Amino acid dipepetide frequency for Eimeria maxima (Coccidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	59.111AlaAla: 59.111 ± 0.904	1.617AlaCys: 1.617 ± 0.026	4.938AlaAsp: 4.938 ± 0.056	7.368AlaGlu: 7.368 ± 0.09	2.484AlaPhe: 2.484 ± 0.036	7.619AlaGly: 7.619 ± 0.066	1.513AlaHis: 1.513 ± 0.022	2.473AlaIle: 2.473 ± 0.027	3.23AlaLys: 3.23 ± 0.041	7.989AlaLeu: 7.989 ± 0.072	1.193AlaMet: 1.193 ± 0.021	2.202AlaAsn: 2.202 ± 0.027	6.544AlaPro: 6.544 ± 0.083	3.353AlaGln: 3.353 ± 0.037	4.262AlaArg: 4.262 ± 0.037	7.862AlaSer: 7.862 ± 0.068	8.327AlaThr: 8.327 ± 0.094	6.847AlaVal: 6.847 ± 0.065	0.717AlaTrp: 0.717 ± 0.016	1.305AlaTyr: 1.305 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.226CysAla: 1.226 ± 0.022	1.428CysCys: 1.428 ± 0.036	0.544CysAsp: 0.544 ± 0.015	0.653CysGlu: 0.653 ± 0.016	0.628CysPhe: 0.628 ± 0.013	1.255CysGly: 1.255 ± 0.024	0.279CysHis: 0.279 ± 0.009	0.754CysIle: 0.754 ± 0.015	0.561CysLys: 0.561 ± 0.014	1.978CysLeu: 1.978 ± 0.031	0.452CysMet: 0.452 ± 0.011	0.555CysAsn: 0.555 ± 0.014	0.86CysPro: 0.86 ± 0.024	0.436CysGln: 0.436 ± 0.012	1.142CysArg: 1.142 ± 0.02	2.594CysSer: 2.594 ± 0.038	0.889CysThr: 0.889 ± 0.018	1.006CysVal: 1.006 ± 0.021	0.256CysTrp: 0.256 ± 0.009	0.31CysTyr: 0.31 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.621AspAla: 4.621 ± 0.046	0.777AspCys: 0.777 ± 0.015	2.399AspAsp: 2.399 ± 0.041	2.932AspGlu: 2.932 ± 0.037	1.191AspPhe: 1.191 ± 0.022	2.941AspGly: 2.941 ± 0.041	0.521AspHis: 0.521 ± 0.013	1.675AspIle: 1.675 ± 0.027	1.579AspLys: 1.579 ± 0.028	3.326AspLeu: 3.326 ± 0.036	0.736AspMet: 0.736 ± 0.015	1.143AspAsn: 1.143 ± 0.018	2.343AspPro: 2.343 ± 0.037	1.185AspGln: 1.185 ± 0.019	2.008AspArg: 2.008 ± 0.047	3.669AspSer: 3.669 ± 0.039	2.424AspThr: 2.424 ± 0.028	2.252AspVal: 2.252 ± 0.027	0.453AspTrp: 0.453 ± 0.012	0.694AspTyr: 0.694 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	7.808GluAla: 7.808 ± 0.086	0.772GluCys: 0.772 ± 0.019	3.266GluAsp: 3.266 ± 0.041	9.317GluGlu: 9.317 ± 0.183	1.222GluPhe: 1.222 ± 0.021	5.265GluGly: 5.265 ± 0.06	1.003GluHis: 1.003 ± 0.019	1.685GluIle: 1.685 ± 0.026	3.081GluLys: 3.081 ± 0.058	5.018GluLeu: 5.018 ± 0.049	0.958GluMet: 0.958 ± 0.018	1.294GluAsn: 1.294 ± 0.022	2.169GluPro: 2.169 ± 0.031	5.504GluGln: 5.504 ± 0.08	3.42GluArg: 3.42 ± 0.046	3.209GluSer: 3.209 ± 0.037	3.569GluThr: 3.569 ± 0.066	3.212GluVal: 3.212 ± 0.037	0.54GluTrp: 0.54 ± 0.014	0.891GluTyr: 0.891 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.472PheAla: 2.472 ± 0.03	0.717PheCys: 0.717 ± 0.016	1.143PheAsp: 1.143 ± 0.019	1.232PheGlu: 1.232 ± 0.02	1.11PhePhe: 1.11 ± 0.021	1.632PheGly: 1.632 ± 0.03	0.442PheHis: 0.442 ± 0.012	0.978PheIle: 0.978 ± 0.021	0.872PheLys: 0.872 ± 0.017	2.713PheLeu: 2.713 ± 0.037	0.414PheMet: 0.414 ± 0.012	0.724PheAsn: 0.724 ± 0.018	1.383PhePro: 1.383 ± 0.025	0.742PheGln: 0.742 ± 0.016	1.343PheArg: 1.343 ± 0.022	2.289PheSer: 2.289 ± 0.029	1.032PheThr: 1.032 ± 0.02	1.756PheVal: 1.756 ± 0.028	0.283PheTrp: 0.283 ± 0.008	0.561PheTyr: 0.561 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	7.682GlyAla: 7.682 ± 0.077	1.232GlyCys: 1.232 ± 0.023	3.459GlyAsp: 3.459 ± 0.052	4.24GlyGlu: 4.24 ± 0.054	1.677GlyPhe: 1.677 ± 0.026	8.287GlyGly: 8.287 ± 0.119	1.027GlyHis: 1.027 ± 0.016	2.04GlyIle: 2.04 ± 0.031	2.192GlyLys: 2.192 ± 0.036	4.768GlyLeu: 4.768 ± 0.056	0.888GlyMet: 0.888 ± 0.017	1.65GlyAsn: 1.65 ± 0.024	4.349GlyPro: 4.349 ± 0.109	2.077GlyGln: 2.077 ± 0.03	3.569GlyArg: 3.569 ± 0.039	6.26GlySer: 6.26 ± 0.057	3.271GlyThr: 3.271 ± 0.039	3.783GlyVal: 3.783 ± 0.042	0.607GlyTrp: 0.607 ± 0.012	1.063GlyTyr: 1.063 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.069HisAla: 2.069 ± 0.027	0.408HisCys: 0.408 ± 0.01	0.728HisAsp: 0.728 ± 0.015	1.265HisGlu: 1.265 ± 0.023	0.64HisPhe: 0.64 ± 0.014	1.147HisGly: 1.147 ± 0.018	1.087HisHis: 1.087 ± 0.032	0.728HisIle: 0.728 ± 0.015	0.887HisLys: 0.887 ± 0.015	2.366HisLeu: 2.366 ± 0.027	0.466HisMet: 0.466 ± 0.012	0.549HisAsn: 0.549 ± 0.012	1.375HisPro: 1.375 ± 0.021	2.362HisGln: 2.362 ± 0.042	1.498HisArg: 1.498 ± 0.02	1.56HisSer: 1.56 ± 0.022	0.938HisThr: 0.938 ± 0.018	0.982HisVal: 0.982 ± 0.019	0.239HisTrp: 0.239 ± 0.008	0.404HisTyr: 0.404 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.43IleAla: 2.43 ± 0.027	0.724IleCys: 0.724 ± 0.016	1.583IleAsp: 1.583 ± 0.024	1.873IleGlu: 1.873 ± 0.033	0.897IlePhe: 0.897 ± 0.018	1.724IleGly: 1.724 ± 0.025	0.74IleHis: 0.74 ± 0.016	1.16IleIle: 1.16 ± 0.023	1.397IleLys: 1.397 ± 0.027	2.374IleLeu: 2.374 ± 0.028	0.423IleMet: 0.423 ± 0.013	1.026IleAsn: 1.026 ± 0.022	1.655IlePro: 1.655 ± 0.026	1.342IleGln: 1.342 ± 0.02	1.826IleArg: 1.826 ± 0.02	2.465IleSer: 2.465 ± 0.028	1.265IleThr: 1.265 ± 0.021	1.547IleVal: 1.547 ± 0.028	0.277IleTrp: 0.277 ± 0.01	0.605IleTyr: 0.605 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.27LysAla: 3.27 ± 0.044	0.511LysCys: 0.511 ± 0.013	1.673LysAsp: 1.673 ± 0.027	3.943LysGlu: 3.943 ± 0.071	0.687LysPhe: 0.687 ± 0.016	2.786LysGly: 2.786 ± 0.042	0.829LysHis: 0.829 ± 0.016	1.147LysIle: 1.147 ± 0.022	2.737LysLys: 2.737 ± 0.05	2.836LysLeu: 2.836 ± 0.034	0.59LysMet: 0.59 ± 0.013	1.028LysAsn: 1.028 ± 0.022	1.738LysPro: 1.738 ± 0.041	3.412LysGln: 3.412 ± 0.046	2.66LysArg: 2.66 ± 0.034	2.041LysSer: 2.041 ± 0.029	1.887LysThr: 1.887 ± 0.029	1.699LysVal: 1.699 ± 0.028	0.336LysTrp: 0.336 ± 0.01	0.657LysTyr: 0.657 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	6.767LeuAla: 6.767 ± 0.057	1.668LeuCys: 1.668 ± 0.024	3.203LeuAsp: 3.203 ± 0.038	4.891LeuGlu: 4.891 ± 0.055	2.542LeuPhe: 2.542 ± 0.037	4.648LeuGly: 4.648 ± 0.045	2.748LeuHis: 2.748 ± 0.029	2.278LeuIle: 2.278 ± 0.032	3.407LeuLys: 3.407 ± 0.042	15.849LeuLeu: 15.849 ± 0.193	1.424LeuMet: 1.424 ± 0.021	1.981LeuAsn: 1.981 ± 0.026	6.096LeuPro: 6.096 ± 0.047	11.646LeuGln: 11.646 ± 0.146	6.397LeuArg: 6.397 ± 0.054	6.672LeuSer: 6.672 ± 0.048	3.299LeuThr: 3.299 ± 0.037	4.06LeuVal: 4.06 ± 0.042	1.011LeuTrp: 1.011 ± 0.019	1.565LeuTyr: 1.565 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	1.127MetAla: 1.127 ± 0.02	0.206MetCys: 0.206 ± 0.008	0.614MetAsp: 0.614 ± 0.014	1.003MetGlu: 1.003 ± 0.018	0.333MetPhe: 0.333 ± 0.01	1.027MetGly: 1.027 ± 0.019	0.52MetHis: 0.52 ± 0.01	0.342MetIle: 0.342 ± 0.01	0.593MetLys: 0.593 ± 0.014	1.678MetLeu: 1.678 ± 0.02	0.298MetMet: 0.298 ± 0.009	0.376MetAsn: 0.376 ± 0.011	0.83MetPro: 0.83 ± 0.023	1.745MetGln: 1.745 ± 0.031	1.032MetArg: 1.032 ± 0.017	0.87MetSer: 0.87 ± 0.017	0.607MetThr: 0.607 ± 0.014	0.641MetVal: 0.641 ± 0.015	0.168MetTrp: 0.168 ± 0.006	0.287MetTyr: 0.287 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.214AsnAla: 2.214 ± 0.027	0.584AsnCys: 0.584 ± 0.013	1.069AsnAsp: 1.069 ± 0.02	1.322AsnGlu: 1.322 ± 0.022	0.646AsnPhe: 0.646 ± 0.016	1.644AsnGly: 1.644 ± 0.022	0.43AsnHis: 0.43 ± 0.011	1.119AsnIle: 1.119 ± 0.023	1.412AsnLys: 1.412 ± 0.023	1.71AsnLeu: 1.71 ± 0.025	0.43AsnMet: 0.43 ± 0.01	2.253AsnAsn: 2.253 ± 0.064	1.411AsnPro: 1.411 ± 0.02	0.871AsnGln: 0.871 ± 0.018	1.484AsnArg: 1.484 ± 0.021	4.536AsnSer: 4.536 ± 0.069	1.458AsnThr: 1.458 ± 0.023	1.134AsnVal: 1.134 ± 0.021	0.253AsnTrp: 0.253 ± 0.009	0.518AsnTyr: 0.518 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.973ProAla: 6.973 ± 0.083	0.878ProCys: 0.878 ± 0.02	1.841ProAsp: 1.841 ± 0.031	2.951ProGlu: 2.951 ± 0.036	1.741ProPhe: 1.741 ± 0.025	3.062ProGly: 3.062 ± 0.074	1.496ProHis: 1.496 ± 0.023	1.508ProIle: 1.508 ± 0.02	1.842ProLys: 1.842 ± 0.042	6.073ProLeu: 6.073 ± 0.054	0.81ProMet: 0.81 ± 0.018	1.231ProAsn: 1.231 ± 0.021	6.554ProPro: 6.554 ± 0.124	4.115ProGln: 4.115 ± 0.064	2.876ProArg: 2.876 ± 0.034	5.548ProSer: 5.548 ± 0.05	3.093ProThr: 3.093 ± 0.038	3.034ProVal: 3.034 ± 0.032	0.635ProTrp: 0.635 ± 0.015	0.987ProTyr: 0.987 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.48GlnAla: 3.48 ± 0.035	0.566GlnCys: 0.566 ± 0.015	1.876GlnAsp: 1.876 ± 0.023	5.647GlnGlu: 5.647 ± 0.071	0.861GlnPhe: 0.861 ± 0.014	2.907GlnGly: 2.907 ± 0.031	3.713GlnHis: 3.713 ± 0.064	1.308GlnIle: 1.308 ± 0.022	2.919GlnLys: 2.919 ± 0.038	8.958GlnLeu: 8.958 ± 0.112	1.217GlnMet: 1.217 ± 0.026	1.059GlnAsn: 1.059 ± 0.019	3.707GlnPro: 3.707 ± 0.071	52.497GlnGln: 52.497 ± 1.035	5.091GlnArg: 5.091 ± 0.063	2.359GlnSer: 2.359 ± 0.03	2.211GlnThr: 2.211 ± 0.029	2.297GlnVal: 2.297 ± 0.029	0.565GlnTrp: 0.565 ± 0.014	0.75GlnTyr: 0.75 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.454ArgAla: 4.454 ± 0.043	1.316ArgCys: 1.316 ± 0.02	2.286ArgAsp: 2.286 ± 0.035	3.722ArgGlu: 3.722 ± 0.039	1.42ArgPhe: 1.42 ± 0.021	4.243ArgGly: 4.243 ± 0.059	1.564ArgHis: 1.564 ± 0.025	1.825ArgIle: 1.825 ± 0.022	2.453ArgLys: 2.453 ± 0.032	6.034ArgLeu: 6.034 ± 0.049	1.139ArgMet: 1.139 ± 0.02	1.448ArgAsn: 1.448 ± 0.021	2.739ArgPro: 2.739 ± 0.029	4.325ArgGln: 4.325 ± 0.055	5.789ArgArg: 5.789 ± 0.06	4.798ArgSer: 4.798 ± 0.043	2.23ArgThr: 2.23 ± 0.027	2.939ArgVal: 2.939 ± 0.035	0.684ArgTrp: 0.684 ± 0.014	0.972ArgTyr: 0.972 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	8.063SerAla: 8.063 ± 0.069	1.956SerCys: 1.956 ± 0.031	2.763SerAsp: 2.763 ± 0.035	3.285SerGlu: 3.285 ± 0.037	2.351SerPhe: 2.351 ± 0.034	5.219SerGly: 5.219 ± 0.057	1.238SerHis: 1.238 ± 0.021	2.572SerIle: 2.572 ± 0.033	3.001SerLys: 3.001 ± 0.035	7.126SerLeu: 7.126 ± 0.062	1.09SerMet: 1.09 ± 0.019	4.74SerAsn: 4.74 ± 0.072	5.619SerPro: 5.619 ± 0.057	2.437SerGln: 2.437 ± 0.029	5.183SerArg: 5.183 ± 0.044	27.404SerSer: 27.404 ± 0.402	4.547SerThr: 4.547 ± 0.039	3.902SerVal: 3.902 ± 0.039	0.796SerTrp: 0.796 ± 0.014	1.203SerTyr: 1.203 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.179ThrAla: 9.179 ± 0.1	0.744ThrCys: 0.744 ± 0.018	2.114ThrAsp: 2.114 ± 0.029	3.014ThrGlu: 3.014 ± 0.038	1.066ThrPhe: 1.066 ± 0.018	3.394ThrGly: 3.394 ± 0.041	0.899ThrHis: 0.899 ± 0.016	1.408ThrIle: 1.408 ± 0.025	1.603ThrLys: 1.603 ± 0.024	3.573ThrLeu: 3.573 ± 0.039	0.555ThrMet: 0.555 ± 0.013	1.351ThrAsn: 1.351 ± 0.02	3.604ThrPro: 3.604 ± 0.037	2.014ThrGln: 2.014 ± 0.027	2.259ThrArg: 2.259 ± 0.024	4.019ThrSer: 4.019 ± 0.038	3.817ThrThr: 3.817 ± 0.06	2.484ThrVal: 2.484 ± 0.036	0.392ThrTrp: 0.392 ± 0.011	0.698ThrTyr: 0.698 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	6.168ValAla: 6.168 ± 0.058	1.139ValCys: 1.139 ± 0.019	2.304ValAsp: 2.304 ± 0.031	3.135ValGlu: 3.135 ± 0.047	1.543ValPhe: 1.543 ± 0.028	3.317ValGly: 3.317 ± 0.046	1.125ValHis: 1.125 ± 0.018	1.305ValIle: 1.305 ± 0.024	1.598ValLys: 1.598 ± 0.028	5.145ValLeu: 5.145 ± 0.045	0.694ValMet: 0.694 ± 0.015	1.103ValAsn: 1.103 ± 0.02	3.025ValPro: 3.025 ± 0.04	2.689ValGln: 2.689 ± 0.033	2.493ValArg: 2.493 ± 0.031	4.395ValSer: 4.395 ± 0.05	1.998ValThr: 1.998 ± 0.027	3.143ValVal: 3.143 ± 0.041	0.57ValTrp: 0.57 ± 0.016	1.195ValTyr: 1.195 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.676TrpAla: 0.676 ± 0.014	0.183TrpCys: 0.183 ± 0.007	0.376TrpAsp: 0.376 ± 0.009	0.541TrpGlu: 0.541 ± 0.013	0.23TrpPhe: 0.23 ± 0.009	0.959TrpGly: 0.959 ± 0.021	0.206TrpHis: 0.206 ± 0.007	0.335TrpIle: 0.335 ± 0.009	0.388TrpLys: 0.388 ± 0.011	1.068TrpLeu: 1.068 ± 0.018	0.201TrpMet: 0.201 ± 0.007	0.231TrpAsn: 0.231 ± 0.01	0.399TrpPro: 0.399 ± 0.01	0.619TrpGln: 0.619 ± 0.017	0.915TrpArg: 0.915 ± 0.016	0.632TrpSer: 0.632 ± 0.013	0.385TrpThr: 0.385 ± 0.011	0.493TrpVal: 0.493 ± 0.013	0.147TrpTrp: 0.147 ± 0.006	0.148TrpTyr: 0.148 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.162TyrAla: 1.162 ± 0.021	0.38TyrCys: 0.38 ± 0.013	0.692TyrAsp: 0.692 ± 0.016	0.871TyrGlu: 0.871 ± 0.015	0.567TyrPhe: 0.567 ± 0.014	1.046TyrGly: 1.046 ± 0.021	0.318TyrHis: 0.318 ± 0.009	0.69TyrIle: 0.69 ± 0.016	0.714TyrLys: 0.714 ± 0.015	1.572TyrLeu: 1.572 ± 0.024	0.318TyrMet: 0.318 ± 0.01	0.555TyrAsn: 0.555 ± 0.013	0.848TyrPro: 0.848 ± 0.016	0.616TyrGln: 0.616 ± 0.015	1.133TyrArg: 1.133 ± 0.022	1.315TyrSer: 1.315 ± 0.019	0.941TyrThr: 0.941 ± 0.019	0.871TyrVal: 0.871 ± 0.016	0.203TyrTrp: 0.203 ± 0.007	0.439TyrTyr: 0.439 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6057 proteins (4025948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---