Amino acid dipepetide frequency for Micromonospora narathiwatensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.421AlaAla: 23.421 ± 0.171	0.977AlaCys: 0.977 ± 0.023	8.82AlaAsp: 8.82 ± 0.073	8.664AlaGlu: 8.664 ± 0.091	3.254AlaPhe: 3.254 ± 0.051	15.025AlaGly: 15.025 ± 0.122	2.494AlaHis: 2.494 ± 0.039	3.766AlaIle: 3.766 ± 0.046	2.325AlaLys: 2.325 ± 0.048	14.685AlaLeu: 14.685 ± 0.124	2.332AlaMet: 2.332 ± 0.035	2.307AlaAsn: 2.307 ± 0.048	7.337AlaPro: 7.337 ± 0.09	3.511AlaGln: 3.511 ± 0.043	10.708AlaArg: 10.708 ± 0.091	5.385AlaSer: 5.385 ± 0.062	8.286AlaThr: 8.286 ± 0.094	13.05AlaVal: 13.05 ± 0.114	1.997AlaTrp: 1.997 ± 0.037	3.029AlaTyr: 3.029 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.014CysAla: 1.014 ± 0.022	0.101CysCys: 0.101 ± 0.007	0.49CysAsp: 0.49 ± 0.016	0.302CysGlu: 0.302 ± 0.014	0.199CysPhe: 0.199 ± 0.009	0.915CysGly: 0.915 ± 0.025	0.194CysHis: 0.194 ± 0.01	0.121CysIle: 0.121 ± 0.008	0.093CysLys: 0.093 ± 0.007	0.706CysLeu: 0.706 ± 0.02	0.096CysMet: 0.096 ± 0.007	0.14CysAsn: 0.14 ± 0.009	0.5CysPro: 0.5 ± 0.016	0.191CysGln: 0.191 ± 0.01	0.646CysArg: 0.646 ± 0.021	0.367CysSer: 0.367 ± 0.016	0.442CysThr: 0.442 ± 0.017	0.642CysVal: 0.642 ± 0.017	0.14CysTrp: 0.14 ± 0.008	0.18CysTyr: 0.18 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.593AspAla: 7.593 ± 0.073	0.393AspCys: 0.393 ± 0.013	3.628AspAsp: 3.628 ± 0.058	3.725AspGlu: 3.725 ± 0.056	1.434AspPhe: 1.434 ± 0.028	6.392AspGly: 6.392 ± 0.068	1.259AspHis: 1.259 ± 0.029	1.562AspIle: 1.562 ± 0.028	0.93AspLys: 0.93 ± 0.026	6.616AspLeu: 6.616 ± 0.067	0.665AspMet: 0.665 ± 0.019	0.981AspAsn: 0.981 ± 0.027	5.046AspPro: 5.046 ± 0.056	1.682AspGln: 1.682 ± 0.03	5.725AspArg: 5.725 ± 0.064	2.182AspSer: 2.182 ± 0.033	2.836AspThr: 2.836 ± 0.048	4.959AspVal: 4.959 ± 0.057	1.044AspTrp: 1.044 ± 0.024	1.11AspTyr: 1.11 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.423GluAla: 6.423 ± 0.071	0.33GluCys: 0.33 ± 0.014	2.031GluAsp: 2.031 ± 0.033	2.565GluGlu: 2.565 ± 0.048	1.421GluPhe: 1.421 ± 0.025	3.097GluGly: 3.097 ± 0.046	1.331GluHis: 1.331 ± 0.03	2.117GluIle: 2.117 ± 0.034	1.006GluLys: 1.006 ± 0.029	6.643GluLeu: 6.643 ± 0.078	0.773GluMet: 0.773 ± 0.019	0.834GluAsn: 0.834 ± 0.02	3.498GluPro: 3.498 ± 0.05	2.127GluGln: 2.127 ± 0.04	5.229GluArg: 5.229 ± 0.072	2.139GluSer: 2.139 ± 0.033	2.462GluThr: 2.462 ± 0.033	4.633GluVal: 4.633 ± 0.056	0.698GluTrp: 0.698 ± 0.018	1.01GluTyr: 1.01 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.696PheAla: 3.696 ± 0.044	0.231PheCys: 0.231 ± 0.011	1.909PheAsp: 1.909 ± 0.033	1.127PheGlu: 1.127 ± 0.027	0.843PhePhe: 0.843 ± 0.025	2.94PheGly: 2.94 ± 0.042	0.57PheHis: 0.57 ± 0.017	0.668PheIle: 0.668 ± 0.02	0.398PheLys: 0.398 ± 0.017	2.429PheLeu: 2.429 ± 0.037	0.311PheMet: 0.311 ± 0.013	0.572PheAsn: 0.572 ± 0.019	1.358PhePro: 1.358 ± 0.027	0.65PheGln: 0.65 ± 0.021	1.845PheArg: 1.845 ± 0.031	1.278PheSer: 1.278 ± 0.023	1.887PheThr: 1.887 ± 0.035	2.427PheVal: 2.427 ± 0.034	0.43PheTrp: 0.43 ± 0.016	0.586PheTyr: 0.586 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.888GlyAla: 10.888 ± 0.091	0.859GlyCys: 0.859 ± 0.024	5.199GlyAsp: 5.199 ± 0.052	4.715GlyGlu: 4.715 ± 0.06	2.787GlyPhe: 2.787 ± 0.042	8.987GlyGly: 8.987 ± 0.077	2.168GlyHis: 2.168 ± 0.037	3.021GlyIle: 3.021 ± 0.039	1.907GlyLys: 1.907 ± 0.044	9.7GlyLeu: 9.7 ± 0.081	1.891GlyMet: 1.891 ± 0.034	1.832GlyAsn: 1.832 ± 0.041	5.622GlyPro: 5.622 ± 0.076	2.922GlyGln: 2.922 ± 0.044	8.369GlyArg: 8.369 ± 0.074	4.819GlySer: 4.819 ± 0.06	5.881GlyThr: 5.881 ± 0.077	8.215GlyVal: 8.215 ± 0.073	1.979GlyTrp: 1.979 ± 0.04	2.521GlyTyr: 2.521 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.464HisAla: 2.464 ± 0.04	0.196HisCys: 0.196 ± 0.01	1.273HisAsp: 1.273 ± 0.027	1.026HisGlu: 1.026 ± 0.022	0.538HisPhe: 0.538 ± 0.018	2.159HisGly: 2.159 ± 0.034	0.611HisHis: 0.611 ± 0.022	0.517HisIle: 0.517 ± 0.018	0.253HisLys: 0.253 ± 0.012	2.463HisLeu: 2.463 ± 0.042	0.264HisMet: 0.264 ± 0.012	0.358HisAsn: 0.358 ± 0.014	1.813HisPro: 1.813 ± 0.04	0.636HisGln: 0.636 ± 0.02	2.142HisArg: 2.142 ± 0.039	0.828HisSer: 0.828 ± 0.022	1.168HisThr: 1.168 ± 0.039	1.617HisVal: 1.617 ± 0.028	0.365HisTrp: 0.365 ± 0.013	0.436HisTyr: 0.436 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.513IleAla: 4.513 ± 0.051	0.291IleCys: 0.291 ± 0.013	2.207IleAsp: 2.207 ± 0.039	1.892IleGlu: 1.892 ± 0.036	0.831IlePhe: 0.831 ± 0.024	3.364IleGly: 3.364 ± 0.043	0.564IleHis: 0.564 ± 0.018	0.912IleIle: 0.912 ± 0.023	0.631IleLys: 0.631 ± 0.021	2.342IleLeu: 2.342 ± 0.038	0.427IleMet: 0.427 ± 0.015	0.742IleAsn: 0.742 ± 0.022	1.603IlePro: 1.603 ± 0.031	0.661IleGln: 0.661 ± 0.019	2.428IleArg: 2.428 ± 0.039	1.565IleSer: 1.565 ± 0.03	2.052IleThr: 2.052 ± 0.031	2.716IleVal: 2.716 ± 0.041	0.427IleTrp: 0.427 ± 0.018	0.591IleTyr: 0.591 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.185LysAla: 2.185 ± 0.048	0.104LysCys: 0.104 ± 0.008	0.845LysAsp: 0.845 ± 0.027	0.789LysGlu: 0.789 ± 0.026	0.395LysPhe: 0.395 ± 0.016	1.29LysGly: 1.29 ± 0.032	0.319LysHis: 0.319 ± 0.013	0.779LysIle: 0.779 ± 0.024	0.513LysLys: 0.513 ± 0.023	1.785LysLeu: 1.785 ± 0.034	0.291LysMet: 0.291 ± 0.015	0.397LysAsn: 0.397 ± 0.02	1.139LysPro: 1.139 ± 0.029	0.604LysGln: 0.604 ± 0.017	1.226LysArg: 1.226 ± 0.03	0.838LysSer: 0.838 ± 0.025	1.017LysThr: 1.017 ± 0.028	1.595LysVal: 1.595 ± 0.036	0.227LysTrp: 0.227 ± 0.012	0.357LysTyr: 0.357 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	17.242LeuAla: 17.242 ± 0.129	0.747LeuCys: 0.747 ± 0.02	6.963LeuAsp: 6.963 ± 0.082	3.662LeuGlu: 3.662 ± 0.051	2.598LeuPhe: 2.598 ± 0.037	9.421LeuGly: 9.421 ± 0.08	2.284LeuHis: 2.284 ± 0.041	3.235LeuIle: 3.235 ± 0.045	1.437LeuLys: 1.437 ± 0.034	12.093LeuLeu: 12.093 ± 0.124	1.375LeuMet: 1.375 ± 0.025	1.699LeuAsn: 1.699 ± 0.03	6.969LeuPro: 6.969 ± 0.073	1.837LeuGln: 1.837 ± 0.032	9.474LeuArg: 9.474 ± 0.091	4.685LeuSer: 4.685 ± 0.056	7.035LeuThr: 7.035 ± 0.071	10.041LeuVal: 10.041 ± 0.087	1.299LeuTrp: 1.299 ± 0.024	1.723LeuTyr: 1.723 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.043MetAla: 2.043 ± 0.033	0.097MetCys: 0.097 ± 0.007	0.688MetAsp: 0.688 ± 0.016	0.559MetGlu: 0.559 ± 0.019	0.462MetPhe: 0.462 ± 0.015	1.096MetGly: 1.096 ± 0.023	0.274MetHis: 0.274 ± 0.014	0.625MetIle: 0.625 ± 0.02	0.313MetLys: 0.313 ± 0.013	1.674MetLeu: 1.674 ± 0.034	0.259MetMet: 0.259 ± 0.013	0.352MetAsn: 0.352 ± 0.013	1.035MetPro: 1.035 ± 0.025	0.376MetGln: 0.376 ± 0.015	1.383MetArg: 1.383 ± 0.026	1.155MetSer: 1.155 ± 0.026	1.501MetThr: 1.501 ± 0.03	1.232MetVal: 1.232 ± 0.028	0.183MetTrp: 0.183 ± 0.01	0.269MetTyr: 0.269 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.253AsnAla: 2.253 ± 0.043	0.168AsnCys: 0.168 ± 0.009	0.969AsnAsp: 0.969 ± 0.026	0.751AsnGlu: 0.751 ± 0.021	0.498AsnPhe: 0.498 ± 0.019	1.963AsnGly: 1.963 ± 0.048	0.399AsnHis: 0.399 ± 0.016	0.604AsnIle: 0.604 ± 0.018	0.354AsnLys: 0.354 ± 0.015	1.871AsnLeu: 1.871 ± 0.034	0.269AsnMet: 0.269 ± 0.012	0.506AsnAsn: 0.506 ± 0.024	1.525AsnPro: 1.525 ± 0.032	0.585AsnGln: 0.585 ± 0.018	1.412AsnArg: 1.412 ± 0.028	0.912AsnSer: 0.912 ± 0.027	1.098AsnThr: 1.098 ± 0.029	1.431AsnVal: 1.431 ± 0.03	0.331AsnTrp: 0.331 ± 0.013	0.47AsnTyr: 0.47 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	10.557ProAla: 10.557 ± 0.107	0.323ProCys: 0.323 ± 0.013	4.744ProAsp: 4.744 ± 0.053	3.944ProGlu: 3.944 ± 0.057	1.42ProPhe: 1.42 ± 0.03	6.828ProGly: 6.828 ± 0.081	1.232ProHis: 1.232 ± 0.029	1.597ProIle: 1.597 ± 0.027	1.013ProLys: 1.013 ± 0.029	5.432ProLeu: 5.432 ± 0.063	0.966ProMet: 0.966 ± 0.024	1.117ProAsn: 1.117 ± 0.026	4.487ProPro: 4.487 ± 0.096	1.537ProGln: 1.537 ± 0.032	4.204ProArg: 4.204 ± 0.045	3.031ProSer: 3.031 ± 0.046	4.095ProThr: 4.095 ± 0.061	6.153ProVal: 6.153 ± 0.074	0.97ProTrp: 0.97 ± 0.022	1.373ProTyr: 1.373 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.605GlnAla: 3.605 ± 0.052	0.147GlnCys: 0.147 ± 0.009	1.102GlnAsp: 1.102 ± 0.023	1.127GlnGlu: 1.127 ± 0.026	0.714GlnPhe: 0.714 ± 0.021	1.91GlnGly: 1.91 ± 0.033	0.609GlnHis: 0.609 ± 0.02	1.023GlnIle: 1.023 ± 0.026	0.445GlnLys: 0.445 ± 0.015	3.181GlnLeu: 3.181 ± 0.042	0.403GlnMet: 0.403 ± 0.015	0.506GlnAsn: 0.506 ± 0.02	1.978GlnPro: 1.978 ± 0.039	1.128GlnGln: 1.128 ± 0.03	2.717GlnArg: 2.717 ± 0.039	1.102GlnSer: 1.102 ± 0.023	1.33GlnThr: 1.33 ± 0.029	2.769GlnVal: 2.769 ± 0.043	0.463GlnTrp: 0.463 ± 0.016	0.526GlnTyr: 0.526 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.593ArgAla: 10.593 ± 0.09	0.649ArgCys: 0.649 ± 0.02	4.716ArgAsp: 4.716 ± 0.047	4.395ArgGlu: 4.395 ± 0.06	2.441ArgPhe: 2.441 ± 0.037	5.916ArgGly: 5.916 ± 0.062	2.232ArgHis: 2.232 ± 0.039	3.127ArgIle: 3.127 ± 0.046	1.325ArgLys: 1.325 ± 0.032	9.883ArgLeu: 9.883 ± 0.084	1.832ArgMet: 1.832 ± 0.03	1.437ArgAsn: 1.437 ± 0.028	5.769ArgPro: 5.769 ± 0.072	2.725ArgGln: 2.725 ± 0.035	9.299ArgArg: 9.299 ± 0.1	3.987ArgSer: 3.987 ± 0.052	4.965ArgThr: 4.965 ± 0.051	6.608ArgVal: 6.608 ± 0.068	1.764ArgTrp: 1.764 ± 0.033	2.137ArgTyr: 2.137 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.177SerAla: 6.177 ± 0.059	0.387SerCys: 0.387 ± 0.016	2.282SerAsp: 2.282 ± 0.036	1.801SerGlu: 1.801 ± 0.032	1.375SerPhe: 1.375 ± 0.027	5.342SerGly: 5.342 ± 0.054	0.839SerHis: 0.839 ± 0.02	1.474SerIle: 1.474 ± 0.029	0.767SerLys: 0.767 ± 0.022	4.143SerLeu: 4.143 ± 0.049	0.933SerMet: 0.933 ± 0.023	0.894SerAsn: 0.894 ± 0.023	3.091SerPro: 3.091 ± 0.049	1.091SerGln: 1.091 ± 0.027	3.628SerArg: 3.628 ± 0.046	2.46SerSer: 2.46 ± 0.046	3.028SerThr: 3.028 ± 0.043	3.943SerVal: 3.943 ± 0.048	0.911SerTrp: 0.911 ± 0.027	1.233SerTyr: 1.233 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.859ThrAla: 8.859 ± 0.089	0.439ThrCys: 0.439 ± 0.018	3.594ThrAsp: 3.594 ± 0.04	2.946ThrGlu: 2.946 ± 0.037	1.562ThrPhe: 1.562 ± 0.034	6.819ThrGly: 6.819 ± 0.074	1.07ThrHis: 1.07 ± 0.028	1.873ThrIle: 1.873 ± 0.034	0.97ThrLys: 0.97 ± 0.026	5.743ThrLeu: 5.743 ± 0.066	0.911ThrMet: 0.911 ± 0.021	1.138ThrAsn: 1.138 ± 0.033	4.357ThrPro: 4.357 ± 0.06	1.226ThrGln: 1.226 ± 0.027	4.214ThrArg: 4.214 ± 0.052	2.926ThrSer: 2.926 ± 0.046	3.899ThrThr: 3.899 ± 0.072	6.467ThrVal: 6.467 ± 0.071	0.961ThrTrp: 0.961 ± 0.024	1.325ThrTyr: 1.325 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	13.014ValAla: 13.014 ± 0.102	0.692ValCys: 0.692 ± 0.022	5.981ValAsp: 5.981 ± 0.061	4.755ValGlu: 4.755 ± 0.054	2.272ValPhe: 2.272 ± 0.036	7.609ValGly: 7.609 ± 0.074	1.82ValHis: 1.82 ± 0.034	2.827ValIle: 2.827 ± 0.039	1.43ValLys: 1.43 ± 0.034	9.983ValLeu: 9.983 ± 0.092	1.106ValMet: 1.106 ± 0.024	1.731ValAsn: 1.731 ± 0.031	5.69ValPro: 5.69 ± 0.07	1.933ValGln: 1.933 ± 0.031	7.483ValArg: 7.483 ± 0.067	4.213ValSer: 4.213 ± 0.056	6.154ValThr: 6.154 ± 0.071	8.854ValVal: 8.854 ± 0.091	1.147ValTrp: 1.147 ± 0.024	1.511ValTyr: 1.511 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.75TrpAla: 1.75 ± 0.032	0.162TrpCys: 0.162 ± 0.01	0.762TrpAsp: 0.762 ± 0.023	0.627TrpGlu: 0.627 ± 0.019	0.518TrpPhe: 0.518 ± 0.017	1.007TrpGly: 1.007 ± 0.026	0.403TrpHis: 0.403 ± 0.016	0.54TrpIle: 0.54 ± 0.018	0.278TrpLys: 0.278 ± 0.013	2.063TrpLeu: 2.063 ± 0.033	0.271TrpMet: 0.271 ± 0.013	0.4TrpAsn: 0.4 ± 0.016	0.949TrpPro: 0.949 ± 0.024	0.66TrpGln: 0.66 ± 0.018	1.72TrpArg: 1.72 ± 0.028	1.037TrpSer: 1.037 ± 0.025	1.054TrpThr: 1.054 ± 0.03	1.125TrpVal: 1.125 ± 0.026	0.398TrpTrp: 0.398 ± 0.015	0.405TrpTyr: 0.405 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.084TyrAla: 3.084 ± 0.043	0.187TyrCys: 0.187 ± 0.01	1.555TyrAsp: 1.555 ± 0.041	0.996TyrGlu: 0.996 ± 0.023	0.593TyrPhe: 0.593 ± 0.017	2.201TyrGly: 2.201 ± 0.04	0.455TyrHis: 0.455 ± 0.016	0.371TyrIle: 0.371 ± 0.015	0.307TyrLys: 0.307 ± 0.014	2.384TyrLeu: 2.384 ± 0.035	0.199TyrMet: 0.199 ± 0.011	0.429TyrAsn: 0.429 ± 0.019	1.255TyrPro: 1.255 ± 0.029	0.704TyrGln: 0.704 ± 0.022	1.946TyrArg: 1.946 ± 0.029	0.889TyrSer: 0.889 ± 0.027	1.109TyrThr: 1.109 ± 0.031	1.729TyrVal: 1.729 ± 0.033	0.395TyrTrp: 0.395 ± 0.016	0.414TyrTyr: 0.414 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5762 proteins (1962101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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