Amino acid dipepetide frequency for Zerdali virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.755AlaAla: 4.755 ± 1.94
1.001AlaCys: 1.001 ± 0.33
2.753AlaAsp: 2.753 ± 1.039
3.253AlaGlu: 3.253 ± 0.414
1.752AlaPhe: 1.752 ± 0.292
2.503AlaGly: 2.503 ± 1.262
1.752AlaHis: 1.752 ± 0.432
6.006AlaIle: 6.006 ± 0.587
3.003AlaLys: 3.003 ± 1.289
3.504AlaLeu: 3.504 ± 0.991
3.754AlaMet: 3.754 ± 0.961
1.251AlaAsn: 1.251 ± 0.293
1.752AlaPro: 1.752 ± 0.382
1.251AlaGln: 1.251 ± 0.366
3.003AlaArg: 3.003 ± 0.992
4.254AlaSer: 4.254 ± 0.678
4.254AlaThr: 4.254 ± 0.769
2.252AlaVal: 2.252 ± 0.778
1.251AlaTrp: 1.251 ± 0.37
3.253AlaTyr: 3.253 ± 1.437
0.0AlaXaa: 0.0 ± 0.0
Cys
1.752CysAla: 1.752 ± 0.929
0.25CysCys: 0.25 ± 0.165
1.001CysAsp: 1.001 ± 0.583
0.751CysGlu: 0.751 ± 0.41
1.251CysPhe: 1.251 ± 0.48
1.502CysGly: 1.502 ± 0.704
1.001CysHis: 1.001 ± 0.583
1.001CysIle: 1.001 ± 0.583
2.252CysLys: 2.252 ± 0.748
2.503CysLeu: 2.503 ± 1.349
0.751CysMet: 0.751 ± 0.192
1.502CysAsn: 1.502 ± 0.418
0.501CysPro: 0.501 ± 0.139
1.001CysGln: 1.001 ± 0.279
0.501CysArg: 0.501 ± 0.473
3.253CysSer: 3.253 ± 0.818
1.001CysThr: 1.001 ± 0.583
1.251CysVal: 1.251 ± 0.596
0.25CysTrp: 0.25 ± 0.237
1.251CysTyr: 1.251 ± 0.596
0.0CysXaa: 0.0 ± 0.0
Asp
2.753AspAla: 2.753 ± 1.092
1.752AspCys: 1.752 ± 1.289
4.004AspAsp: 4.004 ± 0.572
5.756AspGlu: 5.756 ± 0.71
2.503AspPhe: 2.503 ± 1.32
1.251AspGly: 1.251 ± 0.313
0.751AspHis: 0.751 ± 0.494
3.253AspIle: 3.253 ± 0.99
5.506AspLys: 5.506 ± 0.948
4.004AspLeu: 4.004 ± 0.764
2.002AspMet: 2.002 ± 0.717
1.251AspAsn: 1.251 ± 0.293
3.003AspPro: 3.003 ± 0.152
1.251AspGln: 1.251 ± 0.283
2.252AspArg: 2.252 ± 0.75
4.505AspSer: 4.505 ± 0.776
2.252AspThr: 2.252 ± 0.94
2.503AspVal: 2.503 ± 1.089
1.251AspTrp: 1.251 ± 0.545
2.002AspTyr: 2.002 ± 0.382
0.0AspXaa: 0.0 ± 0.0
Glu
5.255GluAla: 5.255 ± 1.41
1.502GluCys: 1.502 ± 0.809
6.006GluAsp: 6.006 ± 1.077
6.757GluGlu: 6.757 ± 1.019
4.004GluPhe: 4.004 ± 1.21
4.004GluGly: 4.004 ± 0.49
0.751GluHis: 0.751 ± 0.192
4.505GluIle: 4.505 ± 0.535
6.006GluLys: 6.006 ± 0.723
6.256GluLeu: 6.256 ± 1.338
3.003GluMet: 3.003 ± 0.43
1.502GluAsn: 1.502 ± 0.385
3.253GluPro: 3.253 ± 0.535
0.501GluGln: 0.501 ± 0.139
4.254GluArg: 4.254 ± 0.879
5.255GluSer: 5.255 ± 0.709
2.753GluThr: 2.753 ± 0.843
3.754GluVal: 3.754 ± 0.435
0.751GluTrp: 0.751 ± 0.192
2.753GluTyr: 2.753 ± 0.347
0.0GluXaa: 0.0 ± 0.0
Phe
2.252PheAla: 2.252 ± 0.682
1.001PheCys: 1.001 ± 0.41
3.003PheAsp: 3.003 ± 1.065
4.254PheGlu: 4.254 ± 0.734
3.003PhePhe: 3.003 ± 0.152
1.752PheGly: 1.752 ± 0.567
0.501PheHis: 0.501 ± 0.139
3.754PheIle: 3.754 ± 0.594
4.004PheLys: 4.004 ± 1.085
4.254PheLeu: 4.254 ± 0.866
1.502PheMet: 1.502 ± 0.515
2.002PheAsn: 2.002 ± 0.251
1.502PhePro: 1.502 ± 0.427
0.25PheGln: 0.25 ± 0.165
1.502PheArg: 1.502 ± 0.821
4.254PheSer: 4.254 ± 0.676
2.753PheThr: 2.753 ± 0.591
3.253PheVal: 3.253 ± 0.765
0.751PheTrp: 0.751 ± 0.352
1.251PheTyr: 1.251 ± 0.951
0.0PheXaa: 0.0 ± 0.0
Gly
3.253GlyAla: 3.253 ± 0.414
1.502GlyCys: 1.502 ± 0.418
1.502GlyAsp: 1.502 ± 0.385
2.503GlyGlu: 2.503 ± 1.119
4.254GlyPhe: 4.254 ± 0.347
3.253GlyGly: 3.253 ± 1.022
2.002GlyHis: 2.002 ± 1.317
3.003GlyIle: 3.003 ± 1.054
3.253GlyLys: 3.253 ± 0.481
5.506GlyLeu: 5.506 ± 0.935
2.002GlyMet: 2.002 ± 0.271
3.003GlyAsn: 3.003 ± 0.927
1.251GlyPro: 1.251 ± 0.48
2.002GlyGln: 2.002 ± 0.528
2.503GlyArg: 2.503 ± 1.368
6.006GlySer: 6.006 ± 2.185
2.002GlyThr: 2.002 ± 0.988
3.504GlyVal: 3.504 ± 1.301
0.501GlyTrp: 0.501 ± 0.473
1.502GlyTyr: 1.502 ± 0.215
0.0GlyXaa: 0.0 ± 0.0
His
0.751HisAla: 0.751 ± 0.192
0.751HisCys: 0.751 ± 0.71
1.752HisAsp: 1.752 ± 0.542
1.251HisGlu: 1.251 ± 0.283
1.752HisPhe: 1.752 ± 0.258
2.252HisGly: 2.252 ± 0.44
0.25HisHis: 0.25 ± 0.165
1.251HisIle: 1.251 ± 0.485
0.501HisLys: 0.501 ± 0.329
1.251HisLeu: 1.251 ± 0.293
0.501HisMet: 0.501 ± 0.473
0.751HisAsn: 0.751 ± 0.192
1.251HisPro: 1.251 ± 0.652
0.751HisGln: 0.751 ± 0.192
1.502HisArg: 1.502 ± 0.612
2.002HisSer: 2.002 ± 0.66
0.25HisThr: 0.25 ± 0.237
1.251HisVal: 1.251 ± 0.485
0.0HisTrp: 0.0 ± 0.0
0.751HisTyr: 0.751 ± 0.494
0.0HisXaa: 0.0 ± 0.0
Ile
5.756IleAla: 5.756 ± 2.491
1.502IleCys: 1.502 ± 0.451
4.004IleAsp: 4.004 ± 1.571
6.006IleGlu: 6.006 ± 0.714
2.252IlePhe: 2.252 ± 0.414
2.753IleGly: 2.753 ± 1.517
1.752IleHis: 1.752 ± 0.663
6.256IleIle: 6.256 ± 1.044
5.005IleLys: 5.005 ± 0.608
4.004IleLeu: 4.004 ± 1.66
2.252IleMet: 2.252 ± 0.703
2.252IleAsn: 2.252 ± 0.699
3.003IlePro: 3.003 ± 0.77
0.751IleGln: 0.751 ± 0.192
3.754IleArg: 3.754 ± 1.431
5.005IleSer: 5.005 ± 1.02
3.504IleThr: 3.504 ± 0.584
5.005IleVal: 5.005 ± 0.65
0.25IleTrp: 0.25 ± 0.165
3.003IleTyr: 3.003 ± 0.95
0.0IleXaa: 0.0 ± 0.0
Lys
5.005LysAla: 5.005 ± 1.252
1.251LysCys: 1.251 ± 1.012
3.253LysAsp: 3.253 ± 0.49
5.255LysGlu: 5.255 ± 0.558
3.003LysPhe: 3.003 ± 0.854
4.505LysGly: 4.505 ± 0.625
1.502LysHis: 1.502 ± 0.385
4.755LysIle: 4.755 ± 1.502
6.507LysLys: 6.507 ± 2.617
5.506LysLeu: 5.506 ± 0.474
4.004LysMet: 4.004 ± 1.031
1.251LysAsn: 1.251 ± 0.313
3.504LysPro: 3.504 ± 0.914
2.002LysGln: 2.002 ± 0.701
4.505LysArg: 4.505 ± 0.832
5.756LysSer: 5.756 ± 1.003
4.254LysThr: 4.254 ± 0.836
5.756LysVal: 5.756 ± 1.078
1.502LysTrp: 1.502 ± 0.215
3.253LysTyr: 3.253 ± 0.479
0.0LysXaa: 0.0 ± 0.0
Leu
4.505LeuAla: 4.505 ± 0.897
2.503LeuCys: 2.503 ± 0.703
3.253LeuAsp: 3.253 ± 0.647
6.507LeuGlu: 6.507 ± 0.608
4.505LeuPhe: 4.505 ± 2.282
4.505LeuGly: 4.505 ± 0.855
2.252LeuHis: 2.252 ± 1.132
4.505LeuIle: 4.505 ± 1.523
8.509LeuLys: 8.509 ± 0.985
8.258LeuLeu: 8.258 ± 1.464
3.003LeuMet: 3.003 ± 0.494
2.002LeuAsn: 2.002 ± 0.289
2.252LeuPro: 2.252 ± 1.545
2.002LeuGln: 2.002 ± 0.66
5.506LeuArg: 5.506 ± 1.598
6.256LeuSer: 6.256 ± 0.641
4.505LeuThr: 4.505 ± 0.545
5.005LeuVal: 5.005 ± 1.364
0.25LeuTrp: 0.25 ± 0.237
2.252LeuTyr: 2.252 ± 0.49
0.0LeuXaa: 0.0 ± 0.0
Met
1.502MetAla: 1.502 ± 0.29
1.001MetCys: 1.001 ± 0.279
2.002MetAsp: 2.002 ± 0.375
2.252MetGlu: 2.252 ± 0.813
1.752MetPhe: 1.752 ± 0.417
2.503MetGly: 2.503 ± 0.586
0.751MetHis: 0.751 ± 0.471
2.503MetIle: 2.503 ± 0.788
2.753MetLys: 2.753 ± 1.287
2.753MetLeu: 2.753 ± 0.263
2.753MetMet: 2.753 ± 1.589
0.751MetAsn: 0.751 ± 0.494
0.751MetPro: 0.751 ± 0.494
3.504MetGln: 3.504 ± 1.315
1.502MetArg: 1.502 ± 0.809
3.504MetSer: 3.504 ± 0.66
2.002MetThr: 2.002 ± 0.766
1.001MetVal: 1.001 ± 0.512
0.25MetTrp: 0.25 ± 0.237
1.001MetTyr: 1.001 ± 0.512
0.0MetXaa: 0.0 ± 0.0
Asn
1.502AsnAla: 1.502 ± 0.418
0.751AsnCys: 0.751 ± 0.352
1.251AsnAsp: 1.251 ± 0.545
1.001AsnGlu: 1.001 ± 0.887
1.001AsnPhe: 1.001 ± 0.659
1.001AsnGly: 1.001 ± 0.279
1.001AsnHis: 1.001 ± 0.279
2.002AsnIle: 2.002 ± 1.167
3.504AsnLys: 3.504 ± 0.638
3.754AsnLeu: 3.754 ± 1.431
0.751AsnMet: 0.751 ± 0.409
1.251AsnAsn: 1.251 ± 0.48
3.253AsnPro: 3.253 ± 0.635
1.251AsnGln: 1.251 ± 0.485
2.503AsnArg: 2.503 ± 0.586
4.505AsnSer: 4.505 ± 0.776
1.502AsnThr: 1.502 ± 0.418
1.251AsnVal: 1.251 ± 0.293
0.0AsnTrp: 0.0 ± 0.0
1.752AsnTyr: 1.752 ± 0.613
0.0AsnXaa: 0.0 ± 0.0
Pro
2.002ProAla: 2.002 ± 0.251
0.25ProCys: 0.25 ± 0.237
1.752ProAsp: 1.752 ± 0.537
4.254ProGlu: 4.254 ± 1.472
2.002ProPhe: 2.002 ± 0.528
2.753ProGly: 2.753 ± 0.287
0.25ProHis: 0.25 ± 0.237
3.003ProIle: 3.003 ± 0.594
2.002ProLys: 2.002 ± 0.468
2.002ProLeu: 2.002 ± 0.717
0.751ProMet: 0.751 ± 0.352
1.752ProAsn: 1.752 ± 0.744
1.001ProPro: 1.001 ± 0.41
1.251ProGln: 1.251 ± 0.293
3.003ProArg: 3.003 ± 0.973
4.505ProSer: 4.505 ± 1.469
3.003ProThr: 3.003 ± 1.158
2.252ProVal: 2.252 ± 0.274
1.502ProTrp: 1.502 ± 0.78
1.502ProTyr: 1.502 ± 0.385
0.0ProXaa: 0.0 ± 0.0
Gln
1.502GlnAla: 1.502 ± 0.768
1.251GlnCys: 1.251 ± 0.48
0.501GlnAsp: 0.501 ± 0.473
2.252GlnGlu: 2.252 ± 0.577
2.252GlnPhe: 2.252 ± 0.577
2.002GlnGly: 2.002 ± 1.066
0.751GlnHis: 0.751 ± 0.494
1.752GlnIle: 1.752 ± 0.932
1.752GlnLys: 1.752 ± 0.663
2.002GlnLeu: 2.002 ± 1.42
0.501GlnMet: 0.501 ± 0.139
1.001GlnAsn: 1.001 ± 0.279
1.502GlnPro: 1.502 ± 0.29
1.001GlnGln: 1.001 ± 0.33
1.752GlnArg: 1.752 ± 0.806
2.503GlnSer: 2.503 ± 0.97
2.002GlnThr: 2.002 ± 0.476
1.752GlnVal: 1.752 ± 0.515
0.0GlnTrp: 0.0 ± 0.0
1.001GlnTyr: 1.001 ± 0.583
0.0GlnXaa: 0.0 ± 0.0
Arg
4.505ArgAla: 4.505 ± 1.327
1.001ArgCys: 1.001 ± 0.279
4.755ArgAsp: 4.755 ± 1.148
4.755ArgGlu: 4.755 ± 1.046
2.002ArgPhe: 2.002 ± 0.938
2.252ArgGly: 2.252 ± 0.682
0.0ArgHis: 0.0 ± 0.0
4.004ArgIle: 4.004 ± 1.239
3.504ArgLys: 3.504 ± 0.589
4.004ArgLeu: 4.004 ± 1.04
1.251ArgMet: 1.251 ± 0.48
2.002ArgAsn: 2.002 ± 0.969
3.003ArgPro: 3.003 ± 0.658
1.001ArgGln: 1.001 ± 0.279
2.002ArgArg: 2.002 ± 0.468
4.254ArgSer: 4.254 ± 0.893
2.503ArgThr: 2.503 ± 0.834
3.003ArgVal: 3.003 ± 0.756
1.251ArgTrp: 1.251 ± 0.64
1.001ArgTyr: 1.001 ± 0.261
0.0ArgXaa: 0.0 ± 0.0
Ser
3.504SerAla: 3.504 ± 0.638
3.504SerCys: 3.504 ± 1.914
6.256SerAsp: 6.256 ± 1.416
7.007SerGlu: 7.007 ± 0.839
3.253SerPhe: 3.253 ± 0.953
4.254SerGly: 4.254 ± 0.68
1.752SerHis: 1.752 ± 0.681
6.757SerIle: 6.757 ± 1.01
7.007SerLys: 7.007 ± 0.656
7.257SerLeu: 7.257 ± 0.678
2.252SerMet: 2.252 ± 0.548
4.755SerAsn: 4.755 ± 1.122
3.504SerPro: 3.504 ± 0.793
2.753SerGln: 2.753 ± 0.664
4.505SerArg: 4.505 ± 1.072
10.01SerSer: 10.01 ± 1.688
4.004SerThr: 4.004 ± 1.055
6.757SerVal: 6.757 ± 0.957
1.502SerTrp: 1.502 ± 0.215
1.502SerTyr: 1.502 ± 0.446
0.0SerXaa: 0.0 ± 0.0
Thr
1.251ThrAla: 1.251 ± 0.658
1.251ThrCys: 1.251 ± 0.596
2.503ThrAsp: 2.503 ± 0.586
3.003ThrGlu: 3.003 ± 0.707
1.752ThrPhe: 1.752 ± 1.071
4.755ThrGly: 4.755 ± 1.151
1.001ThrHis: 1.001 ± 0.583
4.004ThrIle: 4.004 ± 1.54
3.003ThrLys: 3.003 ± 1.49
5.756ThrLeu: 5.756 ± 1.304
1.502ThrMet: 1.502 ± 0.951
2.002ThrAsn: 2.002 ± 0.83
2.753ThrPro: 2.753 ± 0.263
1.752ThrGln: 1.752 ± 0.515
2.002ThrArg: 2.002 ± 1.024
4.505ThrSer: 4.505 ± 0.855
2.753ThrThr: 2.753 ± 0.471
4.254ThrVal: 4.254 ± 1.106
0.0ThrTrp: 0.0 ± 0.0
0.501ThrTyr: 0.501 ± 0.329
0.0ThrXaa: 0.0 ± 0.0
Val
3.003ValAla: 3.003 ± 0.973
1.752ValCys: 1.752 ± 0.417
1.752ValAsp: 1.752 ± 0.542
3.504ValGlu: 3.504 ± 1.315
2.503ValPhe: 2.503 ± 0.627
3.253ValGly: 3.253 ± 1.133
2.002ValHis: 2.002 ± 0.251
3.504ValIle: 3.504 ± 1.557
4.755ValLys: 4.755 ± 0.352
4.755ValLeu: 4.755 ± 0.37
3.003ValMet: 3.003 ± 0.42
2.002ValAsn: 2.002 ± 0.565
0.751ValPro: 0.751 ± 0.471
3.253ValGln: 3.253 ± 0.787
3.754ValArg: 3.754 ± 0.755
6.507ValSer: 6.507 ± 0.808
3.003ValThr: 3.003 ± 0.575
5.255ValVal: 5.255 ± 2.19
0.751ValTrp: 0.751 ± 0.192
2.503ValTyr: 2.503 ± 0.348
0.0ValXaa: 0.0 ± 0.0
Trp
0.25TrpAla: 0.25 ± 0.165
0.25TrpCys: 0.25 ± 0.165
0.501TrpAsp: 0.501 ± 0.329
1.001TrpGlu: 1.001 ± 0.947
1.001TrpPhe: 1.001 ± 0.279
0.501TrpGly: 0.501 ± 0.413
0.0TrpHis: 0.0 ± 0.0
0.751TrpIle: 0.751 ± 0.494
1.502TrpLys: 1.502 ± 0.29
1.752TrpLeu: 1.752 ± 0.326
0.501TrpMet: 0.501 ± 0.329
1.001TrpAsn: 1.001 ± 0.33
0.751TrpPro: 0.751 ± 0.72
0.0TrpGln: 0.0 ± 0.0
0.501TrpArg: 0.501 ± 0.329
0.0TrpSer: 0.0 ± 0.0
1.251TrpThr: 1.251 ± 0.658
0.751TrpVal: 0.751 ± 0.409
0.25TrpTrp: 0.25 ± 0.165
0.25TrpTyr: 0.25 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.502TyrAla: 1.502 ± 0.215
0.501TyrCys: 0.501 ± 0.473
2.002TyrAsp: 2.002 ± 0.91
1.502TyrGlu: 1.502 ± 0.809
1.001TyrPhe: 1.001 ± 0.512
3.003TyrGly: 3.003 ± 0.658
0.751TyrHis: 0.751 ± 0.41
1.502TyrIle: 1.502 ± 0.427
2.002TyrLys: 2.002 ± 0.66
3.253TyrLeu: 3.253 ± 1.027
0.501TyrMet: 0.501 ± 0.329
1.502TyrAsn: 1.502 ± 0.644
2.252TyrPro: 2.252 ± 0.98
1.502TyrGln: 1.502 ± 0.817
1.251TyrArg: 1.251 ± 0.826
5.255TyrSer: 5.255 ± 3.196
0.751TyrThr: 0.751 ± 0.494
1.752TyrVal: 1.752 ± 0.258
0.501TyrTrp: 0.501 ± 0.139
1.251TyrTyr: 1.251 ± 1.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski