Amino acid dipepetide frequency for Streptococcus phage Javan562

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.083AlaAla: 3.083 ± 0.69
0.674AlaCys: 0.674 ± 0.229
4.624AlaAsp: 4.624 ± 0.691
6.647AlaGlu: 6.647 ± 0.819
2.408AlaPhe: 2.408 ± 0.643
5.684AlaGly: 5.684 ± 0.96
1.349AlaHis: 1.349 ± 0.398
6.647AlaIle: 6.647 ± 1.036
6.936AlaLys: 6.936 ± 0.687
5.78AlaLeu: 5.78 ± 0.784
1.638AlaMet: 1.638 ± 0.429
4.817AlaAsn: 4.817 ± 0.791
0.771AlaPro: 0.771 ± 0.227
2.601AlaGln: 2.601 ± 0.52
2.794AlaArg: 2.794 ± 0.504
4.913AlaSer: 4.913 ± 0.82
4.624AlaThr: 4.624 ± 1.128
5.395AlaVal: 5.395 ± 0.499
0.674AlaTrp: 0.674 ± 0.295
1.83AlaTyr: 1.83 ± 0.395
0.0AlaXaa: 0.0 ± 0.0
Cys
0.289CysAla: 0.289 ± 0.183
0.193CysCys: 0.193 ± 0.123
0.578CysAsp: 0.578 ± 0.213
0.385CysGlu: 0.385 ± 0.198
0.289CysPhe: 0.289 ± 0.176
0.771CysGly: 0.771 ± 0.3
0.096CysHis: 0.096 ± 0.084
0.096CysIle: 0.096 ± 0.094
0.289CysLys: 0.289 ± 0.175
0.482CysLeu: 0.482 ± 0.284
0.0CysMet: 0.0 ± 0.0
0.096CysAsn: 0.096 ± 0.1
0.289CysPro: 0.289 ± 0.153
0.193CysGln: 0.193 ± 0.124
0.578CysArg: 0.578 ± 0.311
0.482CysSer: 0.482 ± 0.21
0.193CysThr: 0.193 ± 0.138
0.096CysVal: 0.096 ± 0.084
0.0CysTrp: 0.0 ± 0.0
0.385CysTyr: 0.385 ± 0.202
0.0CysXaa: 0.0 ± 0.0
Asp
3.276AspAla: 3.276 ± 0.567
0.674AspCys: 0.674 ± 0.218
3.661AspAsp: 3.661 ± 0.818
4.528AspGlu: 4.528 ± 0.774
2.89AspPhe: 2.89 ± 0.666
4.913AspGly: 4.913 ± 0.527
0.963AspHis: 0.963 ± 0.3
5.106AspIle: 5.106 ± 0.749
4.721AspLys: 4.721 ± 0.698
6.647AspLeu: 6.647 ± 0.705
2.216AspMet: 2.216 ± 0.34
4.143AspAsn: 4.143 ± 0.744
1.734AspPro: 1.734 ± 0.497
1.445AspGln: 1.445 ± 0.322
2.312AspArg: 2.312 ± 0.421
3.468AspSer: 3.468 ± 0.513
3.083AspThr: 3.083 ± 0.608
4.913AspVal: 4.913 ± 0.73
1.06AspTrp: 1.06 ± 0.261
2.216AspTyr: 2.216 ± 0.564
0.0AspXaa: 0.0 ± 0.0
Glu
6.551GluAla: 6.551 ± 0.935
0.193GluCys: 0.193 ± 0.135
3.276GluAsp: 3.276 ± 0.558
5.202GluGlu: 5.202 ± 0.803
2.89GluPhe: 2.89 ± 0.442
3.372GluGly: 3.372 ± 0.561
1.349GluHis: 1.349 ± 0.361
5.877GluIle: 5.877 ± 0.688
5.588GluLys: 5.588 ± 1.098
6.936GluLeu: 6.936 ± 1.233
1.927GluMet: 1.927 ± 0.536
3.565GluAsn: 3.565 ± 0.496
2.023GluPro: 2.023 ± 0.438
3.854GluGln: 3.854 ± 0.606
4.143GluArg: 4.143 ± 0.622
3.179GluSer: 3.179 ± 0.624
4.528GluThr: 4.528 ± 0.54
4.721GluVal: 4.721 ± 0.654
0.867GluTrp: 0.867 ± 0.256
2.023GluTyr: 2.023 ± 0.575
0.0GluXaa: 0.0 ± 0.0
Phe
3.179PheAla: 3.179 ± 0.627
0.096PheCys: 0.096 ± 0.113
2.697PheAsp: 2.697 ± 0.504
4.913PheGlu: 4.913 ± 0.679
1.734PhePhe: 1.734 ± 0.301
2.89PheGly: 2.89 ± 0.439
0.482PheHis: 0.482 ± 0.199
1.734PheIle: 1.734 ± 0.443
2.697PheLys: 2.697 ± 0.488
2.505PheLeu: 2.505 ± 0.529
1.349PheMet: 1.349 ± 0.418
2.312PheAsn: 2.312 ± 0.421
0.578PhePro: 0.578 ± 0.244
1.156PheGln: 1.156 ± 0.631
1.06PheArg: 1.06 ± 0.277
2.216PheSer: 2.216 ± 0.593
1.927PheThr: 1.927 ± 0.532
1.83PheVal: 1.83 ± 0.417
0.385PheTrp: 0.385 ± 0.187
1.927PheTyr: 1.927 ± 0.477
0.0PheXaa: 0.0 ± 0.0
Gly
4.335GlyAla: 4.335 ± 1.033
0.193GlyCys: 0.193 ± 0.132
3.468GlyAsp: 3.468 ± 0.56
3.276GlyGlu: 3.276 ± 0.568
3.179GlyPhe: 3.179 ± 0.64
4.624GlyGly: 4.624 ± 0.778
1.06GlyHis: 1.06 ± 0.243
3.95GlyIle: 3.95 ± 0.708
5.202GlyLys: 5.202 ± 0.664
6.166GlyLeu: 6.166 ± 0.861
2.216GlyMet: 2.216 ± 0.565
3.565GlyAsn: 3.565 ± 0.601
0.963GlyPro: 0.963 ± 0.33
3.661GlyGln: 3.661 ± 0.458
3.757GlyArg: 3.757 ± 0.495
3.276GlySer: 3.276 ± 0.724
3.468GlyThr: 3.468 ± 0.526
4.239GlyVal: 4.239 ± 0.67
0.963GlyTrp: 0.963 ± 0.279
3.179GlyTyr: 3.179 ± 0.54
0.0GlyXaa: 0.0 ± 0.0
His
1.06HisAla: 1.06 ± 0.3
0.193HisCys: 0.193 ± 0.153
0.771HisAsp: 0.771 ± 0.326
0.963HisGlu: 0.963 ± 0.265
0.771HisPhe: 0.771 ± 0.292
1.445HisGly: 1.445 ± 0.342
0.289HisHis: 0.289 ± 0.167
0.674HisIle: 0.674 ± 0.251
0.963HisLys: 0.963 ± 0.303
1.541HisLeu: 1.541 ± 0.326
0.289HisMet: 0.289 ± 0.14
0.771HisAsn: 0.771 ± 0.265
1.06HisPro: 1.06 ± 0.295
0.482HisGln: 0.482 ± 0.19
0.578HisArg: 0.578 ± 0.259
0.578HisSer: 0.578 ± 0.19
0.674HisThr: 0.674 ± 0.259
0.963HisVal: 0.963 ± 0.265
0.096HisTrp: 0.096 ± 0.085
0.578HisTyr: 0.578 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
4.624IleAla: 4.624 ± 0.67
0.674IleCys: 0.674 ± 0.251
5.395IleAsp: 5.395 ± 0.766
5.684IleGlu: 5.684 ± 0.739
2.023IlePhe: 2.023 ± 0.442
4.239IleGly: 4.239 ± 0.57
0.578IleHis: 0.578 ± 0.251
3.468IleIle: 3.468 ± 0.528
7.033IleLys: 7.033 ± 0.61
3.95IleLeu: 3.95 ± 0.694
1.349IleMet: 1.349 ± 0.5
3.757IleAsn: 3.757 ± 0.861
1.541IlePro: 1.541 ± 0.395
2.697IleGln: 2.697 ± 0.442
2.216IleArg: 2.216 ± 0.408
4.432IleSer: 4.432 ± 0.81
4.432IleThr: 4.432 ± 0.937
4.239IleVal: 4.239 ± 0.657
0.482IleTrp: 0.482 ± 0.204
2.697IleTyr: 2.697 ± 0.484
0.0IleXaa: 0.0 ± 0.0
Lys
6.166LysAla: 6.166 ± 0.872
0.096LysCys: 0.096 ± 0.113
4.528LysAsp: 4.528 ± 0.613
5.01LysGlu: 5.01 ± 1.014
2.89LysPhe: 2.89 ± 0.564
4.335LysGly: 4.335 ± 0.85
1.156LysHis: 1.156 ± 0.351
4.528LysIle: 4.528 ± 0.627
6.84LysLys: 6.84 ± 1.16
5.973LysLeu: 5.973 ± 0.781
2.023LysMet: 2.023 ± 0.477
4.913LysAsn: 4.913 ± 0.867
2.794LysPro: 2.794 ± 0.482
4.239LysGln: 4.239 ± 0.761
5.01LysArg: 5.01 ± 0.701
5.491LysSer: 5.491 ± 0.553
5.78LysThr: 5.78 ± 0.839
6.358LysVal: 6.358 ± 0.939
1.156LysTrp: 1.156 ± 0.262
2.601LysTyr: 2.601 ± 0.477
0.0LysXaa: 0.0 ± 0.0
Leu
8.382LeuAla: 8.382 ± 0.828
0.482LeuCys: 0.482 ± 0.212
5.395LeuAsp: 5.395 ± 0.742
5.973LeuGlu: 5.973 ± 0.998
3.276LeuPhe: 3.276 ± 0.498
5.395LeuGly: 5.395 ± 0.767
1.252LeuHis: 1.252 ± 0.422
4.817LeuIle: 4.817 ± 0.547
8.574LeuLys: 8.574 ± 0.999
6.84LeuLeu: 6.84 ± 0.751
1.445LeuMet: 1.445 ± 0.296
4.432LeuAsn: 4.432 ± 0.68
2.987LeuPro: 2.987 ± 0.613
2.987LeuGln: 2.987 ± 0.531
2.89LeuArg: 2.89 ± 0.514
5.78LeuSer: 5.78 ± 0.867
5.202LeuThr: 5.202 ± 0.739
4.913LeuVal: 4.913 ± 0.561
0.867LeuTrp: 0.867 ± 0.244
0.867LeuTyr: 0.867 ± 0.315
0.0LeuXaa: 0.0 ± 0.0
Met
1.83MetAla: 1.83 ± 0.437
0.193MetCys: 0.193 ± 0.124
1.252MetAsp: 1.252 ± 0.218
2.119MetGlu: 2.119 ± 0.464
0.674MetPhe: 0.674 ± 0.185
1.349MetGly: 1.349 ± 0.432
0.289MetHis: 0.289 ± 0.187
1.541MetIle: 1.541 ± 0.391
1.734MetLys: 1.734 ± 0.44
1.927MetLeu: 1.927 ± 0.54
0.289MetMet: 0.289 ± 0.135
1.541MetAsn: 1.541 ± 0.464
1.252MetPro: 1.252 ± 0.265
0.771MetGln: 0.771 ± 0.244
0.867MetArg: 0.867 ± 0.331
2.023MetSer: 2.023 ± 0.521
2.312MetThr: 2.312 ± 0.552
1.734MetVal: 1.734 ± 0.442
0.385MetTrp: 0.385 ± 0.168
1.06MetTyr: 1.06 ± 0.304
0.0MetXaa: 0.0 ± 0.0
Asn
3.468AsnAla: 3.468 ± 0.524
0.289AsnCys: 0.289 ± 0.159
3.083AsnAsp: 3.083 ± 0.615
2.697AsnGlu: 2.697 ± 0.482
2.794AsnPhe: 2.794 ± 0.433
4.239AsnGly: 4.239 ± 0.684
0.578AsnHis: 0.578 ± 0.214
3.372AsnIle: 3.372 ± 0.66
3.179AsnLys: 3.179 ± 0.642
5.684AsnLeu: 5.684 ± 0.874
1.06AsnMet: 1.06 ± 0.292
2.601AsnAsn: 2.601 ± 0.532
2.601AsnPro: 2.601 ± 0.647
2.987AsnGln: 2.987 ± 0.386
3.276AsnArg: 3.276 ± 0.504
3.95AsnSer: 3.95 ± 0.65
2.697AsnThr: 2.697 ± 0.431
3.565AsnVal: 3.565 ± 0.556
1.156AsnTrp: 1.156 ± 0.315
2.601AsnTyr: 2.601 ± 0.542
0.0AsnXaa: 0.0 ± 0.0
Pro
2.023ProAla: 2.023 ± 0.47
0.096ProCys: 0.096 ± 0.084
2.505ProAsp: 2.505 ± 0.648
1.734ProGlu: 1.734 ± 0.396
1.156ProPhe: 1.156 ± 0.382
1.349ProGly: 1.349 ± 0.319
0.578ProHis: 0.578 ± 0.252
1.927ProIle: 1.927 ± 0.518
2.794ProLys: 2.794 ± 0.555
2.505ProLeu: 2.505 ± 0.379
1.156ProMet: 1.156 ± 0.268
1.734ProAsn: 1.734 ± 0.369
0.289ProPro: 0.289 ± 0.161
0.771ProGln: 0.771 ± 0.263
0.867ProArg: 0.867 ± 0.271
2.312ProSer: 2.312 ± 0.549
1.638ProThr: 1.638 ± 0.41
2.601ProVal: 2.601 ± 0.644
0.289ProTrp: 0.289 ± 0.16
0.963ProTyr: 0.963 ± 0.311
0.0ProXaa: 0.0 ± 0.0
Gln
4.046GlnAla: 4.046 ± 0.709
0.193GlnCys: 0.193 ± 0.134
2.216GlnAsp: 2.216 ± 0.402
2.987GlnGlu: 2.987 ± 0.531
1.445GlnPhe: 1.445 ± 0.349
1.638GlnGly: 1.638 ± 0.519
0.674GlnHis: 0.674 ± 0.278
2.312GlnIle: 2.312 ± 0.401
3.083GlnLys: 3.083 ± 0.505
3.661GlnLeu: 3.661 ± 0.538
0.482GlnMet: 0.482 ± 0.23
1.83GlnAsn: 1.83 ± 0.381
1.252GlnPro: 1.252 ± 0.386
1.252GlnGln: 1.252 ± 0.318
2.023GlnArg: 2.023 ± 0.382
2.794GlnSer: 2.794 ± 0.497
3.179GlnThr: 3.179 ± 0.642
2.987GlnVal: 2.987 ± 0.644
0.482GlnTrp: 0.482 ± 0.186
1.349GlnTyr: 1.349 ± 0.382
0.0GlnXaa: 0.0 ± 0.0
Arg
2.119ArgAla: 2.119 ± 0.503
0.482ArgCys: 0.482 ± 0.245
2.794ArgAsp: 2.794 ± 0.587
3.083ArgGlu: 3.083 ± 0.546
1.445ArgPhe: 1.445 ± 0.346
1.252ArgGly: 1.252 ± 0.32
1.252ArgHis: 1.252 ± 0.31
3.757ArgIle: 3.757 ± 0.514
3.372ArgLys: 3.372 ± 0.749
4.721ArgLeu: 4.721 ± 0.846
1.156ArgMet: 1.156 ± 0.309
3.372ArgAsn: 3.372 ± 0.629
1.541ArgPro: 1.541 ± 0.417
1.541ArgGln: 1.541 ± 0.403
2.119ArgArg: 2.119 ± 0.4
2.023ArgSer: 2.023 ± 0.496
2.794ArgThr: 2.794 ± 0.442
2.697ArgVal: 2.697 ± 0.608
0.771ArgTrp: 0.771 ± 0.29
2.505ArgTyr: 2.505 ± 0.478
0.0ArgXaa: 0.0 ± 0.0
Ser
5.202SerAla: 5.202 ± 1.15
0.482SerCys: 0.482 ± 0.19
5.01SerAsp: 5.01 ± 0.555
4.335SerGlu: 4.335 ± 0.62
2.408SerPhe: 2.408 ± 0.396
4.913SerGly: 4.913 ± 0.733
0.771SerHis: 0.771 ± 0.22
3.757SerIle: 3.757 ± 0.584
4.624SerLys: 4.624 ± 0.673
5.106SerLeu: 5.106 ± 0.772
2.023SerMet: 2.023 ± 0.497
3.083SerAsn: 3.083 ± 0.536
1.349SerPro: 1.349 ± 0.339
1.83SerGln: 1.83 ± 0.667
2.601SerArg: 2.601 ± 0.542
4.046SerSer: 4.046 ± 0.693
3.372SerThr: 3.372 ± 0.742
5.491SerVal: 5.491 ± 0.788
0.867SerTrp: 0.867 ± 0.314
2.216SerTyr: 2.216 ± 0.308
0.0SerXaa: 0.0 ± 0.0
Thr
5.491ThrAla: 5.491 ± 0.818
0.0ThrCys: 0.0 ± 0.0
3.468ThrAsp: 3.468 ± 0.554
4.913ThrGlu: 4.913 ± 0.702
2.023ThrPhe: 2.023 ± 0.432
4.143ThrGly: 4.143 ± 0.501
0.771ThrHis: 0.771 ± 0.265
4.913ThrIle: 4.913 ± 0.676
6.069ThrLys: 6.069 ± 0.855
4.335ThrLeu: 4.335 ± 0.586
1.06ThrMet: 1.06 ± 0.424
2.794ThrAsn: 2.794 ± 0.405
1.349ThrPro: 1.349 ± 0.27
2.505ThrGln: 2.505 ± 0.901
2.216ThrArg: 2.216 ± 0.439
3.757ThrSer: 3.757 ± 0.621
3.854ThrThr: 3.854 ± 0.57
5.202ThrVal: 5.202 ± 0.686
0.289ThrTrp: 0.289 ± 0.174
2.119ThrTyr: 2.119 ± 0.419
0.0ThrXaa: 0.0 ± 0.0
Val
5.299ValAla: 5.299 ± 0.759
0.289ValCys: 0.289 ± 0.174
5.684ValAsp: 5.684 ± 0.764
4.913ValGlu: 4.913 ± 0.888
1.734ValPhe: 1.734 ± 0.397
4.624ValGly: 4.624 ± 0.875
0.771ValHis: 0.771 ± 0.263
4.721ValIle: 4.721 ± 0.861
5.106ValLys: 5.106 ± 0.717
4.817ValLeu: 4.817 ± 0.922
1.445ValMet: 1.445 ± 0.32
4.143ValAsn: 4.143 ± 0.659
2.987ValPro: 2.987 ± 0.532
2.601ValGln: 2.601 ± 0.557
2.89ValArg: 2.89 ± 0.491
5.684ValSer: 5.684 ± 0.881
4.528ValThr: 4.528 ± 0.647
5.491ValVal: 5.491 ± 0.865
0.674ValTrp: 0.674 ± 0.24
2.312ValTyr: 2.312 ± 0.587
0.0ValXaa: 0.0 ± 0.0
Trp
0.674TrpAla: 0.674 ± 0.249
0.096TrpCys: 0.096 ± 0.099
0.771TrpAsp: 0.771 ± 0.253
0.963TrpGlu: 0.963 ± 0.301
0.578TrpPhe: 0.578 ± 0.251
1.156TrpGly: 1.156 ± 0.372
0.096TrpHis: 0.096 ± 0.107
0.674TrpIle: 0.674 ± 0.294
1.541TrpLys: 1.541 ± 0.332
0.482TrpLeu: 0.482 ± 0.217
0.193TrpMet: 0.193 ± 0.143
0.674TrpAsn: 0.674 ± 0.287
0.193TrpPro: 0.193 ± 0.128
0.578TrpGln: 0.578 ± 0.35
0.482TrpArg: 0.482 ± 0.201
0.771TrpSer: 0.771 ± 0.278
0.771TrpThr: 0.771 ± 0.219
0.674TrpVal: 0.674 ± 0.218
0.096TrpTrp: 0.096 ± 0.094
0.578TrpTyr: 0.578 ± 0.206
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.794TyrAla: 2.794 ± 0.553
0.193TyrCys: 0.193 ± 0.144
2.794TyrAsp: 2.794 ± 0.541
1.734TyrGlu: 1.734 ± 0.364
1.06TyrPhe: 1.06 ± 0.288
2.408TyrGly: 2.408 ± 0.488
0.385TyrHis: 0.385 ± 0.161
1.734TyrIle: 1.734 ± 0.427
1.541TyrLys: 1.541 ± 0.375
2.697TyrLeu: 2.697 ± 0.421
1.734TyrMet: 1.734 ± 0.452
1.734TyrAsn: 1.734 ± 0.37
1.734TyrPro: 1.734 ± 0.559
1.734TyrGln: 1.734 ± 0.443
2.119TyrArg: 2.119 ± 0.626
2.312TyrSer: 2.312 ± 0.431
2.216TyrThr: 2.216 ± 0.401
2.601TyrVal: 2.601 ± 0.435
0.482TyrTrp: 0.482 ± 0.227
0.482TyrTyr: 0.482 ± 0.174
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (10381 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski