Amino acid dipepetide frequency for Mucilaginibacter limnophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.805AlaAla: 6.805 ± 0.093	0.71AlaCys: 0.71 ± 0.027	4.869AlaAsp: 4.869 ± 0.07	4.792AlaGlu: 4.792 ± 0.071	3.633AlaPhe: 3.633 ± 0.054	6.007AlaGly: 6.007 ± 0.067	1.25AlaHis: 1.25 ± 0.025	5.434AlaIle: 5.434 ± 0.071	4.688AlaLys: 4.688 ± 0.062	7.148AlaLeu: 7.148 ± 0.077	1.753AlaMet: 1.753 ± 0.038	3.894AlaAsn: 3.894 ± 0.053	2.379AlaPro: 2.379 ± 0.048	3.032AlaGln: 3.032 ± 0.051	2.72AlaArg: 2.72 ± 0.053	4.369AlaSer: 4.369 ± 0.065	4.143AlaThr: 4.143 ± 0.068	5.198AlaVal: 5.198 ± 0.072	0.883AlaTrp: 0.883 ± 0.025	3.047AlaTyr: 3.047 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.534CysAla: 0.534 ± 0.022	0.114CysCys: 0.114 ± 0.01	0.421CysAsp: 0.421 ± 0.017	0.36CysGlu: 0.36 ± 0.017	0.423CysPhe: 0.423 ± 0.018	0.666CysGly: 0.666 ± 0.026	0.207CysHis: 0.207 ± 0.014	0.608CysIle: 0.608 ± 0.024	0.48CysLys: 0.48 ± 0.017	0.771CysLeu: 0.771 ± 0.023	0.175CysMet: 0.175 ± 0.011	0.37CysAsn: 0.37 ± 0.018	0.32CysPro: 0.32 ± 0.017	0.194CysGln: 0.194 ± 0.012	0.36CysArg: 0.36 ± 0.018	0.547CysSer: 0.547 ± 0.024	0.422CysThr: 0.422 ± 0.019	0.471CysVal: 0.471 ± 0.016	0.086CysTrp: 0.086 ± 0.008	0.327CysTyr: 0.327 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.175AspAla: 4.175 ± 0.058	0.398AspCys: 0.398 ± 0.019	2.946AspAsp: 2.946 ± 0.053	3.642AspGlu: 3.642 ± 0.048	2.891AspPhe: 2.891 ± 0.053	3.846AspGly: 3.846 ± 0.056	0.914AspHis: 0.914 ± 0.027	4.233AspIle: 4.233 ± 0.058	3.983AspLys: 3.983 ± 0.055	4.532AspLeu: 4.532 ± 0.064	1.253AspMet: 1.253 ± 0.03	3.065AspAsn: 3.065 ± 0.047	2.131AspPro: 2.131 ± 0.041	1.579AspGln: 1.579 ± 0.034	2.151AspArg: 2.151 ± 0.045	2.76AspSer: 2.76 ± 0.045	2.868AspThr: 2.868 ± 0.05	3.638AspVal: 3.638 ± 0.057	0.781AspTrp: 0.781 ± 0.026	2.57AspTyr: 2.57 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.487GluAla: 4.487 ± 0.066	0.335GluCys: 0.335 ± 0.016	2.705GluAsp: 2.705 ± 0.044	3.607GluGlu: 3.607 ± 0.072	2.435GluPhe: 2.435 ± 0.045	3.417GluGly: 3.417 ± 0.054	1.126GluHis: 1.126 ± 0.027	4.067GluIle: 4.067 ± 0.062	4.469GluLys: 4.469 ± 0.069	5.712GluLeu: 5.712 ± 0.071	1.38GluMet: 1.38 ± 0.033	3.048GluAsn: 3.048 ± 0.051	1.825GluPro: 1.825 ± 0.043	2.545GluGln: 2.545 ± 0.044	2.681GluArg: 2.681 ± 0.046	2.658GluSer: 2.658 ± 0.047	2.931GluThr: 2.931 ± 0.047	3.864GluVal: 3.864 ± 0.054	0.665GluTrp: 0.665 ± 0.023	2.211GluTyr: 2.211 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.513PheAla: 3.513 ± 0.056	0.435PheCys: 0.435 ± 0.02	2.963PheAsp: 2.963 ± 0.051	2.719PheGlu: 2.719 ± 0.05	2.382PhePhe: 2.382 ± 0.051	3.402PheGly: 3.402 ± 0.052	0.777PheHis: 0.777 ± 0.022	3.559PheIle: 3.559 ± 0.057	3.296PheLys: 3.296 ± 0.047	4.012PheLeu: 4.012 ± 0.069	1.079PheMet: 1.079 ± 0.032	3.154PheAsn: 3.154 ± 0.06	1.742PhePro: 1.742 ± 0.027	1.291PheGln: 1.291 ± 0.029	1.938PheArg: 1.938 ± 0.036	3.38PheSer: 3.38 ± 0.053	3.33PheThr: 3.33 ± 0.052	2.881PheVal: 2.881 ± 0.051	0.595PheTrp: 0.595 ± 0.025	2.202PheTyr: 2.202 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.627GlyAla: 4.627 ± 0.064	0.625GlyCys: 0.625 ± 0.025	3.557GlyAsp: 3.557 ± 0.062	3.425GlyGlu: 3.425 ± 0.055	3.657GlyPhe: 3.657 ± 0.061	5.075GlyGly: 5.075 ± 0.099	1.234GlyHis: 1.234 ± 0.033	5.287GlyIle: 5.287 ± 0.076	5.283GlyLys: 5.283 ± 0.056	6.22GlyLeu: 6.22 ± 0.067	1.645GlyMet: 1.645 ± 0.035	3.775GlyAsn: 3.775 ± 0.06	1.684GlyPro: 1.684 ± 0.036	2.262GlyGln: 2.262 ± 0.034	2.808GlyArg: 2.808 ± 0.048	4.361GlySer: 4.361 ± 0.062	4.269GlyThr: 4.269 ± 0.078	4.524GlyVal: 4.524 ± 0.066	1.027GlyTrp: 1.027 ± 0.03	3.324GlyTyr: 3.324 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.234HisAla: 1.234 ± 0.034	0.165HisCys: 0.165 ± 0.011	1.012HisAsp: 1.012 ± 0.03	1.087HisGlu: 1.087 ± 0.032	1.07HisPhe: 1.07 ± 0.029	1.245HisGly: 1.245 ± 0.028	0.546HisHis: 0.546 ± 0.02	1.39HisIle: 1.39 ± 0.032	1.028HisLys: 1.028 ± 0.027	1.853HisLeu: 1.853 ± 0.037	0.392HisMet: 0.392 ± 0.016	0.975HisAsn: 0.975 ± 0.024	1.047HisPro: 1.047 ± 0.029	0.726HisGln: 0.726 ± 0.023	0.774HisArg: 0.774 ± 0.026	1.0HisSer: 1.0 ± 0.025	1.085HisThr: 1.085 ± 0.027	1.026HisVal: 1.026 ± 0.026	0.267HisTrp: 0.267 ± 0.015	0.852HisTyr: 0.852 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.913IleAla: 5.913 ± 0.07	0.673IleCys: 0.673 ± 0.022	4.278IleAsp: 4.278 ± 0.056	4.127IleGlu: 4.127 ± 0.064	3.083IlePhe: 3.083 ± 0.051	4.695IleGly: 4.695 ± 0.067	1.221IleHis: 1.221 ± 0.029	5.129IleIle: 5.129 ± 0.079	4.969IleLys: 4.969 ± 0.059	5.863IleLeu: 5.863 ± 0.084	1.397IleMet: 1.397 ± 0.033	4.399IleAsn: 4.399 ± 0.063	2.951IlePro: 2.951 ± 0.047	2.15IleGln: 2.15 ± 0.039	2.919IleArg: 2.919 ± 0.051	5.016IleSer: 5.016 ± 0.061	4.807IleThr: 4.807 ± 0.061	4.274IleVal: 4.274 ± 0.061	0.726IleTrp: 0.726 ± 0.023	2.678IleTyr: 2.678 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.418LysAla: 5.418 ± 0.075	0.341LysCys: 0.341 ± 0.017	3.654LysAsp: 3.654 ± 0.049	4.152LysGlu: 4.152 ± 0.067	2.711LysPhe: 2.711 ± 0.044	4.485LysGly: 4.485 ± 0.059	1.365LysHis: 1.365 ± 0.033	4.527LysIle: 4.527 ± 0.058	5.17LysLys: 5.17 ± 0.065	6.411LysLeu: 6.411 ± 0.082	1.621LysMet: 1.621 ± 0.034	3.936LysAsn: 3.936 ± 0.06	2.971LysPro: 2.971 ± 0.051	3.121LysGln: 3.121 ± 0.051	2.863LysArg: 2.863 ± 0.049	3.649LysSer: 3.649 ± 0.051	3.931LysThr: 3.931 ± 0.057	4.426LysVal: 4.426 ± 0.06	0.8LysTrp: 0.8 ± 0.022	2.93LysTyr: 2.93 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	6.874LeuAla: 6.874 ± 0.082	0.801LeuCys: 0.801 ± 0.028	4.623LeuAsp: 4.623 ± 0.06	4.537LeuGlu: 4.537 ± 0.068	4.644LeuPhe: 4.644 ± 0.077	5.563LeuGly: 5.563 ± 0.07	1.784LeuHis: 1.784 ± 0.039	6.462LeuIle: 6.462 ± 0.087	6.935LeuLys: 6.935 ± 0.072	9.412LeuLeu: 9.412 ± 0.113	2.19LeuMet: 2.19 ± 0.042	5.691LeuAsn: 5.691 ± 0.069	4.115LeuPro: 4.115 ± 0.057	3.789LeuGln: 3.789 ± 0.055	3.797LeuArg: 3.797 ± 0.055	6.493LeuSer: 6.493 ± 0.085	5.664LeuThr: 5.664 ± 0.064	5.486LeuVal: 5.486 ± 0.068	0.984LeuTrp: 0.984 ± 0.03	3.456LeuTyr: 3.456 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.887MetAla: 1.887 ± 0.035	0.14MetCys: 0.14 ± 0.01	1.079MetAsp: 1.079 ± 0.031	1.212MetGlu: 1.212 ± 0.032	0.841MetPhe: 0.841 ± 0.028	1.422MetGly: 1.422 ± 0.036	0.456MetHis: 0.456 ± 0.019	1.407MetIle: 1.407 ± 0.031	1.797MetLys: 1.797 ± 0.037	2.317MetLeu: 2.317 ± 0.044	0.56MetMet: 0.56 ± 0.02	1.142MetAsn: 1.142 ± 0.031	1.118MetPro: 1.118 ± 0.025	1.03MetGln: 1.03 ± 0.029	1.032MetArg: 1.032 ± 0.026	1.306MetSer: 1.306 ± 0.029	0.999MetThr: 0.999 ± 0.026	1.491MetVal: 1.491 ± 0.036	0.186MetTrp: 0.186 ± 0.012	0.721MetTyr: 0.721 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	4.157AsnAla: 4.157 ± 0.055	0.401AsnCys: 0.401 ± 0.017	2.994AsnAsp: 2.994 ± 0.049	3.117AsnGlu: 3.117 ± 0.053	2.695AsnPhe: 2.695 ± 0.051	4.086AsnGly: 4.086 ± 0.062	0.991AsnHis: 0.991 ± 0.025	4.315AsnIle: 4.315 ± 0.055	3.725AsnLys: 3.725 ± 0.054	4.945AsnLeu: 4.945 ± 0.068	1.22AsnMet: 1.22 ± 0.029	3.495AsnAsn: 3.495 ± 0.062	2.645AsnPro: 2.645 ± 0.042	1.975AsnGln: 1.975 ± 0.036	2.411AsnArg: 2.411 ± 0.046	3.254AsnSer: 3.254 ± 0.05	3.488AsnThr: 3.488 ± 0.061	3.355AsnVal: 3.355 ± 0.059	0.798AsnTrp: 0.798 ± 0.028	2.687AsnTyr: 2.687 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.479ProAla: 3.479 ± 0.062	0.234ProCys: 