Amino acid dipepetide frequency for Infectious spleen and kidney necrosis virus (isolate Mandarin fish/China/Nanhai/1998) (ISKNV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.461AlaAla: 9.461 ± 0.662
2.192AlaCys: 2.192 ± 0.244
4.759AlaAsp: 4.759 ± 0.368
3.663AlaGlu: 3.663 ± 0.361
3.057AlaPhe: 3.057 ± 0.295
3.923AlaGly: 3.923 ± 0.35
3.317AlaHis: 3.317 ± 0.355
3.548AlaIle: 3.548 ± 0.337
2.884AlaLys: 2.884 ± 0.355
7.759AlaLeu: 7.759 ± 0.699
3.548AlaMet: 3.548 ± 0.337
3.029AlaAsn: 3.029 ± 0.304
4.673AlaPro: 4.673 ± 0.434
3.606AlaGln: 3.606 ± 0.371
5.827AlaArg: 5.827 ± 0.491
4.788AlaSer: 4.788 ± 0.367
6.576AlaThr: 6.576 ± 0.515
8.076AlaVal: 8.076 ± 0.512
1.125AlaTrp: 1.125 ± 0.177
3.086AlaTyr: 3.086 ± 0.286
0.0AlaXaa: 0.0 ± 0.0
Cys
2.798CysAla: 2.798 ± 0.335
0.981CysCys: 0.981 ± 0.174
2.134CysAsp: 2.134 ± 0.254
1.413CysGlu: 1.413 ± 0.222
0.635CysPhe: 0.635 ± 0.106
2.192CysGly: 2.192 ± 0.293
1.096CysHis: 1.096 ± 0.196
1.067CysIle: 1.067 ± 0.142
1.154CysLys: 1.154 ± 0.221
2.25CysLeu: 2.25 ± 0.308
1.327CysMet: 1.327 ± 0.194
1.269CysAsn: 1.269 ± 0.213
1.817CysPro: 1.817 ± 0.42
0.952CysGln: 0.952 ± 0.167
1.875CysArg: 1.875 ± 0.258
2.192CysSer: 2.192 ± 0.274
2.279CysThr: 2.279 ± 0.311
3.173CysVal: 3.173 ± 0.283
0.231CysTrp: 0.231 ± 0.084
0.894CysTyr: 0.894 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
5.105AspAla: 5.105 ± 0.392
1.471AspCys: 1.471 ± 0.259
4.211AspAsp: 4.211 ± 0.389
2.019AspGlu: 2.019 ± 0.313
1.529AspPhe: 1.529 ± 0.249
3.952AspGly: 3.952 ± 0.361
1.586AspHis: 1.586 ± 0.231
3.548AspIle: 3.548 ± 0.375
2.25AspLys: 2.25 ± 0.25
3.606AspLeu: 3.606 ± 0.308
3.375AspMet: 3.375 ± 0.335
2.769AspAsn: 2.769 ± 0.265
2.423AspPro: 2.423 ± 0.253
1.413AspGln: 1.413 ± 0.212
3.375AspArg: 3.375 ± 0.289
3.404AspSer: 3.404 ± 0.272
4.759AspThr: 4.759 ± 0.443
5.625AspVal: 5.625 ± 0.442
0.49AspTrp: 0.49 ± 0.125
2.221AspTyr: 2.221 ± 0.308
0.0AspXaa: 0.0 ± 0.0
Glu
3.288GluAla: 3.288 ± 0.316
1.731GluCys: 1.731 ± 0.295
2.625GluAsp: 2.625 ± 0.313
1.788GluGlu: 1.788 ± 0.263
0.75GluPhe: 0.75 ± 0.145
1.99GluGly: 1.99 ± 0.276
1.933GluHis: 1.933 ± 0.238
1.269GluIle: 1.269 ± 0.185
1.067GluLys: 1.067 ± 0.186
3.057GluLeu: 3.057 ± 0.294
1.183GluMet: 1.183 ± 0.197
1.183GluAsn: 1.183 ± 0.201
1.933GluPro: 1.933 ± 0.29
1.99GluGln: 1.99 ± 0.236
3.029GluArg: 3.029 ± 0.257
1.731GluSer: 1.731 ± 0.227
