Amino acid dipepetide frequency for Neisseria subflava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.507AlaAla: 12.507 ± 0.22
1.115AlaCys: 1.115 ± 0.046
5.791AlaAsp: 5.791 ± 0.111
7.137AlaGlu: 7.137 ± 0.149
3.787AlaPhe: 3.787 ± 0.088
6.876AlaGly: 6.876 ± 0.104
1.924AlaHis: 1.924 ± 0.065
4.848AlaIle: 4.848 ± 0.11
5.701AlaLys: 5.701 ± 0.142
10.471AlaLeu: 10.471 ± 0.148
2.546AlaMet: 2.546 ± 0.07
3.268AlaAsn: 3.268 ± 0.079
3.473AlaPro: 3.473 ± 0.092
4.862AlaGln: 4.862 ± 0.12
4.49AlaArg: 4.49 ± 0.108
4.516AlaSer: 4.516 ± 0.094
4.49AlaThr: 4.49 ± 0.303
7.949AlaVal: 7.949 ± 0.138
1.22AlaTrp: 1.22 ± 0.056
2.871AlaTyr: 2.871 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.044
0.156CysCys: 0.156 ± 0.017
0.453CysAsp: 0.453 ± 0.034
0.526CysGlu: 0.526 ± 0.031
0.369CysPhe: 0.369 ± 0.025
1.04CysGly: 1.04 ± 0.044
0.318CysHis: 0.318 ± 0.025
0.496CysIle: 0.496 ± 0.032
0.414CysLys: 0.414 ± 0.028
0.947CysLeu: 0.947 ± 0.041
0.215CysMet: 0.215 ± 0.018
0.346CysAsn: 0.346 ± 0.023
0.506CysPro: 0.506 ± 0.031
0.389CysGln: 0.389 ± 0.024
0.626CysArg: 0.626 ± 0.027
0.572CysSer: 0.572 ± 0.03
0.518CysThr: 0.518 ± 0.031
0.682CysVal: 0.682 ± 0.036
0.088CysTrp: 0.088 ± 0.013
0.285CysTyr: 0.285 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.766AspAla: 4.766 ± 0.106
0.464AspCys: 0.464 ± 0.028
2.686AspAsp: 2.686 ± 0.076
3.694AspGlu: 3.694 ± 0.09
2.44AspPhe: 2.44 ± 0.069
4.27AspGly: 4.27 ± 0.097
0.877AspHis: 0.877 ± 0.041
3.614AspIle: 3.614 ± 0.079
3.405AspLys: 3.405 ± 0.085
5.204AspLeu: 5.204 ± 0.101
1.37AspMet: 1.37 ± 0.055
2.21AspAsn: 2.21 ± 0.072
1.907AspPro: 1.907 ± 0.064
1.458AspGln: 1.458 ± 0.052
2.162AspArg: 2.162 ± 0.072
2.842AspSer: 2.842 ± 0.067
3.022AspThr: 3.022 ± 0.089
3.574AspVal: 3.574 ± 0.087
0.894AspTrp: 0.894 ± 0.042
2.078AspTyr: 2.078 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
6.606GluAla: 6.606 ± 0.133
0.539GluCys: 0.539 ± 0.032
2.791GluAsp: 2.791 ± 0.073
4.047GluGlu: 4.047 ± 0.112
2.252GluPhe: 2.252 ± 0.063
3.807GluGly: 3.807 ± 0.102
1.608GluHis: 1.608 ± 0.054
4.094GluIle: 4.094 ± 0.074
4.11GluLys: 4.11 ± 0.087
5.876GluLeu: 5.876 ± 0.115
1.711GluMet: 1.711 ± 0.052
3.225GluAsn: 3.225 ± 0.065
1.997GluPro: 1.997 ± 0.061
3.218GluGln: 3.218 ± 0.074
3.496GluArg: 3.496 ± 0.074
2.935GluSer: 2.935 ± 0.076
3.679GluThr: 3.679 ± 0.075
3.849GluVal: 3.849 ± 0.083
0.827GluTrp: 0.827 ± 0.035
