Amino acid dipepetide frequency for Variovorax sp. CF079

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.366AlaAla: 19.366 ± 0.134	1.368AlaCys: 1.368 ± 0.026	6.457AlaAsp: 6.457 ± 0.066	7.081AlaGlu: 7.081 ± 0.072	4.318AlaPhe: 4.318 ± 0.043	11.45AlaGly: 11.45 ± 0.087	2.746AlaHis: 2.746 ± 0.038	5.475AlaIle: 5.475 ± 0.06	4.105AlaLys: 4.105 ± 0.053	15.429AlaLeu: 15.429 ± 0.1	3.614AlaMet: 3.614 ± 0.047	2.85AlaAsn: 2.85 ± 0.043	6.744AlaPro: 6.744 ± 0.084	5.56AlaGln: 5.56 ± 0.056	9.518AlaArg: 9.518 ± 0.085	7.216AlaSer: 7.216 ± 0.061	6.172AlaThr: 6.172 ± 0.056	9.368AlaVal: 9.368 ± 0.076	1.959AlaTrp: 1.959 ± 0.034	2.489AlaTyr: 2.489 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.026	0.121CysCys: 0.121 ± 0.007	0.54CysAsp: 0.54 ± 0.016	0.576CysGlu: 0.576 ± 0.017	0.33CysPhe: 0.33 ± 0.013	1.003CysGly: 1.003 ± 0.026	0.241CysHis: 0.241 ± 0.011	0.432CysIle: 0.432 ± 0.017	0.244CysLys: 0.244 ± 0.011	0.783CysLeu: 0.783 ± 0.02	0.217CysMet: 0.217 ± 0.01	0.231CysAsn: 0.231 ± 0.011	0.458CysPro: 0.458 ± 0.015	0.231CysGln: 0.231 ± 0.01	0.614CysArg: 0.614 ± 0.019	0.514CysSer: 0.514 ± 0.015	0.506CysThr: 0.506 ± 0.016	0.716CysVal: 0.716 ± 0.018	0.139CysTrp: 0.139 ± 0.008	0.19CysTyr: 0.19 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.477AspAla: 7.477 ± 0.069	0.457AspCys: 0.457 ± 0.014	2.622AspAsp: 2.622 ± 0.037	3.209AspGlu: 3.209 ± 0.047	2.038AspPhe: 2.038 ± 0.032	4.524AspGly: 4.524 ± 0.06	1.056AspHis: 1.056 ± 0.023	2.367AspIle: 2.367 ± 0.038	1.567AspLys: 1.567 ± 0.031	5.181AspLeu: 5.181 ± 0.052	1.151AspMet: 1.151 ± 0.021	1.161AspAsn: 1.161 ± 0.025	2.911AspPro: 2.911 ± 0.036	1.378AspGln: 1.378 ± 0.025	3.333AspArg: 3.333 ± 0.041	2.218AspSer: 2.218 ± 0.032	2.39AspThr: 2.39 ± 0.037	3.832AspVal: 3.832 ± 0.046	0.874AspTrp: 0.874 ± 0.022	1.323AspTyr: 1.323 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.391GluAla: 7.391 ± 0.069	0.396GluCys: 0.396 ± 0.015	2.201GluAsp: 2.201 ± 0.033	2.644GluGlu: 2.644 ± 0.043	1.761GluPhe: 1.761 ± 0.026	4.028GluGly: 4.028 ± 0.046	1.276GluHis: 1.276 ± 0.024	2.738GluIle: 2.738 ± 0.041	1.796GluLys: 1.796 ± 0.038	6.207GluLeu: 6.207 ± 0.063	1.336GluMet: 1.336 ± 0.028	1.18GluAsn: 1.18 ± 0.024	2.66GluPro: 2.66 ± 0.041	2.314GluGln: 2.314 ± 0.032	4.992GluArg: 4.992 ± 0.056	2.613GluSer: 2.613 ± 0.039	2.457GluThr: 2.457 ± 0.036	4.175GluVal: 4.175 ± 0.048	0.732GluTrp: 0.732 ± 0.02	0.973GluTyr: 0.973 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.554PheAla: 4.554 ± 0.047	0.416PheCys: 0.416 ± 0.014	2.586PheAsp: 2.586 ± 0.034	2.226PheGlu: 2.226 ± 0.031	1.324PhePhe: 1.324 ± 0.026	3.562PheGly: 3.562 ± 0.042	0.734PheHis: 0.734 ± 0.018	1.513PheIle: 1.513 ± 0.029	1.183PheLys: 1.183 ± 0.025	2.974PheLeu: 2.974 ± 0.036	0.8PheMet: 0.8 ± 0.02	1.067PheAsn: 1.067 ± 0.023	1.545PhePro: 1.545 ± 0.026	0.995PheGln: 0.995 ± 0.021	1.979PheArg: 1.979 ± 0.029	2.113PheSer: 2.113 ± 0.031	1.822PheThr: 1.822 ± 0.032	2.928PheVal: 2.928 ± 0.04	0.511PheTrp: 0.511 ± 0.017	0.804PheTyr: 0.804 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.931GlyAla: 9.931 ± 0.082	0.927GlyCys: 0.927 ± 0.021	3.842GlyAsp: 3.842 ± 0.046	4.515GlyGlu: 4.515 ± 0.052	3.416GlyPhe: 3.416 ± 0.041	7.177GlyGly: 7.177 ± 0.102	1.89GlyHis: 1.89 ± 0.027	4.122GlyIle: 4.122 ± 0.045	3.181GlyLys: 3.181 ± 0.048	8.862GlyLeu: 8.862 ± 0.076	2.273GlyMet: 2.273 ± 0.034	2.136GlyAsn: 2.136 ± 0.043	3.423GlyPro: 3.423 ± 0.045	3.123GlyGln: 3.123 ± 0.044	5.819GlyArg: 5.819 ± 0.056	4.814GlySer: 4.814 ± 0.062	4.711GlyThr: 4.711 ± 0.068	6.54GlyVal: 6.54 ± 0.06	1.442GlyTrp: 1.442 ± 0.028	2.289GlyTyr: 2.289 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	3.011HisAla: 3.011 ± 0.041	0.28HisCys: 0.28 ± 0.013	1.118HisAsp: 1.118 ± 0.023	1.185HisGlu: 1.185 ± 0.022	0.84HisPhe: 0.84 ± 0.02	2.157HisGly: 2.157 ± 0.037	0.6HisHis: 0.6 ± 0.021	0.919HisIle: 0.919 ± 0.021	0.552HisLys: 0.552 ± 0.017	2.139HisLeu: 2.139 ± 0.043	0.512HisMet: 0.512 ± 0.017	0.478HisAsn: 0.478 ± 0.015	1.506HisPro: 1.506 ± 0.028	0.653HisGln: 0.653 ± 0.019	1.558HisArg: 1.558 ± 0.03	1.043HisSer: 1.043 ± 0.019	0.994HisThr: 0.994 ± 0.021	1.658HisVal: 1.658 ± 0.029	0.392HisTrp: 0.392 ± 0.015	0.572HisTyr: 0.572 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.763IleAla: 6.763 ± 0.061	0.421IleCys: 0.421 ± 0.013	3.26IleAsp: 3.26 ± 0.039	3.251IleGlu: 3.251 ± 0.045	1.258IlePhe: 1.258 ± 0.027	4.469IleGly: 4.469 ± 0.055	0.849IleHis: 0.849 ± 0.021	1.268IleIle: 1.268 ± 0.032	1.403IleLys: 1.403 ± 0.027	3.12IleLeu: 3.12 ± 0.045	0.686IleMet: 0.686 ± 0.021	1.276IleAsn: 1.276 ± 0.028	2.067IlePro: 2.067 ± 0.033	1.167IleGln: 1.167 ± 0.024	2.653IleArg: 2.653 ± 0.038	2.263IleSer: 2.263 ± 0.03	2.277IleThr: 2.277 ± 0.034	3.786IleVal: 3.786 ± 0.047	0.478IleTrp: 0.478 ± 0.017	0.941IleTyr: 0.941 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.061LysAla: 4.061 ± 0.06	0.151LysCys: 0.151 ± 0.009	1.609LysAsp: 1.609 ± 0.029	1.542LysGlu: 1.542 ± 0.037	0.921LysPhe: 0.921 ± 0.023	2.397LysGly: 2.397 ± 0.04	0.638LysHis: 0.638 ± 0.016	1.428LysIle: 1.428 ± 0.027	1.419LysLys: 1.419 ± 0.032	3.667LysLeu: 3.667 ± 0.055	0.738LysMet: 0.738 ± 0.023	0.898LysAsn: 0.898 ± 0.019	2.082LysPro: 2.082 ± 0.035	1.092LysGln: 1.092 ± 0.025	2.185LysArg: 2.185 ± 0.034	1.805LysSer: 1.805 ± 0.032	1.905LysThr: 1.905 ± 0.032	2.494LysVal: 2.494 ± 0.04	0.375LysTrp: 0.375 ± 0.013	0.659LysTyr: 0.659 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.477LeuAla: 15.477 ± 0.106	1.038LeuCys: 1.038 ± 0.026	5.749LeuAsp: 5.749 ± 0.061	5.159LeuGlu: 5.159 ± 0.048	3.59LeuPhe: 3.59 ± 0.046	8.777LeuGly: 8.777 ± 0.073	2.416LeuHis: 2.416 ± 0.04	4.375LeuIle: 4.375 ± 0.052	3.463LeuLys: 3.463 ± 0.046	11.033LeuLeu: 11.033 ± 0.116	2.569LeuMet: 2.569 ± 0.036	2.533LeuAsn: 2.533 ± 0.036	6.055LeuPro: 6.055 ± 0.064	3.906LeuGln: 3.906 ± 0.048	7.893LeuArg: 7.893 ± 0.071	5.952LeuSer: 5.952 ± 0.051	5.013LeuThr: 5.013 ± 0.044	7.981LeuVal: 7.981 ± 0.068	1.313LeuTrp: 1.313 ± 0.03	1.966LeuTyr: 1.966 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.985MetAla: 2.985 ± 0.045	0.181MetCys: 0.181 ± 0.01	1.05MetAsp: 1.05 ± 0.026	1.018MetGlu: 1.018 ± 0.021	0.739MetPhe: 0.739 ± 0.019	1.787MetGly: 1.787 ± 0.028	0.562MetHis: 0.562 ± 0.018	0.944MetIle: 0.944 ± 0.023	1.083MetLys: 1.083 ± 0.027	2.702MetLeu: 2.702 ± 0.038	0.539MetMet: 0.539 ± 0.015	0.856MetAsn: 0.856 ± 0.021	1.57MetPro: 1.57 ± 0.03	1.054MetGln: 1.054 ± 0.023	1.861MetArg: 1.861 ± 0.028	1.63MetSer: 1.63 ± 0.029	1.633MetThr: 1.633 ± 0.029	1.719MetVal: 1.719 ± 0.028	0.209MetTrp: 0.209 ± 0.011	0.363MetTyr: 0.363 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.235AsnAla: 3.235 ± 0.041	0.255AsnCys: 0.255 ± 0.011	1.231AsnAsp: 1.231 ± 0.027	1.214AsnGlu: 1.214 ± 0.025	0.933AsnPhe: 0.933 ± 0.02	2.221AsnGly: 2.221 ± 0.042	0.489AsnHis: 0.489 ± 0.016	1.171AsnIle: 1.171 ± 0.026	0.788AsnLys: 0.788 ± 0.02	2.493AsnLeu: 2.493 ± 0.036	0.548AsnMet: 0.548 ± 0.018	0.707AsnAsn: 0.707 ± 0.025	1.775AsnPro: 1.775 ± 0.03	0.768AsnGln: 0.768 ± 0.019	1.553AsnArg: 1.553 ± 0.028	1.162AsnSer: 1.162 ± 0.027	1.342AsnThr: 1.342 ± 0.03	1.876AsnVal: 1.876 ± 0.031	0.395AsnTrp: 0.395 ± 0.013	0.642AsnTyr: 0.642 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.556ProAla: 7.556 ± 0.094	0.344ProCys: 0.344 ± 0.013	3.005ProAsp: 3.005 ± 0.038	3.422ProGlu: 3.422 ± 0.04	1.899ProPhe: 1.899 ± 0.03	4.76ProGly: 4.76 ± 0.051	1.168ProHis: 1.168 ± 0.024	2.078ProIle: 2.078 ± 0.032	1.604ProLys: 1.604 ± 0.03	5.278ProLeu: 5.278 ± 0.05	1.361ProMet: 1.361 ± 0.026	1.301ProAsn: 1.301 ± 0.029	2.87ProPro: 2.87 ± 0.05	2.03ProGln: 2.03 ± 0.03	3.19ProArg: 3.19 ± 0.043	2.963ProSer: 2.963 ± 0.048	2.633ProThr: 2.633 ± 0.043	4.38ProVal: 4.38 ± 0.051	0.818ProTrp: 0.818 ± 0.02	1.256ProTyr: 1.256 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.004GlnAla: 5.004 ± 0.057	0.292GlnCys: 0.292 ± 0.013	1.427GlnAsp: 1.427 ± 0.029	1.477GlnGlu: 1.477 ± 0.026	1.187GlnPhe: 1.187 ± 0.023	2.812GlnGly: 2.812 ± 0.038	0.837GlnHis: 0.837 ± 0.02	1.679GlnIle: 1.679 ± 0.031	1.102GlnLys: 1.102 ± 0.025	4.06GlnLeu: 4.06 ± 0.045	0.907GlnMet: 0.907 ± 0.02	0.793GlnAsn: 0.793 ± 0.021	2.134GlnPro: 2.134 ± 0.033	1.825GlnGln: 1.825 ± 0.05	3.265GlnArg: 3.265 ± 0.045	1.954GlnSer: 1.954 ± 0.03	1.745GlnThr: 1.745 ± 0.028	2.753GlnVal: 2.753 ± 0.038	0.613GlnTrp: 0.613 ± 0.019	0.689GlnTyr: 0.689 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.506ArgAla: 8.506 ± 0.073	0.654ArgCys: 0.654 ± 0.02	3.584ArgAsp: 3.584 ± 0.044	4.452ArgGlu: 4.452 ± 0.053	2.918ArgPhe: 2.918 ± 0.039	4.827ArgGly: 4.827 ± 0.047	1.863ArgHis: 1.863 ± 0.031	3.613ArgIle: 3.613 ± 0.044	2.148ArgLys: 2.148 ± 0.033	7.846ArgLeu: 7.846 ± 0.079	1.965ArgMet: 1.965 ± 0.028	1.776ArgAsn: 1.776 ± 0.029	3.374ArgPro: 3.374 ± 0.048	2.591ArgGln: 2.591 ± 0.035	5.426ArgArg: 5.426 ± 0.069	3.912ArgSer: 3.912 ± 0.035	3.413ArgThr: 3.413 ± 0.043	5.215ArgVal: 5.215 ± 0.056	1.222ArgTrp: 1.222 ± 0.022	1.755ArgTyr: 1.755 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.784SerAla: 6.784 ± 0.067	0.478SerCys: 0.478 ± 0.017	2.559SerAsp: 2.559 ± 0.039	2.598SerGlu: 2.598 ± 0.038	2.263SerPhe: 2.263 ± 0.035	5.191SerGly: 5.191 ± 0.059	1.153SerHis: 1.153 ± 0.022	2.443SerIle: 2.443 ± 0.034	1.585SerLys: 1.585 ± 0.031	5.586SerLeu: 5.586 ± 0.058	1.422SerMet: 1.422 ± 0.027	1.407SerAsn: 1.407 ± 0.03	3.017SerPro: 3.017 ± 0.042	1.778SerGln: 1.778 ± 0.031	3.556SerArg: 3.556 ± 0.04	3.181SerSer: 3.181 ± 0.053	2.988SerThr: 2.988 ± 0.045	4.008SerVal: 4.008 ± 0.048	0.757SerTrp: 0.757 ± 0.019	1.291SerTyr: 1.291 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.994ThrAla: 5.994 ± 0.063	0.388ThrCys: 0.388 ± 0.013	2.359ThrAsp: 2.359 ± 0.035	2.397ThrGlu: 2.397 ± 0.035	1.662ThrPhe: 1.662 ± 0.03	4.602ThrGly: 4.602 ± 0.06	1.199ThrHis: 1.199 ± 0.024	2.196ThrIle: 2.196 ± 0.037	1.231ThrLys: 1.231 ± 0.025	6.103ThrLeu: 6.103 ± 0.056	1.143ThrMet: 1.143 ± 0.024	1.143ThrAsn: 1.143 ± 0.029	3.497ThrPro: 3.497 ± 0.053	1.893ThrGln: 1.893 ± 0.028	3.435ThrArg: 3.435 ± 0.044	2.703ThrSer: 2.703 ± 0.039	2.766ThrThr: 2.766 ± 0.051	4.186ThrVal: 4.186 ± 0.049	0.67ThrTrp: 0.67 ± 0.018	0.96ThrTyr: 0.96 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	9.917ValAla: 9.917 ± 0.086	0.765ValCys: 0.765 ± 0.02	4.08ValAsp: 4.08 ± 0.051	4.187ValGlu: 4.187 ± 0.046	2.746ValPhe: 2.746 ± 0.04	5.693ValGly: 5.693 ± 0.057	1.654ValHis: 1.654 ± 0.028	3.431ValIle: 3.431 ± 0.042	2.44ValLys: 2.44 ± 0.043	8.471ValLeu: 8.471 ± 0.082	1.865ValMet: 1.865 ± 0.031	2.041ValAsn: 2.041 ± 0.036	4.34ValPro: 4.34 ± 0.044	2.754ValGln: 2.754 ± 0.036	5.336ValArg: 5.336 ± 0.057	4.079ValSer: 4.079 ± 0.049	3.904ValThr: 3.904 ± 0.044	6.483ValVal: 6.483 ± 0.07	0.977ValTrp: 0.977 ± 0.023	1.568ValTyr: 1.568 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.385TrpAla: 1.385 ± 0.027	0.166TrpCys: 0.166 ± 0.009	0.603TrpAsp: 0.603 ± 0.018	0.562TrpGlu: 0.562 ± 0.015	0.569TrpPhe: 0.569 ± 0.017	0.984TrpGly: 0.984 ± 0.021	0.385TrpHis: 0.385 ± 0.015	0.685TrpIle: 0.685 ± 0.017	0.481TrpLys: 0.481 ± 0.016	2.043TrpLeu: 2.043 ± 0.036	0.408TrpMet: 0.408 ± 0.012	0.42TrpAsn: 0.42 ± 0.014	0.75TrpPro: 0.75 ± 0.02	0.725TrpGln: 0.725 ± 0.02	1.262TrpArg: 1.262 ± 0.027	0.817TrpSer: 0.817 ± 0.022	0.723TrpThr: 0.723 ± 0.02	0.967TrpVal: 0.967 ± 0.021	0.267TrpTrp: 0.267 ± 0.012	0.301TrpTyr: 0.301 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.036	0.23TyrCys: 0.23 ± 0.01	1.184TyrAsp: 1.184 ± 0.025	1.152TyrGlu: 1.152 ± 0.025	0.923TyrPhe: 0.923 ± 0.022	2.014TyrGly: 2.014 ± 0.027	0.413TyrHis: 0.413 ± 0.014	0.78TyrIle: 0.78 ± 0.02	0.69TyrLys: 0.69 ± 0.02	2.281TyrLeu: 2.281 ± 0.035	0.43TyrMet: 0.43 ± 0.015	0.545TyrAsn: 0.545 ± 0.017	1.137TyrPro: 1.137 ± 0.022	0.714TyrGln: 0.714 ± 0.018	1.633TyrArg: 1.633 ± 0.028	1.095TyrSer: 1.095 ± 0.025	1.133TyrThr: 1.133 ± 0.025	1.666TyrVal: 1.666 ± 0.029	0.361TyrTrp: 0.361 ± 0.014	0.584TyrTyr: 0.584 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6678 proteins (2095554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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