Amino acid dipepetide frequency for Meira miltonrushii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.391AlaAla: 8.391 ± 0.073	0.935AlaCys: 0.935 ± 0.018	4.035AlaAsp: 4.035 ± 0.033	4.965AlaGlu: 4.965 ± 0.045	3.248AlaPhe: 3.248 ± 0.035	5.736AlaGly: 5.736 ± 0.051	1.801AlaHis: 1.801 ± 0.022	4.675AlaIle: 4.675 ± 0.038	4.98AlaLys: 4.98 ± 0.048	7.822AlaLeu: 7.822 ± 0.067	1.98AlaMet: 1.98 ± 0.024	3.847AlaAsn: 3.847 ± 0.036	4.217AlaPro: 4.217 ± 0.045	3.847AlaGln: 3.847 ± 0.041	5.033AlaArg: 5.033 ± 0.044	8.25AlaSer: 8.25 ± 0.059	4.937AlaThr: 4.937 ± 0.034	4.486AlaVal: 4.486 ± 0.036	1.03AlaTrp: 1.03 ± 0.016	2.164AlaTyr: 2.164 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.825CysAla: 0.825 ± 0.017	0.192CysCys: 0.192 ± 0.009	0.557CysAsp: 0.557 ± 0.014	0.494CysGlu: 0.494 ± 0.011	0.485CysPhe: 0.485 ± 0.013	0.734CysGly: 0.734 ± 0.015	0.259CysHis: 0.259 ± 0.01	0.664CysIle: 0.664 ± 0.013	0.544CysLys: 0.544 ± 0.013	1.073CysLeu: 1.073 ± 0.017	0.231CysMet: 0.231 ± 0.008	0.387CysAsn: 0.387 ± 0.011	0.507CysPro: 0.507 ± 0.014	0.399CysGln: 0.399 ± 0.011	0.545CysArg: 0.545 ± 0.015	0.803CysSer: 0.803 ± 0.017	0.611CysThr: 0.611 ± 0.012	0.656CysVal: 0.656 ± 0.016	0.141CysTrp: 0.141 ± 0.006	0.278CysTyr: 0.278 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.992AspAla: 4.992 ± 0.037	0.517AspCys: 0.517 ± 0.014	4.602AspAsp: 4.602 ± 0.058	5.122AspGlu: 5.122 ± 0.059	1.933AspPhe: 1.933 ± 0.027	4.034AspGly: 4.034 ± 0.037	1.264AspHis: 1.264 ± 0.021	2.66AspIle: 2.66 ± 0.03	2.515AspLys: 2.515 ± 0.032	4.895AspLeu: 4.895 ± 0.041	1.123AspMet: 1.123 ± 0.016	1.777AspAsn: 1.777 ± 0.025	2.854AspPro: 2.854 ± 0.028	2.441AspGln: 2.441 ± 0.027	3.021AspArg: 3.021 ± 0.032	4.132AspSer: 4.132 ± 0.042	2.627AspThr: 2.627 ± 0.03	3.713AspVal: 3.713 ± 0.032	0.797AspTrp: 0.797 ± 0.014	1.37AspTyr: 1.37 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.505GluAla: 5.505 ± 0.046	0.526GluCys: 0.526 ± 0.012	4.419GluAsp: 4.419 ± 0.051	6.643GluGlu: 6.643 ± 0.084	1.58GluPhe: 1.58 ± 0.02	4.009GluGly: 4.009 ± 0.037	1.337GluHis: 1.337 ± 0.021	2.825GluIle: 2.825 ± 0.033	4.233GluLys: 4.233 ± 0.049	4.713GluLeu: 4.713 ± 0.041	1.611GluMet: 1.611 ± 0.023	2.407GluAsn: 2.407 ± 0.026	2.182GluPro: 2.182 ± 0.025	3.133GluGln: 3.133 ± 0.034	4.287GluArg: 4.287 ± 0.039	4.649GluSer: 4.649 ± 0.043	2.975GluThr: 2.975 ± 0.028	3.297GluVal: 3.297 ± 0.032	0.777GluTrp: 0.777 ± 0.016	1.465GluTyr: 1.465 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.161PheAla: 3.161 ± 0.031	0.505PheCys: 0.505 ± 0.012	2.382PheAsp: 2.382 ± 0.029	2.048PheGlu: 2.048 ± 0.024	1.525PhePhe: 1.525 ± 0.025	2.876PheGly: 2.876 ± 0.039	0.818PheHis: 0.818 ± 0.017	1.81PheIle: 1.81 ± 0.027	1.553PheLys: 1.553 ± 0.021	3.188PheLeu: 3.188 ± 0.036	0.726PheMet: 0.726 ± 0.014	1.469PheAsn: 1.469 ± 0.021	1.55PhePro: 1.55 ± 0.019	1.219PheGln: 1.219 ± 0.019	1.695PheArg: 1.695 ± 0.02	3.001PheSer: 3.001 ± 0.028	2.05PheThr: 2.05 ± 0.024	2.33PheVal: 2.33 ± 0.029	0.528PheTrp: 0.528 ± 0.013	1.022PheTyr: 1.022 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.241GlyAla: 5.241 ± 0.051	0.688GlyCys: 0.688 ± 0.014	3.371GlyAsp: 3.371 ± 0.036	3.717GlyGlu: 3.717 ± 0.037	2.437GlyPhe: 2.437 ± 0.03	6.128GlyGly: 6.128 ± 0.092	1.597GlyHis: 1.597 ± 0.023	3.458GlyIle: 3.458 ± 0.033	4.293GlyLys: 4.293 ± 0.045	5.564GlyLeu: 5.564 ± 0.049	1.697GlyMet: 1.697 ± 0.024	2.974GlyAsn: 2.974 ± 0.036	2.892GlyPro: 2.892 ± 0.035	3.093GlyGln: 3.093 ± 0.033	3.815GlyArg: 3.815 ± 0.039	6.435GlySer: 6.435 ± 0.07	3.889GlyThr: 3.889 ± 0.035	3.7GlyVal: 3.7 ± 0.039	0.958GlyTrp: 0.958 ± 0.016	1.864GlyTyr: 1.864 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.922HisAla: 1.922 ± 0.022	0.285HisCys: 0.285 ± 0.009	1.259HisAsp: 1.259 ± 0.019	1.199HisGlu: 1.199 ± 0.019	0.94HisPhe: 0.94 ± 0.017	1.536HisGly: 1.536 ± 0.022	0.912HisHis: 0.912 ± 0.02	1.2HisIle: 1.2 ± 0.018	1.039HisLys: 1.039 ± 0.019	2.284HisLeu: 2.284 ± 0.025	0.459HisMet: 0.459 ± 0.011	0.869HisAsn: 0.869 ± 0.018	1.508HisPro: 1.508 ± 0.025	1.103HisGln: 1.103 ± 0.021	1.41HisArg: 1.41 ± 0.024	2.112HisSer: 2.112 ± 0.027	1.269HisThr: 1.269 ± 0.02	1.321HisVal: 1.321 ± 0.022	0.287HisTrp: 0.287 ± 0.009	0.63HisTyr: 0.63 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.488IleAla: 4.488 ± 0.044	0.703IleCys: 0.703 ± 0.013	3.117IleAsp: 3.117 ± 0.029	3.139IleGlu: 3.139 ± 0.028	1.949IlePhe: 1.949 ± 0.027	3.36IleGly: 3.36 ± 0.034	1.186IleHis: 1.186 ± 0.019	2.492IleIle: 2.492 ± 0.033	2.497IleLys: 2.497 ± 0.033	4.621IleLeu: 4.621 ± 0.045	0.983IleMet: 0.983 ± 0.016	1.995IleAsn: 1.995 ± 0.025	2.793IlePro: 2.793 ± 0.028	2.11IleGln: 2.11 ± 0.028	3.004IleArg: 3.004 ± 0.032	3.988IleSer: 3.988 ± 0.034	2.732IleThr: 2.732 ± 0.03	3.278IleVal: 3.278 ± 0.036	0.68IleTrp: 0.68 ± 0.014	1.224IleTyr: 1.224 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	5.031LysAla: 5.031 ± 0.053	0.459LysCys: 0.459 ± 0.013	3.267LysAsp: 3.267 ± 0.036	4.153LysGlu: 4.153 ± 0.048	1.366LysPhe: 1.366 ± 0.022	3.606LysGly: 3.606 ± 0.039	1.244LysHis: 1.244 ± 0.023	2.437LysIle: 2.437 ± 0.03	4.057LysLys: 4.057 ± 0.061	4.139LysLeu: 4.139 ± 0.038	1.282LysMet: 1.282 ± 0.02	2.062LysAsn: 2.062 ± 0.026	2.725LysPro: 2.725 ± 0.029	2.647LysGln: 2.647 ± 0.03	4.351LysArg: 4.351 ± 0.046	4.217LysSer: 4.217 ± 0.046	2.925LysThr: 2.925 ± 0.029	3.074LysVal: 3.074 ± 0.034	0.622LysTrp: 0.622 ± 0.013	1.319LysTyr: 1.319 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	7.693LeuAla: 7.693 ± 0.046	1.088LeuCys: 1.088 ± 0.019	4.898LeuAsp: 4.898 ± 0.043	4.913LeuGlu: 4.913 ± 0.041	3.317LeuPhe: 3.317 ± 0.041	5.361LeuGly: 5.361 ± 0.046	2.21LeuHis: 2.21 ± 0.031	4.231LeuIle: 4.231 ± 0.04	4.047LeuLys: 4.047 ± 0.04	8.1LeuLeu: 8.1 ± 0.075	1.808LeuMet: 1.808 ± 0.023	3.418LeuAsn: 3.418 ± 0.036	5.215LeuPro: 5.215 ± 0.043	4.251LeuGln: 4.251 ± 0.043	5.502LeuArg: 5.502 ± 0.045	7.501LeuSer: 7.501 ± 0.055	4.738LeuThr: 4.738 ± 0.044	4.637LeuVal: 4.637 ± 0.045	0.976LeuTrp: 0.976 ± 0.02	2.196LeuTyr: 2.196 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.06MetAla: 2.06 ± 0.023	0.219MetCys: 0.219 ± 0.008	1.2MetAsp: 1.2 ± 0.017	1.308MetGlu: 1.308 ± 0.019	0.687MetPhe: 0.687 ± 0.014	1.444MetGly: 1.444 ± 0.02	0.562MetHis: 0.562 ± 0.013	1.113MetIle: 1.113 ± 0.017	1.04MetLys: 1.04 ± 0.02	1.895MetLeu: 1.895 ± 0.023	0.681MetMet: 0.681 ± 0.016	0.98MetAsn: 0.98 ± 0.016	1.277MetPro: 1.277 ± 0.018	1.19MetGln: 1.19 ± 0.02	1.378MetArg: 1.378 ± 0.02	1.996MetSer: 1.996 ± 0.023	1.382MetThr: 1.382 ± 0.02	1.181MetVal: 1.181 ± 0.018	0.204MetTrp: 0.204 ± 0.008	0.513MetTyr: 0.513 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	4.171AsnAla: 4.171 ± 0.038	0.35AsnCys: 0.35 ± 0.01	2.503AsnAsp: 2.503 ± 0.023	2.629AsnGlu: 2.629 ± 0.032	1.355AsnPhe: 1.355 ± 0.022	3.675AsnGly: 3.675 ± 0.046	0.905AsnHis: 0.905 ± 0.018	1.924AsnIle: 1.924 ± 0.028	2.071AsnLys: 2.071 ± 0.027	3.38AsnLeu: 3.38 ± 0.031	0.889AsnMet: 0.889 ± 0.017	1.93AsnAsn: 1.93 ± 0.036	2.195AsnPro: 2.195 ± 0.023	1.697AsnGln: 1.697 ± 0.021	2.208AsnArg: 2.208 ± 0.024	3.37AsnSer: 3.37 ± 0.038	2.468AsnThr: 2.468 ± 0.028	2.786AsnVal: 2.786 ± 0.03	0.473AsnTrp: 0.473 ± 0.011	0.961AsnTyr: 0.961 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.427ProAla: 4.427 ± 0.046	0.403ProCys: 0.403 ± 0.012	2.516ProAsp: 2.516 ± 0.028	2.897ProGlu: 2.897 ± 0.029	2.073ProPhe: 2.073 ± 0.024	3.09ProGly: 3.09 ± 0.036	1.194ProHis: 1.194 ± 0.022	2.774ProIle: 2.774 ± 0.025	2.733ProLys: 2.733 ± 0.032	4.398ProLeu: 4.398 ± 0.036	1.052ProMet: 1.052 ± 0.019	2.374ProAsn: 2.374 ± 0.028	4.051ProPro: 4.051 ± 0.072	2.215ProGln: 2.215 ± 0.033	2.601ProArg: 2.601 ± 0.033	6.178ProSer: 6.178 ± 0.066	3.544ProThr: 3.544 ± 0.036	2.824ProVal: 2.824 ± 0.031	0.548ProTrp: 0.548 ± 0.01	1.316ProTyr: 1.316 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.044GlnAla: 4.044 ± 0.045	0.42GlnCys: 0.42 ± 0.011	2.407GlnAsp: 2.407 ± 0.025	2.752GlnGlu: 2.752 ± 0.031	1.358GlnPhe: 1.358 ± 0.019	2.705GlnGly: 2.705 ± 0.029	1.219GlnHis: 1.219 ± 0.018	2.208GlnIle: 2.208 ± 0.028	2.676GlnLys: 2.676 ± 0.032	3.615GlnLeu: 3.615 ± 0.036	1.117GlnMet: 1.117 ± 0.02	2.09GlnAsn: 2.09 ± 0.027	2.356GlnPro: 2.356 ± 0.033	3.386GlnGln: 3.386 ± 0.088	3.144GlnArg: 3.144 ± 0.028	4.415GlnSer: 4.415 ± 0.045	2.587GlnThr: 2.587 ± 0.028	2.195GlnVal: 2.195 ± 0.028	0.534GlnTrp: 0.534 ± 0.012	1.133GlnTyr: 1.133 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	4.707ArgAla: 4.707 ± 0.044	0.599ArgCys: 0.599 ± 0.014	3.027ArgAsp: 3.027 ± 0.036	3.715ArgGlu: 3.715 ± 0.037	2.125ArgPhe: 2.125 ± 0.026	3.439ArgGly: 3.439 ± 0.035	1.382ArgHis: 1.382 ± 0.018	3.197ArgIle: 3.197 ± 0.035	4.272ArgLys: 4.272 ± 0.042	5.351ArgLeu: 5.351 ± 0.048	1.448ArgMet: 1.448 ± 0.022	2.484ArgAsn: 2.484 ± 0.026	2.853ArgPro: 2.853 ± 0.037	2.976ArgGln: 2.976 ± 0.031	4.798ArgArg: 4.798 ± 0.05	5.583ArgSer: 5.583 ± 0.053	3.252ArgThr: 3.252 ± 0.034	2.827ArgVal: 2.827 ± 0.028	0.764ArgTrp: 0.764 ± 0.013	1.548ArgTyr: 1.548 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	7.517SerAla: 7.517 ± 0.057	0.73SerCys: 0.73 ± 0.017	4.514SerAsp: 4.514 ± 0.044	4.35SerGlu: 4.35 ± 0.044	3.2SerPhe: 3.2 ± 0.031	6.026SerGly: 6.026 ± 0.058	2.076SerHis: 2.076 ± 0.025	4.762SerIle: 4.762 ± 0.047	4.703SerLys: 4.703 ± 0.035	7.485SerLeu: 7.485 ± 0.053	2.018SerMet: 2.018 ± 0.025	4.409SerAsn: 4.409 ± 0.045	5.29SerPro: 5.29 ± 0.072	3.915SerGln: 3.915 ± 0.037	5.014SerArg: 5.014 ± 0.046	11.74SerSer: 11.74 ± 0.112	6.517SerThr: 6.517 ± 0.046	4.643SerVal: 4.643 ± 0.041	0.91SerTrp: 0.91 ± 0.015	1.956SerTyr: 1.956 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	4.731ThrAla: 4.731 ± 0.042	0.584ThrCys: 0.584 ± 0.015	2.691ThrAsp: 2.691 ± 0.029	2.866ThrGlu: 2.866 ± 0.028	2.345ThrPhe: 2.345 ± 0.027	3.812ThrGly: 3.812 ± 0.045	1.213ThrHis: 1.213 ± 0.018	3.145ThrIle: 3.145 ± 0.032	2.889ThrLys: 2.889 ± 0.031	5.205ThrLeu: 5.205 ± 0.042	1.21ThrMet: 1.21 ± 0.018	2.55ThrAsn: 2.55 ± 0.026	3.865ThrPro: 3.865 ± 0.045	2.362ThrGln: 2.362 ± 0.024	2.817ThrArg: 2.817 ± 0.029	6.141ThrSer: 6.141 ± 0.051	3.749ThrThr: 3.749 ± 0.046	3.122ThrVal: 3.122 ± 0.032	0.656ThrTrp: 0.656 ± 0.014	1.466ThrTyr: 1.466 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	4.567ValAla: 4.567 ± 0.039	0.678ValCys: 0.678 ± 0.013	3.282ValAsp: 3.282 ± 0.034	3.601ValGlu: 3.601 ± 0.033	2.007ValPhe: 2.007 ± 0.027	3.65ValGly: 3.65 ± 0.04	1.369ValHis: 1.369 ± 0.022	2.849ValIle: 2.849 ± 0.037	3.003ValLys: 3.003 ± 0.035	4.917ValLeu: 4.917 ± 0.042	1.192ValMet: 1.192 ± 0.017	2.263ValAsn: 2.263 ± 0.029	3.138ValPro: 3.138 ± 0.028	2.694ValGln: 2.694 ± 0.029	3.446ValArg: 3.446 ± 0.033	4.26ValSer: 4.26 ± 0.036	2.94ValThr: 2.94 ± 0.031	3.367ValVal: 3.367 ± 0.04	0.741ValTrp: 0.741 ± 0.017	1.489ValTyr: 1.489 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.826TrpAla: 0.826 ± 0.015	0.175TrpCys: 0.175 ± 0.006	0.722TrpAsp: 0.722 ± 0.015	0.606TrpGlu: 0.606 ± 0.013	0.45TrpPhe: 0.45 ± 0.011	0.689TrpGly: 0.689 ± 0.014	0.316TrpHis: 0.316 ± 0.01	0.691TrpIle: 0.691 ± 0.014	0.705TrpLys: 0.705 ± 0.013	1.158TrpLeu: 1.158 ± 0.021	0.294TrpMet: 0.294 ± 0.01	0.587TrpAsn: 0.587 ± 0.015	0.513TrpPro: 0.513 ± 0.012	0.661TrpGln: 0.661 ± 0.016	0.797TrpArg: 0.797 ± 0.014	1.066TrpSer: 1.066 ± 0.02	0.788TrpThr: 0.788 ± 0.015	0.559TrpVal: 0.559 ± 0.011	0.212TrpTrp: 0.212 ± 0.008	0.363TrpTyr: 0.363 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.079TyrAla: 2.079 ± 0.021	0.33TyrCys: 0.33 ± 0.01	1.621TyrAsp: 1.621 ± 0.021	1.455TyrGlu: 1.455 ± 0.02	1.074TyrPhe: 1.074 ± 0.02	1.899TyrGly: 1.899 ± 0.026	0.683TyrHis: 0.683 ± 0.016	1.225TyrIle: 1.225 ± 0.019	1.133TyrLys: 1.133 ± 0.017	2.296TyrLeu: 2.296 ± 0.027	0.513TyrMet: 0.513 ± 0.011	1.067TyrAsn: 1.067 ± 0.018	1.227TyrPro: 1.227 ± 0.02	1.022TyrGln: 1.022 ± 0.018	1.482TyrArg: 1.482 ± 0.02	1.938TyrSer: 1.938 ± 0.024	1.437TyrThr: 1.437 ± 0.02	1.456TyrVal: 1.456 ± 0.022	0.342TyrTrp: 0.342 ± 0.011	0.769TyrTyr: 0.769 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7452 proteins (3681814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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