Amino acid dipepetide frequency for Tetrasphaera australiensis Ben110

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.794AlaAla: 19.794 ± 0.198	1.075AlaCys: 1.075 ± 0.032	8.195AlaAsp: 8.195 ± 0.094	7.366AlaGlu: 7.366 ± 0.099	3.574AlaPhe: 3.574 ± 0.067	12.492AlaGly: 12.492 ± 0.122	2.779AlaHis: 2.779 ± 0.048	5.304AlaIle: 5.304 ± 0.079	3.19AlaLys: 3.19 ± 0.061	13.364AlaLeu: 13.364 ± 0.127	2.973AlaMet: 2.973 ± 0.055	2.344AlaAsn: 2.344 ± 0.048	6.252AlaPro: 6.252 ± 0.076	4.011AlaGln: 4.011 ± 0.061	9.551AlaArg: 9.551 ± 0.114	6.554AlaSer: 6.554 ± 0.088	7.837AlaThr: 7.837 ± 0.1	10.562AlaVal: 10.562 ± 0.106	1.964AlaTrp: 1.964 ± 0.042	2.939AlaTyr: 2.939 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.009CysAla: 1.009 ± 0.031	0.152CysCys: 0.152 ± 0.014	0.46CysAsp: 0.46 ± 0.02	0.417CysGlu: 0.417 ± 0.016	0.245CysPhe: 0.245 ± 0.014	0.941CysGly: 0.941 ± 0.03	0.201CysHis: 0.201 ± 0.014	0.251CysIle: 0.251 ± 0.014	0.119CysLys: 0.119 ± 0.009	0.664CysLeu: 0.664 ± 0.023	0.137CysMet: 0.137 ± 0.011	0.153CysAsn: 0.153 ± 0.011	0.533CysPro: 0.533 ± 0.019	0.204CysGln: 0.204 ± 0.012	0.701CysArg: 0.701 ± 0.028	0.469CysSer: 0.469 ± 0.021	0.502CysThr: 0.502 ± 0.024	0.592CysVal: 0.592 ± 0.023	0.136CysTrp: 0.136 ± 0.013	0.138CysTyr: 0.138 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.803AspAla: 7.803 ± 0.086	0.398AspCys: 0.398 ± 0.019	3.86AspAsp: 3.86 ± 0.066	3.927AspGlu: 3.927 ± 0.065	1.788AspPhe: 1.788 ± 0.043	5.856AspGly: 5.856 ± 0.072	1.461AspHis: 1.461 ± 0.034	2.422AspIle: 2.422 ± 0.054	1.388AspLys: 1.388 ± 0.036	6.883AspLeu: 6.883 ± 0.075	0.932AspMet: 0.932 ± 0.028	1.145AspAsn: 1.145 ± 0.032	4.528AspPro: 4.528 ± 0.058	1.823AspGln: 1.823 ± 0.043	4.472AspArg: 4.472 ± 0.071	2.536AspSer: 2.536 ± 0.045	2.964AspThr: 2.964 ± 0.053	5.158AspVal: 5.158 ± 0.079	0.98AspTrp: 0.98 ± 0.03	1.262AspTyr: 1.262 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.746GluAla: 6.746 ± 0.087	0.373GluCys: 0.373 ± 0.019	2.713GluAsp: 2.713 ± 0.057	3.036GluGlu: 3.036 ± 0.059	1.6GluPhe: 1.6 ± 0.037	4.039GluGly: 4.039 ± 0.063	1.556GluHis: 1.556 ± 0.039	2.668GluIle: 2.668 ± 0.047	1.427GluLys: 1.427 ± 0.045	5.619GluLeu: 5.619 ± 0.081	1.11GluMet: 1.11 ± 0.03	1.003GluAsn: 1.003 ± 0.031	2.906GluPro: 2.906 ± 0.06	2.133GluGln: 2.133 ± 0.048	5.02GluArg: 5.02 ± 0.069	2.777GluSer: 2.777 ± 0.051	2.703GluThr: 2.703 ± 0.05	4.757GluVal: 4.757 ± 0.07	0.807GluTrp: 0.807 ± 0.031	0.984GluTyr: 0.984 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.771PheAla: 3.771 ± 0.047	0.23PheCys: 0.23 ± 0.015	2.064PheAsp: 2.064 ± 0.039	1.519PheGlu: 1.519 ± 0.037	0.942PhePhe: 0.942 ± 0.032	3.245PheGly: 3.245 ± 0.06	0.628PheHis: 0.628 ± 0.021	0.957PheIle: 0.957 ± 0.032	0.546PheLys: 0.546 ± 0.02	2.57PheLeu: 2.57 ± 0.05	0.459PheMet: 0.459 ± 0.022	0.609PheAsn: 0.609 ± 0.026	1.356PhePro: 1.356 ± 0.039	0.621PheGln: 0.621 ± 0.026	1.711PheArg: 1.711 ± 0.04	1.521PheSer: 1.521 ± 0.038	1.96PheThr: 1.96 ± 0.046	2.642PheVal: 2.642 ± 0.044	0.437PheTrp: 0.437 ± 0.023	0.577PheTyr: 0.577 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.449GlyAla: 10.449 ± 0.114	0.857GlyCys: 0.857 ± 0.029	5.102GlyAsp: 5.102 ± 0.066	4.94GlyGlu: 4.94 ± 0.059	2.827GlyPhe: 2.827 ± 0.055	7.866GlyGly: 7.866 ± 0.103	2.266GlyHis: 2.266 ± 0.044	4.266GlyIle: 4.266 ± 0.067	2.521GlyLys: 2.521 ± 0.05	8.92GlyLeu: 8.92 ± 0.107	2.324GlyMet: 2.324 ± 0.045	1.895GlyAsn: 1.895 ± 0.044	4.71GlyPro: 4.71 ± 0.069	2.834GlyGln: 2.834 ± 0.048	6.958GlyArg: 6.958 ± 0.085	5.48GlySer: 5.48 ± 0.068	5.528GlyThr: 5.528 ± 0.081	7.485GlyVal: 7.485 ± 0.093	1.727GlyTrp: 1.727 ± 0.038	2.263GlyTyr: 2.263 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.596HisAla: 2.596 ± 0.048	0.213HisCys: 0.213 ± 0.013	1.5HisAsp: 1.5 ± 0.033	1.268HisGlu: 1.268 ± 0.039	0.622HisPhe: 0.622 ± 0.023	2.219HisGly: 2.219 ± 0.04	0.683HisHis: 0.683 ± 0.027	0.802HisIle: 0.802 ± 0.026	0.384HisLys: 0.384 ± 0.021	2.473HisLeu: 2.473 ± 0.047	0.362HisMet: 0.362 ± 0.02	0.442HisAsn: 0.442 ± 0.02	1.75HisPro: 1.75 ± 0.041	0.653HisGln: 0.653 ± 0.023	1.953HisArg: 1.953 ± 0.046	1.026HisSer: 1.026 ± 0.027	1.377HisThr: 1.377 ± 0.032	1.868HisVal: 1.868 ± 0.037	0.366HisTrp: 0.366 ± 0.018	0.475HisTyr: 0.475 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.095IleAla: 6.095 ± 0.085	0.314IleCys: 0.314 ± 0.015	3.096IleAsp: 3.096 ± 0.053	2.506IleGlu: 2.506 ± 0.053	1.118IlePhe: 1.118 ± 0.033	4.102IleGly: 4.102 ± 0.068	0.836IleHis: 0.836 ± 0.03	1.399IleIle: 1.399 ± 0.042	0.844IleLys: 0.844 ± 0.029	3.408IleLeu: 3.408 ± 0.066	0.609IleMet: 0.609 ± 0.026	0.929IleAsn: 0.929 ± 0.03	2.511IlePro: 2.511 ± 0.052	0.904IleGln: 0.904 ± 0.031	2.722IleArg: 2.722 ± 0.047	2.184IleSer: 2.184 ± 0.044	2.672IleThr: 2.672 ± 0.045	3.81IleVal: 3.81 ± 0.055	0.534IleTrp: 0.534 ± 0.023	0.752IleTyr: 0.752 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.011LysAla: 3.011 ± 0.059	0.136LysCys: 0.136 ± 0.01	1.36LysAsp: 1.36 ± 0.036	1.177LysGlu: 1.177 ± 0.036	0.591LysPhe: 0.591 ± 0.026	1.873LysGly: 1.873 ± 0.048	0.466LysHis: 0.466 ± 0.019	1.038LysIle: 1.038 ± 0.035	0.772LysLys: 0.772 ± 0.031	1.962LysLeu: 1.962 ± 0.042	0.438LysMet: 0.438 ± 0.018	0.494LysAsn: 0.494 ± 0.022	1.294LysPro: 1.294 ± 0.032	0.719LysGln: 0.719 ± 0.024	1.589LysArg: 1.589 ± 0.041	1.218LysSer: 1.218 ± 0.038	1.519LysThr: 1.519 ± 0.037	2.063LysVal: 2.063 ± 0.048	0.306LysTrp: 0.306 ± 0.018	0.495LysTyr: 0.495 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.636LeuAla: 14.636 ± 0.137	0.684LeuCys: 0.684 ± 0.025	6.569LeuAsp: 6.569 ± 0.092	4.706LeuGlu: 4.706 ± 0.067	2.464LeuPhe: 2.464 ± 0.058	9.254LeuGly: 9.254 ± 0.098	2.15LeuHis: 2.15 ± 0.046	4.067LeuIle: 4.067 ± 0.069	1.879LeuLys: 1.879 ± 0.051	9.913LeuLeu: 9.913 ± 0.125	1.793LeuMet: 1.793 ± 0.039	1.71LeuAsn: 1.71 ± 0.041	5.636LeuPro: 5.636 ± 0.071	2.356LeuGln: 2.356 ± 0.041	7.672LeuArg: 7.672 ± 0.092	5.118LeuSer: 5.118 ± 0.067	6.576LeuThr: 6.576 ± 0.089	8.713LeuVal: 8.713 ± 0.102	1.198LeuTrp: 1.198 ± 0.034	1.552LeuTyr: 1.552 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.608MetAla: 2.608 ± 0.049	0.163MetCys: 0.163 ± 0.011	1.029MetAsp: 1.029 ± 0.032	0.789MetGlu: 0.789 ± 0.028	0.535MetPhe: 0.535 ± 0.019	1.523MetGly: 1.523 ± 0.036	0.394MetHis: 0.394 ± 0.02	0.839MetIle: 0.839 ± 0.03	0.525MetLys: 0.525 ± 0.021	1.948MetLeu: 1.948 ± 0.042	0.398MetMet: 0.398 ± 0.02	0.48MetAsn: 0.48 ± 0.02	1.429MetPro: 1.429 ± 0.035	0.548MetGln: 0.548 ± 0.021	1.677MetArg: 1.677 ± 0.042	1.608MetSer: 1.608 ± 0.037	2.044MetThr: 2.044 ± 0.04	1.44MetVal: 1.44 ± 0.036	0.27MetTrp: 0.27 ± 0.014	0.29MetTyr: 0.29 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.48AsnAla: 2.48 ± 0.045	0.164AsnCys: 0.164 ± 0.011	1.099AsnAsp: 1.099 ± 0.036	0.902AsnGlu: 0.902 ± 0.03	0.544AsnPhe: 0.544 ± 0.022	1.801AsnGly: 1.801 ± 0.043	0.452AsnHis: 0.452 ± 0.02	0.749AsnIle: 0.749 ± 0.025	0.421AsnLys: 0.421 ± 0.022	1.897AsnLeu: 1.897 ± 0.04	0.362AsnMet: 0.362 ± 0.016	0.446AsnAsn: 0.446 ± 0.022	1.63AsnPro: 1.63 ± 0.037	0.546AsnGln: 0.546 ± 0.022	1.369AsnArg: 1.369 ± 0.033	1.065AsnSer: 1.065 ± 0.028	1.162AsnThr: 1.162 ± 0.033	1.572AsnVal: 1.572 ± 0.034	0.319AsnTrp: 0.319 ± 0.018	0.497AsnTyr: 0.497 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.599ProAla: 7.599 ± 0.093	0.34ProCys: 0.34 ± 0.017	4.425ProAsp: 4.425 ± 0.063	3.716ProGlu: 3.716 ± 0.062	1.475ProPhe: 1.475 ± 0.035	6.013ProGly: 6.013 ± 0.073	1.336ProHis: 1.336 ± 0.041	2.017ProIle: 2.017 ± 0.041	1.313ProLys: 1.313 ± 0.037	4.715ProLeu: 4.715 ± 0.062	1.3ProMet: 1.3 ± 0.029	1.082ProAsn: 1.082 ± 0.034	3.057ProPro: 3.057 ± 0.06	1.681ProGln: 1.681 ± 0.038	3.845ProArg: 3.845 ± 0.064	3.064ProSer: 3.064 ± 0.056	3.536ProThr: 3.536 ± 0.058	5.035ProVal: 5.035 ± 0.073	0.939ProTrp: 0.939 ± 0.032	1.179ProTyr: 1.179 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.741GlnAla: 3.741 ± 0.057	0.223GlnCys: 0.223 ± 0.014	1.437GlnAsp: 1.437 ± 0.039	1.454GlnGlu: 1.454 ± 0.037	0.823GlnPhe: 0.823 ± 0.025	2.187GlnGly: 2.187 ± 0.046	0.678GlnHis: 0.678 ± 0.023	1.407GlnIle: 1.407 ± 0.042	0.575GlnLys: 0.575 ± 0.022	3.069GlnLeu: 3.069 ± 0.05	0.569GlnMet: 0.569 ± 0.024	0.489GlnAsn: 0.489 ± 0.021	1.72GlnPro: 1.72 ± 0.034	1.153GlnGln: 1.153 ± 0.036	2.575GlnArg: 2.575 ± 0.053	1.299GlnSer: 1.299 ± 0.031	1.431GlnThr: 1.431 ± 0.035	2.708GlnVal: 2.708 ± 0.054	0.543GlnTrp: 0.543 ± 0.019	0.532GlnTyr: 0.532 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.088ArgAla: 9.088 ± 0.093	0.613ArgCys: 0.613 ± 0.029	4.38ArgAsp: 4.38 ± 0.063	4.329ArgGlu: 4.329 ± 0.063	2.241ArgPhe: 2.241 ± 0.044	5.658ArgGly: 5.658 ± 0.07	2.099ArgHis: 2.099 ± 0.039	3.506ArgIle: 3.506 ± 0.053	1.575ArgLys: 1.575 ± 0.036	7.952ArgLeu: 7.952 ± 0.099	1.922ArgMet: 1.922 ± 0.043	1.392ArgAsn: 1.392 ± 0.036	4.489ArgPro: 4.489 ± 0.075	2.269ArgGln: 2.269 ± 0.049	7.176ArgArg: 7.176 ± 0.116	4.274ArgSer: 4.274 ± 0.068	4.405ArgThr: 4.405 ± 0.071	5.872ArgVal: 5.872 ± 0.08	1.373ArgTrp: 1.373 ± 0.036	1.671ArgTyr: 1.671 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.888SerAla: 6.888 ± 0.075	0.429SerCys: 0.429 ± 0.018	2.991SerAsp: 2.991 ± 0.05	2.544SerGlu: 2.544 ± 0.053	1.529SerPhe: 1.529 ± 0.036	5.844SerGly: 5.844 ± 0.08	1.06SerHis: 1.06 ± 0.031	2.01SerIle: 2.01 ± 0.044	1.064SerLys: 1.064 ± 0.03	4.821SerLeu: 4.821 ± 0.068	1.424SerMet: 1.424 ± 0.033	1.043SerAsn: 1.043 ± 0.029	3.203SerPro: 3.203 ± 0.059	1.404SerGln: 1.404 ± 0.038	4.009SerArg: 4.009 ± 0.069	3.333SerSer: 3.333 ± 0.073	3.4SerThr: 3.4 ± 0.064	4.387SerVal: 4.387 ± 0.061	0.971SerTrp: 0.971 ± 0.032	1.232SerTyr: 1.232 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.652ThrAla: 7.652 ± 0.092	0.523ThrCys: 0.523 ± 0.023	3.61ThrAsp: 3.61 ± 0.05	2.897ThrGlu: 2.897 ± 0.059	1.866ThrPhe: 1.866 ± 0.038	6.021ThrGly: 6.021 ± 0.083	1.36ThrHis: 1.36 ± 0.033	2.77ThrIle: 2.77 ± 0.053	1.461ThrLys: 1.461 ± 0.041	5.633ThrLeu: 5.633 ± 0.08	1.29ThrMet: 1.29 ± 0.031	1.279ThrAsn: 1.279 ± 0.034	4.087ThrPro: 4.087 ± 0.068	1.558ThrGln: 1.558 ± 0.038	4.181ThrArg: 4.181 ± 0.059	3.653ThrSer: 3.653 ± 0.059	4.296ThrThr: 4.296 ± 0.074	5.225ThrVal: 5.225 ± 0.064	0.967ThrTrp: 0.967 ± 0.031	1.39ThrTyr: 1.39 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.387ValAla: 11.387 ± 0.109	0.769ValCys: 0.769 ± 0.025	5.431ValAsp: 5.431 ± 0.07	4.683ValGlu: 4.683 ± 0.081	2.387ValPhe: 2.387 ± 0.046	7.185ValGly: 7.185 ± 0.091	1.837ValHis: 1.837 ± 0.041	3.677ValIle: 3.677 ± 0.057	1.826ValLys: 1.826 ± 0.044	8.858ValLeu: 8.858 ± 0.098	1.568ValMet: 1.568 ± 0.037	1.689ValAsn: 1.689 ± 0.042	4.602ValPro: 4.602 ± 0.061	2.067ValGln: 2.067 ± 0.047	6.116ValArg: 6.116 ± 0.073	4.432ValSer: 4.432 ± 0.063	5.827ValThr: 5.827 ± 0.078	8.267ValVal: 8.267 ± 0.1	1.179ValTrp: 1.179 ± 0.032	1.399ValTyr: 1.399 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.725TrpAla: 1.725 ± 0.044	0.184TrpCys: 0.184 ± 0.012	0.807TrpAsp: 0.807 ± 0.026	0.69TrpGlu: 0.69 ± 0.024	0.541TrpPhe: 0.541 ± 0.021	1.131TrpGly: 1.131 ± 0.034	0.378TrpHis: 0.378 ± 0.021	0.648TrpIle: 0.648 ± 0.025	0.312TrpLys: 0.312 ± 0.018	1.864TrpLeu: 1.864 ± 0.046	0.329TrpMet: 0.329 ± 0.018	0.397TrpAsn: 0.397 ± 0.02	0.868TrpPro: 0.868 ± 0.028	0.573TrpGln: 0.573 ± 0.023	1.369TrpArg: 1.369 ± 0.037	1.034TrpSer: 1.034 ± 0.031	0.968TrpThr: 0.968 ± 0.028	1.229TrpVal: 1.229 ± 0.034	0.358TrpTrp: 0.358 ± 0.019	0.308TrpTyr: 0.308 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.043TyrAla: 3.043 ± 0.046	0.185TyrCys: 0.185 ± 0.013	1.458TyrAsp: 1.458 ± 0.038	1.107TyrGlu: 1.107 ± 0.034	0.651TyrPhe: 0.651 ± 0.023	1.97TyrGly: 1.97 ± 0.045	0.411TyrHis: 0.411 ± 0.021	0.547TyrIle: 0.547 ± 0.021	0.381TyrLys: 0.381 ± 0.019	2.113TyrLeu: 2.113 ± 0.043	0.234TyrMet: 0.234 ± 0.016	0.458TyrAsn: 0.458 ± 0.024	1.105TyrPro: 1.105 ± 0.034	0.555TyrGln: 0.555 ± 0.023	1.621TyrArg: 1.621 ± 0.038	0.941TyrSer: 0.941 ± 0.028	1.014TyrThr: 1.014 ± 0.03	1.801TyrVal: 1.801 ± 0.043	0.339TyrTrp: 0.339 ± 0.015	0.445TyrTyr: 0.445 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4162 proteins (1186567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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