2.394GluThr: 2.394 ± 0.226
2.308GluVal: 2.308 ± 0.284
0.721GluTrp: 0.721 ± 0.156
2.163GluTyr: 2.163 ± 0.259
0.0GluXaa: 0.0 ± 0.0
Phe
2.567PheAla: 2.567 ± 0.269
0.663PheCys: 0.663 ± 0.138
2.279PheAsp: 2.279 ± 0.321
1.846PheGlu: 1.846 ± 0.208
1.125PhePhe: 1.125 ± 0.156
1.269PheGly: 1.269 ± 0.171
0.836PheHis: 0.836 ± 0.111
1.471PheIle: 1.471 ± 0.219
1.471PheLys: 1.471 ± 0.228
1.558PheLeu: 1.558 ± 0.219
1.5PheMet: 1.5 ± 0.223
1.356PheAsn: 1.356 ± 0.162
1.211PhePro: 1.211 ± 0.172
1.038PheGln: 1.038 ± 0.161
1.529PheArg: 1.529 ± 0.191
1.817PheSer: 1.817 ± 0.266
2.25PheThr: 2.25 ± 0.265
2.971PheVal: 2.971 ± 0.339
0.346PheTrp: 0.346 ± 0.097
0.721PheTyr: 0.721 ± 0.128
0.0PheXaa: 0.0 ± 0.0
Gly
4.471GlyAla: 4.471 ± 0.344
1.269GlyCys: 1.269 ± 0.214
3.029GlyAsp: 3.029 ± 0.254
1.759GlyGlu: 1.759 ± 0.256
1.731GlyPhe: 1.731 ± 0.236
4.009GlyGly: 4.009 ± 0.369
2.481GlyHis: 2.481 ± 0.27
2.279GlyIle: 2.279 ± 0.235
1.933GlyLys: 1.933 ± 0.265
4.355GlyLeu: 4.355 ± 0.625
2.221GlyMet: 2.221 ± 0.204
2.106GlyAsn: 2.106 ± 0.277
3.086GlyPro: 3.086 ± 0.354
2.163GlyGln: 2.163 ± 0.286
3.432GlyArg: 3.432 ± 0.301
3.317GlySer: 3.317 ± 0.339
4.384GlyThr: 4.384 ± 0.392
5.365GlyVal: 5.365 ± 0.342
0.49GlyTrp: 0.49 ± 0.127
2.567GlyTyr: 2.567 ± 0.301
0.0GlyXaa: 0.0 ± 0.0
His
2.942HisAla: 2.942 ± 0.285
1.298HisCys: 1.298 ± 0.193
1.933HisAsp: 1.933 ± 0.253
1.298HisGlu: 1.298 ± 0.237
0.779HisPhe: 0.779 ± 0.138
2.452HisGly: 2.452 ± 0.281
1.154HisHis: 1.154 ± 0.253
2.567HisIle: 2.567 ± 0.314
1.24HisLys: 1.24 ± 0.201
2.683HisLeu: 2.683 ± 0.25
1.846HisMet: 1.846 ± 0.231
2.019HisAsn: 2.019 ± 0.232
1.096HisPro: 1.096 ± 0.191
1.154HisGln: 1.154 ± 0.164
2.596HisArg: 2.596 ± 0.252
2.106HisSer: 2.106 ± 0.224
3.173HisThr: 3.173 ± 0.32
3.779HisVal: 3.779 ± 0.357
0.375HisTrp: 0.375 ± 0.093
1.125HisTyr: 1.125 ± 0.186
0.0HisXaa: 0.0 ± 0.0
Ile
3.721IleAla: 3.721 ± 0.269
1.24IleCys: 1.24 ± 0.185
2.971IleAsp: 2.971 ± 0.27
1.933IleGlu: 1.933 ± 0.271
1.038IlePhe: 1.038 ± 0.151
2.25IleGly: 2.25 ± 0.306
1.471IleHis: 1.471 ± 0.216
2.423IleIle: 2.423 ± 0.272
1.904IleLys: 1.904 ± 0.27
3.086IleLeu: 3.086 ± 0.329
2.077IleMet: 2.077 ± 0.225
1.702IleAsn: 1.702 ± 0.215
2.279IlePro: 2.279 ± 0.251
1.702IleGln: 1.702 ± 0.232
2.683IleArg: 2.683 ± 0.249
2.827IleSer: 2.827 ± 0.346
2.654IleThr: 2.654 ± 0.259
3.721IleVal: 3.721 ± 0.376
0.375IleTrp: 0.375 ± 0.115
1.211IleTyr: 1.211 ± 0.201
0.0IleXaa: 0.0 ± 0.0
Lys
2.538LysAla: 2.538 ± 0.283
1.154LysCys: 1.154 ± 0.178
1.961LysAsp: 1.961 ± 0.228
1.471LysGlu: 1.471 ± 0.249
0.836LysPhe: 0.836 ± 0.157
1.529LysGly: 1.529 ± 0.227
1.269LysHis: 1.269 ± 0.169
1.24LysIle: 1.24 ± 0.219
1.24LysLys: 1.24 ± 0.327
2.74LysLeu: 2.74 ± 0.294
1.269LysMet: 1.269 ± 0.178
0.894LysAsn: 0.894 ± 0.168
2.048LysPro: 2.048 ± 0.24
1.673LysGln: 1.673 ± 0.258
2.856LysArg: 2.856 ± 0.355
1.5LysSer: 1.5 ± 0.209
2.106LysThr: 2.106 ± 0.263
2.596LysVal: 2.596 ± 0.261
0.375LysTrp: 0.375 ± 0.099
1.471LysTyr: 1.471 ± 0.205
0.0LysXaa: 0.0 ± 0.0
Leu
7.211LeuAla: 7.211 ± 0.58
2.971LeuCys: 2.971 ± 0.262
4.615LeuAsp: 4.615 ± 0.318
3.432LeuGlu: 3.432 ± 0.281
2.884LeuPhe: 2.884 ± 0.257
3.721LeuGly: 3.721 ± 0.345
3.0LeuHis: 3.0 ± 0.293
3.115LeuIle: 3.115 ± 0.307
2.856LeuLys: 2.856 ± 0.273
8.278LeuLeu: 8.278 ± 0.505
3.317LeuMet: 3.317 ± 0.307
2.596LeuAsn: 2.596 ± 0.225
4.269LeuPro: 4.269 ± 0.235
3.404LeuGln: 3.404 ± 0.344
6.144LeuArg: 6.144 ± 0.48
4.759LeuSer: 4.759 ± 0.398
5.913LeuThr: 5.913 ± 0.679
5.336LeuVal: 5.336 ± 0.435
1.385LeuTrp: 1.385 ± 0.221
3.0LeuTyr: 3.0 ± 0.323
0.0LeuXaa: 0.0 ± 0.0
Met
4.413MetAla: 4.413 ± 0.404
1.904MetCys: 1.904 ± 0.249
2.481MetAsp: 2.481 ± 0.265
1.471MetGlu: 1.471 ± 0.176
1.269MetPhe: 1.269 ± 0.189
1.702MetGly: 1.702 ± 0.194
1.211MetHis: 1.211 ± 0.17
1.356MetIle: 1.356 ± 0.201
0.836MetLys: 0.836 ± 0.147
3.692MetLeu: 3.692 ± 0.295
1.154MetMet: 1.154 ± 0.191
0.923MetAsn: 0.923 ± 0.125
2.711MetPro: 2.711 ± 0.253
1.269MetGln: 1.269 ± 0.21
2.625MetArg: 2.625 ± 0.29
3.231MetSer: 3.231 ± 0.242
2.913MetThr: 2.913 ± 0.36
2.509MetVal: 2.509 ± 0.236
0.433MetTrp: 0.433 ± 0.102
2.192MetTyr: 2.192 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
2.913AsnAla: 2.913 ± 0.351
0.606AsnCys: 0.606 ± 0.115
1.558AsnAsp: 1.558 ± 0.229
1.096AsnGlu: 1.096 ± 0.172
0.981AsnPhe: 0.981 ± 0.218
2.423AsnGly: 2.423 ± 0.317
0.865AsnHis: 0.865 ± 0.149
2.625AsnIle: 2.625 ± 0.241
1.644AsnLys: 1.644 ± 0.198
2.452AsnLeu: 2.452 ± 0.286
1.269AsnMet: 1.269 ± 0.187
1.615AsnAsn: 1.615 ± 0.268
1.961AsnPro: 1.961 ± 0.251
0.923AsnGln: 0.923 ± 0.154
1.933AsnArg: 1.933 ± 0.291
2.192AsnSer: 2.192 ± 0.211
3.606AsnThr: 3.606 ± 0.296
3.519AsnVal: 3.519 ± 0.356
0.202AsnTrp: 0.202 ± 0.071
1.183AsnTyr: 1.183 ± 0.177
0.0AsnXaa: 0.0 ± 0.0
Pro
4.384ProAla: 4.384 ± 0.364
1.846ProCys: 1.846 ± 0.324
3.317ProAsp: 3.317 ± 0.33
2.538ProGlu: 2.538 ± 0.41
1.615ProPhe: 1.615 ± 0.179
3.231ProGly: 3.231 ± 0.325
2.077ProHis: 2.077 ± 0.264
1.933ProIle: 1.933 ± 0.258
1.211ProLys: 1.211 ± 0.211
4.961ProLeu: 4.961 ± 0.444
1.673ProMet: 1.673 ± 0.171
1.702ProAsn: 1.702 ± 0.217
3.894ProPro: 3.894 ± 0.695
2.683ProGln: 2.683 ± 0.342
2.625ProArg: 2.625 ± 0.333
3.173ProSer: 3.173 ± 0.266
3.432ProThr: 3.432 ± 0.351
4.875ProVal: 4.875 ± 0.335
0.606ProTrp: 0.606 ± 0.163
2.019ProTyr: 2.019 ± 0.297
0.0ProXaa: 0.0 ± 0.0
Gln
3.288GlnAla: 3.288 ± 0.321
1.961GlnCys: 1.961 ± 0.409
2.221GlnAsp: 2.221 ± 0.4
1.413GlnGlu: 1.413 ± 0.19
1.327GlnPhe: 1.327 ± 0.183
1.933GlnGly: 1.933 ± 0.229
2.048GlnHis: 2.048 ± 0.267
1.01GlnIle: 1.01 ± 0.151
0.836GlnLys: 0.836 ± 0.139
3.807GlnLeu: 3.807 ± 0.44
1.673GlnMet: 1.673 ± 0.175
0.663GlnAsn: 0.663 ± 0.118
1.904GlnPro: 1.904 ± 0.277
2.394GlnGln: 2.394 ± 0.341
2.798GlnArg: 2.798 ± 0.288
2.25GlnSer: 2.25 ± 0.261
2.077GlnThr: 2.077 ± 0.316
2.509GlnVal: 2.509 ± 0.24
0.606GlnTrp: 0.606 ± 0.146
1.933GlnTyr: 1.933 ± 0.243
0.0GlnXaa: 0.0 ± 0.0
Arg
5.74ArgAla: 5.74 ± 0.531
1.961ArgCys: 1.961 ± 0.232
3.75ArgAsp: 3.75 ± 0.332
2.481ArgGlu: 2.481 ± 0.303
1.817ArgPhe: 1.817 ± 0.221
3.057ArgGly: 3.057 ± 0.302
3.173ArgHis: 3.173 ± 0.365
2.654ArgIle: 2.654 ± 0.265
1.673ArgLys: 1.673 ± 0.256
5.163ArgLeu: 5.163 ± 0.395
2.25ArgMet: 2.25 ± 0.237
2.423ArgAsn: 2.423 ± 0.296
3.317ArgPro: 3.317 ± 0.469
2.596ArgGln: 2.596 ± 0.256
5.971ArgArg: 5.971 ± 0.817
3.144ArgSer: 3.144 ± 0.411
4.759ArgThr: 4.759 ± 0.593
5.682ArgVal: 5.682 ± 0.379
1.038ArgTrp: 1.038 ± 0.16
2.423ArgTyr: 2.423 ± 0.236
0.0ArgXaa: 0.0 ± 0.0
Ser
4.932SerAla: 4.932 ± 0.395
2.019SerCys: 2.019 ± 0.29
3.202SerAsp: 3.202 ± 0.272
1.673SerGlu: 1.673 ± 0.236
1.673SerPhe: 1.673 ± 0.223
4.413SerGly: 4.413 ± 0.433
2.048SerHis: 2.048 ± 0.208
2.509SerIle: 2.509 ± 0.253
1.904SerLys: 1.904 ± 0.302
5.163SerLeu: 5.163 ± 0.437
2.481SerMet: 2.481 ± 0.263
2.163SerAsn: 2.163 ± 0.225
3.346SerPro: 3.346 ± 0.437
1.904SerGln: 1.904 ± 0.184
3.317SerArg: 3.317 ± 0.261
4.529SerSer: 4.529 ± 0.599
3.894SerThr: 3.894 ± 0.367
5.25SerVal: 5.25 ± 0.373
0.548SerTrp: 0.548 ± 0.114
1.904SerTyr: 1.904 ± 0.251
0.0SerXaa: 0.0 ± 0.0
Thr
6.778ThrAla: 6.778 ± 0.531
2.134ThrCys: 2.134 ± 0.258
3.779ThrAsp: 3.779 ± 0.393
2.798ThrGlu: 2.798 ± 0.315
2.192ThrPhe: 2.192 ± 0.234
5.307ThrGly: 5.307 ± 0.646
2.913ThrHis: 2.913 ± 0.301
2.625ThrIle: 2.625 ± 0.264
2.221ThrLys: 2.221 ± 0.245
6.576ThrLeu: 6.576 ± 0.498
3.086ThrMet: 3.086 ± 0.271
1.846ThrAsn: 1.846 ± 0.268
4.73ThrPro: 4.73 ± 0.34
2.711ThrGln: 2.711 ± 0.324
4.038ThrArg: 4.038 ± 0.627
4.038ThrSer: 4.038 ± 0.422
5.336ThrThr: 5.336 ± 0.844
6.692ThrVal: 6.692 ± 0.471
0.981ThrTrp: 0.981 ± 0.15
2.394ThrTyr: 2.394 ± 0.282
0.0ThrXaa: 0.0 ± 0.0
Val
7.961ValAla: 7.961 ± 0.522
2.769ValCys: 2.769 ± 0.37
5.019ValAsp: 5.019 ± 0.406
2.25ValGlu: 2.25 ± 0.243
2.971ValPhe: 2.971 ± 0.311
4.298ValGly: 4.298 ± 0.342
3.952ValHis: 3.952 ± 0.407
3.346ValIle: 3.346 ± 0.289
2.452ValLys: 2.452 ± 0.293
7.73ValLeu: 7.73 ± 0.544
2.884ValMet: 2.884 ± 0.291
2.596ValAsn: 2.596 ± 0.356
5.307ValPro: 5.307 ± 0.427
3.231ValGln: 3.231 ± 0.328
5.452ValArg: 5.452 ± 0.434
5.25ValSer: 5.25 ± 0.42
6.259ValThr: 6.259 ± 0.505
6.288ValVal: 6.288 ± 0.514
0.894ValTrp: 0.894 ± 0.15
3.807ValTyr: 3.807 ± 0.424
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.153
0.577TrpCys: 0.577 ± 0.112
0.519TrpAsp: 0.519 ± 0.124
0.317TrpGlu: 0.317 ± 0.098
0.404TrpPhe: 0.404 ± 0.124
0.606TrpGly: 0.606 ± 0.156
0.462TrpHis: 0.462 ± 0.11
0.462TrpIle: 0.462 ± 0.108
0.404TrpLys: 0.404 ± 0.106
1.183TrpLeu: 1.183 ± 0.187
0.288TrpMet: 0.288 ± 0.093
0.49TrpAsn: 0.49 ± 0.111
0.808TrpPro: 0.808 ± 0.161
0.894TrpGln: 0.894 ± 0.142
0.808TrpArg: 0.808 ± 0.154
0.548TrpSer: 0.548 ± 0.118
0.779TrpThr: 0.779 ± 0.163
0.635TrpVal: 0.635 ± 0.14
0.173TrpTrp: 0.173 ± 0.085
0.433TrpTyr: 0.433 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.404TyrAla: 3.404 ± 0.273
0.981TyrCys: 0.981 ± 0.144
2.769TyrAsp: 2.769 ± 0.24
1.471TyrGlu: 1.471 ± 0.196
1.211TyrPhe: 1.211 ± 0.219
2.192TyrGly: 2.192 ± 0.24
0.721TyrHis: 0.721 ± 0.131
2.221TyrIle: 2.221 ± 0.255
1.586TyrLys: 1.586 ± 0.2
2.106TyrLeu: 2.106 ± 0.214
1.846TyrMet: 1.846 ± 0.253
2.221TyrAsn: 2.221 ± 0.208
0.981TyrPro: 0.981 ± 0.159
0.952TyrGln: 0.952 ± 0.161
2.163TyrArg: 2.163 ± 0.263
2.077TyrSer: 2.077 ± 0.212
3.634TyrThr: 3.634 ± 0.258
3.836TyrVal: 3.836 ± 0.324
0.375TyrTrp: 0.375 ± 0.106
1.327TyrTyr: 1.327 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 125 proteins (34670 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski