Amino acid dipepetide frequency for Rhodococcus sp. WMMA185

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.085AlaAla: 17.085 ± 0.19
0.883AlaCys: 0.883 ± 0.031
7.649AlaAsp: 7.649 ± 0.093
7.791AlaGlu: 7.791 ± 0.088
3.497AlaPhe: 3.497 ± 0.054
10.915AlaGly: 10.915 ± 0.104
2.345AlaHis: 2.345 ± 0.044
5.259AlaIle: 5.259 ± 0.089
2.847AlaLys: 2.847 ± 0.066
12.582AlaLeu: 12.582 ± 0.133
2.535AlaMet: 2.535 ± 0.055
2.481AlaAsn: 2.481 ± 0.051
5.649AlaPro: 5.649 ± 0.076
3.584AlaGln: 3.584 ± 0.059
8.027AlaArg: 8.027 ± 0.105
6.525AlaSer: 6.525 ± 0.083
7.005AlaThr: 7.005 ± 0.083
11.223AlaVal: 11.223 ± 0.11
1.422AlaTrp: 1.422 ± 0.036
2.303AlaTyr: 2.303 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.94CysAla: 0.94 ± 0.027
0.086CysCys: 0.086 ± 0.009
0.496CysAsp: 0.496 ± 0.023
0.41CysGlu: 0.41 ± 0.017
0.261CysPhe: 0.261 ± 0.016
0.895CysGly: 0.895 ± 0.031
0.174CysHis: 0.174 ± 0.012
0.289CysIle: 0.289 ± 0.016
0.13CysLys: 0.13 ± 0.011
0.647CysLeu: 0.647 ± 0.024
0.114CysMet: 0.114 ± 0.01
0.168CysAsn: 0.168 ± 0.012
0.42CysPro: 0.42 ± 0.022
0.145CysGln: 0.145 ± 0.01
0.514CysArg: 0.514 ± 0.019
0.511CysSer: 0.511 ± 0.022
0.527CysThr: 0.527 ± 0.02
0.604CysVal: 0.604 ± 0.024
0.11CysTrp: 0.11 ± 0.01
0.139CysTyr: 0.139 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.297AspAla: 7.297 ± 0.085
0.428AspCys: 0.428 ± 0.022
3.819AspAsp: 3.819 ± 0.063
4.079AspGlu: 4.079 ± 0.064
1.881AspPhe: 1.881 ± 0.042
6.083AspGly: 6.083 ± 0.086
1.315AspHis: 1.315 ± 0.036
2.573AspIle: 2.573 ± 0.052
1.279AspLys: 1.279 ± 0.038
6.531AspLeu: 6.531 ± 0.105
0.934AspMet: 0.934 ± 0.028
1.283AspAsn: 1.283 ± 0.039
4.314AspPro: 4.314 ± 0.074
1.743AspGln: 1.743 ± 0.043
4.751AspArg: 4.751 ± 0.075
3.578AspSer: 3.578 ± 0.059
3.592AspThr: 3.592 ± 0.069
5.503AspVal: 5.503 ± 0.08
0.944AspTrp: 0.944 ± 0.028
1.279AspTyr: 1.279 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.359GluAla: 6.359 ± 0.076
0.391GluCys: 0.391 ± 0.019
2.899GluAsp: 2.899 ± 0.051
3.187GluGlu: 3.187 ± 0.058
1.96GluPhe: 1.96 ± 0.035
4.105GluGly: 4.105 ± 0.066
1.588GluHis: 1.588 ± 0.041
2.899GluIle: 2.899 ± 0.052
1.557GluLys: 1.557 ± 0.041
6.633GluLeu: 6.633 ± 0.103
1.107GluMet: 1.107 ± 0.031
1.438GluAsn: 1.438 ± 0.037
3.044GluPro: 3.044 ± 0.057
2.297GluGln: 2.297 ± 0.046
4.726GluArg: 4.726 ± 0.086
3.622GluSer: 3.622 ± 0.059
2.961GluThr: 2.961 ± 0.053
5.006GluVal: 5.006 ± 0.073
0.813GluTrp: 0.813 ± 0.026
1.194GluTyr: 1.194 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.023PheAla: 4.023 ± 0.063
0.283PheCys: 0.283 ± 0.016
2.578PheAsp: 2.578 ± 0.049
1.859PheGlu: 1.859 ± 0.042
1.008PhePhe: 1.008 ± 0.035
3.6PheGly: 3.6 ± 0.061
0.618PheHis: 0.618 ± 0.023
1.015PheIle: 1.015 ± 0.032
0.518PheLys: 0.518 ± 0.026
2.598PheLeu: 2.598 ± 0.048
0.456PheMet: 0.456 ± 0.02
0.689PheAsn: 0.689 ± 0.025
1.447PhePro: 1.447 ± 0.039
0.713PheGln: 0.713 ± 0.03
1.786PheArg: 1.786 ± 0.038
1.829PheSer: 1.829 ± 0.041
2.061PheThr: 2.061 ± 0.045
2.787PheVal: 2.787 ± 0.045
0.395PheTrp: 0.395 ± 0.017
0.656PheTyr: 0.656 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.955GlyAla: 9.955 ± 0.118
0.724GlyCys: 0.724 ± 0.026
5.216GlyAsp: 5.216 ± 0.07
4.891GlyGlu: 4.891 ± 0.065
3.171GlyPhe: 3.171 ± 0.056
7.93GlyGly: 7.93 ± 0.105
1.941GlyHis: 1.941 ± 0.04
4.66GlyIle: 4.66 ± 0.066
2.518GlyLys: 2.518 ± 0.052
8.548GlyLeu: 8.548 ± 0.09
2.084GlyMet: 2.084 ± 0.04
2.148GlyAsn: 2.148 ± 0.045
4.269GlyPro: 4.269 ± 0.069
2.53GlyGln: 2.53 ± 0.055
6.218GlyArg: 6.218 ± 0.082
6.32GlySer: 6.32 ± 0.093
5.69GlyThr: 5.69 ± 0.088
7.902GlyVal: 7.902 ± 0.093
1.537GlyTrp: 1.537 ± 0.04
2.271GlyTyr: 2.271 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.319HisAla: 2.319 ± 0.051
0.22HisCys: 0.22 ± 0.014
1.253HisAsp: 1.253 ± 0.038
1.156HisGlu: 1.156 ± 0.035
0.64HisPhe: 0.64 ± 0.021
1.958HisGly: 1.958 ± 0.044
0.668HisHis: 0.668 ± 0.03
0.795HisIle: 0.795 ± 0.022
0.337HisLys: 0.337 ± 0.019
2.05HisLeu: 2.05 ± 0.04
0.337HisMet: 0.337 ± 0.02
0.45HisAsn: 0.45 ± 0.021
1.507HisPro: 1.507 ± 0.036
0.625HisGln: 0.625 ± 0.024
1.721HisArg: 1.721 ± 0.038
1.202HisSer: 1.202 ± 0.036
1.163HisThr: 1.163 ± 0.031
1.632HisVal: 1.632 ± 0.031
0.299HisTrp: 0.299 ± 0.017
0.471HisTyr: 0.471 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.341IleAla: 6.341 ± 0.092
0.367IleCys: 0.367 ± 0.018
3.665IleAsp: 3.665 ± 0.073
2.905IleGlu: 2.905 ± 0.053
1.141IlePhe: 1.141 ± 0.034
4.826IleGly: 4.826 ± 0.075
0.768IleHis: 0.768 ± 0.029
1.517IleIle: 1.517 ± 0.046
0.838IleLys: 0.838 ± 0.03
3.582IleLeu: 3.582 ± 0.057
0.627IleMet: 0.627 ± 0.022
1.049IleAsn: 1.049 ± 0.03
2.592IlePro: 2.592 ± 0.045
0.878IleGln: 0.878 ± 0.027
2.726IleArg: 2.726 ± 0.044
2.582IleSer: 2.582 ± 0.047
2.89IleThr: 2.89 ± 0.059
3.94IleVal: 3.94 ± 0.063
0.428IleTrp: 0.428 ± 0.018
0.806IleTyr: 0.806 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