0.234 ± 0.012	2.683ProAsp: 2.683 ± 0.048	2.913ProGlu: 2.913 ± 0.05	1.938ProPhe: 1.938 ± 0.037	3.068ProGly: 3.068 ± 0.053	0.753ProHis: 0.753 ± 0.023	2.082ProIle: 2.082 ± 0.039	2.155ProLys: 2.155 ± 0.045	3.486ProLeu: 3.486 ± 0.049	0.702ProMet: 0.702 ± 0.027	1.925ProAsn: 1.925 ± 0.045	1.157ProPro: 1.157 ± 0.033	1.508ProGln: 1.508 ± 0.034	1.189ProArg: 1.189 ± 0.032	2.204ProSer: 2.204 ± 0.042	1.899ProThr: 1.899 ± 0.038	3.572ProVal: 3.572 ± 0.055	0.453ProTrp: 0.453 ± 0.019	1.646ProTyr: 1.646 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.788GlnAla: 2.788 ± 0.051	0.188GlnCys: 0.188 ± 0.012	1.566GlnAsp: 1.566 ± 0.034	1.909GlnGlu: 1.909 ± 0.035	1.666GlnPhe: 1.666 ± 0.033	2.094GlnGly: 2.094 ± 0.042	0.889GlnHis: 0.889 ± 0.026	2.437GlnIle: 2.437 ± 0.038	2.542GlnLys: 2.542 ± 0.046	3.967GlnLeu: 3.967 ± 0.053	0.927GlnMet: 0.927 ± 0.028	2.015GlnAsn: 2.015 ± 0.047	1.626GlnPro: 1.626 ± 0.037	2.288GlnGln: 2.288 ± 0.063	1.759GlnArg: 1.759 ± 0.04	2.163GlnSer: 2.163 ± 0.042	2.143GlnThr: 2.143 ± 0.039	2.441GlnVal: 2.441 ± 0.046	0.431GlnTrp: 0.431 ± 0.018	1.609GlnTyr: 1.609 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.59ArgAla: 2.59 ± 0.047	0.23ArgCys: 0.23 ± 0.013	2.16ArgAsp: 2.16 ± 0.047	2.361ArgGlu: 2.361 ± 0.046	2.243ArgPhe: 2.243 ± 0.038	2.223ArgGly: 2.223 ± 0.045	0.806ArgHis: 0.806 ± 0.025	3.122ArgIle: 3.122 ± 0.043	2.902ArgLys: 2.902 ± 0.047	4.098ArgLeu: 4.098 ± 0.066	1.031ArgMet: 1.031 ± 0.027	2.323ArgAsn: 2.323 ± 0.042	1.464ArgPro: 1.464 ± 0.035	1.646ArgGln: 1.646 ± 0.043	1.882ArgArg: 1.882 ± 0.037	2.355ArgSer: 2.355 ± 0.045	2.204ArgThr: 2.204 ± 0.04	2.734ArgVal: 2.734 ± 0.047	0.596ArgTrp: 0.596 ± 0.021	2.039ArgTyr: 2.039 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.84SerAla: 4.84 ± 0.061	0.535SerCys: 0.535 ± 0.021	2.853SerAsp: 2.853 ± 0.044	2.962SerGlu: 2.962 ± 0.051	3.315SerPhe: 3.315 ± 0.054	4.852SerGly: 4.852 ± 0.069	1.095SerHis: 1.095 ± 0.027	4.354SerIle: 4.354 ± 0.058	3.64SerLys: 3.64 ± 0.056	5.699SerLeu: 5.699 ± 0.069	1.176SerMet: 1.176 ± 0.031	3.162SerAsn: 3.162 ± 0.058	2.436SerPro: 2.436 ± 0.05	1.949SerGln: 1.949 ± 0.035	2.529SerArg: 2.529 ± 0.043	3.727SerSer: 3.727 ± 0.063	3.52SerThr: 3.52 ± 0.062	4.253SerVal: 4.253 ± 0.059	0.734SerTrp: 0.734 ± 0.024	2.676SerTyr: 2.676 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.883ThrAla: 4.883 ± 0.073	0.392ThrCys: 0.392 ± 0.016	3.593ThrAsp: 3.593 ± 0.057	3.139ThrGlu: 3.139 ± 0.058	2.765ThrPhe: 2.765 ± 0.041	5.053ThrGly: 5.053 ± 0.067	1.01ThrHis: 1.01 ± 0.026	4.309ThrIle: 4.309 ± 0.06	3.031ThrLys: 3.031 ± 0.053	5.399ThrLeu: 5.399 ± 0.076	1.007ThrMet: 1.007 ± 0.026	2.92ThrAsn: 2.92 ± 0.052	2.747ThrPro: 2.747 ± 0.065	1.943ThrGln: 1.943 ± 0.037	2.15ThrArg: 2.15 ± 0.044	3.418ThrSer: 3.418 ± 0.06	3.479ThrThr: 3.479 ± 0.072	4.228ThrVal: 4.228 ± 0.067	0.683ThrTrp: 0.683 ± 0.027	2.481ThrTyr: 2.481 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.756ValAla: 4.756 ± 0.07	0.633ValCys: 0.633 ± 0.024	3.448ValAsp: 3.448 ± 0.053	3.43ValGlu: 3.43 ± 0.051	3.243ValPhe: 3.243 ± 0.054	3.819ValGly: 3.819 ± 0.058	1.119ValHis: 1.119 ± 0.025	4.994ValIle: 4.994 ± 0.06	4.792ValLys: 4.792 ± 0.06	6.223ValLeu: 6.223 ± 0.074	1.481ValMet: 1.481 ± 0.036	3.945ValAsn: 3.945 ± 0.059	2.544ValPro: 2.544 ± 0.046	2.169ValGln: 2.169 ± 0.04	2.442ValArg: 2.442 ± 0.044	4.269ValSer: 4.269 ± 0.062	4.233ValThr: 4.233 ± 0.07	4.431ValVal: 4.431 ± 0.062	0.756ValTrp: 0.756 ± 0.022	2.726ValTyr: 2.726 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.799TrpAla: 0.799 ± 0.027	0.121TrpCys: 0.121 ± 0.009	0.685TrpAsp: 0.685 ± 0.024	0.618TrpGlu: 0.618 ± 0.021	0.631TrpPhe: 0.631 ± 0.025	0.86TrpGly: 0.86 ± 0.023	0.322TrpHis: 0.322 ± 0.015	0.775TrpIle: 0.775 ± 0.024	0.782TrpLys: 0.782 ± 0.027	1.249TrpLeu: 1.249 ± 0.03	0.357TrpMet: 0.357 ± 0.014	0.697TrpAsn: 0.697 ± 0.02	0.395TrpPro: 0.395 ± 0.016	0.582TrpGln: 0.582 ± 0.023	0.584TrpArg: 0.584 ± 0.021	0.63TrpSer: 0.63 ± 0.024	0.636TrpThr: 0.636 ± 0.025	0.758TrpVal: 0.758 ± 0.027	0.22TrpTrp: 0.22 ± 0.013	0.513TrpTyr: 0.513 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.994TyrAla: 2.994 ± 0.053	0.384TyrCys: 0.384 ± 0.018	2.268TyrAsp: 2.268 ± 0.043	2.058TyrGlu: 2.058 ± 0.04	2.385TyrPhe: 2.385 ± 0.047	2.792TyrGly: 2.792 ± 0.056	0.909TyrHis: 0.909 ± 0.025	2.778TyrIle: 2.778 ± 0.045	2.818TyrLys: 2.818 ± 0.041	3.981TyrLeu: 3.981 ± 0.055	0.796TyrMet: 0.796 ± 0.025	2.823TyrAsn: 2.823 ± 0.048	1.749TyrPro: 1.749 ± 0.036	1.668TyrGln: 1.668 ± 0.036	2.021TyrArg: 2.021 ± 0.045	2.751TyrSer: 2.751 ± 0.045	2.579TyrThr: 2.579 ± 0.047	2.401TyrVal: 2.401 ± 0.047	0.542TyrTrp: 0.542 ± 0.02	2.015TyrTyr: 2.015 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4021 proteins (1373873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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