1.811GluTyr: 1.811 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
4.199PheAla: 4.199 ± 0.091
0.503PheCys: 0.503 ± 0.027
2.666PheAsp: 2.666 ± 0.063
2.376PheGlu: 2.376 ± 0.068
1.751PhePhe: 1.751 ± 0.063
3.478PheGly: 3.478 ± 0.076
0.822PheHis: 0.822 ± 0.035
2.415PheIle: 2.415 ± 0.069
2.067PheLys: 2.067 ± 0.062
3.521PheLeu: 3.521 ± 0.099
0.929PheMet: 0.929 ± 0.038
1.791PheAsn: 1.791 ± 0.052
1.521PhePro: 1.521 ± 0.054
1.368PheGln: 1.368 ± 0.049
1.659PheArg: 1.659 ± 0.057
2.698PheSer: 2.698 ± 0.071
2.183PheThr: 2.183 ± 0.06
2.744PheVal: 2.744 ± 0.074
0.592PheTrp: 0.592 ± 0.035
1.331PheTyr: 1.331 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
6.427GlyAla: 6.427 ± 0.35
0.765GlyCys: 0.765 ± 0.037
3.433GlyAsp: 3.433 ± 0.136
4.536GlyGlu: 4.536 ± 0.104
3.303GlyPhe: 3.303 ± 0.078
5.568GlyGly: 5.568 ± 0.122
1.621GlyHis: 1.621 ± 0.052
4.919GlyIle: 4.919 ± 0.099
5.393GlyLys: 5.393 ± 0.097
7.35GlyLeu: 7.35 ± 0.13
2.158GlyMet: 2.158 ± 0.067
2.96GlyAsn: 2.96 ± 0.09
1.22GlyPro: 1.22 ± 0.049
2.744GlyGln: 2.744 ± 0.072
4.155GlyArg: 4.155 ± 0.096
4.342GlySer: 4.342 ± 0.097
3.49GlyThr: 3.49 ± 0.094
5.259GlyVal: 5.259 ± 0.102
1.1GlyTrp: 1.1 ± 0.052
2.39GlyTyr: 2.39 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.947HisAla: 1.947 ± 0.054
0.275HisCys: 0.275 ± 0.022
1.052HisAsp: 1.052 ± 0.051
1.363HisGlu: 1.363 ± 0.054
0.947HisPhe: 0.947 ± 0.04
1.781HisGly: 1.781 ± 0.059
0.739HisHis: 0.739 ± 0.037
1.583HisIle: 1.583 ± 0.053
1.037HisLys: 1.037 ± 0.043
2.2HisLeu: 2.2 ± 0.063
0.426HisMet: 0.426 ± 0.024
0.972HisAsn: 0.972 ± 0.039
1.331HisPro: 1.331 ± 0.046
0.962HisGln: 0.962 ± 0.045
1.072HisArg: 1.072 ± 0.04
1.223HisSer: 1.223 ± 0.043
1.416HisThr: 1.416 ± 0.056
1.152HisVal: 1.152 ± 0.044
0.291HisTrp: 0.291 ± 0.021
0.885HisTyr: 0.885 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.134IleAla: 6.134 ± 0.118
0.589IleCys: 0.589 ± 0.03
3.579IleAsp: 3.579 ± 0.081
3.846IleGlu: 3.846 ± 0.093
2.142IlePhe: 2.142 ± 0.065
4.949IleGly: 4.949 ± 0.108
1.321IleHis: 1.321 ± 0.047
3.431IleIle: 3.431 ± 0.083
2.901IleLys: 2.901 ± 0.074
5.312IleLeu: 5.312 ± 0.108
1.38IleMet: 1.38 ± 0.056
2.501IleAsn: 2.501 ± 0.072
2.574IlePro: 2.574 ± 0.065
2.065IleGln: 2.065 ± 0.061
3.145IleArg: 3.145 ± 0.071
3.581IleSer: 3.581 ± 0.092
3.303IleThr: 3.303 ± 0.074
4.045IleVal: 4.045 ± 0.087
0.664IleTrp: 0.664 ± 0.032
1.641IleTyr: 1.641 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.701LysAla: 5.701 ± 0.139
0.315LysCys: 0.315 ± 0.023
2.877LysAsp: 2.877 ± 0.07
3.458LysGlu: 3.458 ± 0.1
1.724LysPhe: 1.724 ± 0.054
3.822LysGly: 3.822 ± 0.137
1.293LysHis: 1.293 ± 0.047
3.436LysIle: 3.436 ± 0.081
3.298LysLys: 3.298 ± 0.1
5.38LysLeu: 5.38 ± 0.097
1.593LysMet: 1.593 ± 0.05
2.729LysAsn: 2.729 ± 0.079
2.836LysPro: 2.836 ± 0.085
2.924LysGln: 2.924 ± 0.082
2.969LysArg: 2.969 ± 0.074
2.792LysSer: 2.792 ± 0.072
3.495LysThr: 3.495 ± 0.091
3.579LysVal: 3.579 ± 0.077
0.634LysTrp: 0.634 ± 0.035
1.481LysTyr: 1.481 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
10.351LeuAla: 10.351 ± 0.143
1.013LeuCys: 1.013 ± 0.039
5.362LeuAsp: 5.362 ± 0.107
5.265LeuGlu: 5.265 ± 0.112
4.104LeuPhe: 4.104 ± 0.106
7.049LeuGly: 7.049 ± 0.112
2.257LeuHis: 2.257 ± 0.069
5.724LeuIle: 5.724 ± 0.133
6.18LeuLys: 6.18 ± 0.107
10.109LeuLeu: 10.109 ± 0.198
2.521LeuMet: 2.521 ± 0.075
4.605LeuAsn: 4.605 ± 0.083
5.613LeuPro: 5.613 ± 0.097
3.904LeuGln: 3.904 ± 0.096
4.656LeuArg: 4.656 ± 0.093
6.706LeuSer: 6.706 ± 0.102
5.586LeuThr: 5.586 ± 0.095
6.089LeuVal: 6.089 ± 0.123
1.098LeuTrp: 1.098 ± 0.049
2.604LeuTyr: 2.604 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.451MetAla: 2.451 ± 0.065
0.201MetCys: 0.201 ± 0.016
1.137MetAsp: 1.137 ± 0.05
1.173MetGlu: 1.173 ± 0.052
0.914MetPhe: 0.914 ± 0.041
1.742MetGly: 1.742 ± 0.063
0.489MetHis: 0.489 ± 0.031
1.316MetIle: 1.316 ± 0.05
1.706MetLys: 1.706 ± 0.063
2.674MetLeu: 2.674 ± 0.079
0.829MetMet: 0.829 ± 0.039
1.198MetAsn: 1.198 ± 0.043
1.361MetPro: 1.361 ± 0.044
1.172MetGln: 1.172 ± 0.049
1.345MetArg: 1.345 ± 0.057
1.682MetSer: 1.682 ± 0.053
1.446MetThr: 1.446 ± 0.053
1.598MetVal: 1.598 ± 0.057
0.261MetTrp: 0.261 ± 0.019
0.533MetTyr: 0.533 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.837AsnAla: 3.837 ± 0.073
0.378AsnCys: 0.378 ± 0.021
1.965AsnAsp: 1.965 ± 0.069
2.321AsnGlu: 2.321 ± 0.065
1.473AsnPhe: 1.473 ± 0.047
3.628AsnGly: 3.628 ± 0.093
0.995AsnHis: 0.995 ± 0.043
3.02AsnIle: 3.02 ± 0.079
2.152AsnLys: 2.152 ± 0.068
3.956AsnLeu: 3.956 ± 0.09
0.972AsnMet: 0.972 ± 0.038
1.814AsnAsn: 1.814 ± 0.07
2.521AsnPro: 2.521 ± 0.067
1.686AsnGln: 1.686 ± 0.053
2.31AsnArg: 2.31 ± 0.071
2.012AsnSer: 2.012 ± 0.062
2.406AsnThr: 2.406 ± 0.08
2.729AsnVal: 2.729 ± 0.064
0.533AsnTrp: 0.533 ± 0.029
1.208AsnTyr: 1.208 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.681ProAla: 3.681 ± 0.092
0.358ProCys: 0.358 ± 0.023
2.731ProAsp: 2.731 ± 0.07
3.812ProGlu: 3.812 ± 0.075
1.862ProPhe: 1.862 ± 0.058
1.984ProGly: 1.984 ± 0.062
1.075ProHis: 1.075 ± 0.045
2.142ProIle: 2.142 ± 0.057
2.375ProLys: 2.375 ± 0.071
4.08ProLeu: 4.08 ± 0.091
0.995ProMet: 0.995 ± 0.041
1.874ProAsn: 1.874 ± 0.05
1.336ProPro: 1.336 ± 0.056
2.035ProGln: 2.035 ± 0.06
1.573ProArg: 1.573 ± 0.053
2.478ProSer: 2.478 ± 0.073
2.1ProThr: 2.1 ± 0.057
3.418ProVal: 3.418 ± 0.082
0.433ProTrp: 0.433 ± 0.027
1.296ProTyr: 1.296 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.658GlnAla: 4.658 ± 0.111
0.296GlnCys: 0.296 ± 0.024
1.97GlnAsp: 1.97 ± 0.059
2.48GlnGlu: 2.48 ± 0.073
1.378GlnPhe: 1.378 ± 0.05
2.811GlnGly: 2.811 ± 0.074
1.082GlnHis: 1.082 ± 0.044
2.558GlnIle: 2.558 ± 0.067
2.415GlnLys: 2.415 ± 0.071
3.5GlnLeu: 3.5 ± 0.08
1.15GlnMet: 1.15 ± 0.049
2.188GlnAsn: 2.188 ± 0.065
1.699GlnPro: 1.699 ± 0.055
2.158GlnGln: 2.158 ± 0.089
2.105GlnArg: 2.105 ± 0.065
2.476GlnSer: 2.476 ± 0.068
3.07GlnThr: 3.07 ± 0.08
2.593GlnVal: 2.593 ± 0.064
0.584GlnTrp: 0.584 ± 0.037
1.376GlnTyr: 1.376 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.084ArgAla: 4.084 ± 0.083
0.421ArgCys: 0.421 ± 0.028
2.538ArgAsp: 2.538 ± 0.064
3.25ArgGlu: 3.25 ± 0.073
2.611ArgPhe: 2.611 ± 0.074
2.899ArgGly: 2.899 ± 0.078
1.278ArgHis: 1.278 ± 0.051
3.178ArgIle: 3.178 ± 0.076
2.619ArgLys: 2.619 ± 0.073
5.891ArgLeu: 5.891 ± 0.114
1.298ArgMet: 1.298 ± 0.049
2.122ArgAsn: 2.122 ± 0.057
2.145ArgPro: 2.145 ± 0.063
2.456ArgGln: 2.456 ± 0.072
3.092ArgArg: 3.092 ± 0.076
2.521ArgSer: 2.521 ± 0.064
2.298ArgThr: 2.298 ± 0.077
3.17ArgVal: 3.17 ± 0.079
0.584ArgTrp: 0.584 ± 0.035
2.052ArgTyr: 2.052 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
5.22SerAla: 5.22 ± 0.102
0.597SerCys: 0.597 ± 0.036
3.258SerAsp: 3.258 ± 0.083
3.52SerGlu: 3.52 ± 0.083
2.368SerPhe: 2.368 ± 0.067
4.982SerGly: 4.982 ± 0.102
1.255SerHis: 1.255 ± 0.045
3.143SerIle: 3.143 ± 0.077
2.911SerLys: 2.911 ± 0.072
5.906SerLeu: 5.906 ± 0.114
1.298SerMet: 1.298 ± 0.054
2.07SerAsn: 2.07 ± 0.065
2.286SerPro: 2.286 ± 0.064
2.022SerGln: 2.022 ± 0.054
2.972SerArg: 2.972 ± 0.076
3.248SerSer: 3.248 ± 0.083
2.603SerThr: 2.603 ± 0.065
3.989SerVal: 3.989 ± 0.075
0.694SerTrp: 0.694 ± 0.039
1.722SerTyr: 1.722 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
5.901ThrAla: 5.901 ± 0.102
0.476ThrCys: 0.476 ± 0.027
3.129ThrAsp: 3.129 ± 0.085
3.257ThrGlu: 3.257 ± 0.071
2.058ThrPhe: 2.058 ± 0.065
4.451ThrGly: 4.451 ± 0.359
1.226ThrHis: 1.226 ± 0.046
2.887ThrIle: 2.887 ± 0.063
2.08ThrLys: 2.08 ± 0.056
5.956ThrLeu: 5.956 ± 0.108
1.052ThrMet: 1.052 ± 0.04
1.731ThrAsn: 1.731 ± 0.061
2.901ThrPro: 2.901 ± 0.083
2.192ThrGln: 2.192 ± 0.051
2.451ThrArg: 2.451 ± 0.06
2.579ThrSer: 2.579 ± 0.067
2.465ThrThr: 2.465 ± 0.063
4.385ThrVal: 4.385 ± 0.092
0.569ThrTrp: 0.569 ± 0.034
1.396ThrTyr: 1.396 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
6.731ValAla: 6.731 ± 0.114
0.882ValCys: 0.882 ± 0.037
3.24ValAsp: 3.24 ± 0.068
4.2ValGlu: 4.2 ± 0.09
2.992ValPhe: 2.992 ± 0.074
4.768ValGly: 4.768 ± 0.102
1.313ValHis: 1.313 ± 0.047
4.012ValIle: 4.012 ± 0.079
3.628ValLys: 3.628 ± 0.084
7.43ValLeu: 7.43 ± 0.132
1.9ValMet: 1.9 ± 0.062
2.724ValAsn: 2.724 ± 0.076
2.659ValPro: 2.659 ± 0.075
2.463ValGln: 2.463 ± 0.057
3.536ValArg: 3.536 ± 0.08
4.566ValSer: 4.566 ± 0.085
3.232ValThr: 3.232 ± 0.073
4.982ValVal: 4.982 ± 0.112
1.012ValTrp: 1.012 ± 0.042
1.987ValTyr: 1.987 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.005TrpAla: 1.005 ± 0.048
0.145TrpCys: 0.145 ± 0.015
0.567TrpAsp: 0.567 ± 0.029
0.586TrpGlu: 0.586 ± 0.029
0.679TrpPhe: 0.679 ± 0.039
0.81TrpGly: 0.81 ± 0.037
0.356TrpHis: 0.356 ± 0.027
0.672TrpIle: 0.672 ± 0.038
0.617TrpLys: 0.617 ± 0.035
1.84TrpLeu: 1.84 ± 0.062
0.326TrpMet: 0.326 ± 0.024
0.496TrpAsn: 0.496 ± 0.034
0.364TrpPro: 0.364 ± 0.023
0.954TrpGln: 0.954 ± 0.045
0.77TrpArg: 0.77 ± 0.045
0.594TrpSer: 0.594 ± 0.035
0.546TrpThr: 0.546 ± 0.034
0.819TrpVal: 0.819 ± 0.042
0.178TrpTrp: 0.178 ± 0.018
0.363TrpTyr: 0.363 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.741TyrAla: 2.741 ± 0.075
0.353TyrCys: 0.353 ± 0.024
1.712TyrAsp: 1.712 ± 0.082
1.631TyrGlu: 1.631 ± 0.055
1.459TyrPhe: 1.459 ± 0.052
2.418TyrGly: 2.418 ± 0.063
0.804TyrHis: 0.804 ± 0.046
1.614TyrIle: 1.614 ± 0.057
1.328TyrLys: 1.328 ± 0.051
3.195TyrLeu: 3.195 ± 0.086
0.559TyrMet: 0.559 ± 0.028
1.092TyrAsn: 1.092 ± 0.047
1.386TyrPro: 1.386 ± 0.046
1.516TyrGln: 1.516 ± 0.05
1.924TyrArg: 1.924 ± 0.06
1.699TyrSer: 1.699 ± 0.065
1.794TyrThr: 1.794 ± 0.059
1.652TyrVal: 1.652 ± 0.058
0.433TyrTrp: 0.433 ± 0.029
0.969TyrTyr: 0.969 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1949 proteins (600927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski