Amino acid dipepetide frequency for Lichenibacterium minor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.522AlaAla: 24.522 ± 0.226
1.249AlaCys: 1.249 ± 0.029
8.21AlaAsp: 8.21 ± 0.083
8.283AlaGlu: 8.283 ± 0.088
4.671AlaPhe: 4.671 ± 0.061
13.341AlaGly: 13.341 ± 0.112
2.425AlaHis: 2.425 ± 0.033
5.353AlaIle: 5.353 ± 0.055
3.604AlaLys: 3.604 ± 0.056
16.463AlaLeu: 16.463 ± 0.132
3.647AlaMet: 3.647 ± 0.046
2.233AlaAsn: 2.233 ± 0.041
7.603AlaPro: 7.603 ± 0.095
3.471AlaGln: 3.471 ± 0.057
11.236AlaArg: 11.236 ± 0.091
7.046AlaSer: 7.046 ± 0.076
6.638AlaThr: 6.638 ± 0.069
12.101AlaVal: 12.101 ± 0.104
1.751AlaTrp: 1.751 ± 0.038
2.367AlaTyr: 2.367 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.089CysAla: 1.089 ± 0.028
0.129CysCys: 0.129 ± 0.009
0.51CysAsp: 0.51 ± 0.016
0.4CysGlu: 0.4 ± 0.013
0.355CysPhe: 0.355 ± 0.013
0.984CysGly: 0.984 ± 0.024
0.229CysHis: 0.229 ± 0.012
0.343CysIle: 0.343 ± 0.015
0.128CysLys: 0.128 ± 0.009
0.822CysLeu: 0.822 ± 0.022
0.143CysMet: 0.143 ± 0.01
0.17CysAsn: 0.17 ± 0.009
0.492CysPro: 0.492 ± 0.017
0.195CysGln: 0.195 ± 0.01
0.813CysArg: 0.813 ± 0.021
0.465CysSer: 0.465 ± 0.016
0.393CysThr: 0.393 ± 0.017
0.622CysVal: 0.622 ± 0.02
0.118CysTrp: 0.118 ± 0.011
0.168CysTyr: 0.168 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.513AspAla: 9.513 ± 0.093
0.432AspCys: 0.432 ± 0.018
3.453AspAsp: 3.453 ± 0.059
3.253AspGlu: 3.253 ± 0.048
1.916AspPhe: 1.916 ± 0.038
6.635AspGly: 6.635 ± 0.071
1.4AspHis: 1.4 ± 0.031
2.358AspIle: 2.358 ± 0.038
1.267AspLys: 1.267 ± 0.031
6.537AspLeu: 6.537 ± 0.067
1.179AspMet: 1.179 ± 0.025
0.97AspAsn: 0.97 ± 0.027
4.112AspPro: 4.112 ± 0.052
1.272AspGln: 1.272 ± 0.026
5.418AspArg: 5.418 ± 0.068
1.837AspSer: 1.837 ± 0.033
2.584AspThr: 2.584 ± 0.038
4.854AspVal: 4.854 ± 0.055
0.952AspTrp: 0.952 ± 0.023
1.318AspTyr: 1.318 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.944GluAla: 7.944 ± 0.084
0.282GluCys: 0.282 ± 0.012
2.466GluAsp: 2.466 ± 0.045
2.335GluGlu: 2.335 ± 0.043
1.328GluPhe: 1.328 ± 0.029
4.151GluGly: 4.151 ± 0.053
1.057GluHis: 1.057 ± 0.026
2.497GluIle: 2.497 ± 0.039
1.324GluLys: 1.324 ± 0.036
4.229GluLeu: 4.229 ± 0.058
1.186GluMet: 1.186 ± 0.024
0.98GluAsn: 0.98 ± 0.025
2.891GluPro: 2.891 ± 0.052
1.389GluGln: 1.389 ± 0.032
5.294GluArg: 5.294 ± 0.063
1.751GluSer: 1.751 ± 0.033
2.647GluThr: 2.647 ± 0.043
3.889GluVal: 3.889 ± 0.051
0.523GluTrp: 0.523 ± 0.016
0.62GluTyr: 0.62 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
5.064PheAla: 5.064 ± 0.061
0.408PheCys: 0.408 ± 0.018
2.69PheAsp: 2.69 ± 0.046
1.702PheGlu: 1.702 ± 0.036
1.227PhePhe: 1.227 ± 0.038
3.826PheGly: 3.826 ± 0.059
0.742PheHis: 0.742 ± 0.022
1.184PheIle: 1.184 ± 0.034
0.837PheLys: 0.837 ± 0.027
3.02PheLeu: 3.02 ± 0.045
0.69PheMet: 0.69 ± 0.021
0.856PheAsn: 0.856 ± 0.021
1.652PhePro: 1.652 ± 0.029
0.77PheGln: 0.77 ± 0.02
2.319PheArg: 2.319 ± 0.037
1.791PheSer: 1.791 ± 0.035
1.923PheThr: 1.923 ± 0.033
2.829PheVal: 2.829 ± 0.05
0.49PheTrp: 0.49 ± 0.018
0.763PheTyr: 0.763 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
11.975GlyAla: 11.975 ± 0.096
0.95GlyCys: 0.95 ± 0.026
5.158GlyAsp: 5.158 ± 0.064
4.438GlyGlu: 4.438 ± 0.052
3.948GlyPhe: 3.948 ± 0.049
8.75GlyGly: 8.75 ± 0.118
2.101GlyHis: 2.101 ± 0.039
4.135GlyIle: 4.135 ± 0.052
2.383GlyLys: 2.383 ± 0.043
10.114GlyLeu: 10.114 ± 0.086
2.193GlyMet: 2.193 ± 0.038
1.731GlyAsn: 1.731 ± 0.04
4.584GlyPro: 4.584 ± 0.062
2.646GlyGln: 2.646 ± 0.046
8.495GlyArg: 8.495 ± 0.084
4.766GlySer: 4.766 ± 0.053
5.467GlyThr: 5.467 ± 0.076
6.825GlyVal: 6.825 ± 0.057
1.481GlyTrp: 1.481 ± 0.029
2.149GlyTyr: 2.149 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.729HisAla: 2.729 ± 0.039
0.227HisCys: 0.227 ± 0.013
1.387HisAsp: 1.387 ± 0.027
0.968HisGlu: 0.968 ± 0.024
0.766HisPhe: 0.766 ± 0.022
2.206HisGly: 2.206 ± 0.042
0.62HisHis: 0.62 ± 0.023
0.709HisIle: 0.709 ± 0.022
0.365HisLys: 0.365 ± 0.016
2.049HisLeu: 2.049 ± 0.036
0.456HisMet: 0.456 ± 0.015
0.383HisAsn: 0.383 ± 0.017
1.556HisPro: 1.556 ± 0.032
0.477HisGln: 0.477 ± 0.016
1.856HisArg: 1.856 ± 0.033
0.788HisSer: 0.788 ± 0.022
0.777HisThr: 0.777 ± 0.021
1.587HisVal: 1.587 ± 0.038
0.325HisTrp: 0.325 ± 0.014
0.513HisTyr: 0.513 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.088IleAla: 6.088 ± 0.062
0.383IleCys: 0.383 ± 0.015
3.002IleAsp: 3.002 ± 0.045
2.448IleGlu: 2.448 ± 0.045
1.13IlePhe: 1.13 ± 0.028
4.349IleGly: 4.349 ± 0.051
0.763IleHis: 0.763 ± 0.022
1.225IleIle: 1.225 ± 0.035
0.896IleLys: 0.896 ± 0.027
3.445IleLeu: 3.445 ± 0.05
0.674IleMet: 0.674 ± 0.022
0.849IleAsn: 0.849 ± 0.022
1.907IlePro: 1.907 ± 0.037
0.912IleGln: 0.912 ± 0.025
2.749IleArg: 2.749 ± 0.037
1.85IleSer: 1.85 ± 0.041
1.967IleThr: 1.967 ± 0.036
3.696IleVal: 3.696 ± 0.056
0.385IleTrp: 0.385 ± 0.015
0.777IleTyr: 0.777 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.612LysAla: 3.612 ± 0.052
0.114LysCys: 0.114 ± 0.009
1.343LysAsp: 1.343 ± 0.031
0.927LysGlu: 0.927 ± 0.028
0.669LysPhe: 0.669 ± 0.02
2.231LysGly: 2.231 ± 0.038
0.467LysHis: 0.467 ± 0.02
1.012LysIle: 1.012 ± 0.029
0.794LysLys: 0.794 ± 0.026
2.676LysLeu: 2.676 ± 0.044
0.537LysMet: 0.537 ± 0.022
0.498LysAsn: 0.498 ± 0.02
1.846LysPro: 1.846 ± 0.038
0.687LysGln: 0.687 ± 0.024
2.105LysArg: 2.105 ± 0.035
1.322LysSer: 1.322 ± 0.031
1.322LysThr: 1.322 ± 0.032
1.929LysVal: 1.929 ± 0.04
0.222LysTrp: 0.222 ± 0.012
0.404LysTyr: 0.404 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.401LeuAla: 15.401 ± 0.13
1.031LeuCys: 1.031 ± 0.025
7.166LeuAsp: 7.166 ± 0.076
4.082LeuGlu: 4.082 ± 0.054
3.493LeuPhe: 3.493 ± 0.058
9.485LeuGly: 9.485 ± 0.091
2.058LeuHis: 2.058 ± 0.034
3.566LeuIle: 3.566 ± 0.054
2.859LeuLys: 2.859 ± 0.045
9.455LeuLeu: 9.455 ± 0.109
2.166LeuMet: 2.166 ± 0.039
1.955LeuAsn: 1.955 ± 0.035
6.045LeuPro: 6.045 ± 0.062
2.397LeuGln: 2.397 ± 0.04
7.877LeuArg: 7.877 ± 0.074
6.091LeuSer: 6.091 ± 0.073
4.919LeuThr: 4.919 ± 0.063
8.461LeuVal: 8.461 ± 0.086
1.18LeuTrp: 1.18 ± 0.028
1.888LeuTyr: 1.888 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.196MetAla: 3.196 ± 0.042
0.121MetCys: 0.121 ± 0.009
1.101MetAsp: 1.101 ± 0.029
0.88MetGlu: 0.88 ± 0.026
0.585MetPhe: 0.585 ± 0.02
1.775MetGly: 1.775 ± 0.03
0.385MetHis: 0.385 ± 0.015
0.942MetIle: 0.942 ± 0.022
0.703MetLys: 0.703 ± 0.019
2.22MetLeu: 2.22 ± 0.034
0.527MetMet: 0.527 ± 0.019
0.543MetAsn: 0.543 ± 0.02
1.559MetPro: 1.559 ± 0.029
0.564MetGln: 0.564 ± 0.018
1.893MetArg: 1.893 ± 0.034
1.513MetSer: 1.513 ± 0.032
1.662MetThr: 1.662 ± 0.035
1.628MetVal: 1.628 ± 0.031
0.178MetTrp: 0.178 ± 0.01
0.229MetTyr: 0.229 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.658AsnAla: 2.658 ± 0.047
0.174AsnCys: 0.174 ± 0.009
1.095AsnAsp: 1.095 ± 0.03
0.769AsnGlu: 0.769 ± 0.019
0.686AsnPhe: 0.686 ± 0.022
1.939AsnGly: 1.939 ± 0.046
0.405AsnHis: 0.405 ± 0.015
0.869AsnIle: 0.869 ± 0.022
0.469AsnLys: 0.469 ± 0.018
2.061AsnLeu: 2.061 ± 0.037
0.447AsnMet: 0.447 ± 0.017
0.487AsnAsn: 0.487 ± 0.019
1.377AsnPro: 1.377 ± 0.03
0.515AsnGln: 0.515 ± 0.02
1.48AsnArg: 1.48 ± 0.029
0.883AsnSer: 0.883 ± 0.024
0.94AsnThr: 0.94 ± 0.024
1.563AsnVal: 1.563 ± 0.029
0.269AsnTrp: 0.269 ± 0.012
0.477AsnTyr: 0.477 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
8.67ProAla: 8.67 ± 0.084
0.377ProCys: 0.377 ± 0.016
4.409ProAsp: 4.409 ± 0.058
3.342ProGlu: 3.342 ± 0.046
2.096ProPhe: 2.096 ± 0.036
5.743ProGly: 5.743 ± 0.072
1.197ProHis: 1.197 ± 0.027
2.017ProIle: 2.017 ± 0.04
1.543ProLys: 1.543 ± 0.033
5.021ProLeu: 5.021 ± 0.053
1.236ProMet: 1.236 ± 0.027
1.188ProAsn: 1.188 ± 0.027
3.459ProPro: 3.459 ± 0.065
1.318ProGln: 1.318 ± 0.03
4.078ProArg: 4.078 ± 0.061
3.164ProSer: 3.164 ± 0.053
2.73ProThr: 2.73 ± 0.041
4.747ProVal: 4.747 ± 0.056
0.787ProTrp: 0.787 ± 0.021
1.084ProTyr: 1.084 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.69GlnAla: 3.69 ± 0.057
0.17GlnCys: 0.17 ± 0.011
1.305GlnAsp: 1.305 ± 0.031
0.927GlnGlu: 0.927 ± 0.025
0.801GlnPhe: 0.801 ± 0.02
2.234GlnGly: 2.234 ± 0.046
0.534GlnHis: 0.534 ± 0.018
1.157GlnIle: 1.157 ± 0.025
0.731GlnLys: 0.731 ± 0.026
2.172GlnLeu: 2.172 ± 0.036
0.574GlnMet: 0.574 ± 0.021
0.663GlnAsn: 0.663 ± 0.025
1.449GlnPro: 1.449 ± 0.035
0.812GlnGln: 0.812 ± 0.03
1.973GlnArg: 1.973 ± 0.038
1.378GlnSer: 1.378 ± 0.03
1.245GlnThr: 1.245 ± 0.027
2.102GlnVal: 2.102 ± 0.037
0.297GlnTrp: 0.297 ± 0.014
0.475GlnTyr: 0.475 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.7ArgAla: 10.7 ± 0.091
0.701ArgCys: 0.701 ± 0.022
5.482ArgAsp: 5.482 ± 0.065
3.65ArgGlu: 3.65 ± 0.048
3.275ArgPhe: 3.275 ± 0.045
6.356ArgGly: 6.356 ± 0.068
2.141ArgHis: 2.141 ± 0.038
3.58ArgIle: 3.58 ± 0.048
1.673ArgLys: 1.673 ± 0.033
8.715ArgLeu: 8.715 ± 0.076
1.861ArgMet: 1.861 ± 0.031
1.497ArgAsn: 1.497 ± 0.031
4.846ArgPro: 4.846 ± 0.061
2.248ArgGln: 2.248 ± 0.039
8.086ArgArg: 8.086 ± 0.103
4.169ArgSer: 4.169 ± 0.051
3.709ArgThr: 3.709 ± 0.039
5.885ArgVal: 5.885 ± 0.069
1.164ArgTrp: 1.164 ± 0.03
1.657ArgTyr: 1.657 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.614SerAla: 6.614 ± 0.069
0.432SerCys: 0.432 ± 0.017
2.827SerAsp: 2.827 ± 0.05
2.088SerGlu: 2.088 ± 0.039
2.183SerPhe: 2.183 ± 0.035
5.19SerGly: 5.19 ± 0.063
1.028SerHis: 1.028 ± 0.021
2.169SerIle: 2.169 ± 0.037
1.234SerLys: 1.234 ± 0.028
5.077SerLeu: 5.077 ± 0.058
1.116SerMet: 1.116 ± 0.026
1.099SerAsn: 1.099 ± 0.027
3.081SerPro: 3.081 ± 0.048
1.246SerGln: 1.246 ± 0.027
3.799SerArg: 3.799 ± 0.046
2.69SerSer: 2.69 ± 0.053
2.775SerThr: 2.775 ± 0.049
3.707SerVal: 3.707 ± 0.05
0.665SerTrp: 0.665 ± 0.02
1.143SerTyr: 1.143 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.868ThrAla: 6.868 ± 0.076
0.4ThrCys: 0.4 ± 0.015
2.676ThrAsp: 2.676 ± 0.044
2.12ThrGlu: 2.12 ± 0.037
1.806ThrPhe: 1.806 ± 0.032
5.178ThrGly: 5.178 ± 0.079
0.959ThrHis: 0.959 ± 0.022
2.18ThrIle: 2.18 ± 0.038
1.111ThrLys: 1.111 ± 0.026
5.755ThrLeu: 5.755 ± 0.07
1.074ThrMet: 1.074 ± 0.023
0.976ThrAsn: 0.976 ± 0.026
3.292ThrPro: 3.292 ± 0.053
1.023ThrGln: 1.023 ± 0.025
3.37ThrArg: 3.37 ± 0.045
2.59ThrSer: 2.59 ± 0.047
2.719ThrThr: 2.719 ± 0.053
4.868ThrVal: 4.868 ± 0.052
0.611ThrTrp: 0.611 ± 0.019
1.065ThrTyr: 1.065 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
11.944ValAla: 11.944 ± 0.098
0.649ValCys: 0.649 ± 0.021
4.999ValAsp: 4.999 ± 0.056
4.796ValGlu: 4.796 ± 0.053
2.642ValPhe: 2.642 ± 0.045
6.876ValGly: 6.876 ± 0.057
1.473ValHis: 1.473 ± 0.034
3.023ValIle: 3.023 ± 0.05
2.037ValLys: 2.037 ± 0.042
8.333ValLeu: 8.333 ± 0.074
1.805ValMet: 1.805 ± 0.034
1.664ValAsn: 1.664 ± 0.031
4.739ValPro: 4.739 ± 0.053
1.852ValGln: 1.852 ± 0.034
5.527ValArg: 5.527 ± 0.062
4.346ValSer: 4.346 ± 0.055
4.498ValThr: 4.498 ± 0.051
7.212ValVal: 7.212 ± 0.078
0.87ValTrp: 0.87 ± 0.024
1.449ValTyr: 1.449 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.338TrpAla: 1.338 ± 0.032
0.143TrpCys: 0.143 ± 0.009
0.693TrpAsp: 0.693 ± 0.021
0.439TrpGlu: 0.439 ± 0.017
0.508TrpPhe: 0.508 ± 0.018
0.92TrpGly: 0.92 ± 0.023
0.354TrpHis: 0.354 ± 0.014
0.571TrpIle: 0.571 ± 0.019
0.313TrpLys: 0.313 ± 0.013
1.496TrpLeu: 1.496 ± 0.031
0.336TrpMet: 0.336 ± 0.015
0.359TrpAsn: 0.359 ± 0.015
0.705TrpPro: 0.705 ± 0.023
0.38TrpGln: 0.38 ± 0.015
1.308TrpArg: 1.308 ± 0.027
0.831TrpSer: 0.831 ± 0.023
0.835TrpThr: 0.835 ± 0.024
0.779TrpVal: 0.779 ± 0.021
0.223TrpTrp: 0.223 ± 0.012
0.239TrpTyr: 0.239 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.599TyrAla: 2.599 ± 0.046
0.194TyrCys: 0.194 ± 0.01
1.289TyrAsp: 1.289 ± 0.028
0.94TyrGlu: 0.94 ± 0.028
0.698TyrPhe: 0.698 ± 0.02
2.119TyrGly: 2.119 ± 0.049
0.407TyrHis: 0.407 ± 0.016
0.603TyrIle: 0.603 ± 0.022
0.445TyrLys: 0.445 ± 0.017
1.915TyrLeu: 1.915 ± 0.041
0.357TyrMet: 0.357 ± 0.014
0.459TyrAsn: 0.459 ± 0.018
1.012TyrPro: 1.012 ± 0.026
0.516TyrGln: 0.516 ± 0.018
1.716TyrArg: 1.716 ± 0.033
0.896TyrSer: 0.896 ± 0.023
0.889TyrThr: 0.889 ± 0.024
1.45TyrVal: 1.45 ± 0.032
0.279TyrTrp: 0.279 ± 0.012
0.43TyrTyr: 0.43 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5408 proteins (1674681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski