Amino acid dipepetide frequency for Hubei virga-like virus 23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.847AlaAla: 3.847 ± 0.996
1.496AlaCys: 1.496 ± 0.518
2.992AlaAsp: 2.992 ± 0.821
2.137AlaGlu: 2.137 ± 0.552
2.565AlaPhe: 2.565 ± 0.406
2.565AlaGly: 2.565 ± 0.357
2.137AlaHis: 2.137 ± 0.428
4.061AlaIle: 4.061 ± 0.645
1.923AlaLys: 1.923 ± 0.772
5.343AlaLeu: 5.343 ± 1.055
1.282AlaMet: 1.282 ± 0.307
3.633AlaAsn: 3.633 ± 1.22
1.923AlaPro: 1.923 ± 0.278
1.496AlaGln: 1.496 ± 0.362
3.42AlaArg: 3.42 ± 0.699
4.274AlaSer: 4.274 ± 0.534
2.992AlaThr: 2.992 ± 0.607
5.343AlaVal: 5.343 ± 1.384
0.641AlaTrp: 0.641 ± 0.161
2.351AlaTyr: 2.351 ± 0.582
0.0AlaXaa: 0.0 ± 0.0
Cys
1.923CysAla: 1.923 ± 1.176
0.641CysCys: 0.641 ± 0.365
2.137CysAsp: 2.137 ± 0.706
1.069CysGlu: 1.069 ± 0.353
0.641CysPhe: 0.641 ± 0.161
1.282CysGly: 1.282 ± 0.469
0.214CysHis: 0.214 ± 0.226
2.137CysIle: 2.137 ± 0.478
2.137CysLys: 2.137 ± 0.749
1.282CysLeu: 1.282 ± 0.331
0.427CysMet: 0.427 ± 0.248
1.069CysAsn: 1.069 ± 0.622
0.855CysPro: 0.855 ± 0.306
0.641CysGln: 0.641 ± 0.569
1.282CysArg: 1.282 ± 0.469
2.565CysSer: 2.565 ± 1.003
1.496CysThr: 1.496 ± 0.965
2.565CysVal: 2.565 ± 1.075
0.214CysTrp: 0.214 ± 0.588
0.641CysTyr: 0.641 ± 0.401
0.0CysXaa: 0.0 ± 0.0
Asp
3.206AspAla: 3.206 ± 0.881
1.71AspCys: 1.71 ± 0.489
3.633AspAsp: 3.633 ± 0.686
2.351AspGlu: 2.351 ± 1.366
1.496AspPhe: 1.496 ± 0.311
3.42AspGly: 3.42 ± 0.929
0.0AspHis: 0.0 ± 0.0
4.916AspIle: 4.916 ± 0.338
2.565AspLys: 2.565 ± 0.708
5.984AspLeu: 5.984 ± 0.735
0.427AspMet: 0.427 ± 0.248
3.206AspAsn: 3.206 ± 0.779
2.137AspPro: 2.137 ± 0.627
1.496AspGln: 1.496 ± 0.588
2.351AspArg: 2.351 ± 0.703
4.916AspSer: 4.916 ± 0.59
4.061AspThr: 4.061 ± 1.147
5.984AspVal: 5.984 ± 1.147
0.641AspTrp: 0.641 ± 0.365
2.778AspTyr: 2.778 ± 0.711
0.0AspXaa: 0.0 ± 0.0
Glu
2.351GluAla: 2.351 ± 0.599
0.855GluCys: 0.855 ± 0.497
1.282GluAsp: 1.282 ± 0.73
1.282GluGlu: 1.282 ± 0.469
2.137GluPhe: 2.137 ± 0.729
1.282GluGly: 1.282 ± 0.331
1.282GluHis: 1.282 ± 0.469
3.633GluIle: 3.633 ± 0.779
1.923GluLys: 1.923 ± 0.832
4.061GluLeu: 4.061 ± 2.178
1.496GluMet: 1.496 ± 0.436
2.137GluAsn: 2.137 ± 0.712
1.71GluPro: 1.71 ± 0.735
1.496GluGln: 1.496 ± 0.588
2.351GluArg: 2.351 ± 1.118
3.42GluSer: 3.42 ± 1.164
2.351GluThr: 2.351 ± 0.599
3.633GluVal: 3.633 ± 1.541
0.214GluTrp: 0.214 ± 0.124
1.923GluTyr: 1.923 ± 0.594
0.0GluXaa: 0.0 ± 0.0
Phe
2.992PheAla: 2.992 ± 0.43
0.641PheCys: 0.641 ± 0.161
2.351PheAsp: 2.351 ± 0.517
1.923PheGlu: 1.923 ± 0.367
1.71PhePhe: 1.71 ± 0.732
2.992PheGly: 2.992 ± 1.177
0.641PheHis: 0.641 ± 0.373
2.992PheIle: 2.992 ± 1.859
3.206PheLys: 3.206 ± 1.298
3.206PheLeu: 3.206 ± 1.088
0.855PheMet: 0.855 ± 0.304
3.42PheAsn: 3.42 ± 0.779
1.923PhePro: 1.923 ± 0.928
1.282PheGln: 1.282 ± 0.765
1.496PheArg: 1.496 ± 0.505
2.992PheSer: 2.992 ± 0.902
4.061PheThr: 4.061 ± 0.744
2.778PheVal: 2.778 ± 0.38
0.214PheTrp: 0.214 ± 0.124
3.206PheTyr: 3.206 ± 1.771
0.0PheXaa: 0.0 ± 0.0
Gly
2.351GlyAla: 2.351 ± 0.545
1.069GlyCys: 1.069 ± 0.288
2.992GlyAsp: 2.992 ± 0.751
1.71GlyGlu: 1.71 ± 0.471
1.923GlyPhe: 1.923 ± 0.42
2.778GlyGly: 2.778 ± 0.766
0.214GlyHis: 0.214 ± 0.124
2.351GlyIle: 2.351 ± 0.637
1.71GlyLys: 1.71 ± 0.708
3.633GlyLeu: 3.633 ± 1.24
0.641GlyMet: 0.641 ± 0.373
2.992GlyAsn: 2.992 ± 0.946
0.641GlyPro: 0.641 ± 0.566
0.855GlyGln: 0.855 ± 0.716
1.282GlyArg: 1.282 ± 0.693
4.061GlySer: 4.061 ± 0.711
3.633GlyThr: 3.633 ± 0.598
3.42GlyVal: 3.42 ± 0.86
0.427GlyTrp: 0.427 ± 0.152
3.847GlyTyr: 3.847 ± 1.278
0.0GlyXaa: 0.0 ± 0.0
His
2.137HisAla: 2.137 ± 0.749
0.641HisCys: 0.641 ± 1.104
1.069HisAsp: 1.069 ± 0.478
1.496HisGlu: 1.496 ± 0.87
1.069HisPhe: 1.069 ± 0.353
0.855HisGly: 0.855 ± 0.824
1.496HisHis: 1.496 ± 0.588
1.496HisIle: 1.496 ± 0.588
1.71HisLys: 1.71 ± 0.786
1.069HisLeu: 1.069 ± 0.621
0.641HisMet: 0.641 ± 0.369
1.069HisAsn: 1.069 ± 0.364
0.855HisPro: 0.855 ± 0.788
0.214HisGln: 0.214 ± 0.124
0.641HisArg: 0.641 ± 0.536
0.855HisSer: 0.855 ± 0.666
0.855HisThr: 0.855 ± 0.255
2.565HisVal: 2.565 ± 0.768
0.214HisTrp: 0.214 ± 0.124
1.496HisTyr: 1.496 ± 0.436
0.0HisXaa: 0.0 ± 0.0
Ile
5.77IleAla: 5.77 ± 0.838
2.351IleCys: 2.351 ± 0.887
5.343IleAsp: 5.343 ± 1.185
2.351IleGlu: 2.351 ± 0.637
2.351IlePhe: 2.351 ± 0.803
2.565IleGly: 2.565 ± 1.019
1.069IleHis: 1.069 ± 0.847
6.839IleIle: 6.839 ± 1.313
5.343IleLys: 5.343 ± 1.31
5.984IleLeu: 5.984 ± 2.981
2.137IleMet: 2.137 ± 0.552
4.916IleAsn: 4.916 ± 1.113
2.565IlePro: 2.565 ± 0.526
1.496IleGln: 1.496 ± 0.449
2.778IleArg: 2.778 ± 1.179
6.625IleSer: 6.625 ± 2.565
7.48IleThr: 7.48 ± 1.556
5.557IleVal: 5.557 ± 0.588
0.214IleTrp: 0.214 ± 0.124
2.992IleTyr: 2.992 ± 1.784
0.214IleXaa: 0.214 ± 0.124
Lys
1.496LysAla: 1.496 ± 0.588
2.351LysCys: 2.351 ± 0.376
2.137LysAsp: 2.137 ± 0.591
2.137LysGlu: 2.137 ± 0.606
2.778LysPhe: 2.778 ± 0.46
1.282LysGly: 1.282 ± 0.354
1.923LysHis: 1.923 ± 0.832
3.847LysIle: 3.847 ± 0.968
2.565LysLys: 2.565 ± 1.491
5.557LysLeu: 5.557 ± 1.248
1.496LysMet: 1.496 ± 0.432
3.847LysAsn: 3.847 ± 1.198
3.633LysPro: 3.633 ± 0.824
1.923LysGln: 1.923 ± 0.832
2.137LysArg: 2.137 ± 0.534
5.557LysSer: 5.557 ± 1.809
4.916LysThr: 4.916 ± 1.137
3.206LysVal: 3.206 ± 1.295
0.641LysTrp: 0.641 ± 0.683
2.778LysTyr: 2.778 ± 0.838
0.0LysXaa: 0.0 ± 0.0
Leu
4.702LeuAla: 4.702 ± 0.815
1.923LeuCys: 1.923 ± 0.333
4.061LeuAsp: 4.061 ± 1.003
3.206LeuGlu: 3.206 ± 1.307
5.77LeuPhe: 5.77 ± 1.19
1.923LeuGly: 1.923 ± 0.558
1.923LeuHis: 1.923 ± 0.801
6.198LeuIle: 6.198 ± 3.624
3.633LeuLys: 3.633 ± 0.576
8.976LeuLeu: 8.976 ± 1.726
1.282LeuMet: 1.282 ± 0.323
5.557LeuAsn: 5.557 ± 1.171
4.061LeuPro: 4.061 ± 0.443
2.565LeuGln: 2.565 ± 0.718
4.702LeuArg: 4.702 ± 0.516
6.198LeuSer: 6.198 ± 1.052
9.19LeuThr: 9.19 ± 1.677
5.129LeuVal: 5.129 ± 1.184
0.855LeuTrp: 0.855 ± 0.497
4.274LeuTyr: 4.274 ± 1.829
0.0LeuXaa: 0.0 ± 0.0
Met
0.427MetAla: 0.427 ± 0.248
1.069MetCys: 1.069 ± 0.513
1.069MetAsp: 1.069 ± 0.353
1.069MetGlu: 1.069 ± 0.621
1.282MetPhe: 1.282 ± 0.402
0.427MetGly: 0.427 ± 0.248
1.069MetHis: 1.069 ± 0.586
1.923MetIle: 1.923 ± 0.58
1.496MetLys: 1.496 ± 0.588
1.069MetLeu: 1.069 ± 0.936
0.427MetMet: 0.427 ± 0.17
1.282MetAsn: 1.282 ± 0.532
0.427MetPro: 0.427 ± 0.248
0.855MetGln: 0.855 ± 0.588
0.855MetArg: 0.855 ± 0.245
1.496MetSer: 1.496 ± 0.686
1.069MetThr: 1.069 ± 0.282
0.641MetVal: 0.641 ± 0.161
0.214MetTrp: 0.214 ± 0.124
0.641MetTyr: 0.641 ± 0.373
0.0MetXaa: 0.0 ± 0.0
Asn
3.42AsnAla: 3.42 ± 1.798
1.282AsnCys: 1.282 ± 0.612
4.061AsnAsp: 4.061 ± 1.515
1.923AsnGlu: 1.923 ± 1.118
2.992AsnPhe: 2.992 ± 0.476
2.565AsnGly: 2.565 ± 0.346
1.069AsnHis: 1.069 ± 0.294
3.633AsnIle: 3.633 ± 0.504
3.633AsnLys: 3.633 ± 1.238
4.274AsnLeu: 4.274 ± 0.853
0.855AsnMet: 0.855 ± 0.829
3.847AsnAsn: 3.847 ± 0.619
2.778AsnPro: 2.778 ± 0.519
1.496AsnGln: 1.496 ± 0.541
1.923AsnArg: 1.923 ± 0.96
6.198AsnSer: 6.198 ± 0.882
3.42AsnThr: 3.42 ± 1.235
5.557AsnVal: 5.557 ± 1.585
0.0AsnTrp: 0.0 ± 0.0
4.061AsnTyr: 4.061 ± 1.374
0.0AsnXaa: 0.0 ± 0.0
Pro
2.137ProAla: 2.137 ± 0.953
0.855ProCys: 0.855 ± 0.454
2.778ProAsp: 2.778 ± 0.562
1.71ProGlu: 1.71 ± 0.777
0.855ProPhe: 0.855 ± 0.245
1.282ProGly: 1.282 ± 0.331
0.214ProHis: 0.214 ± 0.124
3.633ProIle: 3.633 ± 1.353
2.992ProLys: 2.992 ± 0.839
3.847ProLeu: 3.847 ± 1.911
0.427ProMet: 0.427 ± 0.152
2.992ProAsn: 2.992 ± 0.489
2.778ProPro: 2.778 ± 1.632
2.137ProGln: 2.137 ± 0.893
1.923ProArg: 1.923 ± 0.669
5.343ProSer: 5.343 ± 1.969
1.923ProThr: 1.923 ± 0.636
4.274ProVal: 4.274 ± 1.386
0.0ProTrp: 0.0 ± 0.0
2.351ProTyr: 2.351 ± 1.356
0.0ProXaa: 0.0 ± 0.0
Gln
0.214GlnAla: 0.214 ± 0.124
1.069GlnCys: 1.069 ± 0.353
1.282GlnAsp: 1.282 ± 0.354
0.641GlnGlu: 0.641 ± 0.161
2.137GlnPhe: 2.137 ± 0.567
2.137GlnGly: 2.137 ± 0.679
0.641GlnHis: 0.641 ± 0.401
2.137GlnIle: 2.137 ± 0.552
0.641GlnLys: 0.641 ± 0.373
2.565GlnLeu: 2.565 ± 0.755
0.214GlnMet: 0.214 ± 0.124
1.069GlnAsn: 1.069 ± 0.294
1.069GlnPro: 1.069 ± 0.627
1.496GlnGln: 1.496 ± 0.39
2.778GlnArg: 2.778 ± 0.93
4.274GlnSer: 4.274 ± 1.132
2.351GlnThr: 2.351 ± 0.777
1.282GlnVal: 1.282 ± 0.323
0.0GlnTrp: 0.0 ± 0.0
3.206GlnTyr: 3.206 ± 1.079
0.0GlnXaa: 0.0 ± 0.0
Arg
2.351ArgAla: 2.351 ± 0.962
0.855ArgCys: 0.855 ± 0.497
3.206ArgAsp: 3.206 ± 1.009
2.137ArgGlu: 2.137 ± 0.954
1.496ArgPhe: 1.496 ± 1.073
1.923ArgGly: 1.923 ± 0.773
1.069ArgHis: 1.069 ± 1.083
4.061ArgIle: 4.061 ± 1.262
2.137ArgLys: 2.137 ± 0.706
2.992ArgLeu: 2.992 ± 0.621
0.427ArgMet: 0.427 ± 0.152
2.992ArgAsn: 2.992 ± 0.621
0.855ArgPro: 0.855 ± 0.409
1.282ArgGln: 1.282 ± 0.504
2.351ArgArg: 2.351 ± 0.648
4.274ArgSer: 4.274 ± 1.456
3.42ArgThr: 3.42 ± 0.786
2.565ArgVal: 2.565 ± 0.649
0.0ArgTrp: 0.0 ± 0.0
2.137ArgTyr: 2.137 ± 0.405
0.0ArgXaa: 0.0 ± 0.0
Ser
4.061SerAla: 4.061 ± 0.501
1.71SerCys: 1.71 ± 0.756
6.412SerAsp: 6.412 ± 0.743
4.274SerGlu: 4.274 ± 1.014
4.274SerPhe: 4.274 ± 0.667
4.488SerGly: 4.488 ± 1.875
1.71SerHis: 1.71 ± 0.559
6.412SerIle: 6.412 ± 0.961
5.129SerLys: 5.129 ± 1.392
8.121SerLeu: 8.121 ± 1.331
1.069SerMet: 1.069 ± 0.291
4.061SerAsn: 4.061 ± 1.31
6.625SerPro: 6.625 ± 0.652
2.992SerGln: 2.992 ± 0.877
3.206SerArg: 3.206 ± 0.863
8.121SerSer: 8.121 ± 1.85
7.053SerThr: 7.053 ± 2.341
4.916SerVal: 4.916 ± 1.278
0.641SerTrp: 0.641 ± 0.364
4.488SerTyr: 4.488 ± 1.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.488ThrAla: 4.488 ± 1.166
1.923ThrCys: 1.923 ± 0.738
2.992ThrAsp: 2.992 ± 1.696
2.992ThrGlu: 2.992 ± 0.791
3.42ThrPhe: 3.42 ± 0.835
2.992ThrGly: 2.992 ± 0.652
2.565ThrHis: 2.565 ± 1.359
6.839ThrIle: 6.839 ± 1.754
5.343ThrLys: 5.343 ± 0.933
7.908ThrLeu: 7.908 ± 2.401
1.923ThrMet: 1.923 ± 0.484
3.42ThrAsn: 3.42 ± 1.376
3.847ThrPro: 3.847 ± 0.839
2.565ThrGln: 2.565 ± 0.395
3.206ThrArg: 3.206 ± 1.699
4.274ThrSer: 4.274 ± 0.916
5.77ThrThr: 5.77 ± 2.073
4.702ThrVal: 4.702 ± 0.727
0.214ThrTrp: 0.214 ± 0.588
2.992ThrTyr: 2.992 ± 0.64
0.0ThrXaa: 0.0 ± 0.0
Val
5.129ValAla: 5.129 ± 0.715
1.923ValCys: 1.923 ± 0.58
4.274ValAsp: 4.274 ± 0.853
3.42ValGlu: 3.42 ± 0.943
2.992ValPhe: 2.992 ± 0.506
3.42ValGly: 3.42 ± 1.633
1.496ValHis: 1.496 ± 0.87
5.343ValIle: 5.343 ± 1.332
4.488ValLys: 4.488 ± 0.79
5.984ValLeu: 5.984 ± 1.814
1.496ValMet: 1.496 ± 0.608
3.633ValAsn: 3.633 ± 0.695
3.633ValPro: 3.633 ± 1.183
2.565ValGln: 2.565 ± 0.406
1.71ValArg: 1.71 ± 0.994
9.404ValSer: 9.404 ± 1.093
4.702ValThr: 4.702 ± 0.933
5.343ValVal: 5.343 ± 0.831
0.214ValTrp: 0.214 ± 0.588
2.778ValTyr: 2.778 ± 0.471
0.214ValXaa: 0.214 ± 0.124
Trp
0.641TrpAla: 0.641 ± 0.745
0.214TrpCys: 0.214 ± 0.124
0.0TrpAsp: 0.0 ± 0.0
0.214TrpGlu: 0.214 ± 0.124
0.214TrpPhe: 0.214 ± 0.226
0.855TrpGly: 0.855 ± 0.306
0.0TrpHis: 0.0 ± 0.0
0.855TrpIle: 0.855 ± 1.097
0.214TrpLys: 0.214 ± 0.124
0.641TrpLeu: 0.641 ± 0.161
0.0TrpMet: 0.0 ± 0.0
0.214TrpAsn: 0.214 ± 0.124
0.0TrpPro: 0.0 ± 0.0
0.427TrpGln: 0.427 ± 0.287
0.641TrpArg: 0.641 ± 0.558
0.214TrpSer: 0.214 ± 0.124
0.214TrpThr: 0.214 ± 0.124
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.214TrpTyr: 0.214 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.778TyrAla: 2.778 ± 1.113
0.641TyrCys: 0.641 ± 0.425
2.992TyrAsp: 2.992 ± 1.321
2.778TyrGlu: 2.778 ± 0.384
2.778TyrPhe: 2.778 ± 0.675
1.496TyrGly: 1.496 ± 0.712
1.71TyrHis: 1.71 ± 0.932
3.42TyrIle: 3.42 ± 1.112
3.42TyrLys: 3.42 ± 0.414
3.633TyrLeu: 3.633 ± 1.195
1.282TyrMet: 1.282 ± 0.28
3.633TyrAsn: 3.633 ± 0.547
2.137TyrPro: 2.137 ± 1.573
1.923TyrGln: 1.923 ± 0.587
1.496TyrArg: 1.496 ± 0.661
4.702TyrSer: 4.702 ± 1.318
3.42TyrThr: 3.42 ± 1.357
4.702TyrVal: 4.702 ± 0.953
0.214TyrTrp: 0.214 ± 0.226
1.496TyrTyr: 1.496 ± 0.801
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.214XaaAsp: 0.214 ± 0.124
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.214XaaIle: 0.214 ± 0.124
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski