Amino acid dipepetide frequency for Acidovorax sp. RAC01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.373AlaAla: 19.373 ± 0.199
1.341AlaCys: 1.341 ± 0.037
6.671AlaAsp: 6.671 ± 0.072
6.497AlaGlu: 6.497 ± 0.09
4.023AlaPhe: 4.023 ± 0.058
10.92AlaGly: 10.92 ± 0.108
3.013AlaHis: 3.013 ± 0.053
4.907AlaIle: 4.907 ± 0.074
3.779AlaLys: 3.779 ± 0.075
15.476AlaLeu: 15.476 ± 0.136
3.731AlaMet: 3.731 ± 0.051
2.731AlaAsn: 2.731 ± 0.05
7.005AlaPro: 7.005 ± 0.088
6.693AlaGln: 6.693 ± 0.078
9.257AlaArg: 9.257 ± 0.082
7.142AlaSer: 7.142 ± 0.082
6.755AlaThr: 6.755 ± 0.082
9.767AlaVal: 9.767 ± 0.094
2.022AlaTrp: 2.022 ± 0.045
2.433AlaTyr: 2.433 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.176CysAla: 1.176 ± 0.03
0.113CysCys: 0.113 ± 0.009
0.505CysAsp: 0.505 ± 0.021
0.475CysGlu: 0.475 ± 0.02
0.295CysPhe: 0.295 ± 0.014
0.941CysGly: 0.941 ± 0.03
0.299CysHis: 0.299 ± 0.015
0.44CysIle: 0.44 ± 0.019
0.25CysLys: 0.25 ± 0.014
0.795CysLeu: 0.795 ± 0.028
0.261CysMet: 0.261 ± 0.015
0.266CysAsn: 0.266 ± 0.015
0.51CysPro: 0.51 ± 0.021
0.296CysGln: 0.296 ± 0.019
0.513CysArg: 0.513 ± 0.021
0.525CysSer: 0.525 ± 0.022
0.586CysThr: 0.586 ± 0.023
0.724CysVal: 0.724 ± 0.026
0.126CysTrp: 0.126 ± 0.009
0.186CysTyr: 0.186 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.282AspAla: 7.282 ± 0.098
0.451AspCys: 0.451 ± 0.02
2.618AspAsp: 2.618 ± 0.056
3.037AspGlu: 3.037 ± 0.06
1.928AspPhe: 1.928 ± 0.046
4.368AspGly: 4.368 ± 0.064
1.195AspHis: 1.195 ± 0.029
2.29AspIle: 2.29 ± 0.047
1.731AspLys: 1.731 ± 0.038
5.236AspLeu: 5.236 ± 0.068
1.366AspMet: 1.366 ± 0.036
1.187AspAsn: 1.187 ± 0.036
2.678AspPro: 2.678 ± 0.046
1.637AspGln: 1.637 ± 0.037
3.183AspArg: 3.183 ± 0.055
2.191AspSer: 2.191 ± 0.04
2.642AspThr: 2.642 ± 0.04
4.057AspVal: 4.057 ± 0.06
0.853AspTrp: 0.853 ± 0.028
1.267AspTyr: 1.267 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.482GluAla: 6.482 ± 0.083
0.4GluCys: 0.4 ± 0.017
2.127GluAsp: 2.127 ± 0.044
2.38GluGlu: 2.38 ± 0.054
1.776GluPhe: 1.776 ± 0.039
3.748GluGly: 3.748 ± 0.052
1.297GluHis: 1.297 ± 0.034
2.481GluIle: 2.481 ± 0.049
1.893GluLys: 1.893 ± 0.044
5.506GluLeu: 5.506 ± 0.069
1.251GluMet: 1.251 ± 0.032
1.217GluAsn: 1.217 ± 0.032
2.529GluPro: 2.529 ± 0.047
2.622GluGln: 2.622 ± 0.048
4.412GluArg: 4.412 ± 0.064
2.464GluSer: 2.464 ± 0.048
2.399GluThr: 2.399 ± 0.043
3.975GluVal: 3.975 ± 0.061
0.677GluTrp: 0.677 ± 0.024
0.996GluTyr: 0.996 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.368PheAla: 4.368 ± 0.062
0.379PheCys: 0.379 ± 0.017
2.366PheAsp: 2.366 ± 0.039
1.86PheGlu: 1.86 ± 0.039
1.267PhePhe: 1.267 ± 0.038
3.167PheGly: 3.167 ± 0.054
0.698PheHis: 0.698 ± 0.024
1.424PheIle: 1.424 ± 0.036
1.182PheLys: 1.182 ± 0.032
2.757PheLeu: 2.757 ± 0.042
0.865PheMet: 0.865 ± 0.028
1.055PheAsn: 1.055 ± 0.03
1.465PhePro: 1.465 ± 0.031
1.047PheGln: 1.047 ± 0.025
1.849PheArg: 1.849 ± 0.041
1.984PheSer: 1.984 ± 0.039
1.922PheThr: 1.922 ± 0.045
2.685PheVal: 2.685 ± 0.043
0.515PheTrp: 0.515 ± 0.022
0.813PheTyr: 0.813 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.545GlyAla: 9.545 ± 0.104
0.943GlyCys: 0.943 ± 0.032
3.988GlyAsp: 3.988 ± 0.05
4.09GlyGlu: 4.09 ± 0.051
3.182GlyPhe: 3.182 ± 0.053
7.076GlyGly: 7.076 ± 0.12
2.082GlyHis: 2.082 ± 0.041
3.812GlyIle: 3.812 ± 0.06
3.342GlyLys: 3.342 ± 0.055
8.738GlyLeu: 8.738 ± 0.089
2.529GlyMet: 2.529 ± 0.045
2.125GlyAsn: 2.125 ± 0.038
3.211GlyPro: 3.211 ± 0.05
3.482GlyGln: 3.482 ± 0.056
5.253GlyArg: 5.253 ± 0.075
4.636GlySer: 4.636 ± 0.07
4.782GlyThr: 4.782 ± 0.063
6.631GlyVal: 6.631 ± 0.075
1.465GlyTrp: 1.465 ± 0.039
2.297GlyTyr: 2.297 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
3.143HisAla: 3.143 ± 0.052
0.303HisCys: 0.303 ± 0.017
1.22HisAsp: 1.22 ± 0.033
1.172HisGlu: 1.172 ± 0.029
0.871HisPhe: 0.871 ± 0.028
2.259HisGly: 2.259 ± 0.044
0.695HisHis: 0.695 ± 0.027
1.05HisIle: 1.05 ± 0.032
0.64HisLys: 0.64 ± 0.02
2.388HisLeu: 2.388 ± 0.046
0.571HisMet: 0.571 ± 0.022
0.543HisAsn: 0.543 ± 0.018
1.563HisPro: 1.563 ± 0.037
0.842HisGln: 0.842 ± 0.027
1.564HisArg: 1.564 ± 0.037
1.138HisSer: 1.138 ± 0.031
1.212HisThr: 1.212 ± 0.028
1.552HisVal: 1.552 ± 0.032
0.434HisTrp: 0.434 ± 0.015
0.62HisTyr: 0.62 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.859IleAla: 5.859 ± 0.074
0.388IleCys: 0.388 ± 0.016
2.831IleAsp: 2.831 ± 0.045
2.806IleGlu: 2.806 ± 0.05
1.213IlePhe: 1.213 ± 0.032
3.676IleGly: 3.676 ± 0.064
0.878IleHis: 0.878 ± 0.028
1.562IleIle: 1.562 ± 0.041
1.516IleLys: 1.516 ± 0.044
3.075IleLeu: 3.075 ± 0.053
0.735IleMet: 0.735 ± 0.025
1.359IleAsn: 1.359 ± 0.033
2.018IlePro: 2.018 ± 0.038
1.251IleGln: 1.251 ± 0.032
2.444IleArg: 2.444 ± 0.041
2.292IleSer: 2.292 ± 0.049
2.598IleThr: 2.598 ± 0.046
3.187IleVal: 3.187 ± 0.06
0.453IleTrp: 0.453 ± 0.017
0.885IleTyr: 0.885 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.458LysAla: 4.458 ± 0.069
0.146LysCys: 0.146 ± 0.011
1.674LysAsp: 1.674 ± 0.038
1.547LysGlu: 1.547 ± 0.037
0.892LysPhe: 0.892 ± 0.031
2.53LysGly: 2.53 ± 0.052
0.638LysHis: 0.638 ± 0.023
1.447LysIle: 1.447 ± 0.037
1.503LysLys: 1.503 ± 0.048
3.351LysLeu: 3.351 ± 0.061
0.839LysMet: 0.839 ± 0.027
0.984LysAsn: 0.984 ± 0.027
2.069LysPro: 2.069 ± 0.042
1.145LysGln: 1.145 ± 0.033
2.012LysArg: 2.012 ± 0.043
1.709LysSer: 1.709 ± 0.041
1.947LysThr: 1.947 ± 0.041
2.593LysVal: 2.593 ± 0.056
0.341LysTrp: 0.341 ± 0.016
0.642LysTyr: 0.642 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.983LeuAla: 14.983 ± 0.156
1.069LeuCys: 1.069 ± 0.033
5.404LeuAsp: 5.404 ± 0.068
4.927LeuGlu: 4.927 ± 0.078
3.167LeuPhe: 3.167 ± 0.054
8.483LeuGly: 8.483 ± 0.101
2.527LeuHis: 2.527 ± 0.049
4.06LeuIle: 4.06 ± 0.067
3.407LeuLys: 3.407 ± 0.06
10.961LeuLeu: 10.961 ± 0.131
2.579LeuMet: 2.579 ± 0.049
2.653LeuAsn: 2.653 ± 0.053
6.213LeuPro: 6.213 ± 0.074
4.864LeuGln: 4.864 ± 0.069
7.663LeuArg: 7.663 ± 0.106
5.823LeuSer: 5.823 ± 0.083
5.323LeuThr: 5.323 ± 0.064
7.841LeuVal: 7.841 ± 0.089
1.404LeuTrp: 1.404 ± 0.04
1.969LeuTyr: 1.969 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.518MetAla: 3.518 ± 0.056
0.187MetCys: 0.187 ± 0.012
1.276MetAsp: 1.276 ± 0.034
1.155MetGlu: 1.155 ± 0.03
0.683MetPhe: 0.683 ± 0.026
2.111MetGly: 2.111 ± 0.044
0.636MetHis: 0.636 ± 0.023
0.85MetIle: 0.85 ± 0.026
1.031MetLys: 1.031 ± 0.027
2.69MetLeu: 2.69 ± 0.048
0.555MetMet: 0.555 ± 0.021
0.811MetAsn: 0.811 ± 0.023
1.558MetPro: 1.558 ± 0.035
1.238MetGln: 1.238 ± 0.033
1.67MetArg: 1.67 ± 0.036
1.475MetSer: 1.475 ± 0.034
1.611MetThr: 1.611 ± 0.035
2.002MetVal: 2.002 ± 0.04
0.257MetTrp: 0.257 ± 0.014
0.419MetTyr: 0.419 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.494AsnAla: 3.494 ± 0.055
0.231AsnCys: 0.231 ± 0.014
1.235AsnAsp: 1.235 ± 0.031
1.163AsnGlu: 1.163 ± 0.032
0.889AsnPhe: 0.889 ± 0.028
2.059AsnGly: 2.059 ± 0.044
0.581AsnHis: 0.581 ± 0.02
1.145AsnIle: 1.145 ± 0.033
0.81AsnLys: 0.81 ± 0.025
2.539AsnLeu: 2.539 ± 0.052
0.586AsnMet: 0.586 ± 0.02
0.741AsnAsn: 0.741 ± 0.027
1.807AsnPro: 1.807 ± 0.038
0.925AsnGln: 0.925 ± 0.026
1.588AsnArg: 1.588 ± 0.036
1.088AsnSer: 1.088 ± 0.03
1.463AsnThr: 1.463 ± 0.037
1.903AsnVal: 1.903 ± 0.038
0.397AsnTrp: 0.397 ± 0.02
0.59AsnTyr: 0.59 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.988ProAla: 7.988 ± 0.104
0.395ProCys: 0.395 ± 0.017
3.18ProAsp: 3.18 ± 0.05
3.245ProGlu: 3.245 ± 0.05
1.74ProPhe: 1.74 ± 0.039
5.035ProGly: 5.035 ± 0.068
1.257ProHis: 1.257 ± 0.035
1.737ProIle: 1.737 ± 0.034
1.44ProLys: 1.44 ± 0.037
5.467ProLeu: 5.467 ± 0.066
1.276ProMet: 1.276 ± 0.033
1.14ProAsn: 1.14 ± 0.028
2.916ProPro: 2.916 ± 0.061
2.246ProGln: 2.246 ± 0.043
3.02ProArg: 3.02 ± 0.049
2.828ProSer: 2.828 ± 0.048
2.71ProThr: 2.71 ± 0.049
4.577ProVal: 4.577 ± 0.055
0.862ProTrp: 0.862 ± 0.027
1.093ProTyr: 1.093 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
6.155GlnAla: 6.155 ± 0.087
0.335GlnCys: 0.335 ± 0.018
1.8GlnAsp: 1.8 ± 0.043
1.732GlnGlu: 1.732 ± 0.045
1.382GlnPhe: 1.382 ± 0.033
3.504GlnGly: 3.504 ± 0.051
1.064GlnHis: 1.064 ± 0.029
1.725GlnIle: 1.725 ± 0.036
1.236GlnLys: 1.236 ± 0.03
4.292GlnLeu: 4.292 ± 0.055
1.092GlnMet: 1.092 ± 0.03
0.917GlnAsn: 0.917 ± 0.026
2.579GlnPro: 2.579 ± 0.054
2.162GlnGln: 2.162 ± 0.048
3.673GlnArg: 3.673 ± 0.061
2.142GlnSer: 2.142 ± 0.038
2.021GlnThr: 2.021 ± 0.046
3.168GlnVal: 3.168 ± 0.045
0.849GlnTrp: 0.849 ± 0.025
0.819GlnTyr: 0.819 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
7.936ArgAla: 7.936 ± 0.087
0.58ArgCys: 0.58 ± 0.021
3.388ArgAsp: 3.388 ± 0.054
3.895ArgGlu: 3.895 ± 0.065
2.541ArgPhe: 2.541 ± 0.05
4.514ArgGly: 4.514 ± 0.061
1.802ArgHis: 1.802 ± 0.042
3.243ArgIle: 3.243 ± 0.049
2.222ArgLys: 2.222 ± 0.041
7.41ArgLeu: 7.41 ± 0.097
2.056ArgMet: 2.056 ± 0.04
1.869ArgAsn: 1.869 ± 0.043
3.234ArgPro: 3.234 ± 0.054
3.056ArgGln: 3.056 ± 0.055
4.639ArgArg: 4.639 ± 0.065
3.678ArgSer: 3.678 ± 0.052
3.555ArgThr: 3.555 ± 0.062
4.996ArgVal: 4.996 ± 0.065
1.288ArgTrp: 1.288 ± 0.037
1.702ArgTyr: 1.702 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.778SerAla: 6.778 ± 0.09
0.424SerCys: 0.424 ± 0.019
2.617SerAsp: 2.617 ± 0.047
2.434SerGlu: 2.434 ± 0.05
1.892SerPhe: 1.892 ± 0.042
5.083SerGly: 5.083 ± 0.06
1.271SerHis: 1.271 ± 0.033
2.327SerIle: 2.327 ± 0.044
1.504SerLys: 1.504 ± 0.045
5.543SerLeu: 5.543 ± 0.073
1.405SerMet: 1.405 ± 0.037
1.308SerAsn: 1.308 ± 0.032
2.998SerPro: 2.998 ± 0.046
1.959SerGln: 1.959 ± 0.051
3.359SerArg: 3.359 ± 0.052
3.004SerSer: 3.004 ± 0.052
3.076SerThr: 3.076 ± 0.051
4.026SerVal: 4.026 ± 0.062
0.669SerTrp: 0.669 ± 0.022
1.21SerTyr: 1.21 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.843ThrAla: 6.843 ± 0.087
0.455ThrCys: 0.455 ± 0.019
2.653ThrAsp: 2.653 ± 0.057
2.486ThrGlu: 2.486 ± 0.049
1.733ThrPhe: 1.733 ± 0.04
5.051ThrGly: 5.051 ± 0.068
1.267ThrHis: 1.267 ± 0.033
2.04ThrIle: 2.04 ± 0.043
1.372ThrLys: 1.372 ± 0.04
6.302ThrLeu: 6.302 ± 0.071
1.143ThrMet: 1.143 ± 0.031
1.213ThrAsn: 1.213 ± 0.03
3.684ThrPro: 3.684 ± 0.058
2.088ThrGln: 2.088 ± 0.037
3.332ThrArg: 3.332 ± 0.053
2.827ThrSer: 2.827 ± 0.046
3.057ThrThr: 3.057 ± 0.059
4.459ThrVal: 4.459 ± 0.067
0.707ThrTrp: 0.707 ± 0.027
1.07ThrTyr: 1.07 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
10.028ValAla: 10.028 ± 0.106
0.708ValCys: 0.708 ± 0.024
3.91ValAsp: 3.91 ± 0.053
4.046ValGlu: 4.046 ± 0.055
2.746ValPhe: 2.746 ± 0.046
5.682ValGly: 5.682 ± 0.076
1.748ValHis: 1.748 ± 0.034
3.138ValIle: 3.138 ± 0.059
2.428ValLys: 2.428 ± 0.051
8.452ValLeu: 8.452 ± 0.096
1.997ValMet: 1.997 ± 0.047
2.131ValAsn: 2.131 ± 0.049
4.237ValPro: 4.237 ± 0.059
3.478ValGln: 3.478 ± 0.056
5.355ValArg: 5.355 ± 0.073
3.989ValSer: 3.989 ± 0.056
4.168ValThr: 4.168 ± 0.058
6.657ValVal: 6.657 ± 0.087
1.027ValTrp: 1.027 ± 0.028
1.542ValTyr: 1.542 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.601TrpAla: 1.601 ± 0.04
0.176TrpCys: 0.176 ± 0.012
0.617TrpAsp: 0.617 ± 0.025
0.554TrpGlu: 0.554 ± 0.02
0.577TrpPhe: 0.577 ± 0.024
1.065TrpGly: 1.065 ± 0.031
0.38TrpHis: 0.38 ± 0.017
0.597TrpIle: 0.597 ± 0.024
0.498TrpLys: 0.498 ± 0.02
2.055TrpLeu: 2.055 ± 0.05
0.482TrpMet: 0.482 ± 0.018
0.446TrpAsn: 0.446 ± 0.02
0.754TrpPro: 0.754 ± 0.025
0.785TrpGln: 0.785 ± 0.027
1.172TrpArg: 1.172 ± 0.033
0.792TrpSer: 0.792 ± 0.024
0.741TrpThr: 0.741 ± 0.025
1.116TrpVal: 1.116 ± 0.03
0.323TrpTrp: 0.323 ± 0.018
0.289TrpTyr: 0.289 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.526TyrAla: 2.526 ± 0.043
0.257TyrCys: 0.257 ± 0.015
1.12TyrAsp: 1.12 ± 0.031
1.13TyrGlu: 1.13 ± 0.026
0.869TyrPhe: 0.869 ± 0.026
1.935TyrGly: 1.935 ± 0.041
0.452TyrHis: 0.452 ± 0.017
0.751TyrIle: 0.751 ± 0.022
0.684TyrLys: 0.684 ± 0.024
2.287TyrLeu: 2.287 ± 0.049
0.41TyrMet: 0.41 ± 0.016
0.536TyrAsn: 0.536 ± 0.022
1.123TyrPro: 1.123 ± 0.032
0.831TyrGln: 0.831 ± 0.028
1.648TyrArg: 1.648 ± 0.036
1.158TyrSer: 1.158 ± 0.031
1.22TyrThr: 1.22 ± 0.037
1.553TyrVal: 1.553 ± 0.036
0.352TyrTrp: 0.352 ± 0.017
0.522TyrTyr: 0.522 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3990 proteins (1305772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski