Amino acid dipepetide frequency for Amycolatopsis acidicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.268AlaAla: 19.268 ± 0.132	1.033AlaCys: 1.033 ± 0.021	7.774AlaAsp: 7.774 ± 0.064	9.351AlaGlu: 9.351 ± 0.076	3.617AlaPhe: 3.617 ± 0.035	13.35AlaGly: 13.35 ± 0.073	2.457AlaHis: 2.457 ± 0.031	4.565AlaIle: 4.565 ± 0.042	3.312AlaLys: 3.312 ± 0.04	13.578AlaLeu: 13.578 ± 0.088	2.569AlaMet: 2.569 ± 0.032	2.385AlaAsn: 2.385 ± 0.028	5.953AlaPro: 5.953 ± 0.05	3.607AlaGln: 3.607 ± 0.041	9.753AlaArg: 9.753 ± 0.074	5.902AlaSer: 5.902 ± 0.053	6.794AlaThr: 6.794 ± 0.055	11.449AlaVal: 11.449 ± 0.073	1.726AlaTrp: 1.726 ± 0.024	2.313AlaTyr: 2.313 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.021CysAla: 1.021 ± 0.023	0.096CysCys: 0.096 ± 0.006	0.432CysAsp: 0.432 ± 0.014	0.422CysGlu: 0.422 ± 0.013	0.246CysPhe: 0.246 ± 0.01	0.906CysGly: 0.906 ± 0.025	0.179CysHis: 0.179 ± 0.008	0.197CysIle: 0.197 ± 0.01	0.104CysLys: 0.104 ± 0.007	0.729CysLeu: 0.729 ± 0.016	0.106CysMet: 0.106 ± 0.006	0.129CysAsn: 0.129 ± 0.006	0.447CysPro: 0.447 ± 0.014	0.183CysGln: 0.183 ± 0.009	0.559CysArg: 0.559 ± 0.016	0.409CysSer: 0.409 ± 0.013	0.492CysThr: 0.492 ± 0.015	0.656CysVal: 0.656 ± 0.017	0.123CysTrp: 0.123 ± 0.006	0.199CysTyr: 0.199 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.054AspAla: 7.054 ± 0.056	0.378AspCys: 0.378 ± 0.011	3.188AspAsp: 3.188 ± 0.036	4.288AspGlu: 4.288 ± 0.042	1.697AspPhe: 1.697 ± 0.028	5.756AspGly: 5.756 ± 0.063	1.242AspHis: 1.242 ± 0.023	1.978AspIle: 1.978 ± 0.024	1.244AspLys: 1.244 ± 0.023	6.004AspLeu: 6.004 ± 0.046	0.751AspMet: 0.751 ± 0.016	1.01AspAsn: 1.01 ± 0.022	4.11AspPro: 4.11 ± 0.036	1.611AspGln: 1.611 ± 0.03	4.229AspArg: 4.229 ± 0.041	2.626AspSer: 2.626 ± 0.035	2.825AspThr: 2.825 ± 0.035	5.015AspVal: 5.015 ± 0.046	0.948AspTrp: 0.948 ± 0.02	1.243AspTyr: 1.243 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.995GluAla: 6.995 ± 0.07	0.341GluCys: 0.341 ± 0.013	2.957GluAsp: 2.957 ± 0.038	3.474GluGlu: 3.474 ± 0.043	1.983GluPhe: 1.983 ± 0.027	3.913GluGly: 3.913 ± 0.042	1.748GluHis: 1.748 ± 0.031	2.788GluIle: 2.788 ± 0.033	1.561GluLys: 1.561 ± 0.029	7.978GluLeu: 7.978 ± 0.076	0.967GluMet: 0.967 ± 0.022	1.318GluAsn: 1.318 ± 0.025	3.536GluPro: 3.536 ± 0.045	2.437GluGln: 2.437 ± 0.034	5.336GluArg: 5.336 ± 0.053	2.803GluSer: 2.803 ± 0.031	3.137GluThr: 3.137 ± 0.034	5.008GluVal: 5.008 ± 0.047	0.843GluTrp: 0.843 ± 0.018	1.186GluTyr: 1.186 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.154PheAla: 4.154 ± 0.04	0.326PheCys: 0.326 ± 0.011	2.14PheAsp: 2.14 ± 0.026	1.658PheGlu: 1.658 ± 0.025	0.99PhePhe: 0.99 ± 0.021	3.664PheGly: 3.664 ± 0.036	0.675PheHis: 0.675 ± 0.015	0.78PheIle: 0.78 ± 0.017	0.466PheLys: 0.466 ± 0.014	2.92PheLeu: 2.92 ± 0.033	0.363PheMet: 0.363 ± 0.012	0.569PheAsn: 0.569 ± 0.015	1.57PhePro: 1.57 ± 0.024	0.686PheGln: 0.686 ± 0.016	1.97PheArg: 1.97 ± 0.031	1.741PheSer: 1.741 ± 0.026	2.094PheThr: 2.094 ± 0.027	2.686PheVal: 2.686 ± 0.031	0.412PheTrp: 0.412 ± 0.012	0.635PheTyr: 0.635 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.379GlyAla: 10.379 ± 0.071	0.755GlyCys: 0.755 ± 0.021	4.799GlyAsp: 4.799 ± 0.045	5.697GlyGlu: 5.697 ± 0.059	3.324GlyPhe: 3.324 ± 0.039	8.38GlyGly: 8.38 ± 0.076	2.092GlyHis: 2.092 ± 0.03	4.026GlyIle: 4.026 ± 0.039	2.813GlyLys: 2.813 ± 0.037	9.76GlyLeu: 9.76 ± 0.069	2.124GlyMet: 2.124 ± 0.031	1.952GlyAsn: 1.952 ± 0.031	4.538GlyPro: 4.538 ± 0.044	2.947GlyGln: 2.947 ± 0.04	7.065GlyArg: 7.065 ± 0.048	5.355GlySer: 5.355 ± 0.055	5.674GlyThr: 5.674 ± 0.048	7.982GlyVal: 7.982 ± 0.054	1.736GlyTrp: 1.736 ± 0.026	2.455GlyTyr: 2.455 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.519HisAla: 2.519 ± 0.029	0.204HisCys: 0.204 ± 0.009	1.252HisAsp: 1.252 ± 0.022	1.308HisGlu: 1.308 ± 0.024	0.655HisPhe: 0.655 ± 0.015	2.289HisGly: 2.289 ± 0.036	0.606HisHis: 0.606 ± 0.017	0.654HisIle: 0.654 ± 0.015	0.335HisLys: 0.335 ± 0.01	2.226HisLeu: 2.226 ± 0.031	0.281HisMet: 0.281 ± 0.011	0.43HisAsn: 0.43 ± 0.012	1.581HisPro: 1.581 ± 0.025	0.6HisGln: 0.6 ± 0.016	1.87HisArg: 1.87 ± 0.029	1.016HisSer: 1.016 ± 0.02	1.161HisThr: 1.161 ± 0.022	1.728HisVal: 1.728 ± 0.026	0.377HisTrp: 0.377 ± 0.012	0.523HisTyr: 0.523 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.559IleAla: 5.559 ± 0.046	0.319IleCys: 0.319 ± 0.011	2.426IleAsp: 2.426 ± 0.028	2.275IleGlu: 2.275 ± 0.032	0.917IlePhe: 0.917 ± 0.017	4.124IleGly: 4.124 ± 0.042	0.63IleHis: 0.63 ± 0.013	1.073IleIle: 1.073 ± 0.023	0.723IleLys: 0.723 ± 0.018	2.805IleLeu: 2.805 ± 0.032	0.491IleMet: 0.491 ± 0.013	0.764IleAsn: 0.764 ± 0.02	2.06IlePro: 2.06 ± 0.028	0.816IleGln: 0.816 ± 0.018	2.445IleArg: 2.445 ± 0.03	2.089IleSer: 2.089 ± 0.031	2.526IleThr: 2.526 ± 0.031	3.395IleVal: 3.395 ± 0.036	0.389IleTrp: 0.389 ± 0.011	0.626IleTyr: 0.626 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.883LysAla: 2.883 ± 0.036	0.099LysCys: 0.099 ± 0.007	1.137LysAsp: 1.137 ± 0.024	1.158LysGlu: 1.158 ± 0.02	0.599LysPhe: 0.599 ± 0.015	1.573LysGly: 1.573 ± 0.029	0.478LysHis: 0.478 ± 0.013	1.093LysIle: 1.093 ± 0.023	0.641LysLys: 0.641 ± 0.021	2.526LysLeu: 2.526 ± 0.032	0.429LysMet: 0.429 ± 0.012	0.478LysAsn: 0.478 ± 0.013	1.551LysPro: 1.551 ± 0.027	0.813LysGln: 0.813 ± 0.018	1.606LysArg: 1.606 ± 0.027	1.131LysSer: 1.131 ± 0.022	1.342LysThr: 1.342 ± 0.027	2.066LysVal: 2.066 ± 0.034	0.291LysTrp: 0.291 ± 0.01	0.469LysTyr: 0.469 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.629LeuAla: 15.629 ± 0.1	0.84LeuCys: 0.84 ± 0.022	6.788LeuAsp: 6.788 ± 0.051	5.133LeuGlu: 5.133 ± 0.045	2.863LeuPhe: 2.863 ± 0.039	10.087LeuGly: 10.087 ± 0.07	2.178LeuHis: 2.178 ± 0.031	3.631LeuIle: 3.631 ± 0.042	1.838LeuLys: 1.838 ± 0.031	10.874LeuLeu: 10.874 ± 0.086	1.526LeuMet: 1.526 ± 0.025	1.94LeuAsn: 1.94 ± 0.025	6.263LeuPro: 6.263 ± 0.045	2.203LeuGln: 2.203 ± 0.034	8.817LeuArg: 8.817 ± 0.084	5.96LeuSer: 5.96 ± 0.051	6.397LeuThr: 6.397 ± 0.052	9.52LeuVal: 9.52 ± 0.062	1.198LeuTrp: 1.198 ± 0.025	1.709LeuTyr: 1.709 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.181MetAla: 2.181 ± 0.029	0.13MetCys: 0.13 ± 0.007	0.819MetAsp: 0.819 ± 0.016	0.658MetGlu: 0.658 ± 0.016	0.498MetPhe: 0.498 ± 0.013	1.258MetGly: 1.258 ± 0.023	0.373MetHis: 0.373 ± 0.011	0.79MetIle: 0.79 ± 0.017	0.427MetLys: 0.427 ± 0.013	1.819MetLeu: 1.819 ± 0.033	0.297MetMet: 0.297 ± 0.01	0.443MetAsn: 0.443 ± 0.013	1.136MetPro: 1.136 ± 0.02	0.432MetGln: 0.432 ± 0.012	1.405MetArg: 1.405 ± 0.022	1.35MetSer: 1.35 ± 0.023	1.606MetThr: 1.606 ± 0.022	1.302MetVal: 1.302 ± 0.023	0.196MetTrp: 0.196 ± 0.008	0.273MetTyr: 0.273 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.509AsnAla: 2.509 ± 0.029	0.157AsnCys: 0.157 ± 0.008	0.98AsnAsp: 0.98 ± 0.02	0.962AsnGlu: 0.962 ± 0.02	0.59AsnPhe: 0.59 ± 0.016	1.997AsnGly: 1.997 ± 0.034	0.405AsnHis: 0.405 ± 0.012	0.714AsnIle: 0.714 ± 0.019	0.389AsnLys: 0.389 ± 0.012	2.072AsnLeu: 2.072 ± 0.031	0.31AsnMet: 0.31 ± 0.011	0.471AsnAsn: 0.471 ± 0.015	1.597AsnPro: 1.597 ± 0.022	0.609AsnGln: 0.609 ± 0.016	1.38AsnArg: 1.38 ± 0.023	1.066AsnSer: 1.066 ± 0.024	1.164AsnThr: 1.164 ± 0.022	1.588AsnVal: 1.588 ± 0.024	0.322AsnTrp: 0.322 ± 0.012	0.447AsnTyr: 0.447 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.785ProAla: 7.785 ± 0.065	0.305ProCys: 0.305 ± 0.011	3.984ProAsp: 3.984 ± 0.043	4.541ProGlu: 4.541 ± 0.052	1.622ProPhe: 1.622 ± 0.024	6.455ProGly: 6.455 ± 0.053	1.133ProHis: 1.133 ± 0.02	1.621ProIle: 1.621 ± 0.026	1.317ProLys: 1.317 ± 0.024	5.082ProLeu: 5.082 ± 0.042	1.036ProMet: 1.036 ± 0.024	1.017ProAsn: 1.017 ± 0.019	3.095ProPro: 3.095 ± 0.044	1.478ProGln: 1.478 ± 0.023	3.773ProArg: 3.773 ± 0.045	2.89ProSer: 2.89 ± 0.032	2.694ProThr: 2.694 ± 0.028	5.406ProVal: 5.406 ± 0.046	0.861ProTrp: 0.861 ± 0.017	1.157ProTyr: 1.157 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.788GlnAla: 3.788 ± 0.038	0.176GlnCys: 0.176 ± 0.008	1.26GlnAsp: 1.26 ± 0.023	1.307GlnGlu: 1.307 ± 0.024	0.812GlnPhe: 0.812 ± 0.018	2.216GlnGly: 2.216 ± 0.03	0.66GlnHis: 0.66 ± 0.016	1.138GlnIle: 1.138 ± 0.02	0.569GlnLys: 0.569 ± 0.016	3.451GlnLeu: 3.451 ± 0.038	0.441GlnMet: 0.441 ± 0.013	0.568GlnAsn: 0.568 ± 0.014	1.72GlnPro: 1.72 ± 0.028	1.366GlnGln: 1.366 ± 0.033	2.473GlnArg: 2.473 ± 0.032	1.332GlnSer: 1.332 ± 0.022	1.365GlnThr: 1.365 ± 0.025	2.545GlnVal: 2.545 ± 0.036	0.468GlnTrp: 0.468 ± 0.012	0.592GlnTyr: 0.592 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.383ArgAla: 9.383 ± 0.075	0.561ArgCys: 0.561 ± 0.014	4.087ArgAsp: 4.087 ± 0.047	5.136ArgGlu: 5.136 ± 0.05	2.54ArgPhe: 2.54 ± 0.033	5.661ArgGly: 5.661 ± 0.051	1.851ArgHis: 1.851 ± 0.027	3.214ArgIle: 3.214 ± 0.041	2.009ArgLys: 2.009 ± 0.028	8.274ArgLeu: 8.274 ± 0.068	1.768ArgMet: 1.768 ± 0.025	1.533ArgAsn: 1.533 ± 0.022	4.336ArgPro: 4.336 ± 0.043	2.363ArgGln: 2.363 ± 0.031	7.212ArgArg: 7.212 ± 0.061	3.735ArgSer: 3.735 ± 0.035	4.461ArgThr: 4.461 ± 0.046	5.946ArgVal: 5.946 ± 0.054	1.358ArgTrp: 1.358 ± 0.023	1.885ArgTyr: 1.885 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.794SerAla: 6.794 ± 0.06	0.431SerCys: 0.431 ± 0.014	2.628SerAsp: 2.628 ± 0.034	2.658SerGlu: 2.658 ± 0.029	1.716SerPhe: 1.716 ± 0.024	5.942SerGly: 5.942 ± 0.058	0.949SerHis: 0.949 ± 0.017	1.798SerIle: 1.798 ± 0.029	1.053SerLys: 1.053 ± 0.023	5.183SerLeu: 5.183 ± 0.04	1.195SerMet: 1.195 ± 0.021	0.915SerAsn: 0.915 ± 0.02	3.057SerPro: 3.057 ± 0.034	1.322SerGln: 1.322 ± 0.026	3.666SerArg: 3.666 ± 0.035	3.08SerSer: 3.08 ± 0.046	3.264SerThr: 3.264 ± 0.038	4.571SerVal: 4.571 ± 0.043	0.952SerTrp: 0.952 ± 0.02	1.238SerTyr: 1.238 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.571ThrAla: 7.571 ± 0.057	0.4ThrCys: 0.4 ± 0.015	3.27ThrAsp: 3.27 ± 0.039	3.523ThrGlu: 3.523 ± 0.039	1.757ThrPhe: 1.757 ± 0.024	6.45ThrGly: 6.45 ± 0.049	1.088ThrHis: 1.088 ± 0.02	2.133ThrIle: 2.133 ± 0.026	1.317ThrLys: 1.317 ± 0.022	5.521ThrLeu: 5.521 ± 0.048	1.002ThrMet: 1.002 ± 0.018	1.073ThrAsn: 1.073 ± 0.022	3.578ThrPro: 3.578 ± 0.038	1.35ThrGln: 1.35 ± 0.024	3.683ThrArg: 3.683 ± 0.042	3.154ThrSer: 3.154 ± 0.04	3.784ThrThr: 3.784 ± 0.058	5.789ThrVal: 5.789 ± 0.044	0.824ThrTrp: 0.824 ± 0.018	1.174ThrTyr: 1.174 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.275ValAla: 11.275 ± 0.073	0.75ValCys: 0.75 ± 0.019	5.23ValAsp: 5.23 ± 0.044	4.963ValGlu: 4.963 ± 0.041	2.786ValPhe: 2.786 ± 0.039	6.67ValGly: 6.67 ± 0.058	2.004ValHis: 2.004 ± 0.026	3.209ValIle: 3.209 ± 0.041	1.613ValLys: 1.613 ± 0.029	10.462ValLeu: 10.462 ± 0.071	1.253ValMet: 1.253 ± 0.025	1.941ValAsn: 1.941 ± 0.029	5.157ValPro: 5.157 ± 0.043	2.136ValGln: 2.136 ± 0.026	6.951ValArg: 6.951 ± 0.063	4.804ValSer: 4.804 ± 0.044	5.546ValThr: 5.546 ± 0.047	8.585ValVal: 8.585 ± 0.063	1.065ValTrp: 1.065 ± 0.018	1.51ValTyr: 1.51 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.604TrpAla: 1.604 ± 0.023	0.151TrpCys: 0.151 ± 0.008	0.709TrpAsp: 0.709 ± 0.017	0.67TrpGlu: 0.67 ± 0.015	0.564TrpPhe: 0.564 ± 0.015	1.055TrpGly: 1.055 ± 0.02	0.379TrpHis: 0.379 ± 0.014	0.573TrpIle: 0.573 ± 0.013	0.309TrpLys: 0.309 ± 0.01	1.843TrpLeu: 1.843 ± 0.026	0.278TrpMet: 0.278 ± 0.009	0.361TrpAsn: 0.361 ± 0.012	0.802TrpPro: 0.802 ± 0.016	0.63TrpGln: 0.63 ± 0.016	1.309TrpArg: 1.309 ± 0.024	0.891TrpSer: 0.891 ± 0.019	0.936TrpThr: 0.936 ± 0.021	1.041TrpVal: 1.041 ± 0.021	0.312TrpTrp: 0.312 ± 0.01	0.327TrpTyr: 0.327 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.407TyrAla: 2.407 ± 0.026	0.182TyrCys: 0.182 ± 0.007	1.334TyrAsp: 1.334 ± 0.028	1.13TyrGlu: 1.13 ± 0.02	0.724TyrPhe: 0.724 ± 0.019	2.107TyrGly: 2.107 ± 0.026	0.489TyrHis: 0.489 ± 0.013	0.476TyrIle: 0.476 ± 0.013	0.323TyrLys: 0.323 ± 0.012	2.288TyrLeu: 2.288 ± 0.03	0.206TyrMet: 0.206 ± 0.008	0.435TyrAsn: 0.435 ± 0.015	1.166TyrPro: 1.166 ± 0.022	0.656TyrGln: 0.656 ± 0.016	1.811TyrArg: 1.811 ± 0.03	1.08TyrSer: 1.08 ± 0.022	1.177TyrThr: 1.177 ± 0.023	1.629TyrVal: 1.629 ± 0.025	0.344TyrTrp: 0.344 ± 0.011	0.523TyrTyr: 0.523 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8848 proteins (2858604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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