Amino acid dipepetide frequency for Xylanimonas allomyrinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.22AlaAla: 24.22 ± 0.244
0.943AlaCys: 0.943 ± 0.038
9.16AlaAsp: 9.16 ± 0.11
7.382AlaGlu: 7.382 ± 0.089
3.688AlaPhe: 3.688 ± 0.064
14.382AlaGly: 14.382 ± 0.136
2.98AlaHis: 2.98 ± 0.063
4.319AlaIle: 4.319 ± 0.076
2.2AlaLys: 2.2 ± 0.064
14.966AlaLeu: 14.966 ± 0.162
2.545AlaMet: 2.545 ± 0.053
2.04AlaAsn: 2.04 ± 0.052
7.974AlaPro: 7.974 ± 0.134
4.42AlaGln: 4.42 ± 0.074
11.936AlaArg: 11.936 ± 0.144
7.173AlaSer: 7.173 ± 0.107
8.81AlaThr: 8.81 ± 0.117
14.123AlaVal: 14.123 ± 0.161
2.291AlaTrp: 2.291 ± 0.051
2.416AlaTyr: 2.416 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.034
0.062CysCys: 0.062 ± 0.008
0.36CysAsp: 0.36 ± 0.018
0.295CysGlu: 0.295 ± 0.017
0.145CysPhe: 0.145 ± 0.013
0.701CysGly: 0.701 ± 0.028
0.127CysHis: 0.127 ± 0.012
0.142CysIle: 0.142 ± 0.014
0.062CysLys: 0.062 ± 0.009
0.53CysLeu: 0.53 ± 0.023
0.085CysMet: 0.085 ± 0.009
0.085CysAsn: 0.085 ± 0.008
0.414CysPro: 0.414 ± 0.02
0.132CysGln: 0.132 ± 0.011
0.472CysArg: 0.472 ± 0.024
0.426CysSer: 0.426 ± 0.021
0.43CysThr: 0.43 ± 0.03
0.533CysVal: 0.533 ± 0.026
0.099CysTrp: 0.099 ± 0.01
0.113CysTyr: 0.113 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
9.733AspAla: 9.733 ± 0.118
0.258AspCys: 0.258 ± 0.017
4.775AspAsp: 4.775 ± 0.087
3.632AspGlu: 3.632 ± 0.068
1.283AspPhe: 1.283 ± 0.04
7.101AspGly: 7.101 ± 0.13
1.292AspHis: 1.292 ± 0.039
1.498AspIle: 1.498 ± 0.04
0.846AspLys: 0.846 ± 0.035
6.629AspLeu: 6.629 ± 0.093
0.618AspMet: 0.618 ± 0.026
0.847AspAsn: 0.847 ± 0.03
4.54AspPro: 4.54 ± 0.09
1.51AspGln: 1.51 ± 0.039
4.246AspArg: 4.246 ± 0.072
2.117AspSer: 2.117 ± 0.059
2.762AspThr: 2.762 ± 0.058
6.989AspVal: 6.989 ± 0.09
0.82AspTrp: 0.82 ± 0.033
1.027AspTyr: 1.027 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
6.927GluAla: 6.927 ± 0.097
0.253GluCys: 0.253 ± 0.018
2.439GluAsp: 2.439 ± 0.056
2.289GluGlu: 2.289 ± 0.053
1.178GluPhe: 1.178 ± 0.036
3.738GluGly: 3.738 ± 0.063
1.574GluHis: 1.574 ± 0.047
2.092GluIle: 2.092 ± 0.047
0.992GluLys: 0.992 ± 0.036
5.45GluLeu: 5.45 ± 0.081
0.718GluMet: 0.718 ± 0.027
0.888GluAsn: 0.888 ± 0.034
3.208GluPro: 3.208 ± 0.06
1.896GluGln: 1.896 ± 0.05
5.008GluArg: 5.008 ± 0.077
2.283GluSer: 2.283 ± 0.052
2.749GluThr: 2.749 ± 0.052
4.58GluVal: 4.58 ± 0.074
0.665GluTrp: 0.665 ± 0.027
0.884GluTyr: 0.884 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.726PheAla: 3.726 ± 0.063
0.198PheCys: 0.198 ± 0.015
2.013PheAsp: 2.013 ± 0.045
1.423PheGlu: 1.423 ± 0.036
0.855PhePhe: 0.855 ± 0.036
2.884PheGly: 2.884 ± 0.059
0.5PheHis: 0.5 ± 0.02
0.651PheIle: 0.651 ± 0.029
0.386PheLys: 0.386 ± 0.022
2.39PheLeu: 2.39 ± 0.053
0.372PheMet: 0.372 ± 0.02
0.467PheAsn: 0.467 ± 0.024
1.25PhePro: 1.25 ± 0.036
0.65PheGln: 0.65 ± 0.027
1.602PheArg: 1.602 ± 0.045
1.355PheSer: 1.355 ± 0.044
1.829PheThr: 1.829 ± 0.049
2.602PheVal: 2.602 ± 0.058
0.42PheTrp: 0.42 ± 0.018
0.524PheTyr: 0.524 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
12.54GlyAla: 12.54 ± 0.127
0.58GlyCys: 0.58 ± 0.03
5.438GlyAsp: 5.438 ± 0.11
4.7GlyGlu: 4.7 ± 0.072
2.821GlyPhe: 2.821 ± 0.054
8.218GlyGly: 8.218 ± 0.118
2.131GlyHis: 2.131 ± 0.054
3.456GlyIle: 3.456 ± 0.064
1.959GlyLys: 1.959 ± 0.056
9.526GlyLeu: 9.526 ± 0.116
1.807GlyMet: 1.807 ± 0.043
1.524GlyAsn: 1.524 ± 0.046
4.898GlyPro: 4.898 ± 0.083
2.62GlyGln: 2.62 ± 0.06
7.337GlyArg: 7.337 ± 0.086
5.189GlySer: 5.189 ± 0.091
6.653GlyThr: 6.653 ± 0.096
8.908GlyVal: 8.908 ± 0.11
1.67GlyTrp: 1.67 ± 0.045
2.042GlyTyr: 2.042 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
3.006HisAla: 3.006 ± 0.061
0.103HisCys: 0.103 ± 0.011
1.553HisAsp: 1.553 ± 0.045
1.224HisGlu: 1.224 ± 0.037
0.457HisPhe: 0.457 ± 0.022
2.318HisGly: 2.318 ± 0.053
0.639HisHis: 0.639 ± 0.031
0.472HisIle: 0.472 ± 0.023
0.24HisLys: 0.24 ± 0.016
2.376HisLeu: 2.376 ± 0.05
0.255HisMet: 0.255 ± 0.016
0.337HisAsn: 0.337 ± 0.02
1.562HisPro: 1.562 ± 0.045
0.567HisGln: 0.567 ± 0.024
1.913HisArg: 1.913 ± 0.056
0.768HisSer: 0.768 ± 0.03
1.131HisThr: 1.131 ± 0.033
2.079HisVal: 2.079 ± 0.056
0.27HisTrp: 0.27 ± 0.018
0.396HisTyr: 0.396 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.093IleAla: 5.093 ± 0.078
0.215IleCys: 0.215 ± 0.015
2.499IleAsp: 2.499 ± 0.056
1.937IleGlu: 1.937 ± 0.051
0.712IlePhe: 0.712 ± 0.033
3.224IleGly: 3.224 ± 0.066
0.518IleHis: 0.518 ± 0.026
0.934IleIle: 0.934 ± 0.036
0.598IleLys: 0.598 ± 0.027
2.532IleLeu: 2.532 ± 0.052
0.432IleMet: 0.432 ± 0.02
0.574IleAsn: 0.574 ± 0.024
1.651IlePro: 1.651 ± 0.05
0.656IleGln: 0.656 ± 0.028
1.829IleArg: 1.829 ± 0.046
1.456IleSer: 1.456 ± 0.039
2.235IleThr: 2.235 ± 0.055
3.171IleVal: 3.171 ± 0.069
0.344IleTrp: 0.344 ± 0.022
0.496IleTyr: 0.496 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.312LysAla: 2.312 ± 0.064
0.059LysCys: 0.059 ± 0.008
0.959LysAsp: 0.959 ± 0.036
0.803LysGlu: 0.803 ± 0.034
0.333LysPhe: 0.333 ± 0.022
1.332LysGly: 1.332 ± 0.041
0.372LysHis: 0.372 ± 0.02
0.687LysIle: 0.687 ± 0.028
0.543LysLys: 0.543 ± 0.027
1.278LysLeu: 1.278 ± 0.038
0.256LysMet: 0.256 ± 0.016
0.425LysAsn: 0.425 ± 0.024
0.988LysPro: 0.988 ± 0.037
0.481LysGln: 0.481 ± 0.02
1.088LysArg: 1.088 ± 0.043
0.88LysSer: 0.88 ± 0.033
1.068LysThr: 1.068 ± 0.031
1.565LysVal: 1.565 ± 0.057
0.159LysTrp: 0.159 ± 0.015
0.358LysTyr: 0.358 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
16.412LeuAla: 16.412 ± 0.158
0.593LeuCys: 0.593 ± 0.027
7.083LeuAsp: 7.083 ± 0.107
4.512LeuGlu: 4.512 ± 0.078
2.373LeuPhe: 2.373 ± 0.057
9.625LeuGly: 9.625 ± 0.134
2.059LeuHis: 2.059 ± 0.053
2.566LeuIle: 2.566 ± 0.065
1.357LeuLys: 1.357 ± 0.042
9.934LeuLeu: 9.934 ± 0.131
1.342LeuMet: 1.342 ± 0.041
1.426LeuAsn: 1.426 ± 0.041
5.802LeuPro: 5.802 ± 0.081
2.103LeuGln: 2.103 ± 0.048
8.129LeuArg: 8.129 ± 0.1
4.545LeuSer: 4.545 ± 0.077
6.745LeuThr: 6.745 ± 0.092
10.461LeuVal: 10.461 ± 0.116
1.227LeuTrp: 1.227 ± 0.035
1.515LeuTyr: 1.515 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.988MetAla: 1.988 ± 0.045
0.113MetCys: 0.113 ± 0.01
0.736MetAsp: 0.736 ± 0.031
0.546MetGlu: 0.546 ± 0.025
0.422MetPhe: 0.422 ± 0.021
1.14MetGly: 1.14 ± 0.038
0.335MetHis: 0.335 ± 0.018
0.585MetIle: 0.585 ± 0.026
0.298MetLys: 0.298 ± 0.02
1.67MetLeu: 1.67 ± 0.04
0.212MetMet: 0.212 ± 0.017
0.348MetAsn: 0.348 ± 0.019
1.064MetPro: 1.064 ± 0.037
0.377MetGln: 0.377 ± 0.019
1.347MetArg: 1.347 ± 0.039
1.285MetSer: 1.285 ± 0.037
1.615MetThr: 1.615 ± 0.041
1.259MetVal: 1.259 ± 0.038
0.186MetTrp: 0.186 ± 0.013
0.231MetTyr: 0.231 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.098AsnAla: 2.098 ± 0.056
0.097AsnCys: 0.097 ± 0.01
0.949AsnAsp: 0.949 ± 0.036
0.739AsnGlu: 0.739 ± 0.027
0.444AsnPhe: 0.444 ± 0.021
1.545AsnGly: 1.545 ± 0.05
0.343AsnHis: 0.343 ± 0.02
0.535AsnIle: 0.535 ± 0.025
0.27AsnLys: 0.27 ± 0.018
1.653AsnLeu: 1.653 ± 0.046
0.242AsnMet: 0.242 ± 0.017
0.346AsnAsn: 0.346 ± 0.025
1.339AsnPro: 1.339 ± 0.038
0.478AsnGln: 0.478 ± 0.023
1.012AsnArg: 1.012 ± 0.034
0.676AsnSer: 0.676 ± 0.029
1.009AsnThr: 1.009 ± 0.042
1.591AsnVal: 1.591 ± 0.044
0.215AsnTrp: 0.215 ± 0.017
0.346AsnTyr: 0.346 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.306ProAla: 9.306 ± 0.124
0.283ProCys: 0.283 ± 0.019
4.422ProAsp: 4.422 ± 0.08
3.44ProGlu: 3.44 ± 0.058
1.542ProPhe: 1.542 ± 0.04
6.642ProGly: 6.642 ± 0.103
1.321ProHis: 1.321 ± 0.042
1.351ProIle: 1.351 ± 0.038
0.745ProLys: 0.745 ± 0.026
4.958ProLeu: 4.958 ± 0.065
0.881ProMet: 0.881 ± 0.028
0.818ProAsn: 0.818 ± 0.035
3.087ProPro: 3.087 ± 0.079
1.738ProGln: 1.738 ± 0.047
4.292ProArg: 4.292 ± 0.071
3.424ProSer: 3.424 ± 0.068
3.789ProThr: 3.789 ± 0.074
5.739ProVal: 5.739 ± 0.081
0.984ProTrp: 0.984 ± 0.031
0.991ProTyr: 0.991 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.072GlnAla: 4.072 ± 0.066
0.14GlnCys: 0.14 ± 0.012
1.334GlnAsp: 1.334 ± 0.042
1.191GlnGlu: 1.191 ± 0.036
0.731GlnPhe: 0.731 ± 0.029
2.179GlnGly: 2.179 ± 0.052
0.668GlnHis: 0.668 ± 0.026
1.141GlnIle: 1.141 ± 0.037
0.433GlnLys: 0.433 ± 0.024
2.488GlnLeu: 2.488 ± 0.055
0.429GlnMet: 0.429 ± 0.024
0.442GlnAsn: 0.442 ± 0.025
1.513GlnPro: 1.513 ± 0.043
1.024GlnGln: 1.024 ± 0.037
2.412GlnArg: 2.412 ± 0.057
1.16GlnSer: 1.16 ± 0.037
1.511GlnThr: 1.511 ± 0.042
3.105GlnVal: 3.105 ± 0.056
0.43GlnTrp: 0.43 ± 0.02
0.55GlnTyr: 0.55 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
11.053ArgAla: 11.053 ± 0.152
0.504ArgCys: 0.504 ± 0.025
4.368ArgAsp: 4.368 ± 0.073
4.2ArgGlu: 4.2 ± 0.071
2.127ArgPhe: 2.127 ± 0.047
5.909ArgGly: 5.909 ± 0.089
1.935ArgHis: 1.935 ± 0.05
2.762ArgIle: 2.762 ± 0.061
1.23ArgLys: 1.23 ± 0.034
8.061ArgLeu: 8.061 ± 0.121
1.623ArgMet: 1.623 ± 0.044
1.153ArgAsn: 1.153 ± 0.033
4.835ArgPro: 4.835 ± 0.076
2.136ArgGln: 2.136 ± 0.052
8.195ArgArg: 8.195 ± 0.135
4.181ArgSer: 4.181 ± 0.083
5.223ArgThr: 5.223 ± 0.074
6.722ArgVal: 6.722 ± 0.092
1.471ArgTrp: 1.471 ± 0.037
1.576ArgTyr: 1.576 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.971SerAla: 6.971 ± 0.102
0.327SerCys: 0.327 ± 0.019
2.665SerAsp: 2.665 ± 0.068
1.998SerGlu: 1.998 ± 0.054
1.473SerPhe: 1.473 ± 0.039
5.484SerGly: 5.484 ± 0.078
0.908SerHis: 0.908 ± 0.03
1.64SerIle: 1.64 ± 0.043
0.795SerLys: 0.795 ± 0.032
4.695SerLeu: 4.695 ± 0.068
1.018SerMet: 1.018 ± 0.035
0.892SerAsn: 0.892 ± 0.032
3.199SerPro: 3.199 ± 0.066
1.299SerGln: 1.299 ± 0.039
3.82SerArg: 3.82 ± 0.07
2.936SerSer: 2.936 ± 0.072
3.404SerThr: 3.404 ± 0.078
4.545SerVal: 4.545 ± 0.07
0.911SerTrp: 0.911 ± 0.036
0.911SerTyr: 0.911 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
8.791ThrAla: 8.791 ± 0.141
0.471ThrCys: 0.471 ± 0.025
3.543ThrAsp: 3.543 ± 0.079
2.65ThrGlu: 2.65 ± 0.06
1.963ThrPhe: 1.963 ± 0.054
6.427ThrGly: 6.427 ± 0.103
1.326ThrHis: 1.326 ± 0.036
2.368ThrIle: 2.368 ± 0.056
1.012ThrLys: 1.012 ± 0.039
6.357ThrLeu: 6.357 ± 0.087
0.959ThrMet: 0.959 ± 0.033
1.015ThrAsn: 1.015 ± 0.035
4.763ThrPro: 4.763 ± 0.096
1.62ThrGln: 1.62 ± 0.045
4.281ThrArg: 4.281 ± 0.067
3.653ThrSer: 3.653 ± 0.066
4.703ThrThr: 4.703 ± 0.083
6.604ThrVal: 6.604 ± 0.135
1.055ThrTrp: 1.055 ± 0.032
1.313ThrTyr: 1.313 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
14.543ValAla: 14.543 ± 0.162
0.618ValCys: 0.618 ± 0.026
6.127ValAsp: 6.127 ± 0.085
5.195ValGlu: 5.195 ± 0.073
2.495ValPhe: 2.495 ± 0.055
8.353ValGly: 8.353 ± 0.11
1.965ValHis: 1.965 ± 0.045
3.011ValIle: 3.011 ± 0.063
1.43ValLys: 1.43 ± 0.045
10.667ValLeu: 10.667 ± 0.123
1.473ValMet: 1.473 ± 0.039
1.599ValAsn: 1.599 ± 0.043
5.987ValPro: 5.987 ± 0.086
2.221ValGln: 2.221 ± 0.052
7.612ValArg: 7.612 ± 0.108
4.566ValSer: 4.566 ± 0.075
7.045ValThr: 7.045 ± 0.15
12.138ValVal: 12.138 ± 0.14
1.176ValTrp: 1.176 ± 0.04
1.476ValTyr: 1.476 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.914TrpAla: 1.914 ± 0.042
0.15TrpCys: 0.15 ± 0.011
0.874TrpAsp: 0.874 ± 0.03
0.648TrpGlu: 0.648 ± 0.026
0.513TrpPhe: 0.513 ± 0.025
1.095TrpGly: 1.095 ± 0.034
0.345TrpHis: 0.345 ± 0.022
0.486TrpIle: 0.486 ± 0.025
0.251TrpLys: 0.251 ± 0.016
1.674TrpLeu: 1.674 ± 0.043
0.261TrpMet: 0.261 ± 0.017
0.377TrpAsn: 0.377 ± 0.023
0.75TrpPro: 0.75 ± 0.031
0.511TrpGln: 0.511 ± 0.022
1.28TrpArg: 1.28 ± 0.036
0.965TrpSer: 0.965 ± 0.035
1.01TrpThr: 1.01 ± 0.034
1.285TrpVal: 1.285 ± 0.034
0.374TrpTrp: 0.374 ± 0.021
0.283TrpTyr: 0.283 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.393TyrAla: 2.393 ± 0.048
0.117TyrCys: 0.117 ± 0.011
1.226TyrAsp: 1.226 ± 0.038
1.006TyrGlu: 1.006 ± 0.036
0.541TyrPhe: 0.541 ± 0.022
1.72TyrGly: 1.72 ± 0.046
0.329TyrHis: 0.329 ± 0.018
0.409TyrIle: 0.409 ± 0.022
0.298TyrLys: 0.298 ± 0.021
1.976TyrLeu: 1.976 ± 0.049
0.227TyrMet: 0.227 ± 0.014
0.323TyrAsn: 0.323 ± 0.021
0.928TyrPro: 0.928 ± 0.029
0.514TyrGln: 0.514 ± 0.027
1.455TyrArg: 1.455 ± 0.039
0.855TyrSer: 0.855 ± 0.033
1.155TyrThr: 1.155 ± 0.049
1.698TyrVal: 1.698 ± 0.045
0.276TyrTrp: 0.276 ± 0.017
0.377TyrTyr: 0.377 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3038 proteins (992373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski