MetTyr: 0.337 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.116AsnAla: 3.116 ± 0.063	0.252AsnCys: 0.252 ± 0.017	1.525AsnAsp: 1.525 ± 0.075	1.228AsnGlu: 1.228 ± 0.031	0.948AsnPhe: 0.948 ± 0.03	2.444AsnGly: 2.444 ± 0.067	0.447AsnHis: 0.447 ± 0.019	1.142AsnIle: 1.142 ± 0.033	0.68AsnLys: 0.68 ± 0.028	2.791AsnLeu: 2.791 ± 0.057	0.469AsnMet: 0.469 ± 0.019	0.775AsnAsn: 0.775 ± 0.032	1.766AsnPro: 1.766 ± 0.039	0.948AsnGln: 0.948 ± 0.034	1.789AsnArg: 1.789 ± 0.039	1.243AsnSer: 1.243 ± 0.036	1.482AsnThr: 1.482 ± 0.048	1.977AsnVal: 1.977 ± 0.054	0.361AsnTrp: 0.361 ± 0.017	0.689AsnTyr: 0.689 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.116ProAla: 7.116 ± 0.107	0.308ProCys: 0.308 ± 0.021	3.499ProAsp: 3.499 ± 0.062	2.914ProGlu: 2.914 ± 0.052	1.636ProPhe: 1.636 ± 0.039	4.568ProGly: 4.568 ± 0.074	0.952ProHis: 0.952 ± 0.025	2.13ProIle: 2.13 ± 0.044	1.338ProLys: 1.338 ± 0.036	5.72ProLeu: 5.72 ± 0.081	1.37ProMet: 1.37 ± 0.031	1.327ProAsn: 1.327 ± 0.036	3.228ProPro: 3.228 ± 0.081	2.208ProGln: 2.208 ± 0.048	3.409ProArg: 3.409 ± 0.063	3.072ProSer: 3.072 ± 0.06	2.816ProThr: 2.816 ± 0.048	4.214ProVal: 4.214 ± 0.064	0.72ProTrp: 0.72 ± 0.027	1.246ProTyr: 1.246 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.348GlnAla: 5.348 ± 0.083	0.304GlnCys: 0.304 ± 0.016	1.525GlnAsp: 1.525 ± 0.037	1.121GlnGlu: 1.121 ± 0.032	1.31GlnPhe: 1.31 ± 0.031	2.685GlnGly: 2.685 ± 0.054	0.96GlnHis: 0.96 ± 0.025	2.119GlnIle: 2.119 ± 0.045	1.01GlnLys: 1.01 ± 0.031	4.734GlnLeu: 4.734 ± 0.073	0.906GlnMet: 0.906 ± 0.027	0.896GlnAsn: 0.896 ± 0.031	2.321GlnPro: 2.321 ± 0.045	2.391GlnGln: 2.391 ± 0.05	4.188GlnArg: 4.188 ± 0.078	1.939GlnSer: 1.939 ± 0.044	2.094GlnThr: 2.094 ± 0.045	2.781GlnVal: 2.781 ± 0.053	0.742GlnTrp: 0.742 ± 0.023	1.022GlnTyr: 1.022 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.085ArgAla: 8.085 ± 0.097	0.715ArgCys: 0.715 ± 0.027	4.83ArgAsp: 4.83 ± 0.073	3.94ArgGlu: 3.94 ± 0.076	2.89ArgPhe: 2.89 ± 0.049	5.098ArgGly: 5.098 ± 0.063	1.938ArgHis: 1.938 ± 0.043	3.968ArgIle: 3.968 ± 0.063	1.841ArgLys: 1.841 ± 0.041	8.855ArgLeu: 8.855 ± 0.121	1.753ArgMet: 1.753 ± 0.038	1.896ArgAsn: 1.896 ± 0.041	3.512ArgPro: 3.512 ± 0.057	3.11ArgGln: 3.11 ± 0.056	6.206ArgArg: 6.206 ± 0.096	4.185ArgSer: 4.185 ± 0.055	3.037ArgThr: 3.037 ± 0.055	5.665ArgVal: 5.665 ± 0.08	1.317ArgTrp: 1.317 ± 0.04	2.68ArgTyr: 2.68 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	7.169SerAla: 7.169 ± 0.091	0.434SerCys: 0.434 ± 0.021	3.137SerAsp: 3.137 ± 0.055	2.432SerGlu: 2.432 ± 0.051	2.069SerPhe: 2.069 ± 0.048	5.528SerGly: 5.528 ± 0.099	1.042SerHis: 1.042 ± 0.033	2.609SerIle: 2.609 ± 0.056	1.409SerLys: 1.409 ± 0.047	6.093SerLeu: 6.093 ± 0.069	1.279SerMet: 1.279 ± 0.038	1.473SerAsn: 1.473 ± 0.042	2.95SerPro: 2.95 ± 0.055	2.074SerGln: 2.074 ± 0.043	3.966SerArg: 3.966 ± 0.055	3.514SerSer: 3.514 ± 0.078	3.073SerThr: 3.073 ± 0.059	4.296SerVal: 4.296 ± 0.07	0.746SerTrp: 0.746 ± 0.026	1.32SerTyr: 1.32 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.415ThrAla: 6.415 ± 0.09	0.388ThrCys: 0.388 ± 0.021	2.706ThrAsp: 2.706 ± 0.052	2.257ThrGlu: 2.257 ± 0.039	1.499ThrPhe: 1.499 ± 0.036	4.613ThrGly: 4.613 ± 0.099	1.008ThrHis: 1.008 ± 0.025	2.335ThrIle: 2.335 ± 0.056	0.987ThrLys: 0.987 ± 0.03	6.451ThrLeu: 6.451 ± 0.103	1.064ThrMet: 1.064 ± 0.033	1.161ThrAsn: 1.161 ± 0.042	3.649ThrPro: 3.649 ± 0.059	2.149ThrGln: 2.149 ± 0.049	3.728ThrArg: 3.728 ± 0.051	2.735ThrSer: 2.735 ± 0.055	2.91ThrThr: 2.91 ± 0.062	3.959ThrVal: 3.959 ± 0.071	0.631ThrTrp: 0.631 ± 0.028	1.113ThrTyr: 1.113 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.986ValAla: 8.986 ± 0.089	0.68ValCys: 0.68 ± 0.026	4.904ValAsp: 4.904 ± 0.068	4.139ValGlu: 4.139 ± 0.065	2.426ValPhe: 2.426 ± 0.044	5.65ValGly: 5.65 ± 0.074	1.348ValHis: 1.348 ± 0.041	3.656ValIle: 3.656 ± 0.059	1.958ValLys: 1.958 ± 0.051	7.877ValLeu: 7.877 ± 0.096	1.637ValMet: 1.637 ± 0.038	2.128ValAsn: 2.128 ± 0.052	3.732ValPro: 3.732 ± 0.058	2.625ValGln: 2.625 ± 0.048	5.03ValArg: 5.03 ± 0.065	4.376ValSer: 4.376 ± 0.076	4.043ValThr: 4.043 ± 0.074	5.98ValVal: 5.98 ± 0.096	0.9ValTrp: 0.9 ± 0.031	1.677ValTyr: 1.677 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.244TrpAla: 1.244 ± 0.034	0.177TrpCys: 0.177 ± 0.012	0.68TrpAsp: 0.68 ± 0.022	0.445TrpGlu: 0.445 ± 0.021	0.534TrpPhe: 0.534 ± 0.021	0.821TrpGly: 0.821 ± 0.029	0.333TrpHis: 0.333 ± 0.017	0.689TrpIle: 0.689 ± 0.025	0.396TrpLys: 0.396 ± 0.02	1.964TrpLeu: 1.964 ± 0.051	0.358TrpMet: 0.358 ± 0.017	0.445TrpAsn: 0.445 ± 0.022	0.676TrpPro: 0.676 ± 0.025	0.768TrpGln: 0.768 ± 0.029	1.232TrpArg: 1.232 ± 0.03	0.811TrpSer: 0.811 ± 0.026	0.756TrpThr: 0.756 ± 0.027	0.941TrpVal: 0.941 ± 0.027	0.252TrpTrp: 0.252 ± 0.015	0.333TrpTyr: 0.333 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.906TyrAla: 2.906 ± 0.053	0.267TyrCys: 0.267 ± 0.016	1.586TyrAsp: 1.586 ± 0.043	1.238TyrGlu: 1.238 ± 0.036	0.989TyrPhe: 0.989 ± 0.03	2.258TyrGly: 2.258 ± 0.048	0.456TyrHis: 0.456 ± 0.02	0.861TyrIle: 0.861 ± 0.033	0.643TyrLys: 0.643 ± 0.027	2.754TyrLeu: 2.754 ± 0.054	0.371TyrMet: 0.371 ± 0.02	0.738TyrAsn: 0.738 ± 0.03	1.198TyrPro: 1.198 ± 0.033	1.171TyrGln: 1.171 ± 0.036	2.306TyrArg: 2.306 ± 0.047	1.34TyrSer: 1.34 ± 0.035	1.265TyrThr: 1.265 ± 0.034	1.786TyrVal: 1.786 ± 0.044	0.4TyrTrp: 0.4 ± 0.019	0.7TyrTyr: 0.7 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3253 proteins (1160950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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