Amino acid dipepetide frequency for Sphingomonas sp. S-NIH.Pt15_0812

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.916AlaAla: 21.916 ± 0.221	1.089AlaCys: 1.089 ± 0.031	8.149AlaAsp: 8.149 ± 0.086	7.752AlaGlu: 7.752 ± 0.103	4.182AlaPhe: 4.182 ± 0.057	12.567AlaGly: 12.567 ± 0.131	2.404AlaHis: 2.404 ± 0.048	7.174AlaIle: 7.174 ± 0.079	3.518AlaLys: 3.518 ± 0.059	14.499AlaLeu: 14.499 ± 0.15	4.292AlaMet: 4.292 ± 0.067	3.077AlaAsn: 3.077 ± 0.065	6.952AlaPro: 6.952 ± 0.098	4.502AlaGln: 4.502 ± 0.065	10.924AlaArg: 10.924 ± 0.13	6.565AlaSer: 6.565 ± 0.081	8.273AlaThr: 8.273 ± 0.103	9.513AlaVal: 9.513 ± 0.105	1.778AlaTrp: 1.778 ± 0.045	2.602AlaTyr: 2.602 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.031	0.075CysCys: 0.075 ± 0.008	0.497CysAsp: 0.497 ± 0.022	0.327CysGlu: 0.327 ± 0.019	0.269CysPhe: 0.269 ± 0.016	0.781CysGly: 0.781 ± 0.027	0.169CysHis: 0.169 ± 0.012	0.306CysIle: 0.306 ± 0.015	0.142CysLys: 0.142 ± 0.012	0.661CysLeu: 0.661 ± 0.026	0.146CysMet: 0.146 ± 0.012	0.155CysAsn: 0.155 ± 0.01	0.407CysPro: 0.407 ± 0.021	0.169CysGln: 0.169 ± 0.012	0.594CysArg: 0.594 ± 0.023	0.372CysSer: 0.372 ± 0.015	0.406CysThr: 0.406 ± 0.017	0.507CysVal: 0.507 ± 0.021	0.108CysTrp: 0.108 ± 0.01	0.138CysTyr: 0.138 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.397AspAla: 8.397 ± 0.091	0.406AspCys: 0.406 ± 0.022	3.5AspAsp: 3.5 ± 0.059	2.882AspGlu: 2.882 ± 0.061	1.956AspPhe: 1.956 ± 0.04	5.919AspGly: 5.919 ± 0.088	1.478AspHis: 1.478 ± 0.037	2.479AspIle: 2.479 ± 0.046	1.316AspLys: 1.316 ± 0.037	6.096AspLeu: 6.096 ± 0.07	1.25AspMet: 1.25 ± 0.035	1.182AspAsn: 1.182 ± 0.035	4.075AspPro: 4.075 ± 0.062	2.076AspGln: 2.076 ± 0.044	5.908AspArg: 5.908 ± 0.075	2.323AspSer: 2.323 ± 0.058	2.813AspThr: 2.813 ± 0.046	4.116AspVal: 4.116 ± 0.05	1.209AspTrp: 1.209 ± 0.034	1.585AspTyr: 1.585 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.532GluAla: 7.532 ± 0.101	0.26GluCys: 0.26 ± 0.014	2.392GluAsp: 2.392 ± 0.052	2.38GluGlu: 2.38 ± 0.062	1.156GluPhe: 1.156 ± 0.029	4.055GluGly: 4.055 ± 0.071	1.002GluHis: 1.002 ± 0.032	2.273GluIle: 2.273 ± 0.05	1.291GluLys: 1.291 ± 0.041	4.385GluLeu: 4.385 ± 0.067	1.15GluMet: 1.15 ± 0.028	0.984GluAsn: 0.984 ± 0.031	2.518GluPro: 2.518 ± 0.049	1.92GluGln: 1.92 ± 0.035	5.135GluArg: 5.135 ± 0.079	1.888GluSer: 1.888 ± 0.042	2.892GluThr: 2.892 ± 0.052	3.318GluVal: 3.318 ± 0.054	0.634GluTrp: 0.634 ± 0.027	0.817GluTyr: 0.817 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.872PheAla: 4.872 ± 0.076	0.269PheCys: 0.269 ± 0.016	2.636PheAsp: 2.636 ± 0.049	1.64PheGlu: 1.64 ± 0.038	1.14PhePhe: 1.14 ± 0.032	3.489PheGly: 3.489 ± 0.062	0.676PheHis: 0.676 ± 0.024	1.082PheIle: 1.082 ± 0.032	0.648PheLys: 0.648 ± 0.024	2.859PheLeu: 2.859 ± 0.056	0.596PheMet: 0.596 ± 0.024	0.946PheAsn: 0.946 ± 0.032	1.396PhePro: 1.396 ± 0.037	0.928PheGln: 0.928 ± 0.03	2.215PheArg: 2.215 ± 0.044	1.669PheSer: 1.669 ± 0.041	2.047PheThr: 2.047 ± 0.041	2.532PheVal: 2.532 ± 0.043	0.437PheTrp: 0.437 ± 0.02	0.811PheTyr: 0.811 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.573GlyAla: 10.573 ± 0.113	0.788GlyCys: 0.788 ± 0.024	5.197GlyAsp: 5.197 ± 0.068	4.567GlyGlu: 4.567 ± 0.067	3.533GlyPhe: 3.533 ± 0.057	8.607GlyGly: 8.607 ± 0.124	1.996GlyHis: 1.996 ± 0.043	4.361GlyIle: 4.361 ± 0.06	2.599GlyLys: 2.599 ± 0.054	9.04GlyLeu: 9.04 ± 0.1	2.23GlyMet: 2.23 ± 0.044	2.157GlyAsn: 2.157 ± 0.053	3.727GlyPro: 3.727 ± 0.058	3.247GlyGln: 3.247 ± 0.05	7.524GlyArg: 7.524 ± 0.086	4.609GlySer: 4.609 ± 0.069	5.174GlyThr: 5.174 ± 0.096	6.686GlyVal: 6.686 ± 0.083	1.757GlyTrp: 1.757 ± 0.042	2.407GlyTyr: 2.407 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.563HisAla: 2.563 ± 0.049	0.205HisCys: 0.205 ± 0.012	1.33HisAsp: 1.33 ± 0.034	0.881HisGlu: 0.881 ± 0.03	0.717HisPhe: 0.717 ± 0.024	2.064HisGly: 2.064 ± 0.045	0.596HisHis: 0.596 ± 0.026	0.783HisIle: 0.783 ± 0.024	0.326HisLys: 0.326 ± 0.016	2.002HisLeu: 2.002 ± 0.048	0.406HisMet: 0.406 ± 0.018	0.368HisAsn: 0.368 ± 0.017	1.344HisPro: 1.344 ± 0.034	0.604HisGln: 0.604 ± 0.023	1.683HisArg: 1.683 ± 0.035	0.811HisSer: 0.811 ± 0.023	0.654HisThr: 0.654 ± 0.019	1.528HisVal: 1.528 ± 0.036	0.402HisTrp: 0.402 ± 0.02	0.534HisTyr: 0.534 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.95IleAla: 7.95 ± 0.092	0.335IleCys: 0.335 ± 0.018	3.937IleAsp: 3.937 ± 0.069	2.884IleGlu: 2.884 ± 0.053	1.239IlePhe: 1.239 ± 0.031	5.299IleGly: 5.299 ± 0.072	0.829IleHis: 0.829 ± 0.025	1.573IleIle: 1.573 ± 0.039	0.926IleLys: 0.926 ± 0.028	3.713IleLeu: 3.713 ± 0.056	0.688IleMet: 0.688 ± 0.022	1.117IleAsn: 1.117 ± 0.034	2.033IlePro: 2.033 ± 0.043	1.103IleGln: 1.103 ± 0.029	3.291IleArg: 3.291 ± 0.048	1.92IleSer: 1.92 ± 0.039	2.336IleThr: 2.336 ± 0.04	4.226IleVal: 4.226 ± 0.062	0.521IleTrp: 0.521 ± 0.02	0.863IleTyr: 0.863 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.374LysAla: 3.374 ± 0.063	0.097LysCys: 0.097 ± 0.008	1.207LysAsp: 1.207 ± 0.04	0.83LysGlu: 0.83 ± 0.027	0.601LysPhe: 0.601 ± 0.022	2.17LysGly: 2.17 ± 0.049	0.374LysHis: 0.374 ± 0.018	1.042LysIle: 1.042 ± 0.026	0.722LysLys: 0.722 ± 0.031	2.557LysLeu: 2.557 ± 0.055	0.565LysMet: 0.565 ± 0.024	0.524LysAsn: 0.524 ± 0.02	1.723LysPro: 1.723 ± 0.04	0.759LysGln: 0.759 ± 0.027	1.956LysArg: 1.956 ± 0.046	1.172LysSer: 1.172 ± 0.031	1.442LysThr: 1.442 ± 0.038	1.784LysVal: 1.784 ± 0.046	0.266LysTrp: 0.266 ± 0.015	0.425LysTyr: 0.425 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.227LeuAla: 15.227 ± 0.134	0.762LeuCys: 0.762 ± 0.025	6.331LeuAsp: 6.331 ± 0.077	4.058LeuGlu: 4.058 ± 0.071	3.533LeuPhe: 3.533 ± 0.062	8.419LeuGly: 8.419 ± 0.091	1.911LeuHis: 1.911 ± 0.042	4.444LeuIle: 4.444 ± 0.075	2.46LeuLys: 2.46 ± 0.042	9.695LeuLeu: 9.695 ± 0.125	2.05LeuMet: 2.05 ± 0.041	2.2LeuAsn: 2.2 ± 0.046	5.896LeuPro: 5.896 ± 0.079	2.39LeuGln: 2.39 ± 0.051	7.299LeuArg: 7.299 ± 0.08	5.956LeuSer: 5.956 ± 0.072	6.085LeuThr: 6.085 ± 0.08	7.701LeuVal: 7.701 ± 0.091	1.303LeuTrp: 1.303 ± 0.039	2.038LeuTyr: 2.038 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.332MetAla: 3.332 ± 0.052	0.118MetCys: 0.118 ± 0.011	1.058MetAsp: 1.058 ± 0.031	0.865MetGlu: 0.865 ± 0.027	0.556MetPhe: 0.556 ± 0.023	1.733MetGly: 1.733 ± 0.031	0.369MetHis: 0.369 ± 0.016	1.344MetIle: 1.344 ± 0.035	0.761MetLys: 0.761 ± 0.025	2.652MetLeu: 2.652 ± 0.047	0.661MetMet: 0.661 ± 0.024	0.574MetAsn: 0.574 ± 0.025	1.519MetPro: 1.519 ± 0.038	0.622MetGln: 0.622 ± 0.022	1.805MetArg: 1.805 ± 0.039	1.215MetSer: 1.215 ± 0.033	1.86MetThr: 1.86 ± 0.039	1.655MetVal: 1.655 ± 0.034	0.195MetTrp: 0.195 ± 0.013	0.24MetTyr: 0.24 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.08AsnAla: 3.08 ± 0.062	0.174AsnCys: 0.174 ± 0.012	1.343AsnAsp: 1.343 ± 0.04	0.921AsnGlu: 0.921 ± 0.03	0.805AsnPhe: 0.805 ± 0.034	2.356AsnGly: 2.356 ± 0.063	0.481AsnHis: 0.481 ± 0.02	1.063AsnIle: 1.063 ± 0.034	0.454AsnLys: 0.454 ± 0.022	2.282AsnLeu: 2.282 ± 0.046	0.453AsnMet: 0.453 ± 0.02	0.638AsnAsn: 0.638 ± 0.034	1.514AsnPro: 1.514 ± 0.04	0.729AsnGln: 0.729 ± 0.029	1.785AsnArg: 1.785 ± 0.034	1.099AsnSer: 1.099 ± 0.04	1.122AsnThr: 1.122 ± 0.043	1.652AsnVal: 1.652 ± 0.037	0.372AsnTrp: 0.372 ± 0.018	0.643AsnTyr: 0.643 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.103ProAla: 8.103 ± 0.102	0.353ProCys: 0.353 ± 0.019	3.969ProAsp: 3.969 ± 0.058	3.024ProGlu: 3.024 ± 0.052	1.862ProPhe: 1.862 ± 0.038	5.042ProGly: 5.042 ± 0.067	1.031ProHis: 1.031 ± 0.032	2.507ProIle: 2.507 ± 0.043	1.276ProLys: 1.276 ± 0.034	5.182ProLeu: 5.182 ± 0.073	1.197ProMet: 1.197 ± 0.033	1.212ProAsn: 1.212 ± 0.031	3.085ProPro: 3.085 ± 0.064	1.654ProGln: 1.654 ± 0.035	3.446ProArg: 3.446 ± 0.059	2.656ProSer: 2.656 ± 0.05	2.835ProThr: 2.835 ± 0.055	4.843ProVal: 4.843 ± 0.063	0.694ProTrp: 0.694 ± 0.026	1.145ProTyr: 1.145 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.809GlnAla: 4.809 ± 0.069	0.208GlnCys: 0.208 ± 0.013	1.499GlnAsp: 1.499 ± 0.04	1.108GlnGlu: 1.108 ± 0.028	0.988GlnPhe: 0.988 ± 0.029	2.749GlnGly: 2.749 ± 0.055	0.538GlnHis: 0.538 ± 0.022	1.552GlnIle: 1.552 ± 0.039	0.687GlnLys: 0.687 ± 0.027	2.914GlnLeu: 2.914 ± 0.06	0.78GlnMet: 0.78 ± 0.023	0.693GlnAsn: 0.693 ± 0.024	1.951GlnPro: 1.951 ± 0.039	1.154GlnGln: 1.154 ± 0.038	2.695GlnArg: 2.695 ± 0.051	1.642GlnSer: 1.642 ± 0.034	1.735GlnThr: 1.735 ± 0.036	2.585GlnVal: 2.585 ± 0.049	0.431GlnTrp: 0.431 ± 0.02	0.618GlnTyr: 0.618 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.94ArgAla: 9.94 ± 0.116	0.538ArgCys: 0.538 ± 0.024	4.949ArgAsp: 4.949 ± 0.071	3.632ArgGlu: 3.632 ± 0.065	3.365ArgPhe: 3.365 ± 0.057	5.659ArgGly: 5.659 ± 0.068	1.908ArgHis: 1.908 ± 0.045	4.362ArgIle: 4.362 ± 0.069	1.614ArgLys: 1.614 ± 0.041	9.138ArgLeu: 9.138 ± 0.108	2.065ArgMet: 2.065 ± 0.041	1.781ArgAsn: 1.781 ± 0.04	4.468ArgPro: 4.468 ± 0.071	2.787ArgGln: 2.787 ± 0.054	6.981ArgArg: 6.981 ± 0.112	3.906ArgSer: 3.906 ± 0.055	4.119ArgThr: 4.119 ± 0.058	5.414ArgVal: 5.414 ± 0.073	1.449ArgTrp: 1.449 ± 0.041	2.056ArgTyr: 2.056 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.317SerAla: 6.317 ± 0.085	0.363SerCys: 0.363 ± 0.019	2.866SerAsp: 2.866 ± 0.045	2.105SerGlu: 2.105 ± 0.051	1.935SerPhe: 1.935 ± 0.04	5.112SerGly: 5.112 ± 0.078	0.89SerHis: 0.89 ± 0.026	2.435SerIle: 2.435 ± 0.045	1.127SerLys: 1.127 ± 0.032	4.965SerLeu: 4.965 ± 0.066	1.061SerMet: 1.061 ± 0.029	1.225SerAsn: 1.225 ± 0.038	2.801SerPro: 2.801 ± 0.056	1.488SerGln: 1.488 ± 0.04	3.49SerArg: 3.49 ± 0.063	2.549SerSer: 2.549 ± 0.074	2.694SerThr: 2.694 ± 0.054	3.614SerVal: 3.614 ± 0.057	0.702SerTrp: 0.702 ± 0.024	1.223SerTyr: 1.223 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.325ThrAla: 7.325 ± 0.103	0.341ThrCys: 0.341 ± 0.018	3.167ThrAsp: 3.167 ± 0.054	2.256ThrGlu: 2.256 ± 0.046	1.681ThrPhe: 1.681 ± 0.037	5.835ThrGly: 5.835 ± 0.082	0.964ThrHis: 0.964 ± 0.027	3.279ThrIle: 3.279 ± 0.061	1.138ThrLys: 1.138 ± 0.037	6.548ThrLeu: 6.548 ± 0.089	1.272ThrMet: 1.272 ± 0.033	1.316ThrAsn: 1.316 ± 0.048	3.739ThrPro: 3.739 ± 0.068	1.596ThrGln: 1.596 ± 0.043	3.988ThrArg: 3.988 ± 0.058	2.652ThrSer: 2.652 ± 0.05	2.999ThrThr: 2.999 ± 0.064	4.601ThrVal: 4.601 ± 0.074	0.634ThrTrp: 0.634 ± 0.024	1.218ThrTyr: 1.218 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.241ValAla: 11.241 ± 0.115	0.467ValCys: 0.467 ± 0.021	4.598ValAsp: 4.598 ± 0.063	4.395ValGlu: 4.395 ± 0.058	2.053ValPhe: 2.053 ± 0.04	5.846ValGly: 5.846 ± 0.072	1.344ValHis: 1.344 ± 0.03	3.342ValIle: 3.342 ± 0.059	1.713ValLys: 1.713 ± 0.046	6.772ValLeu: 6.772 ± 0.083	1.582ValMet: 1.582 ± 0.04	1.851ValAsn: 1.851 ± 0.049	4.219ValPro: 4.219 ± 0.059	2.224ValGln: 2.224 ± 0.041	5.852ValArg: 5.852 ± 0.076	3.941ValSer: 3.941 ± 0.056	5.024ValThr: 5.024 ± 0.076	5.877ValVal: 5.877 ± 0.08	0.811ValTrp: 0.811 ± 0.026	1.327ValTyr: 1.327 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.413TrpAla: 1.413 ± 0.037	0.129TrpCys: 0.129 ± 0.012	0.729TrpAsp: 0.729 ± 0.028	0.478TrpGlu: 0.478 ± 0.021	0.566TrpPhe: 0.566 ± 0.022	0.937TrpGly: 0.937 ± 0.033	0.351TrpHis: 0.351 ± 0.018	0.641TrpIle: 0.641 ± 0.023	0.397TrpLys: 0.397 ± 0.019	1.701TrpLeu: 1.701 ± 0.042	0.354TrpMet: 0.354 ± 0.018	0.397TrpAsn: 0.397 ± 0.018	0.757TrpPro: 0.757 ± 0.027	0.631TrpGln: 0.631 ± 0.021	1.516TrpArg: 1.516 ± 0.041	0.933TrpSer: 0.933 ± 0.026	0.999TrpThr: 0.999 ± 0.027	0.813TrpVal: 0.813 ± 0.029	0.298TrpTrp: 0.298 ± 0.017	0.288TrpTyr: 0.288 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.832TyrAla: 2.832 ± 0.046	0.187TyrCys: 0.187 ± 0.013	1.612TyrAsp: 1.612 ± 0.04	0.995TyrGlu: 0.995 ± 0.03	0.752TyrPhe: 0.752 ± 0.026	2.139TyrGly: 2.139 ± 0.047	0.49TyrHis: 0.49 ± 0.018	0.74TyrIle: 0.74 ± 0.023	0.477TyrLys: 0.477 ± 0.021	2.095TyrLeu: 2.095 ± 0.049	0.336TyrMet: 0.336 ± 0.017	0.57TyrAsn: 0.57 ± 0.025	0.992TyrPro: 0.992 ± 0.026	0.751TyrGln: 0.751 ± 0.025	2.046TyrArg: 2.046 ± 0.052	1.084TyrSer: 1.084 ± 0.032	1.04TyrThr: 1.04 ± 0.031	1.514TyrVal: 1.514 ± 0.036	0.327TyrTrp: 0.327 ± 0.017	0.58TyrTyr: 0.58 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3806 proteins (1221555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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