Amino acid dipepetide frequency for Streptomyces sp. C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.634AlaAla: 23.634 ± 0.18	1.124AlaCys: 1.124 ± 0.022	8.25AlaAsp: 8.25 ± 0.07	9.023AlaGlu: 9.023 ± 0.084	3.675AlaPhe: 3.675 ± 0.046	14.615AlaGly: 14.615 ± 0.096	2.925AlaHis: 2.925 ± 0.034	3.104AlaIle: 3.104 ± 0.048	2.933AlaLys: 2.933 ± 0.054	14.833AlaLeu: 14.833 ± 0.116	2.602AlaMet: 2.602 ± 0.036	1.909AlaAsn: 1.909 ± 0.031	7.951AlaPro: 7.951 ± 0.076	3.746AlaGln: 3.746 ± 0.039	10.86AlaArg: 10.86 ± 0.102	5.858AlaSer: 5.858 ± 0.056	6.636AlaThr: 6.636 ± 0.058	12.463AlaVal: 12.463 ± 0.086	1.933AlaTrp: 1.933 ± 0.031	2.791AlaTyr: 2.791 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.186CysAla: 1.186 ± 0.025	0.121CysCys: 0.121 ± 0.008	0.486CysAsp: 0.486 ± 0.014	0.413CysGlu: 0.413 ± 0.012	0.234CysPhe: 0.234 ± 0.011	1.065CysGly: 1.065 ± 0.023	0.193CysHis: 0.193 ± 0.01	0.167CysIle: 0.167 ± 0.009	0.129CysLys: 0.129 ± 0.008	0.787CysLeu: 0.787 ± 0.019	0.139CysMet: 0.139 ± 0.008	0.141CysAsn: 0.141 ± 0.008	0.542CysPro: 0.542 ± 0.016	0.172CysGln: 0.172 ± 0.009	0.664CysArg: 0.664 ± 0.02	0.472CysSer: 0.472 ± 0.015	0.564CysThr: 0.564 ± 0.017	0.687CysVal: 0.687 ± 0.017	0.149CysTrp: 0.149 ± 0.009	0.151CysTyr: 0.151 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.427AspAla: 7.427 ± 0.065	0.449AspCys: 0.449 ± 0.014	2.95AspAsp: 2.95 ± 0.038	3.612AspGlu: 3.612 ± 0.045	1.579AspPhe: 1.579 ± 0.026	6.241AspGly: 6.241 ± 0.064	1.424AspHis: 1.424 ± 0.027	1.584AspIle: 1.584 ± 0.031	1.095AspLys: 1.095 ± 0.027	5.833AspLeu: 5.833 ± 0.048	0.815AspMet: 0.815 ± 0.022	0.889AspAsn: 0.889 ± 0.02	4.572AspPro: 4.572 ± 0.048	1.453AspGln: 1.453 ± 0.025	4.867AspArg: 4.867 ± 0.049	2.357AspSer: 2.357 ± 0.037	2.974AspThr: 2.974 ± 0.041	4.341AspVal: 4.341 ± 0.047	1.033AspTrp: 1.033 ± 0.024	1.023AspTyr: 1.023 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.767GluAla: 7.767 ± 0.08	0.39GluCys: 0.39 ± 0.014	2.906GluAsp: 2.906 ± 0.04	3.662GluGlu: 3.662 ± 0.051	1.493GluPhe: 1.493 ± 0.025	4.486GluGly: 4.486 ± 0.048	1.517GluHis: 1.517 ± 0.025	2.129GluIle: 2.129 ± 0.034	1.397GluLys: 1.397 ± 0.031	6.796GluLeu: 6.796 ± 0.07	0.875GluMet: 0.875 ± 0.021	1.01GluAsn: 1.01 ± 0.024	3.406GluPro: 3.406 ± 0.043	2.081GluGln: 2.081 ± 0.031	5.485GluArg: 5.485 ± 0.062	2.363GluSer: 2.363 ± 0.034	2.726GluThr: 2.726 ± 0.037	4.557GluVal: 4.557 ± 0.043	0.777GluTrp: 0.777 ± 0.017	1.15GluTyr: 1.15 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.691PheAla: 3.691 ± 0.048	0.285PheCys: 0.285 ± 0.011	1.874PheAsp: 1.874 ± 0.03	1.421PheGlu: 1.421 ± 0.027	0.862PhePhe: 0.862 ± 0.023	3.015PheGly: 3.015 ± 0.036	0.636PheHis: 0.636 ± 0.016	0.688PheIle: 0.688 ± 0.019	0.528PheLys: 0.528 ± 0.016	2.608PheLeu: 2.608 ± 0.036	0.396PheMet: 0.396 ± 0.012	0.558PheAsn: 0.558 ± 0.017	1.444PhePro: 1.444 ± 0.027	0.661PheGln: 0.661 ± 0.017	1.875PheArg: 1.875 ± 0.029	1.435PheSer: 1.435 ± 0.024	1.971PheThr: 1.971 ± 0.036	2.143PheVal: 2.143 ± 0.038	0.414PheTrp: 0.414 ± 0.013	0.572PheTyr: 0.572 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.88GlyAla: 11.88 ± 0.09	0.936GlyCys: 0.936 ± 0.02	4.964GlyAsp: 4.964 ± 0.048	5.246GlyGlu: 5.246 ± 0.055	2.923GlyPhe: 2.923 ± 0.044	9.46GlyGly: 9.46 ± 0.086	2.429GlyHis: 2.429 ± 0.04	3.428GlyIle: 3.428 ± 0.041	2.472GlyLys: 2.472 ± 0.042	9.668GlyLeu: 9.668 ± 0.078	2.001GlyMet: 2.001 ± 0.031	1.761GlyAsn: 1.761 ± 0.037	6.122GlyPro: 6.122 ± 0.064	2.655GlyGln: 2.655 ± 0.038	8.855GlyArg: 8.855 ± 0.095	5.439GlySer: 5.439 ± 0.059	6.325GlyThr: 6.325 ± 0.06	7.414GlyVal: 7.414 ± 0.061	1.74GlyTrp: 1.74 ± 0.032	2.265GlyTyr: 2.265 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.77HisAla: 2.77 ± 0.041	0.21HisCys: 0.21 ± 0.009	1.29HisAsp: 1.29 ± 0.025	1.19HisGlu: 1.19 ± 0.024	0.622HisPhe: 0.622 ± 0.017	2.472HisGly: 2.472 ± 0.037	0.724HisHis: 0.724 ± 0.021	0.581HisIle: 0.581 ± 0.017	0.356HisLys: 0.356 ± 0.012	2.414HisLeu: 2.414 ± 0.032	0.364HisMet: 0.364 ± 0.012	0.356HisAsn: 0.356 ± 0.013	2.011HisPro: 2.011 ± 0.038	0.645HisGln: 0.645 ± 0.017	2.271HisArg: 2.271 ± 0.045	0.991HisSer: 0.991 ± 0.023	1.331HisThr: 1.331 ± 0.022	1.662HisVal: 1.662 ± 0.026	0.378HisTrp: 0.378 ± 0.013	0.468HisTyr: 0.468 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.543IleAla: 4.543 ± 0.054	0.279IleCys: 0.279 ± 0.013	1.98IleAsp: 1.98 ± 0.033	1.883IleGlu: 1.883 ± 0.032	0.599IlePhe: 0.599 ± 0.018	3.405IleGly: 3.405 ± 0.052	0.581IleHis: 0.581 ± 0.016	0.764IleIle: 0.764 ± 0.021	0.708IleLys: 0.708 ± 0.019	2.191IleLeu: 2.191 ± 0.037	0.411IleMet: 0.411 ± 0.014	0.648IleAsn: 0.648 ± 0.016	1.673IlePro: 1.673 ± 0.027	0.669IleGln: 0.669 ± 0.018	2.203IleArg: 2.203 ± 0.035	1.563IleSer: 1.563 ± 0.028	2.127IleThr: 2.127 ± 0.033	2.415IleVal: 2.415 ± 0.036	0.34IleTrp: 0.34 ± 0.013	0.485IleTyr: 0.485 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.069LysAla: 3.069 ± 0.051	0.12LysCys: 0.12 ± 0.007	1.317LysAsp: 1.317 ± 0.03	1.195LysGlu: 1.195 ± 0.027	0.469LysPhe: 0.469 ± 0.015	1.821LysGly: 1.821 ± 0.032	0.414LysHis: 0.414 ± 0.015	0.856LysIle: 0.856 ± 0.024	0.825LysLys: 0.825 ± 0.027	1.964LysLeu: 1.964 ± 0.031	0.373LysMet: 0.373 ± 0.013	0.533LysAsn: 0.533 ± 0.018	1.393LysPro: 1.393 ± 0.034	0.671LysGln: 0.671 ± 0.02	1.408LysArg: 1.408 ± 0.027	1.093LysSer: 1.093 ± 0.025	1.309LysThr: 1.309 ± 0.03	1.863LysVal: 1.863 ± 0.033	0.269LysTrp: 0.269 ± 0.011	0.452LysTyr: 0.452 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.46LeuAla: 15.46 ± 0.106	0.876LeuCys: 0.876 ± 0.021	6.396LeuAsp: 6.396 ± 0.059	4.878LeuGlu: 4.878 ± 0.059	2.571LeuPhe: 2.571 ± 0.04	9.534LeuGly: 9.534 ± 0.078	2.273LeuHis: 2.273 ± 0.037	2.967LeuIle: 2.967 ± 0.047	1.979LeuLys: 1.979 ± 0.037	11.346LeuLeu: 11.346 ± 0.11	1.638LeuMet: 1.638 ± 0.028	1.595LeuAsn: 1.595 ± 0.028	6.716LeuPro: 6.716 ± 0.068	2.116LeuGln: 2.116 ± 0.034	8.683LeuArg: 8.683 ± 0.075	5.03LeuSer: 5.03 ± 0.046	6.645LeuThr: 6.645 ± 0.053	8.602LeuVal: 8.602 ± 0.074	1.332LeuTrp: 1.332 ± 0.025	1.823LeuTyr: 1.823 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.357MetAla: 2.357 ± 0.032	0.156MetCys: 0.156 ± 0.008	0.899MetAsp: 0.899 ± 0.022	0.793MetGlu: 0.793 ± 0.021	0.419MetPhe: 0.419 ± 0.014	1.387MetGly: 1.387 ± 0.026	0.338MetHis: 0.338 ± 0.012	0.63MetIle: 0.63 ± 0.017	0.434MetLys: 0.434 ± 0.014	1.69MetLeu: 1.69 ± 0.029	0.306MetMet: 0.306 ± 0.012	0.434MetAsn: 0.434 ± 0.014	1.198MetPro: 1.198 ± 0.02	0.428MetGln: 0.428 ± 0.015	1.481MetArg: 1.481 ± 0.028	1.3MetSer: 1.3 ± 0.024	1.494MetThr: 1.494 ± 0.026	1.279MetVal: 1.279 ± 0.027	0.221MetTrp: 0.221 ± 0.01	0.318MetTyr: 0.318 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.106AsnAla: 2.106 ± 0.03	0.175AsnCys: 0.175 ± 0.008	0.894AsnAsp: 0.894 ± 0.024	0.831AsnGlu: 0.831 ± 0.018	0.474AsnPhe: 0.474 ± 0.015	1.826AsnGly: 1.826 ± 0.033	0.408AsnHis: 0.408 ± 0.013	0.602AsnIle: 0.602 ± 0.021	0.421AsnLys: 0.421 ± 0.018	1.63AsnLeu: 1.63 ± 0.028	0.296AsnMet: 0.296 ± 0.012	0.42AsnAsn: 0.42 ± 0.014	1.36AsnPro: 1.36 ± 0.027	0.498AsnGln: 0.498 ± 0.016	1.226AsnArg: 1.226 ± 0.023	0.875AsnSer: 0.875 ± 0.02	1.13AsnThr: 1.13 ± 0.026	1.337AsnVal: 1.337 ± 0.03	0.285AsnTrp: 0.285 ± 0.013	0.36AsnTyr: 0.36 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.253ProAla: 10.253 ± 0.097	0.421ProCys: 0.421 ± 0.014	4.359ProAsp: 4.359 ± 0.048	4.44ProGlu: 4.44 ± 0.052	1.566ProPhe: 1.566 ± 0.027	7.658ProGly: 7.658 ± 0.078	1.49ProHis: 1.49 ± 0.03	1.13ProIle: 1.13 ± 0.023	1.21ProLys: 1.21 ± 0.025	5.554ProLeu: 5.554 ± 0.05	1.096ProMet: 1.096 ± 0.025	0.892ProAsn: 0.892 ± 0.019	4.066ProPro: 4.066 ± 0.072	1.868ProGln: 1.868 ± 0.035	4.61ProArg: 4.61 ± 0.067	3.213ProSer: 3.213 ± 0.042	2.973ProThr: 2.973 ± 0.043	5.688ProVal: 5.688 ± 0.06	0.94ProTrp: 0.94 ± 0.021	1.426ProTyr: 1.426 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.69GlnAla: 3.69 ± 0.05	0.177GlnCys: 0.177 ± 0.009	1.394GlnAsp: 1.394 ± 0.025	1.445GlnGlu: 1.445 ± 0.027	0.625GlnPhe: 0.625 ± 0.016	2.346GlnGly: 2.346 ± 0.037	0.634GlnHis: 0.634 ± 0.019	0.979GlnIle: 0.979 ± 0.023	0.601GlnLys: 0.601 ± 0.018	2.882GlnLeu: 2.882 ± 0.043	0.491GlnMet: 0.491 ± 0.015	0.493GlnAsn: 0.493 ± 0.014	1.692GlnPro: 1.692 ± 0.035	1.149GlnGln: 1.149 ± 0.039	2.319GlnArg: 2.319 ± 0.038	1.176GlnSer: 1.176 ± 0.023	1.3GlnThr: 1.3 ± 0.03	2.247GlnVal: 2.247 ± 0.032	0.475GlnTrp: 0.475 ± 0.015	0.587GlnTyr: 0.587 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.474ArgAla: 10.474 ± 0.111	0.696ArgCys: 0.696 ± 0.021	4.16ArgAsp: 4.16 ± 0.044	4.875ArgGlu: 4.875 ± 0.053	2.366ArgPhe: 2.366 ± 0.038	6.429ArgGly: 6.429 ± 0.068	2.26ArgHis: 2.26 ± 0.04	3.276ArgIle: 3.276 ± 0.039	1.631ArgLys: 1.631 ± 0.027	8.861ArgLeu: 8.861 ± 0.087	1.799ArgMet: 1.799 ± 0.026	1.328ArgAsn: 1.328 ± 0.023	5.891ArgPro: 5.891 ± 0.086	2.314ArgGln: 2.314 ± 0.035	8.558ArgArg: 8.558 ± 0.123	4.119ArgSer: 4.119 ± 0.048	5.536ArgThr: 5.536 ± 0.061	5.744ArgVal: 5.744 ± 0.056	1.407ArgTrp: 1.407 ± 0.027	1.717ArgTyr: 1.717 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.74SerAla: 6.74 ± 0.064	0.471SerCys: 0.471 ± 0.015	2.382SerAsp: 2.382 ± 0.031	2.316SerGlu: 2.316 ± 0.035	1.502SerPhe: 1.502 ± 0.024	5.866SerGly: 5.866 ± 0.055	0.966SerHis: 0.966 ± 0.021	1.307SerIle: 1.307 ± 0.023	1.004SerLys: 1.004 ± 0.026	4.642SerLeu: 4.642 ± 0.042	1.047SerMet: 1.047 ± 0.021	0.86SerAsn: 0.86 ± 0.022	3.293SerPro: 3.293 ± 0.039	1.178SerGln: 1.178 ± 0.025	3.666SerArg: 3.666 ± 0.04	2.642SerSer: 2.642 ± 0.041	2.862SerThr: 2.862 ± 0.04	4.107SerVal: 4.107 ± 0.047	0.909SerTrp: 0.909 ± 0.021	1.133SerTyr: 1.133 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.034ThrAla: 9.034 ± 0.073	0.455ThrCys: 0.455 ± 0.015	3.241ThrAsp: 3.241 ± 0.038	3.02ThrGlu: 3.02 ± 0.039	1.506ThrPhe: 1.506 ± 0.034	6.837ThrGly: 6.837 ± 0.06	1.173ThrHis: 1.173 ± 0.023	1.534ThrIle: 1.534 ± 0.027	1.119ThrLys: 1.119 ± 0.024	5.479ThrLeu: 5.479 ± 0.054	0.901ThrMet: 0.901 ± 0.021	0.938ThrAsn: 0.938 ± 0.026	4.245ThrPro: 4.245 ± 0.052	1.242ThrGln: 1.242 ± 0.026	3.98ThrArg: 3.98 ± 0.046	2.852ThrSer: 2.852 ± 0.035	3.63ThrThr: 3.63 ± 0.052	5.651ThrVal: 5.651 ± 0.048	0.906ThrTrp: 0.906 ± 0.021	1.279ThrTyr: 1.279 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.217ValAla: 10.217 ± 0.069	0.775ValCys: 0.775 ± 0.019	4.568ValAsp: 4.568 ± 0.046	4.612ValGlu: 4.612 ± 0.047	2.446ValPhe: 2.446 ± 0.032	6.182ValGly: 6.182 ± 0.058	1.978ValHis: 1.978 ± 0.029	2.748ValIle: 2.748 ± 0.04	1.767ValLys: 1.767 ± 0.035	9.499ValLeu: 9.499 ± 0.076	1.454ValMet: 1.454 ± 0.027	1.63ValAsn: 1.63 ± 0.032	5.417ValPro: 5.417 ± 0.06	1.96ValGln: 1.96 ± 0.029	7.279ValArg: 7.279 ± 0.067	4.279ValSer: 4.279 ± 0.044	5.268ValThr: 5.268 ± 0.049	7.516ValVal: 7.516 ± 0.083	1.144ValTrp: 1.144 ± 0.019	1.577ValTyr: 1.577 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.73TrpAla: 1.73 ± 0.029	0.166TrpCys: 0.166 ± 0.008	0.832TrpAsp: 0.832 ± 0.021	0.767TrpGlu: 0.767 ± 0.02	0.513TrpPhe: 0.513 ± 0.015	1.076TrpGly: 1.076 ± 0.022	0.369TrpHis: 0.369 ± 0.013	0.559TrpIle: 0.559 ± 0.019	0.401TrpLys: 0.401 ± 0.013	1.766TrpLeu: 1.766 ± 0.033	0.308TrpMet: 0.308 ± 0.013	0.392TrpAsn: 0.392 ± 0.015	0.818TrpPro: 0.818 ± 0.021	0.606TrpGln: 0.606 ± 0.017	1.348TrpArg: 1.348 ± 0.027	0.922TrpSer: 0.922 ± 0.021	1.114TrpThr: 1.114 ± 0.023	0.985TrpVal: 0.985 ± 0.022	0.363TrpTrp: 0.363 ± 0.015	0.352TrpTyr: 0.352 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.838TyrAla: 2.838 ± 0.035	0.179TyrCys: 0.179 ± 0.009	1.377TyrAsp: 1.377 ± 0.025	1.349TyrGlu: 1.349 ± 0.026	0.633TyrPhe: 0.633 ± 0.019	2.265TyrGly: 2.265 ± 0.036	0.375TyrHis: 0.375 ± 0.012	0.434TyrIle: 0.434 ± 0.014	0.404TyrLys: 0.404 ± 0.015	2.017TyrLeu: 2.017 ± 0.033	0.251TyrMet: 0.251 ± 0.011	0.365TyrAsn: 0.365 ± 0.013	1.042TyrPro: 1.042 ± 0.022	0.591TyrGln: 0.591 ± 0.015	1.802TyrArg: 1.802 ± 0.033	0.913TyrSer: 0.913 ± 0.02	1.107TyrThr: 1.107 ± 0.021	1.617TyrVal: 1.617 ± 0.026	0.371TyrTrp: 0.371 ± 0.013	0.404TyrTyr: 0.404 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7528 proteins (2294570 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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