2.583LysAla: 2.583 ± 0.061
0.131LysCys: 0.131 ± 0.01
1.084LysAsp: 1.084 ± 0.035
1.058LysGlu: 1.058 ± 0.035
0.681LysPhe: 0.681 ± 0.026
1.658LysGly: 1.658 ± 0.046
0.471LysHis: 0.471 ± 0.02
1.19LysIle: 1.19 ± 0.034
0.773LysLys: 0.773 ± 0.036
2.127LysLeu: 2.127 ± 0.048
0.487LysMet: 0.487 ± 0.023
0.6LysAsn: 0.6 ± 0.025
1.297LysPro: 1.297 ± 0.034
0.709LysGln: 0.709 ± 0.026
1.487LysArg: 1.487 ± 0.042
1.464LysSer: 1.464 ± 0.042
1.346LysThr: 1.346 ± 0.033
2.022LysVal: 2.022 ± 0.049
0.316LysTrp: 0.316 ± 0.014
0.519LysTyr: 0.519 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.079LeuAla: 13.079 ± 0.147
0.754LeuCys: 0.754 ± 0.027
7.072LeuAsp: 7.072 ± 0.136
5.353LeuGlu: 5.353 ± 0.074
2.855LeuPhe: 2.855 ± 0.054
9.185LeuGly: 9.185 ± 0.095
1.932LeuHis: 1.932 ± 0.043
3.997LeuIle: 3.997 ± 0.069
1.566LeuLys: 1.566 ± 0.038
9.399LeuLeu: 9.399 ± 0.11
1.694LeuMet: 1.694 ± 0.04
1.871LeuAsn: 1.871 ± 0.041
5.627LeuPro: 5.627 ± 0.076
2.34LeuGln: 2.34 ± 0.047
7.205LeuArg: 7.205 ± 0.095
6.15LeuSer: 6.15 ± 0.074
6.207LeuThr: 6.207 ± 0.07
8.846LeuVal: 8.846 ± 0.098
1.157LeuTrp: 1.157 ± 0.033
1.618LeuTyr: 1.618 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.269MetAla: 2.269 ± 0.047
0.174MetCys: 0.174 ± 0.012
0.858MetAsp: 0.858 ± 0.027
0.733MetGlu: 0.733 ± 0.028
0.659MetPhe: 0.659 ± 0.026
1.488MetGly: 1.488 ± 0.043
0.388MetHis: 0.388 ± 0.02
0.955MetIle: 0.955 ± 0.029
0.509MetLys: 0.509 ± 0.02
2.052MetLeu: 2.052 ± 0.039
0.398MetMet: 0.398 ± 0.023
0.513MetAsn: 0.513 ± 0.021
1.146MetPro: 1.146 ± 0.033
0.572MetGln: 0.572 ± 0.024
1.42MetArg: 1.42 ± 0.034
1.565MetSer: 1.565 ± 0.036
1.601MetThr: 1.601 ± 0.034
1.712MetVal: 1.712 ± 0.041
0.266MetTrp: 0.266 ± 0.015
0.355MetTyr: 0.355 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.58AsnAla: 2.58 ± 0.05
0.171AsnCys: 0.171 ± 0.011
1.154AsnAsp: 1.154 ± 0.032
1.086AsnGlu: 1.086 ± 0.031
0.717AsnPhe: 0.717 ± 0.025
2.113AsnGly: 2.113 ± 0.054
0.494AsnHis: 0.494 ± 0.02
1.016AsnIle: 1.016 ± 0.029
0.497AsnLys: 0.497 ± 0.019
2.159AsnLeu: 2.159 ± 0.046
0.456AsnMet: 0.456 ± 0.022
0.561AsnAsn: 0.561 ± 0.026
1.8AsnPro: 1.8 ± 0.035
0.634AsnGln: 0.634 ± 0.025
1.514AsnArg: 1.514 ± 0.036
1.38AsnSer: 1.38 ± 0.035
1.497AsnThr: 1.497 ± 0.042
1.813AsnVal: 1.813 ± 0.041
0.352AsnTrp: 0.352 ± 0.019
0.57AsnTyr: 0.57 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.205ProAla: 6.205 ± 0.088
0.288ProCys: 0.288 ± 0.016
4.413ProAsp: 4.413 ± 0.062
3.996ProGlu: 3.996 ± 0.065
1.614ProPhe: 1.614 ± 0.037
5.326ProGly: 5.326 ± 0.067
1.067ProHis: 1.067 ± 0.034
2.291ProIle: 2.291 ± 0.043
1.193ProLys: 1.193 ± 0.032
4.645ProLeu: 4.645 ± 0.078
1.103ProMet: 1.103 ± 0.027
1.312ProAsn: 1.312 ± 0.038
2.778ProPro: 2.778 ± 0.068
1.588ProGln: 1.588 ± 0.036
3.113ProArg: 3.113 ± 0.057
3.393ProSer: 3.393 ± 0.058
3.549ProThr: 3.549 ± 0.05
5.149ProVal: 5.149 ± 0.098
0.756ProTrp: 0.756 ± 0.029
1.13ProTyr: 1.13 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.161GlnAla: 3.161 ± 0.055
0.196GlnCys: 0.196 ± 0.013
1.269GlnAsp: 1.269 ± 0.03
1.268GlnGlu: 1.268 ± 0.034
0.922GlnPhe: 0.922 ± 0.028
1.964GlnGly: 1.964 ± 0.049
0.58GlnHis: 0.58 ± 0.02
1.531GlnIle: 1.531 ± 0.038
0.669GlnLys: 0.669 ± 0.029
3.243GlnLeu: 3.243 ± 0.053
0.611GlnMet: 0.611 ± 0.026
0.668GlnAsn: 0.668 ± 0.027
1.468GlnPro: 1.468 ± 0.039
1.192GlnGln: 1.192 ± 0.043
2.235GlnArg: 2.235 ± 0.049
1.656GlnSer: 1.656 ± 0.038
1.452GlnThr: 1.452 ± 0.037
2.693GlnVal: 2.693 ± 0.05
0.508GlnTrp: 0.508 ± 0.018
0.63GlnTyr: 0.63 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.627ArgAla: 7.627 ± 0.083
0.586ArgCys: 0.586 ± 0.023
4.012ArgAsp: 4.012 ± 0.052
4.215ArgGlu: 4.215 ± 0.059
2.334ArgPhe: 2.334 ± 0.038
5.24ArgGly: 5.24 ± 0.071
1.571ArgHis: 1.571 ± 0.035
3.526ArgIle: 3.526 ± 0.054
1.794ArgLys: 1.794 ± 0.042
6.877ArgLeu: 6.877 ± 0.111
1.741ArgMet: 1.741 ± 0.04
1.643ArgAsn: 1.643 ± 0.039
3.628ArgPro: 3.628 ± 0.059
2.047ArgGln: 2.047 ± 0.044
5.918ArgArg: 5.918 ± 0.109
4.354ArgSer: 4.354 ± 0.065
4.374ArgThr: 4.374 ± 0.065
5.65ArgVal: 5.65 ± 0.085
1.145ArgTrp: 1.145 ± 0.037
1.726ArgTyr: 1.726 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
7.43SerAla: 7.43 ± 0.076
0.419SerCys: 0.419 ± 0.019
3.846SerAsp: 3.846 ± 0.06
3.395SerGlu: 3.395 ± 0.056
1.843SerPhe: 1.843 ± 0.039
6.509SerGly: 6.509 ± 0.075
1.103SerHis: 1.103 ± 0.03
2.641SerIle: 2.641 ± 0.046
1.33SerLys: 1.33 ± 0.038
5.547SerLeu: 5.547 ± 0.068
1.531SerMet: 1.531 ± 0.034
1.361SerAsn: 1.361 ± 0.032
3.362SerPro: 3.362 ± 0.054
1.55SerGln: 1.55 ± 0.041
4.204SerArg: 4.204 ± 0.067
4.026SerSer: 4.026 ± 0.071
3.834SerThr: 3.834 ± 0.053
5.583SerVal: 5.583 ± 0.08
0.911SerTrp: 0.911 ± 0.031
1.261SerTyr: 1.261 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
7.439ThrAla: 7.439 ± 0.088
0.414ThrCys: 0.414 ± 0.024
3.828ThrAsp: 3.828 ± 0.059
3.465ThrGlu: 3.465 ± 0.053
1.877ThrPhe: 1.877 ± 0.046
5.934ThrGly: 5.934 ± 0.07
1.222ThrHis: 1.222 ± 0.032
2.736ThrIle: 2.736 ± 0.061
1.273ThrLys: 1.273 ± 0.041
5.741ThrLeu: 5.741 ± 0.074
1.145ThrMet: 1.145 ± 0.029
1.455ThrAsn: 1.455 ± 0.048
3.839ThrPro: 3.839 ± 0.066
1.431ThrGln: 1.431 ± 0.032
3.762ThrArg: 3.762 ± 0.057
3.66ThrSer: 3.66 ± 0.058
3.975ThrThr: 3.975 ± 0.08
6.416ThrVal: 6.416 ± 0.091
0.784ThrTrp: 0.784 ± 0.026
1.314ThrTyr: 1.314 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
11.273ValAla: 11.273 ± 0.128
0.757ValCys: 0.757 ± 0.022
6.082ValAsp: 6.082 ± 0.077
5.15ValGlu: 5.15 ± 0.073
2.64ValPhe: 2.64 ± 0.05
7.774ValGly: 7.774 ± 0.104
1.843ValHis: 1.843 ± 0.046
4.211ValIle: 4.211 ± 0.071
1.676ValLys: 1.676 ± 0.043
9.18ValLeu: 9.18 ± 0.106
1.594ValMet: 1.594 ± 0.037
2.003ValAsn: 2.003 ± 0.046
4.928ValPro: 4.928 ± 0.083
2.227ValGln: 2.227 ± 0.044
5.986ValArg: 5.986 ± 0.087
5.574ValSer: 5.574 ± 0.071
5.909ValThr: 5.909 ± 0.073
8.909ValVal: 8.909 ± 0.13
1.041ValTrp: 1.041 ± 0.033
1.569ValTyr: 1.569 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.434TrpAla: 1.434 ± 0.039
0.138TrpCys: 0.138 ± 0.011
0.714TrpAsp: 0.714 ± 0.027
0.634TrpGlu: 0.634 ± 0.025
0.505TrpPhe: 0.505 ± 0.023
1.047TrpGly: 1.047 ± 0.031
0.303TrpHis: 0.303 ± 0.016
0.667TrpIle: 0.667 ± 0.024
0.345TrpLys: 0.345 ± 0.018
1.481TrpLeu: 1.481 ± 0.038
0.354TrpMet: 0.354 ± 0.018
0.408TrpAsn: 0.408 ± 0.022
0.678TrpPro: 0.678 ± 0.021
0.496TrpGln: 0.496 ± 0.02
1.034TrpArg: 1.034 ± 0.034
0.992TrpSer: 0.992 ± 0.028
0.892TrpThr: 0.892 ± 0.028
1.097TrpVal: 1.097 ± 0.03
0.325TrpTrp: 0.325 ± 0.016
0.314TrpTyr: 0.314 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.206TyrAla: 2.206 ± 0.042
0.171TyrCys: 0.171 ± 0.011
1.297TyrAsp: 1.297 ± 0.041
1.157TyrGlu: 1.157 ± 0.032
0.711TyrPhe: 0.711 ± 0.029
1.973TyrGly: 1.973 ± 0.045
0.415TyrHis: 0.415 ± 0.019
0.702TyrIle: 0.702 ± 0.026
0.355TyrLys: 0.355 ± 0.017
2.284TyrLeu: 2.284 ± 0.045
0.322TyrMet: 0.322 ± 0.018
0.464TyrAsn: 0.464 ± 0.021
1.116TyrPro: 1.116 ± 0.032
0.617TyrGln: 0.617 ± 0.025
1.661TyrArg: 1.661 ± 0.04
1.302TyrSer: 1.302 ± 0.036
1.182TyrThr: 1.182 ± 0.034
1.842TyrVal: 1.842 ± 0.049
0.348TyrTrp: 0.348 ± 0.017
0.464TyrTyr: 0.464 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3688 proteins (1232631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski