Amino acid dipepetide frequency for Frog virus 3 (isolate Goorha) (FV-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.016AlaAla: 10.016 ± 1.055
1.587AlaCys: 1.587 ± 0.251
4.162AlaAsp: 4.162 ± 0.408
5.572AlaGlu: 5.572 ± 0.583
2.821AlaPhe: 2.821 ± 0.355
7.195AlaGly: 7.195 ± 0.663
1.763AlaHis: 1.763 ± 0.26
2.434AlaIle: 2.434 ± 0.33
4.444AlaLys: 4.444 ± 0.456
7.336AlaLeu: 7.336 ± 0.67
2.892AlaMet: 2.892 ± 0.299
1.693AlaAsn: 1.693 ± 0.257
4.338AlaPro: 4.338 ± 0.506
2.927AlaGln: 2.927 ± 0.418
5.22AlaArg: 5.22 ± 0.618
6.031AlaSer: 6.031 ± 0.581
4.056AlaThr: 4.056 ± 0.327
8.5AlaVal: 8.5 ± 0.616
1.305AlaTrp: 1.305 ± 0.269
2.575AlaTyr: 2.575 ± 0.283
0.0AlaXaa: 0.0 ± 0.0
Cys
1.799CysAla: 1.799 ± 0.251
0.67CysCys: 0.67 ± 0.168
1.305CysAsp: 1.305 ± 0.211
1.058CysGlu: 1.058 ± 0.192
0.529CysPhe: 0.529 ± 0.159
1.622CysGly: 1.622 ± 0.259
0.564CysHis: 0.564 ± 0.155
0.67CysIle: 0.67 ± 0.161
1.728CysLys: 1.728 ± 0.276
1.552CysLeu: 1.552 ± 0.306
0.635CysMet: 0.635 ± 0.135
0.67CysAsn: 0.67 ± 0.19
1.658CysPro: 1.658 ± 0.305
0.6CysGln: 0.6 ± 0.146
1.693CysArg: 1.693 ± 0.297
2.151CysSer: 2.151 ± 0.668
0.846CysThr: 0.846 ± 0.173
1.446CysVal: 1.446 ± 0.223
0.882CysTrp: 0.882 ± 0.463
0.635CysTyr: 0.635 ± 0.165
0.0CysXaa: 0.0 ± 0.0
Asp
5.114AspAla: 5.114 ± 0.468
1.34AspCys: 1.34 ± 0.199
3.492AspAsp: 3.492 ± 0.407
2.892AspGlu: 2.892 ± 0.371
1.693AspPhe: 1.693 ± 0.292
4.691AspGly: 4.691 ± 0.522
1.093AspHis: 1.093 ± 0.157
2.292AspIle: 2.292 ± 0.319
2.821AspLys: 2.821 ± 0.287
5.29AspLeu: 5.29 ± 0.476
2.187AspMet: 2.187 ± 0.286
2.046AspAsn: 2.046 ± 0.359
4.973AspPro: 4.973 ± 0.582
1.481AspGln: 1.481 ± 0.268
3.88AspArg: 3.88 ± 0.397
4.409AspSer: 4.409 ± 0.526
2.434AspThr: 2.434 ± 0.314
4.832AspVal: 4.832 ± 0.41
0.917AspTrp: 0.917 ± 0.212
2.257AspTyr: 2.257 ± 0.277
0.0AspXaa: 0.0 ± 0.0
Glu
5.89GluAla: 5.89 ± 0.414
1.234GluCys: 1.234 ± 0.283
3.703GluAsp: 3.703 ± 0.392
3.774GluGlu: 3.774 ± 0.705
1.799GluPhe: 1.799 ± 0.259
3.844GluGly: 3.844 ± 0.415
0.846GluHis: 0.846 ± 0.176
1.799GluIle: 1.799 ± 0.233
3.315GluLys: 3.315 ± 0.365
3.421GluLeu: 3.421 ± 0.416
2.222GluMet: 2.222 ± 0.316
0.952GluAsn: 0.952 ± 0.163
2.857GluPro: 2.857 ± 0.411
1.763GluGln: 1.763 ± 0.36
3.95GluArg: 3.95 ± 0.377
3.844GluSer: 3.844 ± 0.456
3.668GluThr: 3.668 ± 0.373
3.562GluVal: 3.562 ± 0.378
1.305GluTrp: 1.305 ± 0.192
1.94GluTyr: 1.94 ± 0.293
0.0GluXaa: 0.0 ± 0.0
Phe
2.751PheAla: 2.751 ± 0.36
0.741PheCys: 0.741 ± 0.16
1.481PheAsp: 1.481 ± 0.239
1.763PheGlu: 1.763 ± 0.239
1.058PhePhe: 1.058 ± 0.212
2.434PheGly: 2.434 ± 0.318
0.564PheHis: 0.564 ± 0.161
0.988PheIle: 0.988 ± 0.188
1.375PheLys: 1.375 ± 0.225
2.998PheLeu: 2.998 ± 0.278
0.917PheMet: 0.917 ± 0.159
1.234PheAsn: 1.234 ± 0.19
1.94PhePro: 1.94 ± 0.278
0.776PheGln: 0.776 ± 0.156
2.187PheArg: 2.187 ± 0.335
2.716PheSer: 2.716 ± 0.277
1.975PheThr: 1.975 ± 0.305
2.857PheVal: 2.857 ± 0.365
0.353PheTrp: 0.353 ± 0.116
1.023PheTyr: 1.023 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
6.101GlyAla: 6.101 ± 0.459
1.728GlyCys: 1.728 ± 0.299
4.162GlyAsp: 4.162 ± 0.46
3.315GlyGlu: 3.315 ± 0.321
2.751GlyPhe: 2.751 ± 0.31
5.784GlyGly: 5.784 ± 0.675
2.01GlyHis: 2.01 ± 0.355
2.292GlyIle: 2.292 ± 0.276
4.338GlyLys: 4.338 ± 0.421
5.89GlyLeu: 5.89 ± 0.477
2.046GlyMet: 2.046 ± 0.242
1.411GlyAsn: 1.411 ± 0.287
5.008GlyPro: 5.008 ± 0.646
2.046GlyGln: 2.046 ± 0.255
6.278GlyArg: 6.278 ± 0.763
5.89GlySer: 5.89 ± 0.394
4.585GlyThr: 4.585 ± 0.448
5.713GlyVal: 5.713 ± 0.515
1.517GlyTrp: 1.517 ± 0.337
2.469GlyTyr: 2.469 ± 0.289
0.0GlyXaa: 0.0 ± 0.0
His
1.658HisAla: 1.658 ± 0.194
0.423HisCys: 0.423 ± 0.131
1.058HisAsp: 1.058 ± 0.176
0.635HisGlu: 0.635 ± 0.17
0.494HisPhe: 0.494 ± 0.134
2.046HisGly: 2.046 ± 0.322
0.67HisHis: 0.67 ± 0.211
0.811HisIle: 0.811 ± 0.154
0.882HisLys: 0.882 ± 0.21
2.328HisLeu: 2.328 ± 0.332
0.6HisMet: 0.6 ± 0.13
0.741HisAsn: 0.741 ± 0.201
1.693HisPro: 1.693 ± 0.319
0.846HisGln: 0.846 ± 0.18
1.411HisArg: 1.411 ± 0.229
1.446HisSer: 1.446 ± 0.293
1.27HisThr: 1.27 ± 0.231
1.904HisVal: 1.904 ± 0.267
0.247HisTrp: 0.247 ± 0.091
0.846HisTyr: 0.846 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
2.292IleAla: 2.292 ± 0.33
0.635IleCys: 0.635 ± 0.144
2.01IleAsp: 2.01 ± 0.286
1.517IleGlu: 1.517 ± 0.242
1.023IlePhe: 1.023 ± 0.195
1.658IleGly: 1.658 ± 0.274
1.093IleHis: 1.093 ± 0.228
1.058IleIle: 1.058 ± 0.179
2.222IleLys: 2.222 ± 0.253
3.245IleLeu: 3.245 ± 0.341
1.129IleMet: 1.129 ± 0.176
0.988IleAsn: 0.988 ± 0.195
2.257IlePro: 2.257 ± 0.28
0.811IleGln: 0.811 ± 0.191
2.61IleArg: 2.61 ± 0.303
2.222IleSer: 2.222 ± 0.208
1.552IleThr: 1.552 ± 0.277
2.716IleVal: 2.716 ± 0.345
0.247IleTrp: 0.247 ± 0.098
0.988IleTyr: 0.988 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
4.479LysAla: 4.479 ± 0.544
0.846LysCys: 0.846 ± 0.185
2.927LysAsp: 2.927 ± 0.375
2.927LysGlu: 2.927 ± 0.332
1.481LysPhe: 1.481 ± 0.197
4.373LysGly: 4.373 ± 0.519
0.741LysHis: 0.741 ± 0.126
2.469LysIle: 2.469 ± 0.302
3.562LysLys: 3.562 ± 0.413
3.985LysLeu: 3.985 ± 0.424
1.975LysMet: 1.975 ± 0.217
1.728LysAsn: 1.728 ± 0.214
3.421LysPro: 3.421 ± 0.441
1.622LysGln: 1.622 ± 0.321
4.585LysArg: 4.585 ± 0.494
3.844LysSer: 3.844 ± 0.853
3.703LysThr: 3.703 ± 0.317
3.562LysVal: 3.562 ± 0.324
0.6LysTrp: 0.6 ± 0.167
1.869LysTyr: 1.869 ± 0.235
0.0LysXaa: 0.0 ± 0.0
Leu
6.736LeuAla: 6.736 ± 0.529
2.187LeuCys: 2.187 ± 0.421
5.255LeuAsp: 5.255 ± 0.419
5.255LeuGlu: 5.255 ± 0.474
2.786LeuPhe: 2.786 ± 0.294
5.819LeuGly: 5.819 ± 0.525
2.01LeuHis: 2.01 ± 0.389
2.68LeuIle: 2.68 ± 0.393
4.691LeuLys: 4.691 ± 0.358
6.454LeuLeu: 6.454 ± 0.639
2.222LeuMet: 2.222 ± 0.27
2.575LeuAsn: 2.575 ± 0.285
4.162LeuPro: 4.162 ± 0.487
1.622LeuGln: 1.622 ± 0.245
6.172LeuArg: 6.172 ± 0.549
5.89LeuSer: 5.89 ± 0.459
5.149LeuThr: 5.149 ± 0.418
5.572LeuVal: 5.572 ± 0.416
1.129LeuTrp: 1.129 ± 0.228
2.151LeuTyr: 2.151 ± 0.216
0.0LeuXaa: 0.0 ± 0.0
Met
3.068MetAla: 3.068 ± 0.433
0.776MetCys: 0.776 ± 0.198
2.046MetAsp: 2.046 ± 0.22
2.01MetGlu: 2.01 ± 0.23
1.129MetPhe: 1.129 ± 0.213
2.645MetGly: 2.645 ± 0.277
0.635MetHis: 0.635 ± 0.181
0.6MetIle: 0.6 ± 0.126
0.811MetLys: 0.811 ± 0.162
2.01MetLeu: 2.01 ± 0.258
0.811MetMet: 0.811 ± 0.2
0.353MetAsn: 0.353 ± 0.121
1.411MetPro: 1.411 ± 0.228
0.741MetGln: 0.741 ± 0.177
2.116MetArg: 2.116 ± 0.28
3.174MetSer: 3.174 ± 0.413
2.046MetThr: 2.046 ± 0.246
2.363MetVal: 2.363 ± 0.331
0.564MetTrp: 0.564 ± 0.162
0.776MetTyr: 0.776 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
2.292AsnAla: 2.292 ± 0.297
0.458AsnCys: 0.458 ± 0.126
0.952AsnAsp: 0.952 ± 0.186
0.882AsnGlu: 0.882 ± 0.15
0.635AsnPhe: 0.635 ± 0.127
1.799AsnGly: 1.799 ± 0.242
0.423AsnHis: 0.423 ± 0.153
1.199AsnIle: 1.199 ± 0.252
1.023AsnLys: 1.023 ± 0.161
2.716AsnLeu: 2.716 ± 0.385
0.988AsnMet: 0.988 ± 0.205
0.776AsnAsn: 0.776 ± 0.216
2.328AsnPro: 2.328 ± 0.464
0.705AsnGln: 0.705 ± 0.146
1.446AsnArg: 1.446 ± 0.244
1.799AsnSer: 1.799 ± 0.237
1.34AsnThr: 1.34 ± 0.316
2.892AsnVal: 2.892 ± 0.315
0.494AsnTrp: 0.494 ± 0.133
1.058AsnTyr: 1.058 ± 0.162
0.0AsnXaa: 0.0 ± 0.0
Pro
6.172ProAla: 6.172 ± 0.6
1.234ProCys: 1.234 ± 0.23
3.774ProAsp: 3.774 ± 0.335
4.655ProGlu: 4.655 ± 0.523
2.01ProPhe: 2.01 ± 0.277
4.655ProGly: 4.655 ± 0.535
1.869ProHis: 1.869 ± 0.275
1.869ProIle: 1.869 ± 0.279
3.35ProLys: 3.35 ± 0.529
4.338ProLeu: 4.338 ± 0.566
1.305ProMet: 1.305 ± 0.173
1.411ProAsn: 1.411 ± 0.259
4.409ProPro: 4.409 ± 0.614
2.046ProGln: 2.046 ± 0.352
3.95ProArg: 3.95 ± 0.564
4.973ProSer: 4.973 ± 0.614
3.068ProThr: 3.068 ± 0.451
6.56ProVal: 6.56 ± 0.671
1.164ProTrp: 1.164 ± 0.282
1.587ProTyr: 1.587 ± 0.214
0.0ProXaa: 0.0 ± 0.0
Gln
2.398GlnAla: 2.398 ± 0.325
0.882GlnCys: 0.882 ± 0.191
2.01GlnAsp: 2.01 ± 0.356
2.081GlnGlu: 2.081 ± 0.358
0.67GlnPhe: 0.67 ± 0.165
2.081GlnGly: 2.081 ± 0.303
0.635GlnHis: 0.635 ± 0.155
1.058GlnIle: 1.058 ± 0.161
1.411GlnLys: 1.411 ± 0.215
1.834GlnLeu: 1.834 ± 0.279
0.705GlnMet: 0.705 ± 0.184
0.741GlnAsn: 0.741 ± 0.16
1.869GlnPro: 1.869 ± 0.454
2.363GlnGln: 2.363 ± 1.073
2.187GlnArg: 2.187 ± 0.396
2.187GlnSer: 2.187 ± 0.278
1.869GlnThr: 1.869 ± 0.323
2.116GlnVal: 2.116 ± 0.295
0.317GlnTrp: 0.317 ± 0.118
0.67GlnTyr: 0.67 ± 0.149
0.0GlnXaa: 0.0 ± 0.0
Arg
5.22ArgAla: 5.22 ± 0.517
1.375ArgCys: 1.375 ± 0.255
4.973ArgAsp: 4.973 ± 0.511
4.303ArgGlu: 4.303 ± 0.343
2.046ArgPhe: 2.046 ± 0.295
5.643ArgGly: 5.643 ± 0.494
1.693ArgHis: 1.693 ± 0.256
1.94ArgIle: 1.94 ± 0.268
4.373ArgLys: 4.373 ± 0.815
5.819ArgLeu: 5.819 ± 0.454
2.046ArgMet: 2.046 ± 0.308
2.116ArgAsn: 2.116 ± 0.416
4.797ArgPro: 4.797 ± 0.544
2.363ArgGln: 2.363 ± 0.285
6.278ArgArg: 6.278 ± 0.623
3.915ArgSer: 3.915 ± 0.492
3.668ArgThr: 3.668 ± 0.451
5.749ArgVal: 5.749 ± 0.439
0.988ArgTrp: 0.988 ± 0.217
2.151ArgTyr: 2.151 ± 0.273
0.0ArgXaa: 0.0 ± 0.0
Ser
6.348SerAla: 6.348 ± 0.571
1.622SerCys: 1.622 ± 0.243
4.867SerAsp: 4.867 ± 0.374
3.703SerGlu: 3.703 ± 0.347
2.786SerPhe: 2.786 ± 0.31
5.608SerGly: 5.608 ± 0.371
1.763SerHis: 1.763 ± 0.315
2.187SerIle: 2.187 ± 0.233
3.562SerLys: 3.562 ± 0.505
6.348SerLeu: 6.348 ± 0.564
1.904SerMet: 1.904 ± 0.293
1.799SerAsn: 1.799 ± 0.237
5.572SerPro: 5.572 ± 1.233
2.01SerGln: 2.01 ± 0.295
4.267SerArg: 4.267 ± 0.472
5.361SerSer: 5.361 ± 0.48
3.033SerThr: 3.033 ± 0.307
6.348SerVal: 6.348 ± 0.603
1.693SerTrp: 1.693 ± 0.617
1.763SerTyr: 1.763 ± 0.234
0.0SerXaa: 0.0 ± 0.0
Thr
5.361ThrAla: 5.361 ± 0.527
1.199ThrCys: 1.199 ± 0.202
3.562ThrAsp: 3.562 ± 0.337
2.645ThrGlu: 2.645 ± 0.4
2.328ThrPhe: 2.328 ± 0.267
5.008ThrGly: 5.008 ± 0.506
0.529ThrHis: 0.529 ± 0.118
1.869ThrIle: 1.869 ± 0.216
2.434ThrLys: 2.434 ± 0.269
4.797ThrLeu: 4.797 ± 0.472
1.834ThrMet: 1.834 ± 0.24
1.023ThrAsn: 1.023 ± 0.173
3.985ThrPro: 3.985 ± 0.426
1.622ThrGln: 1.622 ± 0.248
3.386ThrArg: 3.386 ± 0.357
2.927ThrSer: 2.927 ± 0.368
2.151ThrThr: 2.151 ± 0.413
5.96ThrVal: 5.96 ± 0.463
0.494ThrTrp: 0.494 ± 0.167
1.27ThrTyr: 1.27 ± 0.256
0.0ThrXaa: 0.0 ± 0.0
Val
6.101ValAla: 6.101 ± 0.534
1.728ValCys: 1.728 ± 0.294
4.973ValAsp: 4.973 ± 0.421
4.267ValGlu: 4.267 ± 0.505
2.786ValPhe: 2.786 ± 0.328
4.973ValGly: 4.973 ± 0.605
2.398ValHis: 2.398 ± 0.373
2.222ValIle: 2.222 ± 0.261
5.819ValLys: 5.819 ± 0.517
6.736ValLeu: 6.736 ± 0.644
2.434ValMet: 2.434 ± 0.347
2.434ValAsn: 2.434 ± 0.286
4.973ValPro: 4.973 ± 0.654
2.504ValGln: 2.504 ± 0.276
7.054ValArg: 7.054 ± 0.719
6.56ValSer: 6.56 ± 0.541
4.902ValThr: 4.902 ± 0.512
6.701ValVal: 6.701 ± 0.625
1.34ValTrp: 1.34 ± 0.172
2.151ValTyr: 2.151 ± 0.246
0.0ValXaa: 0.0 ± 0.0
Trp
0.846TrpAla: 0.846 ± 0.275
1.34TrpCys: 1.34 ± 1.102
1.129TrpAsp: 1.129 ± 0.201
0.988TrpGlu: 0.988 ± 0.218
0.564TrpPhe: 0.564 ± 0.145
0.952TrpGly: 0.952 ± 0.198
0.353TrpHis: 0.353 ± 0.137
0.529TrpIle: 0.529 ± 0.144
0.846TrpLys: 0.846 ± 0.178
1.375TrpLeu: 1.375 ± 0.186
0.423TrpMet: 0.423 ± 0.115
0.67TrpAsn: 0.67 ± 0.165
0.705TrpPro: 0.705 ± 0.172
0.247TrpGln: 0.247 ± 0.092
1.058TrpArg: 1.058 ± 0.207
0.917TrpSer: 0.917 ± 0.165
1.517TrpThr: 1.517 ± 0.238
0.846TrpVal: 0.846 ± 0.192
0.176TrpTrp: 0.176 ± 0.088
0.458TrpTyr: 0.458 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.222TyrAla: 2.222 ± 0.347
0.705TyrCys: 0.705 ± 0.163
2.292TyrAsp: 2.292 ± 0.298
1.446TyrGlu: 1.446 ± 0.237
0.741TyrPhe: 0.741 ± 0.16
2.504TyrGly: 2.504 ± 0.302
0.353TyrHis: 0.353 ± 0.117
1.305TyrIle: 1.305 ± 0.254
1.693TyrLys: 1.693 ± 0.205
2.081TyrLeu: 2.081 ± 0.276
0.776TyrMet: 0.776 ± 0.145
0.846TyrAsn: 0.846 ± 0.203
2.046TyrPro: 2.046 ± 0.223
0.988TyrGln: 0.988 ± 0.187
1.728TyrArg: 1.728 ± 0.215
2.292TyrSer: 2.292 ± 0.297
1.552TyrThr: 1.552 ± 0.257
2.857TyrVal: 2.857 ± 0.286
0.212TyrTrp: 0.212 ± 0.095
0.846TyrTyr: 0.846 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 98 proteins (28355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski